CN102822197A - 具有降低的免疫原性的bmp-7变体 - Google Patents

具有降低的免疫原性的bmp-7变体 Download PDF

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Publication number
CN102822197A
CN102822197A CN2010800643966A CN201080064396A CN102822197A CN 102822197 A CN102822197 A CN 102822197A CN 2010800643966 A CN2010800643966 A CN 2010800643966A CN 201080064396 A CN201080064396 A CN 201080064396A CN 102822197 A CN102822197 A CN 102822197A
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CN
China
Prior art keywords
bmp
variant
variants
cell
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800643966A
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English (en)
Chinese (zh)
Inventor
M·E·帕特森
M·H·阿拉维-伊斯玛仪
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Stryker Corp
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Stryker Corp
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Application filed by Stryker Corp filed Critical Stryker Corp
Publication of CN102822197A publication Critical patent/CN102822197A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2010800643966A 2009-12-22 2010-12-21 具有降低的免疫原性的bmp-7变体 Pending CN102822197A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28922009P 2009-12-22 2009-12-22
US61/289,220 2009-12-22
PCT/US2010/061437 WO2011087768A1 (en) 2009-12-22 2010-12-21 Bmp-7 variants with reduced immunogenicity

Publications (1)

Publication Number Publication Date
CN102822197A true CN102822197A (zh) 2012-12-12

Family

ID=43735952

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800643966A Pending CN102822197A (zh) 2009-12-22 2010-12-21 具有降低的免疫原性的bmp-7变体

Country Status (7)

Country Link
US (1) US20130190236A1 (enExample)
EP (1) EP2516456A1 (enExample)
JP (1) JP2013514811A (enExample)
CN (1) CN102822197A (enExample)
AU (1) AU2010341565A1 (enExample)
CA (1) CA2785038A1 (enExample)
WO (1) WO2011087768A1 (enExample)

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JP6851965B2 (ja) * 2014-09-26 2021-03-31 サハイ バートナガール ラジェンドラ 疾患及び障害の治療のためのｎｆカッパｂ活性の阻害剤
EP3240563B1 (en) 2014-12-29 2020-12-09 Bioventus LLC Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2019148140A2 (en) * 2018-01-26 2019-08-01 Wu Joseph C Implantable biomaterials that enhance stem cell survival and function

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WO2009086131A1 (en) * 2007-12-21 2009-07-09 Stryker Corporation Bmp mutants with decreased susceptibility to noggin

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WO2009086131A1 (en) * 2007-12-21 2009-07-09 Stryker Corporation Bmp mutants with decreased susceptibility to noggin

Also Published As

Publication number Publication date
EP2516456A1 (en) 2012-10-31
US20130190236A1 (en) 2013-07-25
JP2013514811A (ja) 2013-05-02
AU2010341565A1 (en) 2012-07-12
CA2785038A1 (en) 2011-07-21
WO2011087768A1 (en) 2011-07-21

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Application publication date: 20121212