CN102803467B - 生物样品纯化和富集的装置和方法 - Google Patents

生物样品纯化和富集的装置和方法 Download PDF

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Publication number
CN102803467B
CN102803467B CN201080058448.9A CN201080058448A CN102803467B CN 102803467 B CN102803467 B CN 102803467B CN 201080058448 A CN201080058448 A CN 201080058448A CN 102803467 B CN102803467 B CN 102803467B
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CN
China
Prior art keywords
liquid
sidepiece
strainer
sample
communicated
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CN201080058448.9A
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English (en)
Chinese (zh)
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CN102803467A (zh
Inventor
C·埃里克松
J·卡斯特罗
L·文马尔
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Soma Genomics Co
Original Assignee
Islet Medical
Liquid Biopsy AB
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/20—Vibrating the filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D37/00—Processes of filtration
    • B01D37/04—Controlling the filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201080058448.9A 2009-12-22 2010-12-22 生物样品纯化和富集的装置和方法 Active CN102803467B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0951009A SE0951009A1 (sv) 2009-12-22 2009-12-22 Anordning och förfarande för rening och anrikning av biologiskt prov
SE0951009-0 2009-12-22
PCT/SE2010/051473 WO2011078784A1 (en) 2009-12-22 2010-12-22 Device and method for biological sample purification and enrichment

Publications (2)

Publication Number Publication Date
CN102803467A CN102803467A (zh) 2012-11-28
CN102803467B true CN102803467B (zh) 2015-07-22

Family

ID=44196041

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080058448.9A Active CN102803467B (zh) 2009-12-22 2010-12-22 生物样品纯化和富集的装置和方法

Country Status (10)

Country Link
US (1) US20120270312A1 (https=)
EP (1) EP2516619B1 (https=)
JP (1) JP2013514806A (https=)
KR (1) KR20120121883A (https=)
CN (1) CN102803467B (https=)
BR (1) BR112012015643A2 (https=)
CA (1) CA2783007A1 (https=)
RU (1) RU2012122009A (https=)
SE (1) SE0951009A1 (https=)
WO (1) WO2011078784A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2902476B1 (en) * 2012-09-28 2021-01-06 Sysmex Corporation Sample preparation device and cell analysis device
GB2517063B (en) * 2013-06-19 2018-02-28 Brightwake Ltd Cell collection device
CN105062874A (zh) * 2015-07-16 2015-11-18 南京大学医学院附属鼓楼医院 一种基于闭合环路的循环肿瘤细胞分离富集装置
GB2543660B (en) * 2015-10-19 2018-04-25 Cytosystems Ltd Filtration apparatus comprising two movable ports moved from a first to second position thrugh rotation of the membrane housing
CN108126522B (zh) * 2017-12-21 2020-08-18 深圳汇芯生物医疗科技有限公司 分离芯片、分离装置及分离液体样本中目标颗粒的方法
CN108841713B (zh) * 2018-06-12 2020-10-20 深圳韦拓生物科技有限公司 理化处理单个细胞的微流控芯片、微流控装置及使用其理化处理单个细胞的方法
CN111044514A (zh) * 2019-11-27 2020-04-21 爱威科技股份有限公司 一种富集方法、样本制造方法以及样本检测方法
GB202016433D0 (en) * 2020-10-16 2020-12-02 Dnae Diagnostics Ltd Improvements in or relating to fluid sample preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030134416A1 (en) * 2001-10-11 2003-07-17 Douglas Yamanishi Methods, compositions, and automated systems for separating rare cells from fluid samples
WO2008107652A1 (en) * 2007-03-02 2008-09-12 Smith & Nephew Plc Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples

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SE430218B (sv) * 1981-12-30 1983-10-31 Blombaeck E G B Filter och sett att framstella ett sadant
US5189777A (en) * 1990-12-07 1993-03-02 Wisconsin Alumni Research Foundation Method of producing micromachined differential pressure transducers
GB9113150D0 (en) * 1991-06-18 1991-08-07 Endless Energy Ltd Backwash apparatus
FR2704432B1 (fr) * 1993-04-27 1995-06-23 Hospal Ind Dispositif d'injection de liquide dans un circuit extracorporel de sang.
JPH06327769A (ja) * 1993-05-21 1994-11-29 Terumo Corp 血漿処理装置
CA2278208C (en) * 1997-01-24 2011-09-20 Asahi Medical Co., Ltd. Cell separation method
JPH10234361A (ja) * 1997-02-24 1998-09-08 Asahi Medical Co Ltd 造血幹細胞分離・保存システム
US6693579B2 (en) * 2001-08-01 2004-02-17 Lexmark International, Inc. Method to improve sealing of ink jet printhead purge mechanism to printhead
US7651684B2 (en) * 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
JP4653952B2 (ja) * 2001-12-07 2011-03-16 サイトリ セラピューティクス インコーポレイテッド 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法
TW497494U (en) * 2001-12-28 2002-08-01 Metal Ind Redearch & Amp Dev C Fluid driven stirring device for compressing gas cleaning system
US6905594B2 (en) * 2002-10-11 2005-06-14 G6 Science Corp. Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
EP1683857B1 (en) * 2003-10-10 2011-02-16 Asahi Kasei Kuraray Medical Co., Ltd. Method of preparing cell concentrate and cell composition
US7494809B2 (en) 2004-11-09 2009-02-24 Visiongate, Inc. Automated cell sample enrichment preparation method
US7846393B2 (en) 2005-04-21 2010-12-07 California Institute Of Technology Membrane filter for capturing circulating tumor cells
GB0800311D0 (en) * 2008-01-09 2008-02-20 Cytosystems Ltd Apparatus and method for filtering biological material
JP5336109B2 (ja) 2008-05-30 2013-11-06 旭化成メディカル株式会社 単核細胞と血小板の濃縮方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030134416A1 (en) * 2001-10-11 2003-07-17 Douglas Yamanishi Methods, compositions, and automated systems for separating rare cells from fluid samples
WO2008107652A1 (en) * 2007-03-02 2008-09-12 Smith & Nephew Plc Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples

Also Published As

Publication number Publication date
KR20120121883A (ko) 2012-11-06
JP2013514806A (ja) 2013-05-02
CA2783007A1 (en) 2011-06-30
EP2516619B1 (en) 2017-01-25
EP2516619A1 (en) 2012-10-31
WO2011078784A1 (en) 2011-06-30
RU2012122009A (ru) 2014-01-27
EP2516619A4 (en) 2014-03-05
SE0951009A1 (sv) 2011-06-23
BR112012015643A2 (pt) 2017-05-09
US20120270312A1 (en) 2012-10-25
CN102803467A (zh) 2012-11-28

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Address after: Stockholm

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Address before: Scott: Sweden

Applicant before: Liquid Biopsy AB

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: LIQUID BIOPSY AB TO: ACELIGHT MEDICAL INC.

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Effective date of registration: 20241128

Address after: Schoendal, Sweden

Patentee after: Soma Genomics Co.

Country or region after: Sweden

Address before: Stockholm, Sweden

Patentee before: Islet Medical

Country or region before: Sweden