CN102802670A - 用于皮肤护理中的稳定化蛋白酶 - Google Patents

用于皮肤护理中的稳定化蛋白酶 Download PDF

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Publication number
CN102802670A
CN102802670A CN2011800144498A CN201180014449A CN102802670A CN 102802670 A CN102802670 A CN 102802670A CN 2011800144498 A CN2011800144498 A CN 2011800144498A CN 201180014449 A CN201180014449 A CN 201180014449A CN 102802670 A CN102802670 A CN 102802670A
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CN
China
Prior art keywords
protease
papain
stabilized
cross
dma
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Pending
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CN2011800144498A
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English (en)
Chinese (zh)
Inventor
M·恰范
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BASF Corp
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BASF Corp
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Publication date
Application filed by BASF Corp filed Critical BASF Corp
Priority to CN201610884610.1A priority Critical patent/CN106480008A/zh
Publication of CN102802670A publication Critical patent/CN102802670A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22002—Papain (3.4.22.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Birds (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2011800144498A 2010-01-19 2011-01-19 用于皮肤护理中的稳定化蛋白酶 Pending CN102802670A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610884610.1A CN106480008A (zh) 2010-01-19 2011-01-19 用于皮肤护理中的稳定化蛋白酶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29605210P 2010-01-19 2010-01-19
US61/296,052 2010-01-19
PCT/US2011/021773 WO2011091084A2 (en) 2010-01-19 2011-01-19 Stabilized proteases for use in skin care

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610884610.1A Division CN106480008A (zh) 2010-01-19 2011-01-19 用于皮肤护理中的稳定化蛋白酶

Publications (1)

Publication Number Publication Date
CN102802670A true CN102802670A (zh) 2012-11-28

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CN201610884610.1A Pending CN106480008A (zh) 2010-01-19 2011-01-19 用于皮肤护理中的稳定化蛋白酶
CN2011800144498A Pending CN102802670A (zh) 2010-01-19 2011-01-19 用于皮肤护理中的稳定化蛋白酶

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Country Status (7)

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US (1) US8778336B2 (enExample)
EP (1) EP2525828B1 (enExample)
JP (1) JP5848260B2 (enExample)
KR (1) KR101759755B1 (enExample)
CN (2) CN106480008A (enExample)
ES (1) ES2596402T3 (enExample)
WO (1) WO2011091084A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109248326A (zh) * 2018-11-09 2019-01-22 深圳先进技术研究院 一种骨靶向纳米粒递送系统及其制备方法
CN114867853A (zh) * 2019-10-09 2022-08-05 凤凰鹰股份有限公司 蛋白酶的蛋白水解活性的增强和稳定

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WO2013025986A2 (en) 2011-08-17 2013-02-21 Basf Corporation Marine based cosmetic active ingredients and use thereof
JP6162449B2 (ja) * 2012-03-28 2017-07-12 株式会社コーセー （カルボマー／パパイン）クロスポリマー含有組成物
JP5912759B2 (ja) * 2012-03-29 2016-04-27 株式会社コーセー （カルボマー／パパイン）クロスポリマー含有組成物
KR101936687B1 (ko) * 2012-04-06 2019-01-11 (주)아모레퍼시픽 파우더 타입 화장료 조성물
GB201305023D0 (en) 2013-03-19 2013-05-01 Biocant Associa O De Transfer Ncia De Tecnologia Aspartic proteases
JP6292602B2 (ja) * 2013-04-15 2018-03-14 学校法人神奈川大学 濡れ性低減又は増加に用いられる製剤及びその製造用原料、並びに濡れ性を低減又は増加させる方法
JP6182975B2 (ja) * 2013-05-21 2017-08-23 日油株式会社 ジェル状皮膚化粧料
CN105145717A (zh) * 2015-08-18 2015-12-16 凤台县永新工贸有限责任公司 一种高血脂人群食用的降脂面粉及其制备方法
CN105053811A (zh) * 2015-08-18 2015-11-18 凤台县龙泰面粉有限责任公司 一种咖喱味虾仁面粉及其制备方法
CN105165953A (zh) * 2015-08-18 2015-12-23 凤台县龙泰面粉有限责任公司 一种红曲米健胃消食面粉及其制备方法
CN105053809A (zh) * 2015-08-18 2015-11-18 凤台县永新工贸有限责任公司 一种香菇鸡肉味营养面粉及其制备方法
CN105077064A (zh) * 2015-08-18 2015-11-25 凤台县永新工贸有限责任公司 一种具有健脾益肾功效的蔬菜面粉及其制备方法
CN105053812A (zh) * 2015-08-18 2015-11-18 凤台县龙泰面粉有限责任公司 一种高蛋白含量木耳莲子补血面粉及其制备方法
CN105192017A (zh) * 2015-08-18 2015-12-30 凤台县龙泰面粉有限责任公司 一种蓝莓枸杞明目保健面粉及其制备方法
CN105166657A (zh) * 2015-09-30 2015-12-23 安徽省达亿粮油食品有限公司 一种补肾强筋保健面粉及其制备方法
CN105211696A (zh) * 2015-09-30 2016-01-06 安徽省达亿粮油食品有限公司 一种苦瓜杏仁营养面粉及其制备方法
CN105211695A (zh) * 2015-09-30 2016-01-06 安徽省达亿粮油食品有限公司 一种山慈菇木瓜益气生津保健面粉及其制备方法
CN105166658A (zh) * 2015-09-30 2015-12-23 安徽省达亿粮油食品有限公司 一种辣木籽健胃消食面粉及其制备方法
CN105166660A (zh) * 2015-09-30 2015-12-23 安徽省达亿粮油食品有限公司 一种益气健脾保健面粉及其制备方法
KR102376345B1 (ko) * 2016-01-31 2022-03-18 메디운드 리미티드 상처 치료용 괴사조직제거 조성물
WO2017183018A1 (en) * 2016-04-18 2017-10-26 Mediwound Ltd Methods of debridement of chronic wounds
US9763976B1 (en) 2016-08-02 2017-09-19 Zo Skin Health, Inc. Composition and method for treating skin conditions
BR112022006698A2 (pt) * 2019-10-09 2022-09-06 Phoenix Eagle Company Pty Ltd Aprimoramento e estabilização da atividade proteolítica das proteases
KR102792840B1 (ko) * 2019-10-25 2025-04-11 (주)아모레퍼시픽 프로테이스 보관용 조성물 및 프로테이스를 포함하는 화장 키트
CN116710081A (zh) * 2020-11-25 2023-09-05 塔普克斯制药公司 疤痕治疗组合物
EP4251196A4 (en) * 2020-11-25 2024-10-02 Topix Pharmaceuticals, Inc. Scar treatment composition
KR20230029260A (ko) * 2021-08-24 2023-03-03 (주)아모레퍼시픽 효소 손상을 방지하는 화장료 조성물 및 이를 저장하는 화장품 용기
KR102694602B1 (ko) * 2021-12-01 2024-08-13 주식회사 휴메디솔 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법
WO2023159123A1 (en) * 2022-02-16 2023-08-24 Guild Associates Inc. Immobilized enzyme-based wound debridement

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN109248326A (zh) * 2018-11-09 2019-01-22 深圳先进技术研究院 一种骨靶向纳米粒递送系统及其制备方法
CN114867853A (zh) * 2019-10-09 2022-08-05 凤凰鹰股份有限公司 蛋白酶的蛋白水解活性的增强和稳定

Also Published As

Publication number Publication date
JP2013517328A (ja) 2013-05-16
WO2011091084A2 (en) 2011-07-28
ES2596402T3 (es) 2017-01-09
EP2525828A2 (en) 2012-11-28
EP2525828A4 (en) 2013-07-31
WO2011091084A3 (en) 2011-12-29
KR101759755B1 (ko) 2017-07-19
KR20120118040A (ko) 2012-10-25
CN106480008A (zh) 2017-03-08
US20110177052A1 (en) 2011-07-21
EP2525828B1 (en) 2016-07-06
JP5848260B2 (ja) 2016-01-27
US8778336B2 (en) 2014-07-15

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Application publication date: 20121128