CN102802657A - 用于治疗2型糖尿病的glp-1和fgf21组合 - Google Patents
用于治疗2型糖尿病的glp-1和fgf21组合 Download PDFInfo
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- CN102802657A CN102802657A CN201080026383XA CN201080026383A CN102802657A CN 102802657 A CN102802657 A CN 102802657A CN 201080026383X A CN201080026383X A CN 201080026383XA CN 201080026383 A CN201080026383 A CN 201080026383A CN 102802657 A CN102802657 A CN 102802657A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
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- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
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| EP09162521.0 | 2009-06-11 | ||
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| US18647109P | 2009-06-12 | 2009-06-12 | |
| US61/186471 | 2009-06-12 | ||
| PCT/EP2010/057986 WO2010142665A1 (en) | 2009-06-11 | 2010-06-08 | Glp-1 and fgf21 combinations for treatment of diabetes type 2 |
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| EP (1) | EP2440235A1 (enExample) |
| JP (1) | JP2012529463A (enExample) |
| CN (1) | CN102802657A (enExample) |
| WO (1) | WO2010142665A1 (enExample) |
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| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
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2010
- 2010-06-08 US US13/375,360 patent/US20120172298A1/en not_active Abandoned
- 2010-06-08 CN CN201080026383XA patent/CN102802657A/zh active Pending
- 2010-06-08 EP EP10724816A patent/EP2440235A1/en not_active Withdrawn
- 2010-06-08 WO PCT/EP2010/057986 patent/WO2010142665A1/en not_active Ceased
- 2010-06-08 JP JP2012514442A patent/JP2012529463A/ja not_active Withdrawn
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- 2011-06-06 US US13/702,122 patent/US20130252884A1/en not_active Abandoned
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Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103124562A (zh) * | 2010-06-08 | 2013-05-29 | 诺沃—诺迪斯克有限公司 | Fgf21的类似物和衍生物 |
| CN106414486A (zh) * | 2014-04-07 | 2017-02-15 | 赛诺菲 | 作为肽性双重glp‑1/胰高血糖素受体激动剂的毒蜥外泌肽‑4衍生物 |
| CN106414486B (zh) * | 2014-04-07 | 2021-03-09 | 赛诺菲 | 作为肽性双重glp-1/胰高血糖素受体激动剂的毒蜥外泌肽-4衍生物 |
| CN108350054A (zh) * | 2015-10-28 | 2018-07-31 | 株式会社柳韩洋行 | 双功能蛋白质和包含其的药物组合物 |
| CN108350054B (zh) * | 2015-10-28 | 2022-09-02 | 株式会社柳韩洋行 | 双功能蛋白质和包含其的药物组合物 |
| US11472863B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof |
| US11471513B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Highly glycosylated human blood-clotting factor VIII fusion protein, and manufacturing method and application of same |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| US11833212B2 (en) | 2016-08-19 | 2023-12-05 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
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| CN109836504A (zh) * | 2017-11-24 | 2019-06-04 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的多结构域活性蛋白 |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2012529463A (ja) | 2012-11-22 |
| US20130252884A1 (en) | 2013-09-26 |
| US20120172298A1 (en) | 2012-07-05 |
| EP2440235A1 (en) | 2012-04-18 |
| WO2010142665A1 (en) | 2010-12-16 |
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