CN102791859A - 在缺血和缺血再灌注损伤中的微小rna调节 - Google Patents

在缺血和缺血再灌注损伤中的微小rna调节 Download PDF

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CN102791859A
CN102791859A CN2010800639335A CN201080063933A CN102791859A CN 102791859 A CN102791859 A CN 102791859A CN 2010800639335 A CN2010800639335 A CN 2010800639335A CN 201080063933 A CN201080063933 A CN 201080063933A CN 102791859 A CN102791859 A CN 102791859A
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mir
mirnas
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ischemia
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E.N.奥尔森
E.V.鲁伊杰
D.奎亚特
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University of Texas System
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800639335A 2009-12-15 2010-12-15 在缺血和缺血再灌注损伤中的微小rna调节 Pending CN102791859A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28662209P 2009-12-15 2009-12-15
US61/286,622 2009-12-15
PCT/US2010/060460 WO2011084460A1 (en) 2009-12-15 2010-12-15 Micro-rna regulation in ischemia and ischemia-reperfusion injury

Publications (1)

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CN102791859A true CN102791859A (zh) 2012-11-21

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CN2010800639335A Pending CN102791859A (zh) 2009-12-15 2010-12-15 在缺血和缺血再灌注损伤中的微小rna调节

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US (1) US20130005658A1 (enExample)
EP (1) EP2513307A4 (enExample)
JP (1) JP2013514372A (enExample)
CN (1) CN102791859A (enExample)
AU (1) AU2010340062A1 (enExample)
CA (1) CA2784118A1 (enExample)
RU (1) RU2012129900A (enExample)
WO (1) WO2011084460A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103814131A (zh) * 2011-05-09 2014-05-21 格拉斯哥大学理事会 在肺动脉高血压的治疗中调控microrna的方法
CN105251014A (zh) * 2015-08-17 2016-01-20 南昌大学 Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用
CN105695612A (zh) * 2016-04-19 2016-06-22 中南大学 microRNA-126-5p在心肌损伤中的表达检测方法
CN106692175A (zh) * 2016-12-26 2017-05-24 大连医科大学附属第二医院 miR‑665‑3p抑制物在制备防治缺血再灌注损伤药物中的应用
CN110205374A (zh) * 2019-06-17 2019-09-06 昆山德诺瑞尔生物科技有限公司 检测血小板中miR-34a基因表达量的引物、试剂盒、检测方法及其应用
CN110257508A (zh) * 2019-07-12 2019-09-20 宁夏医科大学 一种在衰老心肌缺血后处理缺血再灌注损伤治疗用miRNA标志物及其应用

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ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9322015B2 (en) 2011-03-09 2016-04-26 The Brigham And Women's Hospital, Inc. Methods of using microRNA-26a to promote angiogenesis
US8871731B2 (en) 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
EP2584040A1 (en) 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Compounds for treatment of ischemic injury
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN102965429B (zh) * 2012-03-15 2015-03-04 汪道文 microRNA-320(miR-320a)及其反义核苷酸在诊断、防治心血管疾病中的用途
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
JP6433896B2 (ja) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
WO2014028762A1 (en) * 2012-08-15 2014-02-20 University Of Virginia Patent Foundation Compositions and methods for treating peripheral arterial disease
US20160076026A1 (en) * 2013-03-15 2016-03-17 The Hospital For Sick Children Diagnostic and therapeutic methods relating to microrna-144
KR101668518B1 (ko) * 2014-05-23 2016-10-24 강원대학교산학협력단 혈관신생을 촉진하는 마이크로rna-101
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
WO2016113702A1 (en) * 2015-01-16 2016-07-21 Bioup Sagl Isolated genetically modified cell population
US10119139B2 (en) 2015-09-14 2018-11-06 Vanderbilt University Treatment for conditions associated with fibrosis and collagen deposition
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
CN108245687A (zh) * 2016-12-29 2018-07-06 贾中芝 一种IpostC在抗肠再灌注损伤中所起作用的实验方法
EP3601567A1 (en) 2017-03-29 2020-02-05 Children's Hospital Medical Center Nucleic acid molecules and their methods of use
CA3059910A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
US11591597B2 (en) * 2018-04-20 2023-02-28 Texas Tech University System MicroRNAs as therapeutic targets for ischemic stroke

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WO2009012468A2 (en) * 2007-07-18 2009-01-22 The Regents Of The University Colorado Differential expression of micrornas in nonfailing versus failing human hearts
WO2009018493A1 (en) * 2007-07-31 2009-02-05 The Board Of Regents Of The University Of Texas System A micro-rna family that modulates fibrosis and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
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US20110160285A1 (en) * 2008-03-13 2011-06-30 The Regents Of The University Of Colorado Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy

Patent Citations (2)

* Cited by examiner, † Cited by third party
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WO2009012468A2 (en) * 2007-07-18 2009-01-22 The Regents Of The University Colorado Differential expression of micrornas in nonfailing versus failing human hearts
WO2009018493A1 (en) * 2007-07-31 2009-02-05 The Board Of Regents Of The University Of Texas System A micro-rna family that modulates fibrosis and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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KIM等: "Ischemic Preconditioning Augments Survival of Stem Cells via miR-210 Expression by Targeting Caspase-8-associated Protein 2", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *
REN等: "MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20", 《CIRCULATION》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103814131A (zh) * 2011-05-09 2014-05-21 格拉斯哥大学理事会 在肺动脉高血压的治疗中调控microrna的方法
CN105251014A (zh) * 2015-08-17 2016-01-20 南昌大学 Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用
CN105251014B (zh) * 2015-08-17 2018-10-19 南昌大学 Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用
CN105695612A (zh) * 2016-04-19 2016-06-22 中南大学 microRNA-126-5p在心肌损伤中的表达检测方法
CN106692175A (zh) * 2016-12-26 2017-05-24 大连医科大学附属第二医院 miR‑665‑3p抑制物在制备防治缺血再灌注损伤药物中的应用
CN110205374A (zh) * 2019-06-17 2019-09-06 昆山德诺瑞尔生物科技有限公司 检测血小板中miR-34a基因表达量的引物、试剂盒、检测方法及其应用
CN110257508A (zh) * 2019-07-12 2019-09-20 宁夏医科大学 一种在衰老心肌缺血后处理缺血再灌注损伤治疗用miRNA标志物及其应用

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US20130005658A1 (en) 2013-01-03
JP2013514372A (ja) 2013-04-25
EP2513307A1 (en) 2012-10-24
WO2011084460A1 (en) 2011-07-14
AU2010340062A1 (en) 2012-07-12
CA2784118A1 (en) 2011-07-14
RU2012129900A (ru) 2014-01-27
EP2513307A4 (en) 2014-02-26

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Application publication date: 20121121