AU2010340062A1 - Micro-RNA regulation in ischemia and ischemia-reperfusion injury - Google Patents

Micro-RNA regulation in ischemia and ischemia-reperfusion injury Download PDF

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Publication number
AU2010340062A1
AU2010340062A1 AU2010340062A AU2010340062A AU2010340062A1 AU 2010340062 A1 AU2010340062 A1 AU 2010340062A1 AU 2010340062 A AU2010340062 A AU 2010340062A AU 2010340062 A AU2010340062 A AU 2010340062A AU 2010340062 A1 AU2010340062 A1 AU 2010340062A1
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AU
Australia
Prior art keywords
mir
mirnas
mmu
subject
agonist
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Abandoned
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AU2010340062A
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English (en)
Inventor
Eric N. Olson
Daniel Quiat
Eva Van Rooij
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University of Texas System
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University of Texas System
University of Texas at Austin
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Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of AU2010340062A1 publication Critical patent/AU2010340062A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2010340062A 2009-12-15 2010-12-15 Micro-RNA regulation in ischemia and ischemia-reperfusion injury Abandoned AU2010340062A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28662209P 2009-12-15 2009-12-15
US61/286,622 2009-12-15
PCT/US2010/060460 WO2011084460A1 (en) 2009-12-15 2010-12-15 Micro-rna regulation in ischemia and ischemia-reperfusion injury

Publications (1)

Publication Number Publication Date
AU2010340062A1 true AU2010340062A1 (en) 2012-07-12

Family

ID=44305697

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010340062A Abandoned AU2010340062A1 (en) 2009-12-15 2010-12-15 Micro-RNA regulation in ischemia and ischemia-reperfusion injury

Country Status (8)

Country Link
US (1) US20130005658A1 (enExample)
EP (1) EP2513307A4 (enExample)
JP (1) JP2013514372A (enExample)
CN (1) CN102791859A (enExample)
AU (1) AU2010340062A1 (enExample)
CA (1) CA2784118A1 (enExample)
RU (1) RU2012129900A (enExample)
WO (1) WO2011084460A1 (enExample)

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* Cited by examiner, † Cited by third party
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ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
EP2683411B1 (en) * 2011-03-09 2016-01-13 The Brigham and Women's Hospital, Inc. Methods of using microrna-26a to promote angiogenesis
US8871731B2 (en) * 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
AU2012252165A1 (en) * 2011-05-09 2013-03-21 Cambridge Enterprise Limited Methods of modulating micrornas in the treatment of pulmonary arterial hypertension
EP2584040A1 (en) 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Compounds for treatment of ischemic injury
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN102965429B (zh) * 2012-03-15 2015-03-04 汪道文 microRNA-320(miR-320a)及其反义核苷酸在诊断、防治心血管疾病中的用途
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
WO2014028493A2 (en) 2012-08-13 2014-02-20 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US9845465B2 (en) 2012-08-15 2017-12-19 University Of Virginia Patent Foundation Compositions and methods for treating peripheral arterial disease
CA2907025A1 (en) * 2013-03-15 2014-09-18 The Hospital For Sick Children Diagnostic and therapeutic methods relating to microrna-144
KR101668518B1 (ko) * 2014-05-23 2016-10-24 강원대학교산학협력단 혈관신생을 촉진하는 마이크로rna-101
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
WO2016113702A1 (en) * 2015-01-16 2016-07-21 Bioup Sagl Isolated genetically modified cell population
CN105251014B (zh) * 2015-08-17 2018-10-19 南昌大学 Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用
US10119139B2 (en) 2015-09-14 2018-11-06 Vanderbilt University Treatment for conditions associated with fibrosis and collagen deposition
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
CN105695612A (zh) * 2016-04-19 2016-06-22 中南大学 microRNA-126-5p在心肌损伤中的表达检测方法
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
CN106692175A (zh) * 2016-12-26 2017-05-24 大连医科大学附属第二医院 miR‑665‑3p抑制物在制备防治缺血再灌注损伤药物中的应用
CN108245687A (zh) * 2016-12-29 2018-07-06 贾中芝 一种IpostC在抗肠再灌注损伤中所起作用的实验方法
US11845935B2 (en) 2017-03-29 2023-12-19 Children's Hospital Medical Center Regulation of MIR-143 using nucleic acid molecules
WO2018195210A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
US11591597B2 (en) * 2018-04-20 2023-02-28 Texas Tech University System MicroRNAs as therapeutic targets for ischemic stroke
CN110205374A (zh) * 2019-06-17 2019-09-06 昆山德诺瑞尔生物科技有限公司 检测血小板中miR-34a基因表达量的引物、试剂盒、检测方法及其应用
CN110257508A (zh) * 2019-07-12 2019-09-20 宁夏医科大学 一种在衰老心肌缺血后处理缺血再灌注损伤治疗用miRNA标志物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008275877B2 (en) * 2007-07-18 2015-01-22 The Regents Of The University Of Colorado, A Body Corporate Differential expression of microRNAs in nonfailing versus failing human hearts
ES2621161T3 (es) * 2007-07-31 2017-07-03 The Board Of Regents Of The University Of Texas System Familia de micro-ARN que modula la fibrosis y usos de la misma
US20110160285A1 (en) * 2008-03-13 2011-06-30 The Regents Of The University Of Colorado Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy

Also Published As

Publication number Publication date
CA2784118A1 (en) 2011-07-14
WO2011084460A1 (en) 2011-07-14
EP2513307A1 (en) 2012-10-24
RU2012129900A (ru) 2014-01-27
JP2013514372A (ja) 2013-04-25
CN102791859A (zh) 2012-11-21
US20130005658A1 (en) 2013-01-03
EP2513307A4 (en) 2014-02-26

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application