JP2013514372A - 虚血および虚血−再灌流傷害におけるマイクロｒｎａ調節 - Google Patents

虚血および虚血−再灌流傷害におけるマイクロｒｎａ調節 Download PDF

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JP2013514372A
JP2013514372A JP2012544748A JP2012544748A JP2013514372A JP 2013514372 A JP2013514372 A JP 2013514372A JP 2012544748 A JP2012544748 A JP 2012544748A JP 2012544748 A JP2012544748 A JP 2012544748A JP 2013514372 A JP2013514372 A JP 2013514372A
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mirna
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mirnas
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JP2013514372A5 (enExample
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エヌ． オルソン，エリック
ヴァン ルーイジ，エヴァ
キアット，ダニエル
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012544748A 2009-12-15 2010-12-15 虚血および虚血−再灌流傷害におけるマイクロｒｎａ調節 Pending JP2013514372A (ja)

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US28662209P 2009-12-15 2009-12-15
US61/286,622 2009-12-15
PCT/US2010/060460 WO2011084460A1 (en) 2009-12-15 2010-12-15 Micro-rna regulation in ischemia and ischemia-reperfusion injury

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JP2013514372A true JP2013514372A (ja) 2013-04-25
JP2013514372A5 JP2013514372A5 (enExample) 2014-02-06

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US (1) US20130005658A1 (enExample)
EP (1) EP2513307A4 (enExample)
JP (1) JP2013514372A (enExample)
CN (1) CN102791859A (enExample)
AU (1) AU2010340062A1 (enExample)
CA (1) CA2784118A1 (enExample)
RU (1) RU2012129900A (enExample)
WO (1) WO2011084460A1 (enExample)

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KR20150135657A (ko) * 2014-05-23 2015-12-03 강원대학교산학협력단 혈관신생을 촉진하는 마이크로rna-101

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ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
WO2012122447A1 (en) 2011-03-09 2012-09-13 The Brigham And Women's Hospital, Inc. Methods of using microrna-26a to promote angiogenesis
US8871731B2 (en) 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
CN103814131A (zh) * 2011-05-09 2014-05-21 格拉斯哥大学理事会 在肺动脉高血压的治疗中调控microrna的方法
EP2584040A1 (en) 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Compounds for treatment of ischemic injury
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN102965429B (zh) * 2012-03-15 2015-03-04 汪道文 microRNA-320(miR-320a)及其反义核苷酸在诊断、防治心血管疾病中的用途
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
US9828603B2 (en) 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US9845465B2 (en) 2012-08-15 2017-12-19 University Of Virginia Patent Foundation Compositions and methods for treating peripheral arterial disease
CA2907025A1 (en) * 2013-03-15 2014-09-18 The Hospital For Sick Children Diagnostic and therapeutic methods relating to microrna-144
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016113702A1 (en) * 2015-01-16 2016-07-21 Bioup Sagl Isolated genetically modified cell population
CN105251014B (zh) * 2015-08-17 2018-10-19 南昌大学 Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用
US10119139B2 (en) 2015-09-14 2018-11-06 Vanderbilt University Treatment for conditions associated with fibrosis and collagen deposition
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
CN105695612A (zh) * 2016-04-19 2016-06-22 中南大学 microRNA-126-5p在心肌损伤中的表达检测方法
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
CN106692175A (zh) * 2016-12-26 2017-05-24 大连医科大学附属第二医院 miR‑665‑3p抑制物在制备防治缺血再灌注损伤药物中的应用
CN108245687A (zh) * 2016-12-29 2018-07-06 贾中芝 一种IpostC在抗肠再灌注损伤中所起作用的实验方法
EP3601567A1 (en) 2017-03-29 2020-02-05 Children's Hospital Medical Center Nucleic acid molecules and their methods of use
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
US11591597B2 (en) * 2018-04-20 2023-02-28 Texas Tech University System MicroRNAs as therapeutic targets for ischemic stroke
CN110205374A (zh) * 2019-06-17 2019-09-06 昆山德诺瑞尔生物科技有限公司 检测血小板中miR-34a基因表达量的引物、试剂盒、检测方法及其应用
CN110257508A (zh) * 2019-07-12 2019-09-20 宁夏医科大学 一种在衰老心肌缺血后处理缺血再灌注损伤治疗用miRNA标志物及其应用

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KR20100049079A (ko) * 2007-07-18 2010-05-11 더 리젠트스 오브 더 유니버시티 오브 콜로라도 인간의 정상 심장과 기능부진 심장에서 마이크로 ｒｎａ의 차등 발현
ES2621161T3 (es) * 2007-07-31 2017-07-03 The Board Of Regents Of The University Of Texas System Familia de micro-ARN que modula la fibrosis y usos de la misma
US20110160285A1 (en) * 2008-03-13 2011-06-30 The Regents Of The University Of Colorado Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy

Non-Patent Citations (9)

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JPN6014050639; Ｐｈｙｓｉｏｌ　Ｇｅｎｏｍｉｃｓ．，　Ｖｏｌ．３１　ｐ．３６７-３７３　（２００７） *
JPN6014050642; Ｐｈａｒｍａｃｏｌ　Ｔｈｅｒ．，　Ｖｏｌ．１２５　Ｎｏ．１　ｐ．９２-１０４　（Ｅｐｕｂ　２００９　Ｎｏｖ　６） *
JPN6014050646; Ｓｃｉｅｎｃｅ，　Ｖｏｌ．３２４　Ｎｏ．５９３５　ｐ．１７１０-１７１３　（２００９．０６．２６） *
JPN6014050649; Ｊ　Ｂｉｏｌ　Ｃｈｅｍ．，　Ｖｏｌ．２８４　Ｎｏ．４８　ｐ．３３１６１-３３１６８　（２００９．１１．２７） *
JPN6014050652; Ｂｉｏｃｈｅｍ　Ｂｉｏｐｈｙｓ　Ｒｅｓ　Ｃｏｍｍｕｎ．，　Ｖｏｌ．３８１　Ｎｏ．４　ｐ．５９７-６０１　（２００９．０４．１７） *
JPN6014050656; Ｊ　Ｂｉｏｌ　Ｃｈｅｍ．，　Ｖｏｌ．２８４　Ｎｏ．４３　ｐ．２９５１４-２９５２５　（２００９．１０．２３） *
JPN6014050659; ＩＵＢＭＢ　Ｌｉｆｅ，　Ｖｏｌ．６１　Ｎｏ．６　ｐ．５６６-５７１　（２００９．０６） *
JPN6014050661; ＦＥＢＳ　Ｌｅｔｔ．，　Ｖｏｌ．５８２　Ｎｏ．１６　ｐ．２３９７-２４０１　（２００８） *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150135657A (ko) * 2014-05-23 2015-12-03 강원대학교산학협력단 혈관신생을 촉진하는 마이크로rna-101
KR101668518B1 (ko) 2014-05-23 2016-10-24 강원대학교산학협력단 혈관신생을 촉진하는 마이크로rna-101

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RU2012129900A (ru) 2014-01-27
CN102791859A (zh) 2012-11-21
CA2784118A1 (en) 2011-07-14
AU2010340062A1 (en) 2012-07-12
WO2011084460A1 (en) 2011-07-14
US20130005658A1 (en) 2013-01-03
EP2513307A1 (en) 2012-10-24
EP2513307A4 (en) 2014-02-26

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