CN102782128A - β-氨基酸的制备 - Google Patents

β-氨基酸的制备 Download PDF

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Publication number
CN102782128A
CN102782128A CN2010800513638A CN201080051363A CN102782128A CN 102782128 A CN102782128 A CN 102782128A CN 2010800513638 A CN2010800513638 A CN 2010800513638A CN 201080051363 A CN201080051363 A CN 201080051363A CN 102782128 A CN102782128 A CN 102782128A
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CN
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Prior art keywords
hydantoinase
enzyme
reaction
optionally substituted
amino acid
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Pending
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CN2010800513638A
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Chinese (zh)
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N·施耐德
B·豪尔
K·迪特里希
M·奥尼尔
N·特纳
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BASF SE
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BASF SE
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01087—N-Carbamoyl-L-amino-acid hydrolase (3.5.1.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02014—N-Methylhydantoinase (ATP-hydrolyzing) (3.5.2.14)

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  • General Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2010800513638A 2009-09-15 2010-09-15 β-氨基酸的制备 Pending CN102782128A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09170364.5 2009-09-15
EP09170364 2009-09-15
US24530309P 2009-09-24 2009-09-24
US61/245,303 2009-09-24
PCT/EP2010/063558 WO2011032990A1 (en) 2009-09-15 2010-09-15 Preparation of beta-amino acids

Publications (1)

Publication Number Publication Date
CN102782128A true CN102782128A (zh) 2012-11-14

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CN2010800513638A Pending CN102782128A (zh) 2009-09-15 2010-09-15 β-氨基酸的制备

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US (1) US9096841B2 (enExample)
EP (1) EP2478098B1 (enExample)
JP (1) JP5919192B2 (enExample)
CN (1) CN102782128A (enExample)
ES (1) ES2628225T3 (enExample)
WO (1) WO2011032990A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106191147A (zh) * 2016-07-08 2016-12-07 凯莱英医药集团（天津）股份有限公司 手性β‑氨基酸的制备方法
CN106831606A (zh) * 2017-01-20 2017-06-13 湖南有色郴州氟化学有限公司 一种5‑三氟甲基‑5,6‑二氢尿嘧啶的制备方法
CN109896980A (zh) * 2017-12-07 2019-06-18 浙江九洲药业股份有限公司 一种西格列汀中间体的生物合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010139651A2 (en) 2009-06-04 2010-12-09 Basf Se A process for the enzymatic reduction of enoates
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
CN119955872B (zh) * 2025-04-11 2025-08-12 中国科学院微生物研究所 R-(-)-3-(氨甲酰甲基)-5-甲基己酸合成蛋白及其突变体与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06261787A (ja) * 1993-03-10 1994-09-20 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸の製造法
CN1458276A (zh) * 2002-05-13 2003-11-26 中国人民解放军军事医学科学院生物工程研究所 一种乙内酰脲酶系及其编码基因与生产菌
CN1908159A (zh) * 2005-02-07 2007-02-07 中国科学院上海生命科学研究院 D－氨基酸生产菌株及其构建方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
DE10019377A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen
EP2065470A1 (en) 2007-11-28 2009-06-03 Basf Se New malonate decarboxylases for industrial applications
JP5992142B2 (ja) 2007-12-10 2016-09-14 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ エノエートレダクターゼを用いるα−およびβ−デヒドロアミノ酸の酵素的還元法
US8344182B2 (en) 2007-12-20 2013-01-01 Basf Se Process for the preparation of (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine
EP2145904A1 (de) 2008-07-18 2010-01-20 Basf Se Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen
WO2010079068A1 (de) 2008-12-17 2010-07-15 Basf Se Verbesserte biokatalysatoren zur herstellung von duloxetinalkohol
DK2387556T3 (da) 2009-01-16 2014-11-03 Basf Se Separation af en enantiomerblanding af (r)- og (s)-3-amino-1-butanol
DE102009003035A1 (de) 2009-05-12 2010-11-18 Basf Se Verfahren zur Herstellung von urethangruppenhaltigen (Meth)acrylsäureestern
WO2010139651A2 (en) 2009-06-04 2010-12-09 Basf Se A process for the enzymatic reduction of enoates
US8759043B2 (en) 2009-06-05 2014-06-24 Basf Se Biocatalytic production of ambroxan
WO2011012632A2 (en) 2009-07-30 2011-02-03 Basf Se Biocatalyst for catalytic hydroamination

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06261787A (ja) * 1993-03-10 1994-09-20 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸の製造法
CN1458276A (zh) * 2002-05-13 2003-11-26 中国人民解放军军事医学科学院生物工程研究所 一种乙内酰脲酶系及其编码基因与生产菌
CN1908159A (zh) * 2005-02-07 2007-02-07 中国科学院上海生命科学研究院 D－氨基酸生产菌株及其构建方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARCURI M B ET AL.: "Stability of immobilized D-hydantoinase from Vigna angularis and repeated cycles of highly enantioenriched production of N-carbamoyl-D-phenylglycines", 《AMINO ACIDS (VIENNA)》, 31 August 2004 (2004-08-31), pages 69 - 74, XP002614142, DOI: doi:10.1007/s00726-004-0071-y *
BRETSCHNEIDER, U. ET AL.: "Synthese enantiomerenreiner beta-Aminosäuren mit Hilfe neuer cyclischer Amidasen", 《CHEMIE INGENIEUR TECHNIK》, vol. 81, no. 8, 19 August 2009 (2009-08-19), pages 1255 *
EBI ACCESSION NO. UNIPROT:A4Z0Y7 DATABASE ACCESSION NO. A4Z0Y7: "SubName: Full=D-hydantoinase (Dihydropyrimidinase) (DHPase); EC=3.5.2.2", 《DATABASE UNIPROT [ONLINE]》, 29 May 2007 (2007-05-29), pages 1 *
EBI ACCESSION NO. UNIPROT:B9SXX3 DATABASE ACCESSION NO. B9SXX3: "SubName: Full=Dihydropyrimidinase, putative; EC=3.5.2.2", 《DATABASE UNIPROT [ONLINE]》, 24 March 2007 (2007-03-24), pages 1 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106191147A (zh) * 2016-07-08 2016-12-07 凯莱英医药集团（天津）股份有限公司 手性β‑氨基酸的制备方法
CN106831606A (zh) * 2017-01-20 2017-06-13 湖南有色郴州氟化学有限公司 一种5‑三氟甲基‑5,6‑二氢尿嘧啶的制备方法
CN106831606B (zh) * 2017-01-20 2019-02-22 湖南有色郴州氟化学有限公司 一种5-三氟甲基-5,6-二氢尿嘧啶的制备方法
CN109896980A (zh) * 2017-12-07 2019-06-18 浙江九洲药业股份有限公司 一种西格列汀中间体的生物合成方法
CN109896980B (zh) * 2017-12-07 2022-04-08 浙江九洲药业股份有限公司 一种西格列汀中间体的生物合成方法

Also Published As

Publication number Publication date
US20120270280A1 (en) 2012-10-25
JP5919192B2 (ja) 2016-05-18
WO2011032990A1 (en) 2011-03-24
US9096841B2 (en) 2015-08-04
ES2628225T3 (es) 2017-08-02
JP2013504313A (ja) 2013-02-07
EP2478098A1 (en) 2012-07-25
EP2478098B1 (en) 2017-03-15

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Application publication date: 20121114