JP5919192B2 - βアミノ酸の調製 - Google Patents

βアミノ酸の調製 Download PDF

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Publication number
JP5919192B2
JP5919192B2 JP2012528394A JP2012528394A JP5919192B2 JP 5919192 B2 JP5919192 B2 JP 5919192B2 JP 2012528394 A JP2012528394 A JP 2012528394A JP 2012528394 A JP2012528394 A JP 2012528394A JP 5919192 B2 JP5919192 B2 JP 5919192B2
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group
reaction
hydantoinase
enzyme
amino acid
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JP2012528394A
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Japanese (ja)
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JP2013504313A (ja
JP2013504313A5 (enExample
Inventor
シュナイダー，ニーナ
ハウアー，ベルンハルト
ディトリッヒ，クラウス
オニール，メーヴ
ターナー，ニック
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BASF SE
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BASF SE
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01087—N-Carbamoyl-L-amino-acid hydrolase (3.5.1.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02014—N-Methylhydantoinase (ATP-hydrolyzing) (3.5.2.14)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012528394A 2009-09-15 2010-09-15 βアミノ酸の調製 Expired - Fee Related JP5919192B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09170364 2009-09-15
EP09170364.5 2009-09-15
US24530309P 2009-09-24 2009-09-24
US61/245,303 2009-09-24
PCT/EP2010/063558 WO2011032990A1 (en) 2009-09-15 2010-09-15 Preparation of beta-amino acids

Publications (3)

Publication Number Publication Date
JP2013504313A JP2013504313A (ja) 2013-02-07
JP2013504313A5 JP2013504313A5 (enExample) 2015-08-13
JP5919192B2 true JP5919192B2 (ja) 2016-05-18

Family

ID=43259766

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012528394A Expired - Fee Related JP5919192B2 (ja) 2009-09-15 2010-09-15 βアミノ酸の調製

Country Status (6)

Country Link
US (1) US9096841B2 (enExample)
EP (1) EP2478098B1 (enExample)
JP (1) JP5919192B2 (enExample)
CN (1) CN102782128A (enExample)
ES (1) ES2628225T3 (enExample)
WO (1) WO2011032990A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010139651A2 (en) 2009-06-04 2010-12-09 Basf Se A process for the enzymatic reduction of enoates
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
CN106191147B (zh) * 2016-07-08 2020-03-27 凯莱英医药集团（天津）股份有限公司 手性β-氨基酸的制备方法
CN106831606B (zh) * 2017-01-20 2019-02-22 湖南有色郴州氟化学有限公司 一种5-三氟甲基-5,6-二氢尿嘧啶的制备方法
CN109896980B (zh) * 2017-12-07 2022-04-08 浙江九洲药业股份有限公司 一种西格列汀中间体的生物合成方法
CN119955872B (zh) * 2025-04-11 2025-08-12 中国科学院微生物研究所 R-(-)-3-(氨甲酰甲基)-5-甲基己酸合成蛋白及其突变体与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06261787A (ja) 1993-03-10 1994-09-20 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸の製造法
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019377A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
CN1260347C (zh) * 2002-05-13 2006-06-21 中国人民解放军军事医学科学院生物工程研究所 一株产乙内酰脲酶系的节杆菌
CN1908159B (zh) * 2005-02-07 2011-04-20 中国科学院上海生命科学研究院 D-氨基酸生产菌株及其构建方法
EP2065470A1 (en) 2007-11-28 2009-06-03 Basf Se New malonate decarboxylases for industrial applications
US20100304448A1 (en) 2007-12-10 2010-12-02 Stuermer Rainer Method for the enzymatic reduction of alpha- and beta-dehydroamino acids using enoate reductases
WO2009080505A1 (de) 2007-12-20 2009-07-02 Basf Se Verfahren zur herstellung von (s)-2-amino-1-propanol (l-alaninol) aus (s)-1-methoxy-2-propylamin
EP2145904A1 (de) 2008-07-18 2010-01-20 Basf Se Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen
MX2011006464A (es) 2008-12-17 2011-09-15 Basf Se Biocatalizadores mejorados para la fabricacion de alcohol duloxetina.
DK2387556T3 (da) 2009-01-16 2014-11-03 Basf Se Separation af en enantiomerblanding af (r)- og (s)-3-amino-1-butanol
DE102009003035A1 (de) 2009-05-12 2010-11-18 Basf Se Verfahren zur Herstellung von urethangruppenhaltigen (Meth)acrylsäureestern
WO2010139651A2 (en) 2009-06-04 2010-12-09 Basf Se A process for the enzymatic reduction of enoates
EP2438182B1 (de) 2009-06-05 2018-10-10 Basf Se Biokatalytische herstellung von ambroxan
WO2011012632A2 (en) 2009-07-30 2011-02-03 Basf Se Biocatalyst for catalytic hydroamination

Also Published As

Publication number Publication date
ES2628225T3 (es) 2017-08-02
CN102782128A (zh) 2012-11-14
JP2013504313A (ja) 2013-02-07
WO2011032990A1 (en) 2011-03-24
US20120270280A1 (en) 2012-10-25
US9096841B2 (en) 2015-08-04
EP2478098A1 (en) 2012-07-25
EP2478098B1 (en) 2017-03-15

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