CN102770151B - 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 - Google Patents

用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 Download PDF

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Publication number
CN102770151B
CN102770151B CN201080034437.7A CN201080034437A CN102770151B CN 102770151 B CN102770151 B CN 102770151B CN 201080034437 A CN201080034437 A CN 201080034437A CN 102770151 B CN102770151 B CN 102770151B
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China
Prior art keywords
capsule
formula capsule
swallows
waveform
enteron aisle
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Expired - Fee Related
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CN201080034437.7A
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Chinese (zh)
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CN102770151A (zh
Inventor
米尔·伊姆兰
米尔·哈什姆
艾米丽·安斯多夫
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Incube Laboratories LLC
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Incube Laboratories LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0509Stomach and intestinal electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37217Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/06Electrodes for high-frequency therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201080034437.7A 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 Expired - Fee Related CN102770151B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810714885.XA CN109157742B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27338909P 2009-08-03 2009-08-03
US61/273,389 2009-08-03
PCT/US2010/044265 WO2011017335A1 (en) 2009-08-03 2010-08-03 Swallowable capsule and method for stimulating incretin production within the intestinal tract

Related Child Applications (1)

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CN201810714885.XA Division CN109157742B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

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CN102770151A CN102770151A (zh) 2012-11-07
CN102770151B true CN102770151B (zh) 2018-07-31

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CN201810714885.XA Active CN109157742B (zh) 2009-08-03 2010-08-03 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法

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Country Status (6)

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US (9) US8682440B2 (https=)
EP (2) EP2461818B1 (https=)
JP (8) JP5854513B2 (https=)
CN (2) CN102770151B (https=)
AU (2) AU2010279575B2 (https=)
WO (1) WO2011017335A1 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2461818B1 (en) 2009-08-03 2018-10-17 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
EP3603624A1 (en) * 2009-12-24 2020-02-05 Rani Therapeutics, LLC Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8759284B2 (en) 2009-12-24 2014-06-24 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2013143603A1 (en) * 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US20140051924A1 (en) * 2012-08-16 2014-02-20 Capso Vision, Inc In Vivo Capsule Device with Electrodes
US10213599B2 (en) 2013-09-23 2019-02-26 Board Of Regents, The University Of Texas System Wireless tissue stimulation devices
US10689460B2 (en) 2014-05-15 2020-06-23 Incube Labs, Llc PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10220076B2 (en) 2014-05-15 2019-03-05 Incube Labs, Llc Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins
US9919152B2 (en) * 2014-11-05 2018-03-20 Enterastim, Inc. Conditional gastrointestinal stimulation for improved motility
US20160183878A1 (en) * 2014-12-27 2016-06-30 John C. Weast Technologies for managing device functions of an ingestible computing device
US10500127B2 (en) * 2016-04-18 2019-12-10 Ankon Medical Technologies (Shanghai) Co., Ltd. Vivo device and method of using the same
WO2018026720A1 (en) * 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
EP3296727B1 (en) * 2016-09-19 2019-04-17 Murata Integrated Passive Solutions Electrical stimulation and monitoring device
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
US11207272B2 (en) 2017-05-17 2021-12-28 Massachusetts Institute Of Technology Tissue anchoring articles
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN108742590A (zh) * 2018-04-08 2018-11-06 南京宽诚科技有限公司 一种胃肠电信号的采集方法、装置、采集设备及存储介质
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
AU2019277199B2 (en) * 2018-05-31 2024-04-04 Lynne Bilston Systems, devices and methods for the treatment of oral and pharyngeal disorders
CN109498989A (zh) * 2018-12-20 2019-03-22 宁波贝思转化医学研究中心有限公司 一种用于判断胃肠电刺激是否有效的装置及其使用方法
JP2020108458A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108456A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108457A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
JP2020108454A (ja) * 2018-12-28 2020-07-16 株式会社三洋物産 遊技機
EP3917598B1 (en) 2019-02-01 2025-10-29 Massachusetts Institute of Technology Systems for liquid injection
AU2020232610A1 (en) 2019-03-01 2021-09-23 Rani Therapeutics, Llc Propulsive drug delivery from a swallowable device into a patient's intestinal tract
US20230317230A1 (en) * 2019-05-02 2023-10-05 Closed Loop Medicine Ltd. Method for treating obesity
JP7291896B2 (ja) * 2019-09-24 2023-06-16 パナソニックIpマネジメント株式会社 レシピ出力方法、レシピ出力システム
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
KR102608853B1 (ko) * 2021-11-15 2023-12-01 재단법인 아산사회복지재단 대사질환 개선용 생체발광 캡슐
US20240415429A1 (en) * 2023-06-14 2024-12-19 University Of Maryland, College Park Real-time ingestible sensing capsule

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7502649B2 (en) * 2003-06-20 2009-03-10 Metacure Ltd. Gastrointestinal methods and apparatus for use in treating disorders

Family Cites Families (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
DE2928477C3 (de) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
JPS60129057A (ja) 1983-12-14 1985-07-10 住友化学工業株式会社 針状固形製剤投与針
US4596819A (en) 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
US4663308A (en) 1984-07-18 1987-05-05 Medical College Of Ohio Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract
FR2597351B1 (fr) * 1986-04-16 1994-03-25 Celsa Composants Electriques Capsule distributrice de drogue implantable et procede et dispositif facilitant son utilisation.
US5137669A (en) 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
US5271945A (en) 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
WO1990000376A1 (fr) * 1988-07-05 1990-01-25 Cantenys Jose Ballon intragastrique
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
EP0607321A1 (en) * 1991-10-10 1994-07-27 Alza Corporation Osmotic drug delivery devices with hydrophobic wall materials
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
DK42093D0 (da) 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
US5437291A (en) * 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US5652216A (en) 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
US5849327A (en) * 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5904935A (en) 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5750926A (en) * 1995-08-16 1998-05-12 Alfred E. Mann Foundation For Scientific Research Hermetically sealed electrical feedthrough for use with implantable electronic devices
US5620476A (en) * 1995-11-13 1997-04-15 Pacesetter, Inc. Implantable medical device having shielded and filtered feedthrough assembly and methods for making such assembly
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5987358A (en) * 1998-02-17 1999-11-16 Intermedics, Inc. Semiconductor device packaging and method of fabrication
IT1299266B1 (it) 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6395273B1 (en) 1998-06-10 2002-05-28 Promega Corporation Prevention and treatment of inflammatory bowel disease
AU2937600A (en) * 1999-03-05 2000-09-28 Impulse Dynamics N.V. Blood glucose level control
US8700161B2 (en) * 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6832114B1 (en) * 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6638246B1 (en) * 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
KR20030074693A (ko) 2000-12-28 2003-09-19 알투스 바이올로직스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
US7069081B2 (en) * 2001-02-08 2006-06-27 Wilson Greatbatch Ltd. One piece header assembly for an implantable medical device
AU2002256168B2 (en) 2001-04-10 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
US7787958B2 (en) * 2001-04-13 2010-08-31 Greatbatch Ltd. RFID detection and identification system for implantable medical lead systems
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
AU2002317466B2 (en) * 2001-07-12 2008-02-28 Given Imaging Ltd Device and method for examining a body lumen
US20070162085A1 (en) * 2001-07-23 2007-07-12 Dilorenzo Biomedical, Llc Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity
US20030226155A1 (en) 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
JP4643089B2 (ja) 2001-09-27 2011-03-02 オリンパス株式会社 カプセル型医療装置
JP2002186672A (ja) 2001-09-28 2002-07-02 Olympus Optical Co Ltd 医療用カプセル装置
AU2002337803A1 (en) 2001-10-03 2003-04-14 Glaxo Group Limited Sustained release pharmaceutical compositions
US6656155B2 (en) 2001-12-17 2003-12-02 Scimed Life Systems, Inc. Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic
FR2835730B1 (fr) 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
US20030186892A1 (en) 2002-03-28 2003-10-02 Rajneesh Taneja Enhancement of endogenous gonadotropin production
US8062573B2 (en) 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
AU2002951734A0 (en) * 2002-09-30 2002-10-17 Cochlear Limited Feedthrough with conductive pathways of varing configurations
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
AU2003284951A1 (en) * 2002-10-25 2004-05-13 Raphael Schumert Gastrointestinal pacemaker
AU2003288516A1 (en) 2002-12-26 2004-07-22 Given Imaging Ltd. Immobilizable in vivo sensing device
US20040143221A1 (en) 2002-12-27 2004-07-22 Shadduck John H. Biomedical implant for sustained agent release
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
CN1774239A (zh) 2003-01-29 2006-05-17 埃-皮尔制药公司 用于胃肠道的有效药物递送
JP2005021677A (ja) 2003-06-10 2005-01-27 Medorekkusu:Kk 経皮投薬用パッドベース、及び注射針
CN1816324A (zh) 2003-07-04 2006-08-09 尼克麦德丹麦公司 口服用的含甲状旁腺激素(pth)的药物组合物
US20070060971A1 (en) * 2003-07-21 2007-03-15 Ofer Glasberg Hepatic device for treatment or glucose detection
BRPI0413197A (pt) 2003-08-01 2006-10-03 Amgen Inc cristal de eta wercept; método para fabricar um cristal de etanercept; composição; uso de um cristal de etanercept
US20050038415A1 (en) * 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
AU2004277419B2 (en) 2003-09-30 2007-10-11 Brown University Research Foundation Nanoparticulate therapeutic biologically active agents
US20050124875A1 (en) 2003-10-01 2005-06-09 Olympus Corporation Vivo observation device
JP4733918B2 (ja) 2003-10-01 2011-07-27 オリンパス株式会社 カプセル投薬システム
JP2007526022A (ja) 2003-10-24 2007-09-13 メドトロニック・インコーポレーテッド 炎症誘発性媒介物質の産生を減弱することによって神経性障害を処置する技法
JP2005143560A (ja) * 2003-11-11 2005-06-09 Olympus Corp カプセル型医療装置
JP4094543B2 (ja) * 2003-12-26 2008-06-04 オリンパス株式会社 カプセル型医療装置システム
EP1690490B1 (en) * 2003-11-11 2012-04-18 Olympus Corporation Capsule type medical device system
CA2536242A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8585771B2 (en) 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
MY162179A (en) 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
DE102004026615A1 (de) 2004-06-01 2005-12-29 Siemens Ag Vorrichtung und Verfahren zur Freisetzung eines in das Körperinnere eines Patienten geführten therapeutischen Mittels
JP2006000307A (ja) 2004-06-16 2006-01-05 Pentax Corp 酸素発生装置を有するカプセル型医療用具
US20060153894A1 (en) 2004-06-30 2006-07-13 Ragae Ghabrial Multi-compartment delivery system
MX2007000510A (es) 2004-07-12 2007-03-29 Emisphere Tech Inc Composiciones para suministrar peptido yy y agonistas de pyy.
WO2006028281A1 (en) * 2004-09-08 2006-03-16 Olympus Corporation Capsule type medical device
US20060063719A1 (en) 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes
WO2006035446A2 (en) 2004-09-30 2006-04-06 Duocure, Inc. Device and method for treating weight disorders
WO2006064502A2 (en) 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Local delivery of drugs or substances using electronic permeability increase
EP1841448A2 (en) 2004-12-30 2007-10-10 Diakine Therapeutics, Inc. Pharmaceutical compositions and methods for restoring beta-cell mass and function
US7556826B2 (en) 2005-01-04 2009-07-07 Gp Medical, Inc. Nanoparticles for protein drug delivery
CN101107038A (zh) 2005-01-18 2008-01-16 皇家飞利浦电子股份有限公司 电控胶囊
US7785291B2 (en) * 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
CN2860501Y (zh) 2005-03-10 2007-01-24 李华 一次性注射器
JP2008540023A (ja) * 2005-05-19 2008-11-20 イー−ピル ファーマ リミティド 組織における一酸化窒素生成のための摂取可能デバイス
JP5148274B2 (ja) 2005-05-27 2013-02-20 オリンパス株式会社 被検体内導入装置
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes
CN101511305B (zh) 2005-07-26 2012-05-30 梅纳赫姆·P·韦斯 伸展的体内胶囊
US8021384B2 (en) * 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
PL1971362T3 (pl) 2005-08-19 2015-05-29 Amylin Pharmaceuticals Llc Eksendyna do leczenia cukrzycy i zmniejszania masy ciała
KR20080065617A (ko) * 2005-09-19 2008-07-14 존슨 앤드 존슨 파머슈티컬 리서치 앤드 디벨로프먼트 엘엘씨 글루코코티코이드 수용체 발현의 조절
US7957796B2 (en) * 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
JP4402648B2 (ja) 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
GB0603252D0 (en) 2006-02-17 2006-03-29 Axcess Ltd Dissolution aids for oral peptide delivery
US20070207141A1 (en) 2006-02-28 2007-09-06 Ivan Lieberburg Methods of treating inflammatory and autoimmune diseases with natalizumab
US20060229529A1 (en) 2006-03-30 2006-10-12 Wright Robert C System, apparatus, and method for marking orientation of a tissue sample
US7818876B2 (en) * 2006-04-25 2010-10-26 Gregg Jorgen Suaning Method for fabrication of hermetic electrical conductor feedthroughs
JP5220001B2 (ja) 2006-05-18 2013-06-26 チューリップ メディカル リミテッド 生体内分解性の自己展開式の胃内インプラントおよび胃以外のインプラント
US20070288033A1 (en) * 2006-06-09 2007-12-13 Allergan, Inc. Intragastric balloon retrieval mechanisms
ES2442258T3 (es) 2006-10-27 2014-02-10 Abbvie Biotechnology Ltd Anticuerpos cristalinos anti-hTNF alfa
RU2009120512A (ru) * 2006-10-31 2010-12-10 Конинклейке Филипс Электроникс Н.В. (Nl) Конструкция глотаемого дозирующего устройства с множеством форсунок для выпуска лекарств в желудочно-кишечный тракт
US20080214919A1 (en) 2006-12-26 2008-09-04 Lifescan, Inc. System and method for implementation of glycemic control protocols
US9037244B2 (en) 2007-02-13 2015-05-19 Virender K. Sharma Method and apparatus for electrical stimulation of the pancreatico-biliary system
US8160708B2 (en) * 2007-04-11 2012-04-17 Pacesetter, Inc. Capacitor-integrated feedthrough assembly with improved grounding for an implantable medical device
US20080260820A1 (en) 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US9364666B2 (en) 2007-05-07 2016-06-14 Transtimulation Research, Inc. Method of using a gastrointestinal stimulator device for digestive and eating disorders
US7925351B2 (en) * 2007-06-13 2011-04-12 Betastim, Ltd. Gastrointestinal device for treating obesity and diabetes
US20090030743A1 (en) 2007-07-24 2009-01-29 Las Vegas Central Reservation Corp. Intelligent Hotel Reservation System and Method
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US7930033B2 (en) 2007-08-17 2011-04-19 Jianfeng Chen Appendicular and rectal stimulator device for digestive and eating disorders
WO2009041525A1 (ja) 2007-09-26 2009-04-02 Olympus Medical Systems Corp. 被検体内導入システム
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
EP2262442B1 (en) * 2008-04-11 2015-03-25 BAL Seal Engineering Connector cartridge stack for electrical transmission
US7875711B2 (en) 2008-04-17 2011-01-25 Alnylam Pharamaceuticals, Inc. Compositions and methods for inhibiting expression of XBP-1 gene
US20110046053A1 (en) * 2008-05-05 2011-02-24 Oramed Ltd. Methods and compositions for oral administration of exenatide
ATE505128T1 (de) 2008-06-04 2011-04-15 Olympus Medical Systems Corp Kapselförmige medizinische vorrichtung
US20090317372A1 (en) 2008-06-20 2009-12-24 Zoltan Kiss Small molecules for the reduction of high blood glucose level
US8287902B2 (en) * 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
WO2010025146A1 (en) * 2008-08-26 2010-03-04 Centocor Ortho Biotech Inc. Stimulation of satiety hormone release
US8948870B2 (en) 2008-09-09 2015-02-03 Incube Labs, Llc Energy harvesting mechanism
CA2735886A1 (en) 2008-09-25 2010-04-01 F. Hoffmann-La Roche Ag Indazole or 4,5,6,7-tetrahydro-indazole derivatives
US8535260B2 (en) 2008-10-15 2013-09-17 Dtherapeutics, Llc Devices, systems, and methods for localized drug delivery
WO2010045477A2 (en) * 2008-10-16 2010-04-22 Obalon Therapeutics, Inc. Intragastric volume-occupying device and method for fabricating same
WO2010045656A2 (en) 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
JP4642934B2 (ja) 2008-11-13 2011-03-02 オリンパスメディカルシステムズ株式会社 カプセル型医療装置
US20100131043A1 (en) 2008-11-26 2010-05-27 Casas Jesus W Endoluminal Implants For Bioactive Material Delivery
WO2010093834A2 (en) 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
WO2010144865A2 (en) 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
EP2461818B1 (en) 2009-08-03 2018-10-17 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP3603624A1 (en) 2009-12-24 2020-02-05 Rani Therapeutics, LLC Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8759284B2 (en) 2009-12-24 2014-06-24 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN102905753B (zh) 2009-12-24 2016-06-29 因卡伯实验室有限责任公司 可吞咽式药剂递送装置和药剂递送方法
US20110295178A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods
US8876761B2 (en) 2010-05-26 2014-11-04 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
US8603023B2 (en) 2010-05-26 2013-12-10 Ethicon Endo-Surgery, Inc. Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods
US20110295337A1 (en) 2010-05-26 2011-12-01 Albrecht Thomas E Systems and Methods For Regulating Metabolic Hormone Producing Tissue
US20130280324A1 (en) 2010-09-17 2013-10-24 Panacea Biotec Ltd. Sustained release pharmaceutical compositions comprising pregabalin
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
EP3653223B1 (en) 2011-06-29 2021-08-25 Rani Therapeutics, LLC Device for the oral delivery of therapeutic compounds
PL2726091T3 (pl) 2011-06-29 2020-08-10 Rani Therapeutics, Llc Preparaty lecznicze dostarczane do kanału przewodu jelitowego za pomocą połykalnego urządzenia dostarczającego lek
WO2013143600A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
WO2013143599A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders.
WO2013143603A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013143609A1 (en) 2012-03-30 2013-10-03 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
US9750660B2 (en) 2012-03-30 2017-09-05 Ethicon Endo-Surgery, Inc. Devices and methods for the treatment of metabolic disorders
WO2013165964A1 (en) 2012-04-30 2013-11-07 Carnegie Mellon University An ingestible, electrical device for stimulating tissues in a gastrointestinal tract of an organism
US8755888B2 (en) 2012-10-17 2014-06-17 Melcap Systems Ltd. Gastrointestinal system
US9168000B2 (en) 2013-03-13 2015-10-27 Ethicon Endo-Surgery, Inc. Meal detection devices and methods
EP2968071B1 (en) 2013-03-15 2021-08-04 Rani Therapeutics, LLC Device for oral delivery of therapeutic compounds
JP2018522650A (ja) 2015-06-28 2018-08-16 イラン,ヤロン 胃腸刺激のための装置およびその使用
CA2993215C (en) 2015-07-02 2023-10-31 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN105997466B (zh) 2016-06-16 2018-01-26 中南民族大学 智能型振动电子胶囊
WO2018026720A1 (en) 2016-07-31 2018-02-08 Hans Gregersen Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs
IL250090B (en) 2017-01-12 2018-10-31 Melcap Systems Ltd A capsule is intended for ingestion by a subject and a system is intended for the digestive system
WO2018146675A1 (en) 2017-02-07 2018-08-16 Yaron Ilan Closed loop organ stimulation
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
US20230285227A1 (en) 2022-03-14 2023-09-14 Massachusetts Institute Of Technology Ingestible capsules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7502649B2 (en) * 2003-06-20 2009-03-10 Metacure Ltd. Gastrointestinal methods and apparatus for use in treating disorders

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