CN102762101B - 取代的稠合咪唑衍生物、药物组合物及其使用方法 - Google Patents

取代的稠合咪唑衍生物、药物组合物及其使用方法 Download PDF

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CN102762101B
CN102762101B CN201180009915.3A CN201180009915A CN102762101B CN 102762101 B CN102762101 B CN 102762101B CN 201180009915 A CN201180009915 A CN 201180009915A CN 102762101 B CN102762101 B CN 102762101B
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methyl
benzimidazole
carboxylic acid
amino
benzothiazole
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CN102762101A (zh
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A·M·M·姆扎里
D·R·波利塞蒂
J·N·卡西斯
M·J·扣斯杜拉
M·古泽尔
O·C·阿图克斯
R·C·安德鲁斯
S·维克多利
S·古泊塔
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vTv Therapeutics LLC
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Trans Tech Pharma Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Dermatology (AREA)
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  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201180009915.3A 2010-02-18 2011-02-10 取代的稠合咪唑衍生物、药物组合物及其使用方法 Active CN102762101B (zh)

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US30572410P 2010-02-18 2010-02-18
US61/305,724 2010-02-18
JO47/2011 2011-02-03
JOP20110047 2011-02-03
PCT/US2011/024311 WO2011103018A1 (en) 2010-02-18 2011-02-10 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

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CN102762101B true CN102762101B (zh) 2014-09-17

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US (1) US12091407B2 (https=)
EP (1) EP2536285B1 (https=)
JP (1) JP5814948B2 (https=)
KR (1) KR101837759B1 (https=)
CN (1) CN102762101B (https=)
AU (1) AU2011218316B2 (https=)
CA (1) CA2789950C (https=)
DK (1) DK2536285T3 (https=)
EA (1) EA201290808A1 (https=)
ES (1) ES2679918T3 (https=)
MX (1) MX339243B (https=)
NZ (1) NZ602395A (https=)
SG (1) SG182629A1 (https=)
WO (1) WO2011103018A1 (https=)

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WO2012094580A2 (en) 2011-01-07 2012-07-12 High Point Pharmaceuticals, Llc Compounds that modulate oxidative stress
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WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
WO2020117886A1 (en) * 2018-12-07 2020-06-11 Vtv Therapeutics Llc Methods of inhibiting osteoclastogenesis and osteoclast activity
CN113557019B (zh) * 2019-01-18 2026-04-10 Vtv治疗有限责任公司 取代的稠和咪唑衍生物和治疗镰状细胞病和相关并发症的方法
WO2020210339A1 (en) 2019-04-12 2020-10-15 Mitobridge, Inc. Hmox1 inducers
US20230093476A1 (en) 2020-02-05 2023-03-23 Vtv Therapeutics Llc Substituted fused imidazole derivatives and methods of treating refractive ocular disorders
CN117658832A (zh) * 2022-09-08 2024-03-08 史梦婷 一种n，n-二甲基双氨乙基醚的制备方法

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