CN1027270C - 14，17β-桥亚乙基-14β-雌三烯和雌四烯的制备方法和含有它们的药物制剂 - Google Patents

14，17β-桥亚乙基-14β-雌三烯和雌四烯的制备方法和含有它们的药物制剂 Download PDF

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Publication number
CN1027270C
CN1027270C CN87105736A CN87105736A CN1027270C CN 1027270 C CN1027270 C CN 1027270C CN 87105736 A CN87105736 A CN 87105736A CN 87105736 A CN87105736 A CN 87105736A CN 1027270 C CN1027270 C CN 1027270C
Authority
CN
China
Prior art keywords
estra
ethylidene
diol
methoxy
triene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN87105736A
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English (en)
Chinese (zh)
Other versions
CN87105736A (zh
Inventor
詹姆斯·R·布尔
拉塞尔·I·汤姆森
亨利·劳伦特
赫尔穆特·施罗德
鲁道夫·维歇特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN87105736A publication Critical patent/CN87105736A/zh
Application granted granted Critical
Publication of CN1027270C publication Critical patent/CN1027270C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN87105736A 1986-08-20 1987-08-19 14，17β-桥亚乙基-14β-雌三烯和雌四烯的制备方法和含有它们的药物制剂 Expired - Fee Related CN1027270C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863628189 DE3628189A1 (de) 1986-08-20 1986-08-20 Oestrogen wirksame mittel und 14,17ss-ethano-14ss-estratriene
DEP3628189.1 1986-08-20

Publications (2)

Publication Number Publication Date
CN87105736A CN87105736A (zh) 1988-03-09
CN1027270C true CN1027270C (zh) 1995-01-04

Family

ID=6307762

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105736A Expired - Fee Related CN1027270C (zh) 1986-08-20 1987-08-19 14，17β-桥亚乙基-14β-雌三烯和雌四烯的制备方法和含有它们的药物制剂

Country Status (22)

Country Link
US (1) US4789671A (enExample)
EP (1) EP0318490B1 (enExample)
JP (1) JPH02500739A (enExample)
KR (1) KR940000167B1 (enExample)
CN (1) CN1027270C (enExample)
AT (1) ATE72248T1 (enExample)
AU (1) AU618939B2 (enExample)
CA (1) CA1269102A (enExample)
DD (1) DD266801A5 (enExample)
DE (2) DE3628189A1 (enExample)
DK (1) DK186788A (enExample)
FI (1) FI94866C (enExample)
HU (1) HU203366B (enExample)
IE (1) IE60319B1 (enExample)
IL (1) IL83302A (enExample)
NO (2) NO167865C (enExample)
NZ (1) NZ221137A (enExample)
PT (1) PT85552B (enExample)
RU (1) RU1820910C (enExample)
UA (1) UA13378A (enExample)
WO (1) WO1988001275A1 (enExample)
ZA (1) ZA875359B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838779A1 (de) * 1988-11-11 1990-05-17 Schering Ag 14(alpha),17(alpha)-ethano-estratriene
DE3925507A1 (de) * 1989-07-28 1991-01-31 Schering Ag 14,17(alpha)-etheno- und ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
RU2087479C1 (ru) * 1989-11-29 1997-08-20 Шеринг Аг Эстратриены, содержащие мостик
DE4114635A1 (de) * 1991-04-30 1992-11-05 Schering Ag 14(alpha),16(alpha)-ethano-estratriene
DE4114634A1 (de) * 1991-04-30 1992-11-05 Schering Ag 14(alpha),17(alpha)-(propano- und 17(pfeil hoch)2(pfeil hoch)-propeno)estratriene
DE4222316A1 (de) * 1992-07-03 1994-01-05 Schering Ag Verfahren zur Herstellung von Etheno- und Ethano-16â,17µ-Steroiddiolen und deren Derivaten
DE4326240A1 (de) * 1993-08-02 1995-02-09 Schering Ag 15,15-Dialkyl-substituierte Derivate des Estradiols
DE4447401A1 (de) 1994-12-23 1996-07-04 Schering Ag 14,17-C¶2¶-überbrückte Steroide
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Also Published As

Publication number Publication date
RU1820910C (ru) 1993-06-07
IE872217L (en) 1988-02-20
CN87105736A (zh) 1988-03-09
CA1269102A (en) 1990-05-15
JPH02500739A (ja) 1990-03-15
AU618939B2 (en) 1992-01-16
DE3628189A1 (de) 1988-02-25
IE60319B1 (en) 1994-06-29
NO168481C (no) 1992-04-01
PT85552B (pt) 1990-05-31
NO881688D0 (no) 1988-04-19
NO881688L (no) 1988-04-19
JPH0515720B2 (enExample) 1993-03-02
DK186788D0 (da) 1988-04-06
KR940000167B1 (ko) 1994-01-08
FI890779L (fi) 1989-02-17
NO167865B (no) 1991-09-09
NO885112L (no) 1988-04-19
PT85552A (en) 1987-09-01
IL83302A0 (en) 1987-12-31
DK186788A (da) 1988-04-06
DE3776572D1 (de) 1992-03-12
IL83302A (en) 1991-09-16
WO1988001275A1 (fr) 1988-02-25
ZA875359B (en) 1988-02-05
FI94866B (fi) 1995-07-31
HU203366B (en) 1991-07-29
UA13378A (uk) 1997-02-28
NO167865C (no) 1991-12-18
DD266801A5 (de) 1989-04-12
EP0318490A1 (de) 1989-06-07
FI890779A0 (fi) 1989-02-17
ATE72248T1 (de) 1992-02-15
NZ221137A (en) 1990-09-26
NO885112D0 (no) 1988-11-16
FI94866C (fi) 1995-11-10
AU7757187A (en) 1988-03-08
EP0318490B1 (de) 1992-01-29
US4789671A (en) 1988-12-06
KR880701731A (ko) 1988-11-04
HUT50845A (en) 1990-03-28
NO168481B (no) 1991-11-18

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