RU1820910C - Способ получени производных 14,17 @ -этано-14 @ -эстратриена - Google Patents

Способ получени производных 14,17 @ -этано-14 @ -эстратриена

Info

Publication number
RU1820910C
RU1820910C SU894613519A SU4613519A RU1820910C RU 1820910 C RU1820910 C RU 1820910C SU 894613519 A SU894613519 A SU 894613519A SU 4613519 A SU4613519 A SU 4613519A RU 1820910 C RU1820910 C RU 1820910C
Authority
RU
Russia
Prior art keywords
estratriene
ethano
hydrogen atom
preparing
beta
Prior art date
Application number
SU894613519A
Other languages
English (en)
Inventor
Булл Джеймз
Томсон Рассел
Лаурент Генри
Шредер Гельмут
Вихерт Рудольф
Original Assignee
Шеринг Аг Берлин
Шеринг Аг Бергкамен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Аг Берлин, Шеринг Аг Бергкамен filed Critical Шеринг Аг Берлин
Application granted granted Critical
Publication of RU1820910C publication Critical patent/RU1820910C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Abstract

Использование: в качестве эстрогеноак- типных веществ с более сильным действием этини эстрадиола. Сущность: продукт производные 14, 17 / -этано-14 эстратриена формулы R2Q f RiO где Ri-H, СНз или ацил с Ci-Cia: или ацил Ст-С(2- Выход 80%. Реагент 1: соответствующий А 15,16 производное 1. Реагент 2: водород над Pd/C Услови  реакции: в среде метанола при комнатной температуре с последующим или ацилиро- ванием, или расщеплением простой эфирной св зи, или омылением сложноэфирной группы. 1 табл.

Description

Опыт по Эллену и Дойзи
SU894613519A 1986-08-20 1989-02-20 Способ получени производных 14,17 @ -этано-14 @ -эстратриена RU1820910C (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863628189 DE3628189A1 (de) 1986-08-20 1986-08-20 Oestrogen wirksame mittel und 14,17ss-ethano-14ss-estratriene
PCT/DE1987/000361 WO1988001275A1 (en) 1986-08-20 1987-08-11 14,17beta-ETHANO-14beta-ESTRATRIENES AND ESTRATETRAENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE

Publications (1)

Publication Number Publication Date
RU1820910C true RU1820910C (ru) 1993-06-07

Family

ID=6307762

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894613519A RU1820910C (ru) 1986-08-20 1989-02-20 Способ получени производных 14,17 @ -этано-14 @ -эстратриена

Country Status (22)

Country Link
US (1) US4789671A (ru)
EP (1) EP0318490B1 (ru)
JP (1) JPH02500739A (ru)
KR (1) KR940000167B1 (ru)
CN (1) CN1027270C (ru)
AT (1) ATE72248T1 (ru)
AU (1) AU618939B2 (ru)
CA (1) CA1269102A (ru)
DD (1) DD266801A5 (ru)
DE (2) DE3628189A1 (ru)
DK (1) DK186788D0 (ru)
FI (1) FI94866C (ru)
HU (1) HU203366B (ru)
IE (1) IE60319B1 (ru)
IL (1) IL83302A (ru)
NO (2) NO167865C (ru)
NZ (1) NZ221137A (ru)
PT (1) PT85552B (ru)
RU (1) RU1820910C (ru)
UA (1) UA13378A (ru)
WO (1) WO1988001275A1 (ru)
ZA (1) ZA875359B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838779A1 (de) * 1988-11-11 1990-05-17 Schering Ag 14(alpha),17(alpha)-ethano-estratriene
DE3925507A1 (de) * 1989-07-28 1991-01-31 Schering Ag 14,17(alpha)-etheno- und ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
RU2087479C1 (ru) * 1989-11-29 1997-08-20 Шеринг Аг Эстратриены, содержащие мостик
DE4114634A1 (de) * 1991-04-30 1992-11-05 Schering Ag 14(alpha),17(alpha)-(propano- und 17(pfeil hoch)2(pfeil hoch)-propeno)estratriene
DE4114635A1 (de) * 1991-04-30 1992-11-05 Schering Ag 14(alpha),16(alpha)-ethano-estratriene
DE4222316A1 (de) * 1992-07-03 1994-01-05 Schering Ag Verfahren zur Herstellung von Etheno- und Ethano-16â,17µ-Steroiddiolen und deren Derivaten
DE4326240A1 (de) * 1993-08-02 1995-02-09 Schering Ag 15,15-Dialkyl-substituierte Derivate des Estradiols
DE4447401A1 (de) 1994-12-23 1996-07-04 Schering Ag 14,17-C¶2¶-überbrückte Steroide
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bull I.R. et al. Cycloaddition route to 14 a- formylestroneand derived 14 «-substituted products.- l.chem. Soc. chem. Commun. 1986 *

Also Published As

Publication number Publication date
AU618939B2 (en) 1992-01-16
PT85552A (en) 1987-09-01
EP0318490B1 (de) 1992-01-29
NO885112D0 (no) 1988-11-16
NO167865B (no) 1991-09-09
FI94866C (fi) 1995-11-10
FI890779A0 (fi) 1989-02-17
CN1027270C (zh) 1995-01-04
WO1988001275A1 (en) 1988-02-25
NZ221137A (en) 1990-09-26
NO881688D0 (no) 1988-04-19
NO168481C (no) 1992-04-01
EP0318490A1 (de) 1989-06-07
JPH02500739A (ja) 1990-03-15
US4789671A (en) 1988-12-06
DE3776572D1 (de) 1992-03-12
HU203366B (en) 1991-07-29
DK186788A (da) 1988-04-06
FI94866B (fi) 1995-07-31
PT85552B (pt) 1990-05-31
KR880701731A (ko) 1988-11-04
CA1269102A (en) 1990-05-15
NO885112L (no) 1988-04-19
NO167865C (no) 1991-12-18
DD266801A5 (de) 1989-04-12
UA13378A (uk) 1997-02-28
HUT50845A (en) 1990-03-28
DK186788D0 (da) 1988-04-06
IE60319B1 (en) 1994-06-29
IE872217L (en) 1988-02-20
ZA875359B (en) 1988-02-05
KR940000167B1 (ko) 1994-01-08
CN87105736A (zh) 1988-03-09
AU7757187A (en) 1988-03-08
FI890779A (fi) 1989-02-17
ATE72248T1 (de) 1992-02-15
DE3628189A1 (de) 1988-02-25
IL83302A (en) 1991-09-16
IL83302A0 (en) 1987-12-31
JPH0515720B2 (ru) 1993-03-02
NO168481B (no) 1991-11-18
NO881688L (no) 1988-04-19

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