CN102725302B - 2＇-氟-6＇-亚甲基碳环核苷和治疗病毒感染的方法 - Google Patents

2＇-氟-6＇-亚甲基碳环核苷和治疗病毒感染的方法 Download PDF

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CN102725302B
CN102725302B CN201080062516.9A CN201080062516A CN102725302B CN 102725302 B CN102725302 B CN 102725302B CN 201080062516 A CN201080062516 A CN 201080062516A CN 102725302 B CN102725302 B CN 102725302B
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functional group
compound
hbv
virus
infection
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CN102725302A (zh
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钟凯楚
王佳宁
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University of Georgia Research Foundation Inc
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CN201080062516.9A 2009-11-16 2010-11-16 2＇-氟-6＇-亚甲基碳环核苷和治疗病毒感染的方法 Expired - Fee Related CN102725302B (zh)

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US28134209P 2009-11-16 2009-11-16
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PCT/US2010/056808 WO2011060408A2 (en) 2009-11-16 2010-11-16 2'-fluoro-6'-methylene carbocyclic nucleosides and methods of treating viral infections

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CN102725302B true CN102725302B (zh) 2016-04-06

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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
AU2003298658A1 (en) 2002-11-15 2004-06-15 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
US9700560B2 (en) 2009-11-16 2017-07-11 University Of Georgia Research Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
US8816074B2 (en) * 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
CN102850402B (zh) * 2011-06-28 2016-08-03 李勤耕 非环核苷环状磷酸酯类衍生物，其制备方法及医药用途
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
AR089650A1 (es) 2011-10-14 2014-09-10 Idenix Pharmaceuticals Inc Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales
CN102603652A (zh) * 2011-12-27 2012-07-25 河南师范大学 5-甲酰基嘧啶碳环核苷及制备方法
AU2013221571A1 (en) * 2012-02-14 2014-08-28 University Of Georgia Research Foundation, Inc. Spiro [2.4] heptanes for treatment of Flaviviridae infections
WO2013177195A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphate prodrugs for hcv infection
MD20140134A2 (ro) 2012-05-22 2015-04-30 Idenix Pharmaceuticals, Inc. Compuşi ai D-aminoacizilor pentru tratamentul bolilor hepatice
EP2852604B1 (en) 2012-05-22 2017-04-12 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphoramidate prodrugs for hcv infection
PT2861611T (pt) 2012-05-25 2016-10-11 Janssen Sciences Ireland Uc Nucleósidos de espirooxetano de uracilo
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
ES2674980T3 (es) 2012-10-08 2018-07-05 Idenix Pharmaceuticals Llc Análogos de 2'-cloro nucleósidos para infección por VHC
CN103804417B (zh) * 2012-11-13 2017-09-19 北京美倍他药物研究有限公司 抗乙肝病毒药物
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9688666B2 (en) * 2013-02-07 2017-06-27 Tobira Therapeutics, Inc. Lamivudine salts
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
EP2970357B1 (en) 2013-03-13 2025-01-01 Idenix Pharmaceuticals LLC Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (en) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoro nucleosides for the treatment of hcv
EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
WO2015013352A2 (en) * 2013-07-25 2015-01-29 Patel Hasmukh B Nucleoside phosphoramidates and phosphoramidites
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US9334273B1 (en) 2014-03-05 2016-05-10 University Of Georgia Research Foundation, Inc. Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
EP3131914B1 (en) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
FI3265102T3 (fi) 2015-03-06 2025-10-31 Atea Pharmaceuticals Inc Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten
CN106466300B (zh) * 2015-08-12 2019-06-21 复旦大学 一种装载难溶性药物的复合壳聚糖纳米粒制剂及其制备方法和应用
WO2017127461A1 (en) * 2016-01-18 2017-07-27 Sensor Electronic Technology, Inc. Semiconductor device with improved light propagation
WO2017155082A1 (ja) 2016-03-11 2017-09-14 国立大学法人鹿児島大学 抗肝腫瘍ウイルス剤
US10533008B2 (en) * 2016-04-07 2020-01-14 University Of Georgia Research Foundation, Inc. Synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG)
US10653678B2 (en) 2016-04-11 2020-05-19 Genfit Methods of treatment for cholestatic and fibrotic diseases
SI3442580T1 (sl) 2016-04-11 2021-01-29 Genfit Metode zdravljenja holestatičnih in fibrotičnih bolezni
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
WO2018092728A1 (ja) * 2016-11-16 2018-05-24 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
CN115477679A (zh) 2017-02-01 2022-12-16 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
KR102337922B1 (ko) 2018-04-19 2021-12-09 가천대학교 산학협력단 담팔수 추출물에서 분리한 화합물을 유효성분으로 함유하는 수두-대상포진 바이러스 억제용 약학적 조성물
KR20190121956A (ko) 2018-04-19 2019-10-29 가천대학교 산학협력단 담팔수 추출물에서 분리한 화합물을 유효성분으로 함유하는 수두-대상포진 바이러스 억제용 약학적 조성물
JP7496132B2 (ja) * 2018-08-31 2024-06-06 国立大学法人 鹿児島大学 核酸アナログ及び抗ｂ型肝炎ウイルス剤
CN109846887B (zh) * 2019-03-22 2022-12-09 南京大学 2-氨基嘌呤-6（h）硫酮在制备单纯疱疹病毒的抑制剂中的应用
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2022164941A1 (en) 2021-01-26 2022-08-04 Atea Pharmaceuticals, Inc. Advantageous morphic form of at-527 hemi-sulfate salt
AU2022291927A1 (en) 2021-06-17 2024-01-04 Atea Pharmaceuticals, Inc. Advantageous anti-hcv combination therapy
WO2025207435A1 (en) * 2024-03-25 2025-10-02 University Of Georgia Research Foundation, Inc. 2'-fluoro-6'-methylene carbocyclic nucleos(t)ides as potent antiviral agents for the treatment of wild-type and mutant hepatitis b virus (hbv) infections
WO2026101522A1 (en) 2024-11-06 2026-05-15 University Of Georgia Research Foundation, Inc. 2'-fluoro-6'methylene carbocyclic nucleosides and nucleotides and methods of treating poxvirus infections with same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396623A (en) * 1981-08-26 1983-08-02 Southern Research Institute Carbocyclic analogs of uracil nucleosides as antiviral agents
CN1431907A (zh) * 2000-03-29 2003-07-23 乔治敦大学 治疗丁型肝炎病毒感染的方法
US20070042990A1 (en) * 2002-06-28 2007-02-22 Gilles Gosselin 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8520553D0 (en) * 1985-08-16 1985-09-25 Glaxo Group Ltd Chemical compound
US6395716B1 (en) * 1998-08-10 2002-05-28 Novirio Pharmaceuticals Limited β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
AU2001259754A1 (en) 2000-05-10 2001-11-20 Phycogen, Inc. Transgenic plants incorporating_genes of zostera marina
MXPA03006514A (es) * 2001-01-22 2004-12-02 Merck & Co Inc Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico.
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
US8816074B2 (en) * 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396623A (en) * 1981-08-26 1983-08-02 Southern Research Institute Carbocyclic analogs of uracil nucleosides as antiviral agents
CN1431907A (zh) * 2000-03-29 2003-07-23 乔治敦大学 治疗丁型肝炎病毒感染的方法
US20070042990A1 (en) * 2002-06-28 2007-02-22 Gilles Gosselin 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections

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PH12012500963B1 (en) 2018-08-10
US20130005677A1 (en) 2013-01-03
CA2781054A1 (en) 2011-05-19
US8946244B2 (en) 2015-02-03
PH12012500963A1 (en) 2018-05-15
WO2011060408A2 (en) 2011-05-19
MX2012005601A (es) 2012-08-01
AU2010319999B2 (en) 2014-01-16
KR101961601B1 (ko) 2019-03-25
KR20120092153A (ko) 2012-08-20
KR20180014179A (ko) 2018-02-07
EP2501709A2 (en) 2012-09-26
AU2010319999A1 (en) 2012-06-21
KR101840479B1 (ko) 2018-03-20
CN102725302A (zh) 2012-10-10
EA201270632A1 (ru) 2013-01-30
ZA201204356B (en) 2013-02-27
EP2501709A4 (en) 2013-11-13
WO2011060408A3 (en) 2011-10-13
HK1172628A1 (zh) 2013-04-26

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