CN102716186A - Composite immune enhancer for sea cucumber Chinese herbal medicines - Google Patents
Composite immune enhancer for sea cucumber Chinese herbal medicines Download PDFInfo
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Abstract
A composite immune enhancer for sea cucumber Chinese herbal medicines is characterized by comprising condonopsis pilosula, poria, schisandras, andrographis and double flowers, and the weight ratio of the condonopsis pilosula to the poria to the schisandras to the andrographis to the double flowers is 1-3:2-4:1-3:1-3:1-3. All the components of the composite immune enhancer are Chinese herbs, so that the composite immune enhancer has high sterilization, de-worming and anti-virus effects, is free of toxic and side effects and pollution, and is low in cost and easy to prepare. The composite immune enhancer for sea cucumber can promote or induce a host to generate defense reaction, so that the immunity is enhanced. The composite immune enhancer further can be applied to the non-specific immunization of other aquatic invertebrates, and the immune defense system of a body can be activated, so that the purpose of enhancing the immunity and improving the resistance to disease is achieved. The sea cucumber is an echinodermata and belongs to invertebrate, and the immune responses mainly include non-specific immunization.
Description
Technical field
The present invention relates to a kind of immunostimulant that is used for the Radix Morinae Bulleyanae growth, particularly a kind of Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent.
Background technology
Radix Morinae Bulleyanae (
Apostichopus japonicus) belong to Echinodermata, migration subphylum, Holothuroidea, shield hands order, Stichopodidae, Apostichopus japonicus and belong to.Radix Morinae Bulleyanae has become the pillar industry and the fishery economic growth strong point of coastal featured agriculture at present.Yet along with the overrun development and the going from bad to worse of cultivation water environment of Stichopus japonicus high-density breeding, the various diseases of Radix Morinae Bulleyanae is also following.At present, sustainable and stable development has produced influence to a certain degree to disease to the apostichopus japonicus culture industry.
Up to the present, the epidemic diseases that is caused by causal organism has caused aquaculture to suffer heavy economic losses.Virus, antibacterial, fungus, protozoacide, parasite are threatening the safety of culture fishery always.Therefore, the searching prevention is extremely urgent with the measure of treatment.In traditional disease prevention and therapeutic process; Chemicals and antibiotic are used on a large scale; The environmental hazard that the abuse of these medicines brings; As destroy the nature microecosystem, influence the degraded of debirs, the generation of drug resistance causal organism etc., and residual in vivo potential harmful effect to human health more and more receives people's attention.Therefore, utilize immunostimulant to improve the immunologic function and the body defence capability of cultivated animals, take place, reach the purpose of defence disease, become main development tendency thereby reduce disease with nuisanceless characteristic.
Summary of the invention
The purpose of this invention is to provide a kind of antibacterial, anthelmintic and antivirus action strong, nontoxic, have no side effect, pollution-free, cost is low, preparation is easy, can obviously improve the Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the immunocompetence of Radix Morinae Bulleyanae, overcomes the deficiency of prior art.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae;
Described Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are:
Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=1 ~ 3 ︰, 2 ~ 4 ︰, 1 ~ 3 ︰, 1 ~ 3 ︰ 1 ~ 3.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention, wherein said Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are:
Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=2 ︰, 3 ︰, 2 ︰, 2 ︰ 2.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention, wherein Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent also comprises following component: Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis;
The quality proportioning of described Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is:
Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰, 1 ~ 3 ︰, 0.8 ~ 1.2 ︰ 0.8 ~ 1.2.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention, the quality proportioning of wherein said Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is:
Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1.5 ︰, 1.5 ︰, 2 ︰, 1 ︰ 1.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention, wherein said Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent also comprises following component: Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae;
The quality proportioning of described Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is:
The Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 0.8 ~ 1.2 ︰, 0.8 ~ 1.2 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰ 0.8 ~ 1.2.
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention, the quality proportioning of wherein said Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is:
The Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 1 ︰, 1 ︰, 1.5 ︰, 1.5 ︰ 1.
All components of Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention are Chinese medicine; Antibacterial, anthelmintic and antivirus action are strong; Nontoxic, have no side effect, pollution-free, cost is low, preparation easily; The reinforcing agent that is used for Radix Morinae Bulleyanae of the present invention has and promotes or bring out the host to produce defense reaction, enhancing human body immunity power.Reinforcing agent of the present invention also can act on the nonspecific immunity of other Aquatic product invertebratess, activates the immune defense system of body, thereby reaches the purpose that enhancing immunity improves its resistance against diseases.Radix Morinae Bulleyanae is an echinoderm, belongs to invertebrates, and immunoreation is main with nonspecific immunity mainly.
The specific embodiment
Embodiment 1:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.The quality proportioning of each component is: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=1 ~ 3 ︰, 2 ~ 4 ︰, 1 ~ 3 ︰, 1 ~ 3 ︰ 1 ~ 3.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.5% of feedstuff gross mass.
Embodiment 2:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.The quality proportioning of each component is: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=2 ︰, 3 ︰, 2 ︰, 2 ︰ 2.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.5% of feedstuff gross mass.
Embodiment 3:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=1 ~ 3 ︰, 2 ~ 4 ︰, 1 ~ 3 ︰, 1 ~ 3 ︰ 1 ~ 3.
Also comprise following component: Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis.The quality proportioning of Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is: Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰, 1 ~ 3 ︰, 0.8 ~ 1.2 ︰ 0.8 ~ 1.2.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.2% of feedstuff gross mass.
Embodiment 4:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=2 ︰, 3 ︰, 2 ︰, 2 ︰ 2.
Also comprise following component: Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis.The quality proportioning of Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is: Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1.5 ︰, 1.5 ︰, 2 ︰, 1 ︰ 1.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.2% of feedstuff gross mass.
Embodiment 5:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=1 ~ 3 ︰, 2 ~ 4 ︰, 1 ~ 3 ︰, 1 ~ 3 ︰ 1 ~ 3.
Also comprise following component: Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae.The quality proportioning of Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is the: Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 0.8 ~ 1.2 ︰, 0.8 ~ 1.2 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰ 0.8 ~ 1.2.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.2% of feedstuff gross mass.
Embodiment 6:
Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent of the present invention comprises following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae.Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are: Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=2 ︰, 3 ︰, 2 ︰, 2 ︰ 2.
Also comprise following component: Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae.The quality proportioning of Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is the: Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 1 ︰, 1 ︰, 1.5 ︰, 1.5 ︰ 1.Above-mentioned each Chinese herbal medicine is the medical material that pharmacy sells.
Utilize the raw material pulverizing of super micron mill, and,, be formed for the Chinese herbal medicine composite immune reinforcing agent of Radix Morinae Bulleyanae by above-mentioned quality proportioning mix homogeneously through behind 200 eye mesh screens with above-mentioned each component.This reinforcing agent is added in the feedstuff of Radix Morinae Bulleyanae, reinforcing agent accounts for 0.2% of feedstuff gross mass.
Utilize of raising and the management of above-mentioned reinforcing agent to Radix Morinae Bulleyanae:
Select for use the same a collection of Radix Morinae Bulleyanae of hatching then to use ginseng as experiment, initial body weight is 3.53 ± 0.85g.Experiment is provided with 4 groups, is respectively matched group, embodiment 1, embodiment 3, embodiment 5.The matched group Radix Morinae Bulleyanae feedstuff of throwing something and feeding and not adding immunostimulant wherein, other embodiment groups have been added the immunostimulant of 0.2-0.5% respectively on the basis of matched group, and its composition carries out according to aforementioned proportion.Every group 3 parallel, and each parallel 30 Radix Morinae Bulleyanae is thrown something and fed 1 every day, and the time of throwing something and feeding is 17:00, is satiated with food and throws something and feeds, and next day, 8:00 absorbed residual bait and feces.Continuous charge between feeding period, water temperature are controlled at 15 ± 0.5 ℃, salinity 32, and pH 7.8-8.2, dissolved oxygen are not less than 5 mg/L.
Radix Morinae Bulleyanae sample collecting, analysis and calculating:
The back was measured various immunoenzyme activity of Radix Morinae Bulleyanae and growing state on the 10th, 20,30,40 and 50 respectively at throwing something and feeding.Computing formula is following:
Rate of body weight gain (WG, %)=100 * (Wt-W0)/W0
Specific growth rate (SGR)=100 * (LnWt – LnW0)/t
Wherein, N0 and Nt are respectively each and repeat an initial number of Radix Morinae Bulleyanae and an eventually last number, and W0 and Wt are respectively initial body weight and whole opisthosoma is heavy, and t is the experiment natural law.
Get coelomic fluid, whole process is carried out on ice chest, prevents enzyme deactivation.Coelomic fluid is packed in the 1.5mL centrifuge tube, temporarily be kept in 4 ℃ of refrigerators.Centrifugal, 3000r ∕ min, 4 ℃ of centrifugal 10min get supernatant ,-80 ℃ of preservations.Measure its AKP of absorbance measurement, ACP, LSZ and SOD enzyme activity with ELIASA.
Adopt SPSS 11.5 for Windows that the gained data are carried out one factor analysis of variance.
Four, experimental result shows: in the Radix Morinae Bulleyanae feedstuff, add Chinese herbal medicine composite immune reinforcing agent of the present invention, can significantly improve specific growth rate, rate of body weight gain and AKP, ACP, LSZ and the SOD enzyme activity of Radix Morinae Bulleyanae.A spot of Radix Morinae Bulleyanae composite immune reinforcing agent just can significantly improve growth and the immunity of Radix Morinae Bulleyanae, is fully feasible as the long-term immunostimulant efficiently of Radix Morinae Bulleyanae.
Table 1 is thrown something and fed, and compound immunopotentiator for apostichopus japonicus is grown to Radix Morinae Bulleyanae and the influence of survival rate
| Group | Survival rate | Rate of body weight gain | Specific growth rate |
| Matched group (A) | 99.12±0.73 | 2.98±0.78 | 0.02±0.01 |
| Embodiment 1 | 98.85±0.89 | 15.42±1.84 | 0.10±0.05 |
| Embodiment 3 | 97.50±0.43 | 19.21±2.75 | 0.15±0.02 |
| Embodiment 5 | 98.15±0.62 | 19.73±0.98 | 0.13±0.01 |
Table 2 influence of compound immunopotentiator for apostichopus japonicus of throwing something and feeding to Radix Morinae Bulleyanae immunoenzyme vigor
| Group | AKP | ACP | LSZ | SOD |
| Matched group (A) | 3.05±0.04 | 2.82±0.30 | 5.60±0.86 | 56.56±8.47 |
| Embodiment 1 | 5.39±0.12 | 4.74±0.21 | 22.58±0.84 | 84.02±4.65 |
| Embodiment 3 | 6.05±0.16 | 4.55±0.12 | 24.66±2.95 | 84.36±5.00 |
| Embodiment 5 | 5.98±0.16 | 4.39±0.12 | 21.73±3.54 | 90.12±4.85 |
Claims (6)
1. a Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent is characterized in that: comprise following component: Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae;
Described Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are:
Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=1 ~ 3 ︰, 2 ~ 4 ︰, 1 ~ 3 ︰, 1 ~ 3 ︰ 1 ~ 3.
2. Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent according to claim 1 is characterized in that: described Radix Codonopsis, Poria, Fructus Schisandrae Chinensis, Herba Andrographis, Flos Lonicerae quality proportioning are:
Dang Can ︰ Fu Ling ︰ Wu Wei ︰ Chuan Xin Lian ︰ Flos Lonicerae=2 ︰, 3 ︰, 2 ︰, 2 ︰ 2.
3. Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent according to claim 1 and 2 is characterized in that: Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent also comprises following component: Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis;
The quality proportioning of described Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is:
Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰, 1 ~ 3 ︰, 0.8 ~ 1.2 ︰ 0.8 ~ 1.2.
4. Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent according to claim 3 is characterized in that: the quality proportioning of described Radix Codonopsis and Herba Epimedii, Cortex Dictamni, Fructus Tribuli, Fructus Forsythiae, Radix Isatidis is:
Dang Can ︰ Yin Yang Huo ︰ Bai Xian Pi ︰ Ji Li ︰ Lian Qiao ︰ Radix Isatidis=1 ︰, 1.5 ︰, 1.5 ︰, 2 ︰, 1 ︰ 1.
5. Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent according to claim 1 and 2 is characterized in that: described Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent also comprises following component: Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae;
The quality proportioning of described Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is:
The Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 0.8 ~ 1.2 ︰, 0.8 ~ 1.2 ︰, 1 ~ 2 ︰, 1 ~ 2 ︰ 0.8 ~ 1.2.
6. Radix Morinae Bulleyanae Chinese herbal medicine composite immune reinforcing agent according to claim 5 is characterized in that: the quality proportioning of described Radix Codonopsis and Bombyx Batryticatus, Periostracum Cicadae, the Fructus Kochiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae is:
The Dang Can ︰ Jiang Chong ︰ Chan Tui ︰ Di Fu ︰ Huang Qi ︰ Rhizoma Atractylodis Macrocephalae=1 ︰, 1 ︰, 1 ︰, 1.5 ︰, 1.5 ︰ 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103392934A (en) * | 2013-08-02 | 2013-11-20 | 青岛七好营养科技有限公司 | Full-balanced powder forage for adult stichopus japonicus |
| CN105943689A (en) * | 2016-06-29 | 2016-09-21 | 苏阳 | Traditional Chinese medicine preparation used for immune-suppression and preparation method of traditional Chinese medicine preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539494A (en) * | 2003-10-27 | 2004-10-27 | 朱翻身 | Chinese traditional medicine for raising immunocompetence of body for anti influenza, SARS, and preparation method |
| CN101658600A (en) * | 2009-09-17 | 2010-03-03 | 大连水产学院 | Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber |
| CN101744125A (en) * | 2010-02-02 | 2010-06-23 | 辽宁省农业科学院大连生物技术研究所 | Sea cucumber culturing feed additive and preparing and using methods thereof |
-
2012
- 2012-06-21 CN CN2012102060563A patent/CN102716186A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539494A (en) * | 2003-10-27 | 2004-10-27 | 朱翻身 | Chinese traditional medicine for raising immunocompetence of body for anti influenza, SARS, and preparation method |
| CN101658600A (en) * | 2009-09-17 | 2010-03-03 | 大连水产学院 | Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber |
| CN101744125A (en) * | 2010-02-02 | 2010-06-23 | 辽宁省农业科学院大连生物技术研究所 | Sea cucumber culturing feed additive and preparing and using methods thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103392934A (en) * | 2013-08-02 | 2013-11-20 | 青岛七好营养科技有限公司 | Full-balanced powder forage for adult stichopus japonicus |
| CN103392934B (en) * | 2013-08-02 | 2014-12-17 | 青岛七好营养科技有限公司 | Full-balanced powder forage for adult stichopus japonicus |
| CN105943689A (en) * | 2016-06-29 | 2016-09-21 | 苏阳 | Traditional Chinese medicine preparation used for immune-suppression and preparation method of traditional Chinese medicine preparation |
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Application publication date: 20121010 |