CN102697807A - Application of health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy - Google Patents
Application of health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses an application of a health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy. The health-care drinking liquid comprises a liquid A and a liquid B; the liquid B is a high-concentration concentrated liquid which is obtained by decompression concentration of concentrated water part separated from deep ocean water through a reverse osmosis apparatus; and the hardness range of the health-care drinking liquid is 200-1000ppm. The health-care drinking liquid is fed to experimental animals with II-type diabetes mellitus in a free drinking manner and can be used for remarkably reducing levels of fasting blood-glucose, fasting plasma insulin, blood lipid and weights in diabetic mice induced by combination of high-glucose and high-fat diets and STZ (Streptozotocin) and improving insulin sensitivities and remarkably improving db/db disease syndromes of spontaneous diabetes model animals and effectively inhibiting diabetic nephropathy lesions, so that the health-care drinking liquid can be applied to preventing, improving or treating II-type diabetes mellitus and diabetic nephropathy diseases. The health-care drinking liquid has the advantages of rich resources and easy industrialization and the like.
Description
Technical field
The invention belongs to the marine biotechnology field, relate to the comprehensive utilization of deep seawater, be specifically related to a kind of healht-care liquid in preparation prevention or treatment Π type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product.
Background technology
The variation of Along with people's living habit and diet structure, the sickness rate of diabetes sharply rises.The data show of WHO issue, the annual whole world probably have 3,000,000 people to die from the relevant disease of diabetes.In China, according to diabetes association of Chinese Medical Association statistics, the sickness rate of diabetes has reached 4%; The diabetics of having made a definite diagnosis reaches 5,000 ten thousand; And with annual 1000000 speed sharp increase, and in the crowd in cities and towns and more rich rural area, the sickness rate of diabetes oneself through reaching 11%; Nearly people's blood glucose regulatory function of 15% is impaired in addition in addition, and China probably can become the global first diabetes big country.
Diabetes are metabolic diseases that one group of cause of disease and pathogenesis are not illustrated as yet fully, and sugar, fat and protein metabolism get muddled in patient's body, and and then cause a series of complication.It has produced serious harm to human health in the world.Diabetes are to healthy generation huge harm; Can cause a plurality of tissues of body to produce serial complication, human health caused to have a strong impact on, almost the diabetic of 75-80% is died from cardiovascular disease; And diabetic gets the high 2-4 of probability times of coronary heart disease than non-diabetic patient; Their treatment is also poorer, and the death that diabetes cause makes the life expectancy of afflicted reduce 12-14, and quality of life greatly reduces.At present, WHO is divided into 3 types with diabetes, comprises type i diabetes, type ii diabetes and gestational diabetes, and wherein the sickness rate of type ii diabetes accounts for about 90% of diabetic sum greatly.
So far, also do not treat the ideal medicament of type ii diabetes.Treatment of diabetes is advocated use more do not stimulate insulin secretion, and have blood sugar lowering, blood fat reducing, can improve the medicine of diabetes and metabolism disorder thereof again.And research shows that additional mineral element can comparatively significantly improve the glycolipid metabolism of body, in the appearance that improves delaying complications of diabetes and improve and have positive role aspect the existing diabetic complication.
Deep seawater typically refer to solar radiation less than, can not carry out photosynthesis, the sea water below about 200m degree of depth.Deep seawater is in the ocean of no sunlight entering does not have photosphere, and away from influence and pollution from the mankind, land and atmospheric chemical substance.Research shows that deep seawater has following main feature: (1) low temperature homeostasis-do not receive solar radiation, and changeable unlike the sea surface coolant-temperature gage, deep seawater is temperature-resistant all the year round, is constant at about 5 ℃; (2) the abundant and stability of mineral element-with sea surface water ratio; Deep seawater is rich in 92 kinds of mineral elements such as the necessary calcium of human body, magnesium, potassium, sodium, ferrum, copper, lithium, molybdenum, manganese, zinc, germanium, iodine, phosphorus, fluorine, selenium, trivalent chromium, silicate ion, has contained the required element kind of human body metabolism.Except its content is abundant; Because these water flow in the bathypelagic of " no photosphere " with the very long time; Ectocine with taking place, not receiving in unglazed cooperation, and therefore the composition of contained mineral element is very stable, has ideally solved the requirement that total balance of the body is absorbed various required mineral elements; (3) aseptic spatter property-the be in deep water of ocean " no photosphere " except away from the influence of human modern civilization and do not receive the pollution of land, Atmospheric Chemistry material, pathogenic bacteria, itself does not have the condition that generates antibacterials such as pathogen yet.Therefore, deep seawater is the water of the aseptic nature that cleans very much; (4) deep seawater water quality is alkalescence.
Owing to have above characteristics, deep seawater is receiving attracting attention of common people as a kind of new natural resources.Deep seawater is rich in various mineral and trace element, and it has good improvement effect to type ii diabetes and complication thereof in theory.China marine site is broad, and the coastline is very long, and marine resources are abundant, but does not still have the research of deep seawater Application and Development aspect; And China's water scarcity, water is seriously polluted, and the sickness rate of type ii diabetes sharply rises, so the bathypelagic water resource of exploitation China has crucial meaning.
Summary of the invention
, water in short supply day by day to present China water resource pollutes and is on the rise and the rapid hot issue such as risings of type ii diabetes sickness rate, the invention provides a kind of healht-care liquid in the preparation prevention or treat type ii diabetes and the medicine of diabetes complicated nephropathy or the application in the health product.
For realizing the foregoing invention purpose, the present invention adopts following technical proposals to be achieved:
A kind of healht-care liquid is in preparation prevention or treatment type ii diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; Said healht-care liquid comprises A liquid and B liquid, and said A liquid is fresh water, and said B liquid makes through following steps: deep seawater is isolated dense water section behind reverse osmosis unit; Dense water section is carried out concentrating under reduced pressure; Make its volume be concentrated into the 0.67-3.33% of original volume, remove by filter the sodium chloride of separating out then, the height concentrated solution that obtains is B liquid; The hardness of said healht-care liquid is at 200-1000ppm, and said deep seawater is below the 500m of sea level and the sea water after desalting processing.
Further improvement to technique scheme: magnesium in the said healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, do not contain Organic substance, and water quality is alkalescence.
Further improvement to technique scheme: said magnesium: calcium: the ratio of greater inequality of the concentration of potassium is 3:1:1.
Further improvement to technique scheme: the water quality of said healht-care liquid is alkalescence, 25 ° of pH value 7.5 ± 0.3 that C measures.
Further improvement to technique scheme: the beneficial element content in the said healht-care liquid is: zinc 0.0325-16.4 μ g/L; Selenium 0.0395-0.712 μ g/L; Chromium 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L.
Further improvement to technique scheme: the harmful element content in the said healht-care liquid is: plumbous < 5 μ g/>L; Hydrargyrum < 0.5 μ g/>L; Arsenic < 5 μ g/>L; Cadmium < 1 μ g/>L.
Further improvement to technique scheme: said deep seawater is taken from apart from beyond the 20km of coastline.
Further improvement to technique scheme: said fresh water sources Yu Haiyang deep water is isolated fresh water after the reverse osmosis unit circulation.
Further improvement to technique scheme: it is the healht-care liquid of 600-1000ppm that diet is selected hardness for use to the less Π diabetes mellitus type of the picked-up of mineral, is the healht-care liquid of 200-400ppm otherwise select hardness.
Compared with prior art; Advantage of the present invention and good effect are: the healht-care liquid that contains deep seawater provided by the invention is rich in healthy trace elements with household magnesium, calcium, vanadium, chromium, manganese, zinc, selenium; And poisonous trace element hydrargyrum is very low with plumbous content; The present invention shows through biotic experiment; This healht-care liquid can significantly improve Π type diabetes laboratory animal disease symptoms, comprise the content that reduces glycolated hemoglobin, fasting glucose, FPI, blood fat, improve islets of langerhans sensitivity; And effectively suppress the diabetes nephropathy, prove that healht-care liquid can be applied to prepare prevention, improves or treat in the medicine or health product of Π type diabetes and diabetes complicated kidney disease.
The specific embodiment
Below in conjunction with the specific embodiment technical scheme of the present invention is done further detailed explanation.
Embodiment 1
One, the preparation of healht-care liquid
The method for preparing of healht-care liquid according to the invention is following:
1) bathypelagic water pretreatment: will take from apart from beyond the 20km of coastline; Sea level 500m puts into water tank with dark deep seawater, adopts filter to filter, and removes phytoplankton and microorganism in the sea water; And, further remove Organic substance through the active carbon filter filtration.
2) fresh water and dense separated form water: the deep seawater that obtains after the pretreatment is divided into the fresh water part through high-pressure pump entering reverse osmosis unit with deep seawater, and (fresh water part water quality is identical with pure water, or water quality is near pure water with dense water section; The concentration of various zwitterions is near 2 times of various ion concentrations in the former sea water in the dense water section), isolated fresh water partly is that A liquid gets into the fresh water water tank, isolated dense water section gets into dense water water tank.The technological parameter of reverse osmosis unit is: 4MPa, power 1.5KW, aquifer yield 1T/d are pressed in running.
3) dense water takes off the sodium processing: the dense water section in the dense water water tank is carried out concentrating under reduced pressure; Make its volume be concentrated into the 0.67-3.33% of original volume; Remove by filter the sodium chloride of separating out then; Obtain highly spissated concentrated solution and be B liquid, magnesium in the said concentrated solution: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, and said magnesium, calcium, potassium, the content concn unit of sodium element in concentrated solution are mg/L.Trace element chromium wherein, zinc, selenium, the concentration of manganese etc. and cycles of concentration are the multiple proportions relation.
Perhaps, also can adopt the selectivity electrodialysis to reverse osmosis after isolated dense water section take off sodium and handle, electrodialysis plant adopts 1 valency cation selective to see through film, cavity block adopts the conventional ion exchange membrane.All aniones all can see through cavity block in electrodialytic process, and only univalent cation sees through anode membrane, and the polyvalent cation that takes off in the sodium dense water afterwards is close with the concentration in the former dense water.
4) healht-care liquid fill: will pass through fresh water A liquid that the step 1) reverse osmosis unit comes out and the resulting B liquid of step 3) can according to demand mixed the healht-care liquid of different hardness, said hardness is with CaCO
3Cubage (GB 5749-2006 drinking water sanitary standard), hardness=Ca (ppm)) * 2.5+Mg (ppm) * 4.1 its computing formula is:, through high temperature sterilize, packing gets final product.
Adopt inductively coupled plasma mass spectrum (ICP-MS) that the inorganic element content in the healht-care liquid is measured: with hardness is that 1000 healht-care liquid is example, and wherein several kinds of main mine materials and micronutrient levels are: magnesium: 200-224mg/L; Calcium: 33-67mg/L; Potassium: 20-67mg/L; Sodium: 20-100mg/L (content of sodium is low more good more); Zinc: 0.0325-16.4 μ g/L; Selenium: 0.0395-0.712 μ g/L; Chromium: 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L, plumbous < 5 μ g/>L; Hydrargyrum < 0.5 μ g/>L; Arsenic < 5 μ g/>L; Cadmium < 1 μ g/>L.
Healht-care liquid mineral under the 200-1000 hardness according to the invention and micronutrient levels are directly proportional with its hardness.Magnesium in the said healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, is rich in healthy trace elements with household zinc, selenium, chromium; Manganese, poisonous trace element lead, hydrargyrum, arsenic; Cadmium content is lower, do not contain Organic substance, and water quality is alkalescence.
Said healthy trace elements with household content is following: zinc: 0.0325-16.4 μ g/L; Selenium: 0.0395-0.712 μ g/L; Chromium: 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L.
Said poisonous micronutrient levels is following: plumbous < 5 μ g/>L; Hydrargyrum < 0.5 μ g/>L; Arsenic < 5 μ g/>L; Cadmium < 1 μ g/>L.
Use pH meter that its pH value is measured (25 ° of C), the result shows healht-care liquid pH value in 7.5 ± 0.3 scopes, and water quality is alkalescence.
Two: the pharmacodynamic experiment of health-care drinking-water prevention Π type diabetes
1, experimental technique
32 of Kunming mouses, male, body weight 18-22g is divided into blank control group, model group, positive control (metformin hydrochloride, Metf) group and healht-care liquid group, 8 every group at random.Experimental session mice ad lib and drinking-water.The normal control group gives normal feedstuff and distilled water; Feed with the high glucose and high fat feedstuff for all the other 24, except that healht-care liquid group gave healht-care liquid that hardness is 1000ppm, all the other all gave distilled water.Positive controls began to give metformin 225mg/kgd in experiment in the 4th week, after 5 weeks, and experimental mice lumbar injection streptozotocin (STZ) 150mg/kgd; Divide to give for 5 times, and continue to give the high glucose and high fat feedstuff after 1 week, the tail intravenous needle is adopted the hematometry fasting glucose; Extract eyeball of mouse again and get blood, centrifuging and taking serum is measured insulin, free fatty (FFA) in the mice serum; Triglyceride (TG), T-CHOL (TC) content.
2, experimental result
(1) healht-care liquid is to the influence of diabetic mice fasting glucose and insulin: can be learnt that by table 1 model group mice fasting glucose obviously increases than blank control group, representation model is set up successfully.Positive drug Metf group and healht-care liquid group mice fasting glucose reduce than model group, and this prompting healht-care liquid group has hypoglycemic activity.Simultaneously, healht-care liquid is handled and is made FPI content have downward trend.Can find out according to insulin sensitivity index result of calculation; Model group animal insulin sensitivity significantly reduces; The Sensitivity Index of healht-care liquid processing then can increasing insulin (p 0.05), this prompting healht-care liquid has the insulin sensitivity of increasing effect.
Table 1: healht-care liquid is to the influence (
n=8) of diabetic mice fasting glucose and insulin
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
(2) healht-care liquid is to the influence of diabetic mice blood lipid level: table 2 can be found out, model group mice FFA, and TG, TC content significantly raises (p < 0.05) than blank control group, and representation model is set up successfully; Healht-care liquid treated animal blood fat has reduction trend, and this prompting healht-care liquid has the blood fat of improvement.
Table 2: healht-care liquid is to diabetic mice blood lipid level influence (
n=8)
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
(3) healht-care liquid is to the influence of diabetic mice body weight level: duration of test; In set time weighing the weight of animals weekly; Through statistical analysis, each treated animal body weight change does not have significant difference (p>0.05) during the administration, but with model group relatively; Since healht-care liquid processed group had downward trend in the 4th week, and this prompting healht-care liquid has antiobesity action.
Table 3: healht-care liquid to diabetic mice body weight level affects (
n=8, g)
(4) duration of test, the food ration of each treated animal and amount of drinking water no significant difference (p>0.05)
The experimental result of above-mentioned (1)-(4) shows that this healht-care liquid can suppress the rising of high glucose and high fat diet associating inductive diabetic mice fasting glucose of STZ and insulin, and significantly improves insulin sensitivity index.Suppress the rising of diabetic mice blood lipid level and body weight simultaneously.These results suggest healht-care liquid are prevent diabetes effectively.
Three, the pharmacodynamic experiment of healht-care liquid treatment Π type diabetes and diabetes complicated nephropathy
1, experimental technique
Get 36 of db/db mices, male, 4～6 ages in week.Experimental session animal ad lib, freely drink water (distilled water or healht-care liquid).The ob/ob mice is divided into 3 groups at random, 12 every group, is respectively model control group, positive controls, healht-care liquid group.Blank control group is 12 C57BL choosing immediately, 5 age in week mice.Positive controls gives Dimethyldiguanide hydrochloride enteric solubility tablet 225mgkg-1d-1, handles continuously 75 days.Measure fasting glucose weekly.And examine the animal state and carry out record.Behind the last medicine, water 12h is can't help in fasting, and the while is also collected urine in metabolic cage, and the tail intravenous needle is adopted the hematometry fasting glucose, extracts eyeball of mouse again and gets blood, and centrifuging and taking serum is measured each item biochemical indicator in mice serum and the urine.
2, experimental result
The db/db mice is a kind of have hyperglycemia and hyperinsulinemia, and with nephropathy and the classical animal model of the insufficient obese type type ii diabetes of islet function, also is simultaneously the animal pattern of research diabetic nephropathy.The result can find out by table 4 glycolated hemoglobin; Healht-care liquid and positive drug metformin be remarkable blood sugar lowering (p < 0.05) all; The data of table 5-6 show that further healht-care liquid can also effectively improve the hyperinsulinemia (p < 0.05) of diabetic mice, improve the sensitivity (p < 0.05) of body insulin; Effect and metformin are suitable, and healht-care liquid also can blood lipid regulation.This shows that healht-care liquid has the huge research and development potentiality of control Π type diabetes.
Data analysis through urine and blood urea nitrogen; As shown in table 7, the healht-care fluid power enough effectively reduces the loss of urine protein and UCr, reduces the infringement of diabetes to kidney; Thereby protection kidney; Delay the decline of diabetes kidney, this shows that healht-care liquid can be applied to prevention, improves and perhaps treats type ii diabetes and diabetes complicated kidney disease.
Table 4: healht-care liquid is to the influence (
n=12) of diabetes db/db mice glycolated hemoglobin
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 5: healht-care liquid is to the influence (
n=12) of diabetes db/db mice fasting glucose and insulin
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 6: healht-care liquid is to the influence (
n=12) of diabetes db/db mice blood lipid level
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 7: healht-care liquid is to diabetes db/db mice blood urea nitrogen, the influence of urine protein etc. (
n=12)
Annotate: contrast with blank control group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
This experimental result shows; This healht-care fluid power enough significantly reduces the level that high glucose and high fat diet associating STZ induces fasting glucose, FPI, blood fat and the body weight of diabetic mice; And the insulin sensitivity index of raising body, prompting healht-care liquid is prevent diabetes effectively; Can significantly improve the disease symptoms of spontaneous diabetes model animal db/db; Comprise and reduce glycolated hemoglobin, fasting glucose, FPI content; Blood lipid regulation; Improve islets of langerhans sensitivity, and effectively suppress the diabetes nephropathy, show that healht-care liquid has therapeutical effect preferably to diabetes and concurrent nephropathy thereof.These results show that healht-care liquid can be applied to prevention, improve and perhaps treat Π type diabetes and diabetes complicated kidney disease.
The healht-care liquid that the Π diabetes mellitus type can be selected corresponding hardness according to oneself health and dietary habit; If diet is less to the picked-up of mineral; Can select the healht-care liquid (600-1000ppm) of high rigidity for use, otherwise select healht-care liquid (200-400ppm) than soft.
This healht-care liquid derives from deep seawater, has aboundresources, is easy to industrialization, and safe advantages of higher, aspect the preventing and treating of Π type diabetes and complication thereof, has vast market and application prospect.The present invention will be the higher value application of deep seawater offer reference meaning and enlightenment.
Above embodiment is only in order to explaining technical scheme of the present invention, but not limits it; Although the present invention has been carried out detailed explanation with reference to previous embodiment, for the person of ordinary skill of the art, still can make amendment to the technical scheme that previous embodiment is put down in writing, perhaps part technical characterictic wherein is equal to replacement; And these modifications or replacement do not make the essence of relevant art scheme break away from the spirit and the scope of the present invention's technical scheme required for protection.
Claims (9)
1. a healht-care liquid that contains deep seawater is in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; Said healht-care liquid comprises A liquid and B liquid, and said A liquid is fresh water, and said B liquid makes through following steps: deep seawater is isolated dense water section behind reverse osmosis unit; Dense water section is carried out concentrating under reduced pressure; Make its volume be concentrated into the 0.67-3.33% of original volume, remove by filter the sodium chloride of separating out then, the height concentrated solution that obtains is B liquid; The hardness of said healht-care liquid is at 200-1000ppm, and said deep seawater is below the 500m of sea level and the sea water after desalting processing.
2. a kind of healht-care liquid that contains deep seawater according to claim 1 is in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; It is characterized in that magnesium in the said healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5: 0.45-1: 0.3-1: 0.3-1.5; Do not contain Organic substance, and water quality is alkalescence.
3. a kind of healht-care liquid that contains deep seawater according to claim 2 is characterized in that said magnesium: calcium in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product: the ratio of greater inequality of the concentration of potassium is 3: 1: 1.
4. a kind of healht-care liquid that contains deep seawater according to claim 2 is in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; The water quality that it is characterized in that said healht-care liquid is alkalescence, the pH value 7.5 ± 0.3 of 25 ℃ of mensuration.
5. a kind of healht-care liquid that contains deep seawater according to claim 1 is characterized in that the beneficial element content in the said healht-care liquid is: zinc 0.0325-16.4 μ g/L in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; Selenium 0.0395-0.712 μ g/L; Chromium 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L.
6. a kind of healht-care liquid that contains deep seawater according to claim 1 is characterized in that the harmful element content in the said healht-care liquid is: lead＜5 μ g/L in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; Hydrargyrum＜0.5 μ g/L; Arsenic＜5 μ g/L; Cadmium＜1 μ g/L.
7. a kind of healht-care liquid that contains deep seawater according to claim 1 is characterized in that in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product said deep seawater is taken from apart from beyond the 20km of coastline.
8. a kind of healht-care liquid that contains deep seawater according to claim 1 is characterized in that said fresh water sources Yu Haiyang deep water isolated fresh water after the reverse osmosis unit circulation in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product.
9. a kind of healht-care liquid that contains deep seawater according to claim 1 is in preparation prevention or treatment ∏ type diabetes and the medicine of diabetes complicated nephropathy or the application in the health product; It is characterized in that it is the healht-care liquid of 600-1000ppm that diet is selected hardness for use to the less ∏ diabetes mellitus type of the picked-up of mineral, is the healht-care liquid of 200-400ppm otherwise select hardness.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602764A (en) * | 2018-05-14 | 2019-04-12 | 山东中医药大学 | A kind of application of health promoting liquid in preparation prevention and treatment Alzheimer disease drugs |
| CN111184737A (en) * | 2020-02-28 | 2020-05-22 | 山东中医药大学 | Application of fucoidan and deep seawater in prevention and treatment of diabetes cognitive impairment |
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| CN1458087A (en) * | 2002-05-15 | 2003-11-26 | 顾志龙 | Method for producing deep sea drinking water and deep sea additive using deep sea water throuth desalination and concentration |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1458087A (en) * | 2002-05-15 | 2003-11-26 | 顾志龙 | Method for producing deep sea drinking water and deep sea additive using deep sea water throuth desalination and concentration |
Non-Patent Citations (1)
| Title |
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| HEE SUN HWANG, ET AL.: ""Anti-obesity and Antidiabetic Effects of Deep Sea Water on ob/ob Mice"", 《MARINE BIOTECHNOLOGY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602764A (en) * | 2018-05-14 | 2019-04-12 | 山东中医药大学 | A kind of application of health promoting liquid in preparation prevention and treatment Alzheimer disease drugs |
| CN111184737A (en) * | 2020-02-28 | 2020-05-22 | 山东中医药大学 | Application of fucoidan and deep seawater in prevention and treatment of diabetes cognitive impairment |
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