CN103933089A - Selenium enriched dahurian angelica root decoction piece prepared by fermentation and transformation of a plurality of microbial bacterium groups and preparation method thereof - Google Patents

Abstract

The invention relates to a selenium enriched dahurian angelica root decoction piece prepared by fermentation and transformation of a plurality of microbial bacterium groups and a preparation method thereof. The preparation method is characterized by comprising the following steps: dissolving sodium selenite and other trace element groups in a solution, transforming the sodium and trace elements by a plurality of microbial probiotic groups such as bifidobacterium to transform the trace elements into organic trace elements that exist in the microbial probiotic groups and the biological enzyme groups secreted by the microbial probiotic groups and metabolism products of the microbial probiotic groups, soaking fresh slices of dahurian angelica root in the organic solution rich in selenium and microorganisms, wherein in this process the solution is absorbed by the dahurian angelica root taken as the drug carrier and trace elements are transformed and enriched; drying the slices, and finally packaging into small packs so as to obtain the selenium enriched dahurian angelica root decoction piece.

Description

The fermentation of the rich selenium multiple-microorganism of a kind of angelica dahurica decoction pieces bacterium group transforms and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, relate to a kind of decoction pieces of medicinal plants, relate in particular to the fermentation of the rich selenium multiple-microorganism of a kind of angelica dahurica decoction pieces bacterium group and transform and preparation method thereof.

Background technology

In recent years to Chinese crude drug, the prepared slices of Chinese crude drugs, the existence of various trace elements material in Chinese patent medicine preparation, and microelement substance, to the generation of human body various diseases, the pharmacologic action for the treatment of and prevention, and is progressively disclosed by Institute of Science.Adopt biotechnology to supplement Traditional Chinese Medicine and increase one or more trace element, the preparing new-type medical herbs drink tablets of innovation Rich in Trace Element, adjusts the more effective treatment disease of health, is a kind of inevitable choice of human health demand.

The Radix Angelicae Dahuricae, nature and flavor with return through; Pungent, temperature, returns stomach, large intestine, lung meridian.Function with cure mainly: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Usage and consumption: 3-9g.Storage: put shady and cool dry place, mothproof.The Radix Angelicae Dahuricae is containing multiple tonkabean spermin, and its byak-angelicin has dilating effect to cardiovascular coronary vasodilator.There are anti-multiple Xenorhabdus, the pathogenic microorganism such as fungus and antiviral effect.The coumarin essence constituents of the Radix Angelicae Dahuricae is after black light irradiates in vitro, can with the combination of intracellular DNA, suppress DNA replication dna, be one of mechanism for the treatment of psoriasis and tumor.The effect of selenium and trace element: enhancing immunity: organic selenium can be removed interior free yl, gets rid of vivotoxin, antioxidation, can effectively suppress the generation of lipid peroxide, prevents blood clot, removes cholesterol, strengthens immune function of human body; Prevent diabetes: selenium is the active component that forms glutathion peroxidase, and it can prevent beta Cell of islet Oxidative demage, makes its function normal, promote sugar part metabolism, reduce blood glucose and glucose in urine, improve the symptom of diabetics; Prevent cataract: retina is because contact computer radiate etc. is more, subject to damage, selenium can be protected retina, and the fineness of reinforcing glass body improves vision, prevents cataractous effect; Prevent cardiovascular and cerebrovascular disease: selenium is the important element that maintains heart normal function, the effect that heart human body is had protection and repaired.The reduction of human body blood selenium level, can cause removing in body the hypofunction of free radical, cause harmful substance deposition to increase, hypertension, blood vessel wall thickening, blood vessel elasticity reduce, blood flow rate is slack-off, send oxygen function reduction, thereby the sickness rate that brings out cardiovascular and cerebrovascular disease raises, but supply Se scientific has good effect to prevention cardiovascular and cerebrovascular disease, hypertension, arteriosclerosis etc.; Prevent Keshan disease, Kaschin-Beck disease, arthritis: scarce selenium is the Etiological of Keshan disease, Kaschin-Beck disease, two kinds of endemic illness, and selenium supplement can prevent bone marrow end pathological changes, promote to repair, and in protein synthesis, promote the removing toxic substances of disulfide bond antagonism metallic element.These two kinds of endemic illness and arthritic are had to good preventive and therapeutic action; Removing toxic substances, toxin expelling: the adhesion of selenium and metal is very strong, can resist the murder by poisoning of cadmium to kidney, gonad and nervus centralis.The heavy metals such as the hydrargyrum of selenium in body, lead, stannum, thallium are combined, form metallic selenium albumen compound and detoxify, toxin expelling etc.

Summary of the invention

Adopt the tcm and herbal slice Radix Angelicae Dahuricae to transform the pharmaceutical carrier of enrichment as rich selenium and various trace elements class medicine.Select multiple-microorganism fermented bacterium to carry out biotechnology fermentation, Chinese crude drug angelica dahurica decoction pieces is carried out to the organic transformation of Enriching Selenium and various trace elements.By trace element-selenium, zinc, germanium, the trace element medicine group of one or more combinations such as manganese is transformed in the prepared slices of Chinese crude drugs Radix Angelicae Dahuricae, makes its enrichment.So as to supplement and increase in the prepared slices of Chinese crude drugs trace element as medicinal containing quantity not sufficient and shortage problem.Object is to make one or more microelement compositions and the sweat through one or more microbial engineering bacteria groups, trace element is transformed in Chinese medicine and angelica dahurica decoction pieces thereof, strengthens and bring into play Chinese medicine decoction pieces dosage form to prevention and cure of cardiovascular disease, antitumor, antibacterium, antiviral, adjusts body metabolism, improves immunity, whitening beauty treatment, eliminate chloasma, remove skin pathomycete, the diseases such as control vitiligo.Manufacture senior spice and cosmetics raw material, improve popualtion healthy level and quality of life, improve the drug quality of the prepared slices of Chinese crude drugs Radix Angelicae Dahuricae, strengthen drug effect, better bring into play the clinical effect of angelica dahurica decoction pieces.

specific implementation method

1, make a kind of two dry bacterium of qi or multiple-microorganism bacterium solvent, wherein can comprise: lactobacillus, acetic acid bacteria, yeast, bacillus bifidus, the microorganism probiotic kind groups such as fermented glutinous rice and fermentation enzyme group thereof and metabolite liquid thereof.Its strain group need to be under the free of contamination condition of overall process, through the training of Fu Xideng various trace elements group, cultivate, amplification, be converted into containing Xi Fu microbial bacteria group, the selection-breeding of described strain, training, cultivate, amplification, the condition of fermentation overall process, need to add deionization sterilized water 10000ml, maltose 10%-20%, sodium salt 0.5%-1%, phosphoric acid dioxy amine 4%, sucrose 5%-20%, carbamide 0.5%-2%, pH value is adjusted to 4.0-5.5, need in the bioreactor that the multiple dimensioned measurement monitoring of microbial bacteria is installed, carry out fermentation reaction, in overall process, keep the culture environment without the pollution of noxious bacteria, temperature is 20-35 degree, 1-2 days.In the time that microorganism fungus kind group reaches the content of 15%-30% in solvent, need add drinks solvent, total amount is the 4%-10% of cumulative volume, also need to add sodium selenite, sodium selenate, Liuization ?, the probiotic bacteria such as lactobacillus, acetic acid bacteria, yeast and bacillus bifidus proceeds to ferment 12-24 hour for process finishes, and is Enrichment by Microorganisms selenium of the present invention and the organic solvent that contains other trace element.

2, described in, being characterized as the section that the place of production is used the root of the Chinese crude drug Radix Angelicae Dahuricae, is the raw root of 2-3.At source when Folium Angelicae is yellow, gather autumn, remove silt, clean Radix Angelicae Dahuricae root, it falls other impurity.

3, state decoction pieces and adopt rotary medicine cutter to cut medicine, adopting the fresh Radix Angelicae Dahuricae root of vertical cutter vertical cut is decoction pieces fresh slices, and specification is 1.5-3 millimeter.By fresh slices dry in the sun 1-2 days under ventilation shading condition, Radix Angelicae Dahuricae section is slightly shunk.Adopt described Selenium-enriched fermentation organic solvent mixing material of the present invention to soak, infiltrate, run through.

4, add maltose when solvent, rich selenium solvent, be added into Chinese liquor, ethanol, yellow wine.Be modulated into containing wine and ethanol class 4-12 degree mixed organic solvents with described tea rich in selenium water.Enter under decompression merceration machine closed environment, Radix Angelicae Dahuricae root fresh cut slice is carried out to aseptic immersion, each 20-50 minute.The infiltration of the Radix Angelicae Dahuricae need to be carried out in vacuum is heated medicine processing device, and the each 1-2 hour of impregnation process, need to be 5-10 time repeatedly, reaches and runs through.Need to be under 20-40 degree ventilation condition before dry shading dry in the sun 1-2 days.The dry cylinder type medicine roasting machine heat drying that adopts, temperature need to operate 5-3 hour under 20-80 condition, and in decoction pieces, moisture is conformance with standard at 5-10%.Dry products is pressed 10g, 20g, and 50g, 100g, carries out fractional pack; Large packaging can be by 500g, 1000g, 5000g loading amount packaging.

Claims (5)

1. the rich selenium multiple-microorganism of angelica dahurica decoction pieces bacterium group fermentation transforms and preparation method thereof, it is characterized in that; According to described sodium selenite and other various trace elements groups, in a kind of liquid of the present invention, transform through pair Qi Ganjundeng microorganism probiotic group, and be present in the microorganism groups such as the two dry bacterium of qi of the present invention with the form of organic trace element group, comprise and being also present among this microorganism group secreted enzyme group and metabolite thereof.

2. and through microorganism organic solvent liquid such as the rich selenium of use the present invention soak, infiltrate the fresh cut slice of Radix Angelicae Dahuricae root, adsorbed by the fresh cut slice of " Baizhi root containing selenium richness selenium organic liquid solvent, absorb, transform, dry, through fractional pack sealing, make the rich selenium angelica dahurica decoction pieces of Chinese medicine.

3. the fermentation of the rich selenium multiple-microorganism of a kind of angelica dahurica decoction pieces according to claim 1 bacterium group transforms and preparation method thereof, it is characterized in that, Selenium-enriched fermentation organic liquid solvent, is by a kind of two dry bacterium of qi or multiple-microorganism flora group, wherein can comprise; Lactobacillus, acetic acid bacteria, yeast, bacillus bifidus, the microorganism probiotic kind groups such as fermented glutinous rice and fermentation enzyme group thereof and metabolite liquid thereof.

4. the fermentation of the rich selenium multiple-microorganism of a kind of angelica dahurica decoction pieces according to claim 1 bacterium group transforms and preparation method thereof, it is characterized in that, its strain group need to be under the free of contamination condition of overall process, through the training of Fu Xideng various trace elements group, cultivate, amplification, be converted into containing Xi Fu microbial bacteria group, the selection-breeding of described strain, training, cultivate, amplification, the condition of fermentation overall process, need to add deionization sterilized water 10000ml, maltose 10%-20%, sodium salt 0.5%-1%, phosphoric acid dioxy amine 4%, sucrose 5%-20%, carbamide 0.5%-2%, pH value is adjusted to 4.0-5.5, need in the bioreactor that the multiple dimensioned measurement monitoring of microbial bacteria is installed, carry out fermentation reaction, in overall process, keep the culture environment without the pollution of noxious bacteria, temperature is 20-35 degree, 1-2 days.

5. the fermentation of the rich selenium multiple-microorganism of a kind of angelica dahurica decoction pieces according to claim 1 bacterium group transforms and preparation method thereof, it is characterized in that, in the time that microorganism fungus kind group reaches the content of 15%-30% in solvent, need add drinks solvent, total amount is the 4%-10% of cumulative volume, also need to add sodium selenite, sodium selenate, Liuization ?, the probiotic bacteria such as lactobacillus, acetic acid bacteria, yeast and bacillus bifidus proceeds to ferment 12-24 hour for process finishes, and is Enrichment by Microorganisms selenium of the present invention and the organic solvent that contains other trace element.