CN102697807B - Application of health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy - Google Patents
Application of health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses an application of a health-care drinking liquid in preparation of medicines or health-care products for preventing or treating II-type diabetes mellitus, diabetes mellitus and diabetic nephropathy. The health-care drinking liquid comprises a liquid A and a liquid B; the liquid B is a high-concentration concentrated liquid which is obtained by decompression concentration of concentrated water part separated from deep ocean water through a reverse osmosis apparatus; and the hardness range of the health-care drinking liquid is 200-1000ppm. The health-care drinking liquid is fed to experimental animals with II-type diabetes mellitus in a free drinking manner and can be used for remarkably reducing levels of fasting blood-glucose, fasting plasma insulin, blood lipid and weights in diabetic mice induced by combination of high-glucose and high-fat diets and STZ (Streptozotocin) and improving insulin sensitivities and remarkably improving db/db disease syndromes of spontaneous diabetes model animals and effectively inhibiting diabetic nephropathy lesions, so that the health-care drinking liquid can be applied to preventing, improving or treating II-type diabetes mellitus and diabetic nephropathy diseases. The health-care drinking liquid has the advantages of rich resources and easy industrialization and the like.
Description
Technical field
The invention belongs to marine biotechnology field, relate to the comprehensive utilization of deep seawater, be specifically related to the application of a kind of healht-care liquid in medicine or the health product of preparation prevention or treatment Π type diabetes and diabetes complicated nephropathy.
Background technology
Along with the variation of people's living habit and diet structure, the sickness rate of diabetes sharply rises.The data show that WHO issues, the annual whole world probably has 3,000,000 people to die from the disease that diabetes are relevant.In China, add up according to diabetes association of Chinese Medical Association, the sickness rate of diabetes has reached 4%, the diabetics of having made a definite diagnosis reaches 5,000 ten thousand, and with annual 1000000 speed sharp increase, and in the crowd in cities and towns and more rich rural area, the sickness rate of diabetes oneself through reaching 11%, in addition nearly people's blood glucose regulatory function of 15% is impaired in addition, and China probably can become global the first diabetes big country.
Diabetes are metabolic diseases that one group of cause of disease and pathogenesis are illustrated not yet completely, and sugar, fat and protein metabolism get muddled in patient's body, and and then cause a series of complication.It has produced serious harm to human health in the world.The harm that diabetes are huge to healthy generation, can cause the multiple tissues of body to produce serial complication, human health is caused and had a strong impact on, almost the diabetic of 75-80% is died from cardiovascular disease, and diabetic obtains the high 2-4 of probability times of coronary heart disease than non-diabetic, their treatment is also poorer, and the death that diabetes cause makes ill crowd's life expectancy reduce 12-14, and quality of life greatly reduces.At present, diabetes are divided into 3 classes by WHO, comprises type i diabetes, type ii diabetes and gestational diabetes, and wherein the sickness rate of type ii diabetes accounts for greatly 90% left and right of diabetic sum.
So far, also do not treat the ideal medicament of type ii diabetes.The treatment of diabetes is advocated to use more and do not stimulate insulin secretion, and there is blood sugar lowering, blood fat reducing, can improve again the medicine of diabetes and metabolism disorder thereof.And research shows, supplementary mineral element can comparatively significantly improve the glycolipid metabolism of body, has positive role improving the appearance of delaying complications of diabetes and improve aspect existing diabetic complication.
Deep seawater typically refer to solar radiation less than, can not carry out photosynthesis, the sea water below the about 200m degree of depth.The ocean of deep seawater in entering without sunlight be without photosphere, and away from impact and the pollution of the chemical substance from the mankind, land and atmosphere.Research shows, deep seawater has following main feature: (1) low temperature homeostasis-be not subject to solar radiation, and changeable unlike sea surface coolant-temperature gage, deep seawater is temperature-resistant all the year round, is constant at 5 ℃ of left and right; (2) the abundant and stability of mineral element-with sea surface water ratio, deep seawater is rich in 92 kinds of mineral elements such as the necessary calcium of human body, magnesium, potassium, sodium, ferrum, copper, lithium, molybdenum, manganese, zinc, germanium, iodine, phosphorus, fluorine, selenium, trivalent chromium, silicate ion, has contained the required element kind of human body metabolism.Except its rich content, because these water flow in the bathypelagic of " without photosphere " with the very long time, occur, be not subject to ectocine without photosynthesis, therefore the composition of contained mineral element is very stable, has ideally solved the requirement of the various required mineral elements of total balance of the body picked-up; (3) deep water of aseptic spatter property-in ocean " without photosphere ", except the impact away from mankind's modern civilization and be not subject to the pollution of land, Atmospheric Chemistry material, pathogenic bacteria, itself is also without the condition that generates the antibacterials such as pathogen.Therefore, deep seawater is the water of the aseptic nature that cleans very much; (4) deep seawater water quality is alkalescence.
Owing to having above feature, deep seawater is being subject to attracting attention of common people as a kind of new natural resources.Deep seawater is rich in various mineral and trace element, and it has good improvement effect to type ii diabetes and complication thereof in theory.China's marine site broadness, coastline is very long, and marine resources are abundant, but there is no the research of deep seawater Application and Development aspect; And China's water scarcity, water is seriously polluted, and the sickness rate of type ii diabetes sharply rises, so the bathypelagic water resource of exploitation China has very important meaning.
Summary of the invention
The hot issues such as, water pollution day by day in short supply for current China water resource is on the rise and type ii diabetes sickness rate sharply raises, the invention provides the application of a kind of healht-care liquid in medicine or the health product of preparation prevention or treatment type ii diabetes and diabetes complicated nephropathy.
For achieving the above object, the present invention adopts following technical proposals to be achieved:
The application of a kind of healht-care liquid in medicine or the health product of preparation prevention or treatment type ii diabetes and diabetes complicated nephropathy, described healht-care liquid comprises A liquid and B liquid, described A liquid is fresh water, described B liquid makes through following steps: deep seawater is isolated dense water section after reverse osmosis unit, dense water section is carried out to concentrating under reduced pressure, make its volume be concentrated into the 0.67-3.33% of original volume, then remove by filter the sodium chloride of separating out, the height concentrated solution obtaining is B liquid, the hardness of described healht-care liquid is at 200-1000ppm, described deep seawater is the sea water below the 500m of sea level and after desalting processing.
Further improvement to technique scheme: magnesium in described healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, not containing Organic substance, and water quality is alkalescence.
Further improvement to technique scheme: described magnesium: calcium: the ratio of greater inequality of concentration of potassium is 3:1:1.
Further improvement to technique scheme: the water quality of described healht-care liquid is alkalescence, 25 ° of pH value 7.5 ± 0.3 that C measures.
Further improvement to technique scheme: the beneficial element content in described healht-care liquid is: zinc 0.0325-16.4 μ g/L; Selenium 0.0395-0.712 μ g/L; Chromium 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L.
Further improvement to technique scheme: the harmful element content in described healht-care liquid is: plumbous <5 μ g/L; Hydrargyrum <0.5 μ g/L; Arsenic <5 μ g/L; Cadmium <1 μ g/L.
Further improvement to technique scheme: described deep seawater is taken from apart from beyond the 20km of coastline.
Further improvement to technique scheme: described fresh water sources Yu Haiyang deep water is isolated fresh water after reverse osmosis unit circulation.
Further improvement to technique scheme: it is the healht-care liquid of 600-1000ppm that diet is selected hardness to the less Π diabetes mellitus type of the picked-up of mineral, on the contrary the healht-care liquid that hardness is 200-400ppm selected.
Compared with prior art, advantage of the present invention and good effect are: the healht-care liquid that contains deep seawater provided by the invention is rich in healthy trace elements with household magnesium, calcium, vanadium, chromium, manganese, zinc, selenium, and Harmful Trace Elements hydrargyrum and plumbous content are very low, the present invention shows by biotic experiment, this healht-care liquid can significantly improve Π type diabetes laboratory animal disease symptoms, comprise reduction glycolated hemoglobin, fasting glucose, fasting insulin, the content of blood fat, improve islets of langerhans sensitivity, and effectively suppress diabetes nephropathy, prove that healht-care liquid can be applied to preparation prevention, improve or the medicine or health product for the treatment of Π type diabetes and diabetes complicated kidney disease in.
The specific embodiment
Below in conjunction with the specific embodiment, technical scheme of the present invention is described in further detail.
Embodiment 1
One, the preparation of healht-care liquid
The preparation method of healht-care liquid of the present invention is as follows:
1) bathypelagic water pretreatment: will take from apart from beyond the 20km of coastline, sea level 500m puts into water tank with dark deep seawater, adopts filter to filter, and removes phytoplankton and microorganism in sea water, and filter by active carbon filter, further remove Organic substance.
2) fresh water separates with dense water: the deep seawater obtaining after pretreatment is entered to reverse osmosis unit by high-pressure pump and deep seawater is divided into fresh water part (fresh water part water quality is identical with pure water, or water quality approaches pure water with dense water section; In dense water section, the concentration of various zwitterions approaches 2 times of various ion concentrations in former sea water), isolated fresh water part is that A liquid enters fresh water water tank, isolated dense water section enters dense water water tank.The technological parameter of reverse osmosis unit is: 4MPa, power 1.5KW, aquifer yield 1T/d are pressed in running.
3) the de-sodium processing of dense water: the dense water section in dense water water tank is carried out to concentrating under reduced pressure, make its volume be concentrated into the 0.67-3.33% of original volume, then remove by filter the sodium chloride of separating out, the concentrated solution that obtains highly concentrating is B liquid, magnesium in described concentrated solution: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, described magnesium, calcium, potassium, the content concn unit of sodium element in concentrated solution are mg/L.Wherein trace element chromium, zinc, selenium, the concentration of manganese etc. and cycles of concentration are multiple proportions relation.
Or, also can adopt selectivity electrodialysis to reverse osmosis after isolated dense water section take off sodium processing, electrodialysis plant adopts 1 valency cation selective to see through film, cavity block adopts conventional ion exchange membrane.In electrodialytic process, all aniones all can see through cavity block, and only univalent cation sees through anode membrane, and the polyvalent cation in the dense water after de-sodium is close with the concentration in former dense water.
4) healht-care liquid fill: the B liquid obtaining through fresh water A liquid out of step 1) reverse osmosis unit and step 3) can be mixed to the healht-care liquid that make different hardness according to demand, and described hardness is with CaCO
3cubage (GB 5749-2006 drinking water sanitary standard), its computing formula is: hardness=Ca (ppm)) × 2.5+Mg (ppm) × 4.1, through high temperature sterilize, subpackage.
Adopt inductively coupled plasma mass spectrum (ICP-MS) to measure the inorganic element content in healht-care liquid: the healht-care liquid take hardness as 1000 is as example, and wherein several main mine materials and micronutrient levels are: magnesium: 200-224mg/L; Calcium: 33-67mg/L; Potassium: 20-67mg/L; Sodium: the content of 20-100mg/L(sodium is more low better); Zinc: 0.0325-16.4 μ g/L; Selenium: 0.0395-0.712 μ g/L; Chromium: 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L, plumbous <5 μ g/L; Hydrargyrum <0.5 μ g/L; Arsenic <5 μ g/L; Cadmium <1 μ g/L.
Healht-care liquid mineral under 200-1000 hardness of the present invention and micronutrient levels are directly proportional to its hardness.Magnesium in described healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, is rich in healthy trace elements with household zinc, selenium, chromium, manganese, Harmful Trace Elements lead, hydrargyrum, arsenic, cadmium content is lower, and not containing Organic substance, and water quality is alkalescence.
Described healthy trace elements with household content is as follows: zinc: 0.0325-16.4 μ g/L; Selenium: 0.0395-0.712 μ g/L; Chromium: 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L.
Described Harmful Trace Elements content is as follows: plumbous <5 μ g/L; Hydrargyrum <0.5 μ g/L; Arsenic <5 μ g/L; Cadmium <1 μ g/L.
Use pH meter to measure (25 ° of C) to its pH value, result shows that healht-care liquid pH value is in 7.5 ± 0.3 scopes, and water quality is alkalescence.
Two: the pharmacodynamic experiment of health-care drinking-water prevention Π type diabetes
1, experimental technique
32 of Kunming mouses, male, body weight 18-22g, is divided into blank group, model group, positive control (metformin hydrochloride, Metf) group and healht-care liquid group, 8 every group at random.Experimental session mice ad lib and drinking-water.Normal group gives normal feedstuff and distilled water; Feed with high glucose and high fat feedstuff for all the other 24, except healht-care liquid group gives healht-care liquid that hardness is 1000ppm, all the other all give distilled water.Positive controls starts to give metformin 225mg/kgd on the 4th week in experiment, after 5 weeks, experimental mice lumbar injection streptozotocin (STZ) 150mg/kgd, divides and gives for 5 times, and continue to give high glucose and high fat feedstuff after 1 week, tail intravenous needle is adopted hematometry fasting glucose, extract eyeball of mouse again and get blood, centrifuging and taking serum, measures insulin, free fatty (FFA) in mice serum, triglyceride (TG), T-CHOL (TC) content.
2, experimental result
(1) impact of healht-care liquid on diabetic mice fasting glucose and insulin: can be learnt by table 1, more blank group of model group mice fasting glucose obviously increases, represents that model is successfully established.Positive drug Metf group and healht-care liquid group mice fasting glucose reduce compared with model group, and this prompting healht-care liquid group has hypoglycemic activity.Meanwhile, the processing of healht-care liquid makes fasting insulin content have downward trend.Can find out according to insulin sensitivity index result of calculation, model group animal insulin sensitivity significantly reduces, healht-care liquid is processed the Sensitivity Index (p<0.05) that can increase insulin, and this prompting healht-care liquid has the insulin sensitivity of increasing effect.
Table 1: the impact of healht-care liquid on diabetic mice fasting glucose and insulin (
n=8)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
(2) impact of healht-care liquid on diabetic mice blood lipid level: table 2 can be found out, model group mice FFA, TG, more blank group of TC content significantly raise (p<0.05), represents that model is successfully established; Healht-care liquid treated animal blood fat has reduction trend, and this prompting healht-care liquid has the blood fat of improvement.
Table 2: healht-care liquid on diabetic mice blood lipid level impact (
n=8)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
(3) impact of healht-care liquid on diabetic mice body weight level: duration of test, in the set time weighs the weight of animals weekly, statistical analysis, during administration, each treated animal body weight change is without significant difference (p>0.05), but with model group comparison, healht-care liquid processed group had downward trend since the 4th week, this prompting healht-care liquid has antiobesity action.
Table 3: healht-care liquid to diabetic mice body weight level affects (
n=8, g)
(4) duration of test, the food ration of each treated animal and amount of drinking water no significant difference (p>0.05)
The experimental result of above-mentioned (1)-(4) shows, this healht-care liquid can suppress the diabetic mice fasting glucose of high glucose and high fat diet associating STZ induction and the rising of insulin, and significantly improves insulin sensitivity index.Suppress the rising of diabetic mice blood lipid level and body weight simultaneously.Effectively prevent diabetes of these results suggest healht-care liquid.
Three, the pharmacodynamic experiment of healht-care liquid treatment Π type diabetes and diabetes complicated nephropathy
1, experimental technique
Get 36 of db/db mices, male, 4～6 week age.Experimental session animal ad lib, freely drink water (distilled water or healht-care liquid).Ob/ob mice is divided into 3 groups at random, 12 every group, is respectively model control group, positive controls, healht-care liquid group.12 C57BLs of blank group for choosing immediately, 5 week age mice.Positive controls gives Dimethyldiguanide hydrochloride enteric solubility tablet 225mgkg-1d-1, processes continuously 75 days.Measure weekly fasting glucose.And examine animal state and make a record.After last medicine, water 12h is can't help in fasting, and the while is also collected urine in metabolic cage, and tail intravenous needle is adopted hematometry fasting glucose, then extracts eyeball of mouse and get blood, and centrifuging and taking serum is measured every biochemical indicator in mice serum and urine.
2, experimental result
Db/db mice is that one has hyperglycemia and hyperinsulinemia, and with the classical animal model of the obese type type ii diabetes of nephropathy and islet function deficiency, is also the animal pattern of research diabetic nephropathy simultaneously.Can be found out by table 4 glycolated hemoglobin result, healht-care liquid and positive drug metformin all can significantly reduce blood glucose (p<0.05), the data of table 5-6 further show, healht-care liquid can also effectively improve the hyperinsulinemia (p<0.05) of diabetic mice, improve the sensitivity (p<0.05) of body insulin, effect and metformin are suitable, and healht-care liquid also can regulate blood fat.This shows that healht-care liquid has the huge research and development potentiality of control Π type diabetes.
By the data analysis of urine and blood urea nitrogen; as shown in table 7; healht-care liquid can effectively reduce the loss of urine protein and urine creatine; reduce the infringement of diabetes to kidney; thereby protection kidney; delay the decline of diabetes kidney, this shows that healht-care liquid can be applied to prevention, improves or treatment type ii diabetes and diabetes complicated kidney disease.
Table 4: the impact of healht-care liquid on diabetes db/db mice glycolated hemoglobin (
n=12)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 5: the impact of healht-care liquid on diabetes db/db mice fasting glucose and insulin (
n=12)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 6: the impact of healht-care liquid on diabetes db/db lipid of mice level (
n=12)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
Table 7: healht-care liquid is to diabetes db/db Mouse Blood blood urea nitrogen, the impact of urine protein etc. (
n=12)
Note: contrast with blank group:
#p<0.05,
##p<0.01; Contrast with model group:
*p<0.05,
*p<0.01
This experimental result shows, this healht-care liquid can significantly reduce the level of fasting glucose, fasting insulin, blood fat and the body weight of high glucose and high fat diet associating STZ induction diabetic mice, and improve the insulin sensitivity index of body, effectively prevent diabetes of prompting healht-care liquid; Can significantly improve the disease symptoms of spontaneous diabetes model animal db/db, comprise and reduce glycolated hemoglobin, fasting glucose, fasting insulin content, regulate blood fat, improve islets of langerhans sensitivity, and effectively suppress diabetes nephropathy, show that healht-care liquid has good therapeutical effect to diabetes and Nephropathy thereof.These results show that healht-care liquid can be applied to prevention, improve or treatment Π type diabetes and diabetes complicated kidney disease.
Π diabetes mellitus type can be selected according to the health of oneself and dietary habit the healht-care liquid of corresponding hardness, if diet is less to the picked-up of mineral, can select the healht-care liquid (600-1000ppm) of high rigidity, otherwise select compared with the healht-care liquid (200-400ppm) of soft.
This healht-care liquid derives from deep seawater, has aboundresources, is easy to industrialization, and safe advantages of higher, aspect the preventing and treating of Π type diabetes and complication thereof, has wide market and application prospect.The present invention is by offer reference for the higher value application of deep seawater meaning and enlightenment.
Above embodiment is only in order to technical scheme of the present invention to be described, but not is limited; Although the present invention is had been described in detail with reference to previous embodiment, for the person of ordinary skill of the art, the technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (4)
1. a healht-care liquid that the contains deep seawater application in medicine or the health product of preparation prevention or treatment Π type diabetes and diabetes complicated nephropathy, described healht-care liquid comprises A liquid and B liquid, described A liquid is fresh water, described B liquid makes through following steps: deep seawater is isolated dense water section after reverse osmosis unit, dense water section is carried out to concentrating under reduced pressure, make its volume be concentrated into the 0.67-3.33% of original volume, then remove by filter the sodium chloride of separating out, the height concentrated solution obtaining is B liquid, the hardness of described healht-care liquid is at 200-1000 ppm, described deep seawater is the sea water below the 500m of sea level and after desalting processing,
Beneficial element content in described healht-care liquid is: zinc 0.0325-16.4 μ g/L; Selenium 0.0395-0.712 μ g/L; Chromium 0.104-4.54 μ g/L; Manganese 0.156-5.52 μ g/L;
Harmful element content in described healht-care liquid is: plumbous < 5 μ g/L; Hydrargyrum < 0. 5 μ g/L; Arsenic < 5 μ g/L; Cadmium < 1 μ g/L;
Magnesium in described healht-care liquid: calcium: potassium: the concentration ratio of sodium element is 2.5-3.5:0.45-1:0.3-1:0.3-1.5, not containing Organic substance, and water quality is alkalescence;
The water quality of described healht-care liquid is alkalescence, 25 ° of pH value 7.5 ± 0.3 that C measures;
Described deep seawater is taken from apart from beyond the 20km of coastline.
2. the application of a kind of healht-care liquid that contains deep seawater according to claim 1 in medicine or the health product of preparation prevention or treatment Π type diabetes and diabetes complicated nephropathy, is characterized in that described magnesium: calcium: the ratio of greater inequality of the concentration of potassium is 3:1:1.
3. the application of a kind of healht-care liquid that contains deep seawater according to claim 1 in medicine or the health product of preparation prevention or treatment Π type diabetes and diabetes complicated nephropathy, is characterized in that described fresh water sources Yu Haiyang deep water isolated fresh water after reverse osmosis unit circulation.
4. the application of a kind of healht-care liquid that contains deep seawater according to claim 1 in medicine or the health product of preparation prevention or treatment Π type diabetes and diabetes complicated nephropathy, it is characterized in that it is the healht-care liquid of 600-1000 ppm that diet is selected hardness to the less Π diabetes mellitus type of the picked-up of mineral, is the healht-care liquid of 200-400 ppm otherwise select hardness.
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