CN102690300B - 克林霉素磷酸酯溶剂化物晶体及其制备方法 - Google Patents
克林霉素磷酸酯溶剂化物晶体及其制备方法 Download PDFInfo
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- CN102690300B CN102690300B CN201210137702.5A CN201210137702A CN102690300B CN 102690300 B CN102690300 B CN 102690300B CN 201210137702 A CN201210137702 A CN 201210137702A CN 102690300 B CN102690300 B CN 102690300B
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- clindamycin phosphate
- water
- crystal
- solvate crystal
- dimethyl sulfoxide
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- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 title claims abstract description 71
- 229960002291 clindamycin phosphate Drugs 0.000 title claims abstract description 71
- 239000013078 crystal Substances 0.000 title claims abstract description 55
- 239000012453 solvate Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 84
- 150000001875 compounds Chemical class 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 21
- 239000012046 mixed solvent Substances 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 230000002269 spontaneous effect Effects 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 125000006850 spacer group Chemical group 0.000 claims description 3
- 239000000126 substance Substances 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 8
- 229910002483 Cu Ka Inorganic materials 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 3
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical group CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 229960002227 clindamycin Drugs 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- -1 lactone compound Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003161 proteinsynthetic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Abstract
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CN201210137702.5A CN102690300B (zh) | 2009-03-16 | 2009-03-16 | 克林霉素磷酸酯溶剂化物晶体及其制备方法 |
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CN201210137702.5A CN102690300B (zh) | 2009-03-16 | 2009-03-16 | 克林霉素磷酸酯溶剂化物晶体及其制备方法 |
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CN 200910019903 Division CN101838298B (zh) | 2009-03-16 | 2009-03-16 | 克林霉素磷酸酯溶剂化物晶体及其制备方法 |
Publications (2)
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CN102690300A CN102690300A (zh) | 2012-09-26 |
CN102690300B true CN102690300B (zh) | 2014-07-30 |
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CN201210137702.5A Active CN102690300B (zh) | 2009-03-16 | 2009-03-16 | 克林霉素磷酸酯溶剂化物晶体及其制备方法 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102973595B (zh) * | 2012-11-28 | 2013-12-11 | 海南锦瑞制药股份有限公司 | 一种克林霉素磷酸酯的药物组合物 |
CN103288893B (zh) * | 2013-06-05 | 2015-08-19 | 天津大学 | 克林霉素磷酸酯二甲基亚砜溶剂化合物晶体及制备方法 |
CN103288894B (zh) * | 2013-06-05 | 2015-08-19 | 天津大学 | 克林霉素磷酸酯甲醇-水溶剂化合物晶体及制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1274313C (zh) * | 2004-08-27 | 2006-09-13 | 北京国仁堂医药科技发展有限公司 | 一种克林霉素磷酸酯粉针剂的制备方法 |
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2009
- 2009-03-16 CN CN201210137702.5A patent/CN102690300B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1274313C (zh) * | 2004-08-27 | 2006-09-13 | 北京国仁堂医药科技发展有限公司 | 一种克林霉素磷酸酯粉针剂的制备方法 |
Non-Patent Citations (4)
Title |
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克林霉素磷酸酯合成新工艺及相关问题的研究;李晓强;《中国优秀硕士学位论文全文数据库》;20020615;B016-6 * |
克林霉素磷酸酯结晶工艺;谌怡等;《化工进展》;20081231;第27卷(第11期);第1846-1850页 * |
李晓强.克林霉素磷酸酯合成新工艺及相关问题的研究.《中国优秀硕士学位论文全文数据库》.2002,B016-6. |
谌怡等.克林霉素磷酸酯结晶工艺.《化工进展》.2008,第27卷(第11期),第1846-1850页. |
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CN102690300A (zh) | 2012-09-26 |
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Address after: 519041 Guangdong province Zhuhai Sanzao Road No. 9 East Coast Co-patentee after: YIBANG GUOCHUANG INSTITUTE OF MATERIA MEDICA (BEIJING) Co.,Ltd. Patentee after: Zhuhai Yibang Pharmaceutical Co.,Ltd. Address before: 519041 Guangdong province Zhuhai Sanzao Road No. 9 East Coast Co-patentee before: YIBANG GUOCHUANG INSTITUTE OF MATERIA MEDICA (BEIJING) Co.,Ltd. Patentee before: ZHUHAI EBANG PHARMACEUTICAL Co.,Ltd. |
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