CN102648210A - Dll4结合分子 - Google Patents

Dll4结合分子 Download PDF

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Publication number
CN102648210A
CN102648210A CN2010800548891A CN201080054889A CN102648210A CN 102648210 A CN102648210 A CN 102648210A CN 2010800548891 A CN2010800548891 A CN 2010800548891A CN 201080054889 A CN201080054889 A CN 201080054889A CN 102648210 A CN102648210 A CN 102648210A
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Prior art keywords
dll4
seq
vhh
variable domain
single variable
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Pending
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CN2010800548891A
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Chinese (zh)
Inventor
E.伯吉斯
A.格什温
J.鲍克尼厄
E.德塔沃尼尔
J.科尔克曼
P.麦切尔斯
D.范胡里克
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN102648210A publication Critical patent/CN102648210A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Biotechnology (AREA)
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CN2010800548891A 2009-10-02 2010-10-01 Dll4结合分子 Pending CN102648210A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09172132 2009-10-02
EP09172132.4 2009-10-02
PCT/EP2010/064693 WO2011039368A2 (en) 2009-10-02 2010-10-01 Dll4-binding molecules

Publications (1)

Publication Number Publication Date
CN102648210A true CN102648210A (zh) 2012-08-22

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ID=42083895

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CN2010800548891A Pending CN102648210A (zh) 2009-10-02 2010-10-01 Dll4结合分子

Country Status (24)

Country Link
US (1) US20110195494A1 (https=)
EP (1) EP2483313A2 (https=)
JP (1) JP2013506410A (https=)
KR (1) KR20120115217A (https=)
CN (1) CN102648210A (https=)
AP (1) AP2012006167A0 (https=)
AR (1) AR078516A1 (https=)
AU (1) AU2010302587A1 (https=)
BR (1) BR112012007294A2 (https=)
CA (1) CA2775420A1 (https=)
CL (1) CL2012000818A1 (https=)
EA (1) EA201200549A1 (https=)
EC (1) ECSP12011828A (https=)
IL (1) IL218544A0 (https=)
IN (1) IN2012DN02715A (https=)
MA (1) MA33609B1 (https=)
MX (1) MX2012003797A (https=)
NZ (1) NZ598650A (https=)
PE (1) PE20121184A1 (https=)
PH (1) PH12012500524A1 (https=)
TN (1) TN2012000144A1 (https=)
TW (1) TW201124532A (https=)
UY (1) UY32917A (https=)
WO (1) WO2011039368A2 (https=)

Cited By (5)

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CN109160948A (zh) * 2018-09-21 2019-01-08 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN111875706A (zh) * 2020-07-16 2020-11-03 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
CN116547006A (zh) * 2021-08-06 2023-08-04 贝达药业股份有限公司 抗pd-l1纳米抗体及其应用
CN117659194A (zh) * 2023-11-30 2024-03-08 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN119861194A (zh) * 2025-03-25 2025-04-22 中国计量大学 一种检测牛乳酪蛋白的纳米酶免疫层析方法及试剂盒

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US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
KR101535341B1 (ko) 2012-07-02 2015-07-13 한화케미칼 주식회사 Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
KR102089591B1 (ko) * 2013-07-29 2020-03-18 삼성전자주식회사 항 EGFR scFv 단편 및 이를 포함하는 항 c-Met/항 EGFR 이중 특이 항체
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US11339213B2 (en) 2015-09-23 2022-05-24 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer
EP3493844A4 (en) 2016-05-20 2021-03-24 Harpoon Therapeutics Inc. SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
AU2017363300A1 (en) 2016-11-23 2019-06-20 Harpoon Therapeutics, Inc. Prostate specific membrane antigen binding protein
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US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
EP3621994A4 (en) 2017-05-12 2020-12-30 Harpoon Therapeutics, Inc. MESOTHELIN BINDING PROTEINS
WO2018209304A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
MX2020003915A (es) 2017-10-13 2020-10-08 Harpoon Therapeutics Inc Proteinas trispecificas y metodos de uso.
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
BR112020023330A2 (pt) 2018-05-14 2021-04-20 Harpoon Therapeutics, Inc. porção de ligação para ativação condicional de moléculas de imunoglobulina
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
AU2020275002A1 (en) 2019-05-14 2021-12-23 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
CN115768463A (zh) 2020-02-21 2023-03-07 哈普恩治疗公司 Flt3结合蛋白及使用方法
EP4608860A1 (en) * 2022-10-26 2025-09-03 Berking Biotechnology SpA Single domain antibody - sdab/vhh against the nucleoprotein of sars-cov-2 virus
WO2025043019A1 (en) * 2023-08-21 2025-02-27 The Research Foundation For The State University Of New York Slc4a1 (band 3) binding single domain antibodies for increased blood retention

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109160948A (zh) * 2018-09-21 2019-01-08 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN109160948B (zh) * 2018-09-21 2021-07-16 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN111875706A (zh) * 2020-07-16 2020-11-03 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
CN116547006A (zh) * 2021-08-06 2023-08-04 贝达药业股份有限公司 抗pd-l1纳米抗体及其应用
CN117659194A (zh) * 2023-11-30 2024-03-08 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN117659194B (zh) * 2023-11-30 2024-08-13 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN119861194A (zh) * 2025-03-25 2025-04-22 中国计量大学 一种检测牛乳酪蛋白的纳米酶免疫层析方法及试剂盒
CN119861194B (zh) * 2025-03-25 2025-06-03 中国计量大学 一种检测牛乳酪蛋白的纳米酶免疫层析方法及试剂盒

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CL2012000818A1 (es) 2012-10-19
WO2011039368A3 (en) 2011-06-23
ECSP12011828A (es) 2012-05-30
MX2012003797A (es) 2012-06-28
WO2011039368A2 (en) 2011-04-07
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