CN102648210A - Dll4结合分子 - Google Patents

Dll4结合分子 Download PDF

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Publication number
CN102648210A
CN102648210A CN2010800548891A CN201080054889A CN102648210A CN 102648210 A CN102648210 A CN 102648210A CN 2010800548891 A CN2010800548891 A CN 2010800548891A CN 201080054889 A CN201080054889 A CN 201080054889A CN 102648210 A CN102648210 A CN 102648210A
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Prior art keywords
dll4
seq
vhh
variable domain
single variable
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Pending
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CN2010800548891A
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Chinese (zh)
Inventor
E.伯吉斯
A.格什温
J.鲍克尼厄
E.德塔沃尼尔
J.科尔克曼
P.麦切尔斯
D.范胡里克
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN102648210A publication Critical patent/CN102648210A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN2010800548891A 2009-10-02 2010-10-01 Dll4结合分子 Pending CN102648210A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09172132.4 2009-10-02
EP09172132 2009-10-02
PCT/EP2010/064693 WO2011039368A2 (en) 2009-10-02 2010-10-01 Dll4-binding molecules

Publications (1)

Publication Number Publication Date
CN102648210A true CN102648210A (zh) 2012-08-22

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ID=42083895

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Application Number Title Priority Date Filing Date
CN2010800548891A Pending CN102648210A (zh) 2009-10-02 2010-10-01 Dll4结合分子

Country Status (24)

Country Link
US (1) US20110195494A1 (https=)
EP (1) EP2483313A2 (https=)
JP (1) JP2013506410A (https=)
KR (1) KR20120115217A (https=)
CN (1) CN102648210A (https=)
AP (1) AP2012006167A0 (https=)
AR (1) AR078516A1 (https=)
AU (1) AU2010302587A1 (https=)
BR (1) BR112012007294A2 (https=)
CA (1) CA2775420A1 (https=)
CL (1) CL2012000818A1 (https=)
EA (1) EA201200549A1 (https=)
EC (1) ECSP12011828A (https=)
IL (1) IL218544A0 (https=)
IN (1) IN2012DN02715A (https=)
MA (1) MA33609B1 (https=)
MX (1) MX2012003797A (https=)
NZ (1) NZ598650A (https=)
PE (1) PE20121184A1 (https=)
PH (1) PH12012500524A1 (https=)
TN (1) TN2012000144A1 (https=)
TW (1) TW201124532A (https=)
UY (1) UY32917A (https=)
WO (1) WO2011039368A2 (https=)

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CN109160948A (zh) * 2018-09-21 2019-01-08 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN111875706A (zh) * 2020-07-16 2020-11-03 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
CN116547006A (zh) * 2021-08-06 2023-08-04 贝达药业股份有限公司 抗pd-l1纳米抗体及其应用
CN117659194A (zh) * 2023-11-30 2024-03-08 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN119861194A (zh) * 2025-03-25 2025-04-22 中国计量大学 一种检测牛乳酪蛋白的纳米酶免疫层析方法及试剂盒

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US20130078247A1 (en) * 2011-04-01 2013-03-28 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to dii4 and ang2
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
KR101535341B1 (ko) 2012-07-02 2015-07-13 한화케미칼 주식회사 Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
KR102089591B1 (ko) 2013-07-29 2020-03-18 삼성전자주식회사 항 EGFR scFv 단편 및 이를 포함하는 항 c-Met/항 EGFR 이중 특이 항체
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CN110198955A (zh) 2016-11-23 2019-09-03 哈普恩治疗公司 前列腺特异性膜抗原结合蛋白质
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WO2018209304A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
HRP20241268T1 (hr) 2017-10-13 2024-12-06 Harpoon Therapeutics, Inc. Trispecifični proteini i postupci primjene
KR20210020903A (ko) 2018-05-14 2021-02-24 하푼 테라퓨틱스, 인크. 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
SG11202103022WA (en) 2018-09-25 2021-04-29 Harpoon Therapeutics Inc Dll3 binding proteins and methods of use
US12516128B2 (en) 2019-05-14 2026-01-06 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
CA3170833A1 (en) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Flt3 binding proteins and methods of use
EP4608860A1 (en) * 2022-10-26 2025-09-03 Berking Biotechnology SpA Single domain antibody - sdab/vhh against the nucleoprotein of sars-cov-2 virus
WO2025043019A1 (en) * 2023-08-21 2025-02-27 The Research Foundation For The State University Of New York Slc4a1 (band 3) binding single domain antibodies for increased blood retention

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109160948A (zh) * 2018-09-21 2019-01-08 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN109160948B (zh) * 2018-09-21 2021-07-16 成都阿帕克生物科技有限公司 一种乙肝表面抗原纳米抗体及核酸分子和应用
CN111875706A (zh) * 2020-07-16 2020-11-03 广州康盛生物科技股份有限公司 一种抗人IgE蛋白的单域抗体及其应用
CN116547006A (zh) * 2021-08-06 2023-08-04 贝达药业股份有限公司 抗pd-l1纳米抗体及其应用
CN117659194A (zh) * 2023-11-30 2024-03-08 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN117659194B (zh) * 2023-11-30 2024-08-13 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
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