CN102647988A - 鱼呼肠弧病毒免疫原性组合物 - Google Patents

鱼呼肠弧病毒免疫原性组合物 Download PDF

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Publication number
CN102647988A
CN102647988A CN2010800446027A CN201080044602A CN102647988A CN 102647988 A CN102647988 A CN 102647988A CN 2010800446027 A CN2010800446027 A CN 2010800446027A CN 201080044602 A CN201080044602 A CN 201080044602A CN 102647988 A CN102647988 A CN 102647988A
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Prior art keywords
prv
polypeptide
seq
antibody
immunogenic composition
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Pending
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CN2010800446027A
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Chinese (zh)
Inventor
W·I·利普金
R·T·康托普
G·帕拉西奥斯
E·布龙
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National Veterinary Institute
Columbia University in the City of New York
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National Veterinary Institute
Columbia University in the City of New York
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43826692&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102647988(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by National Veterinary Institute, Columbia University in the City of New York filed Critical National Veterinary Institute
Publication of CN102647988A publication Critical patent/CN102647988A/zh
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61P31/12—Antivirals
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    • C12N2720/12011—Reoviridae
    • C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
    • C12N2720/12234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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  • Proteomics, Peptides & Aminoacids (AREA)
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CN2010800446027A 2009-10-02 2010-10-04 鱼呼肠弧病毒免疫原性组合物 Pending CN102647988A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US24805809P 2009-10-02 2009-10-02
US61/248,058 2009-10-02
US32504710P 2010-04-16 2010-04-16
US61/325,047 2010-04-16
US38059410P 2010-09-07 2010-09-07
US61/380,594 2010-09-07
PCT/US2010/051346 WO2011041789A1 (en) 2009-10-02 2010-10-04 Piscine reovirus immunogenic compositions

Publications (1)

Publication Number Publication Date
CN102647988A true CN102647988A (zh) 2012-08-22

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ID=43826692

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CN2010800446027A Pending CN102647988A (zh) 2009-10-02 2010-10-04 鱼呼肠弧病毒免疫原性组合物

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US (3) US9395356B2 (https=)
EP (2) EP2482825B1 (https=)
JP (1) JP2013506672A (https=)
CN (1) CN102647988A (https=)
CA (2) CA2776534A1 (https=)
CL (5) CL2012000822A1 (https=)
DK (1) DK179132B1 (https=)
WO (2) WO2011041789A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109022617A (zh) * 2014-04-18 2018-12-18 福又达生物科技股份有限公司 鱼呼吸道与肠道病毒、感染性胰脏坏死病毒、鲑鱼甲病毒、感染性鲑鱼贫血病毒检测方法
CN110079507A (zh) * 2019-05-06 2019-08-02 中国海洋大学 抗牙鲆黏膜免疫球蛋白IgT的单克隆抗体及其应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011041789A1 (en) 2009-10-02 2011-04-07 The Trustees Of Columbia University In The City Of New York Piscine reovirus immunogenic compositions
CA2922621C (en) * 2013-08-30 2023-05-23 Pharmaq As Method for propagating piscine orthoreovirus
IL230970A0 (en) 2014-02-13 2014-09-30 Univ Ramot Tilapia virus vaccines
WO2015185605A1 (en) * 2014-06-03 2015-12-10 Veterinærinstituttet New reovirus infecting rainbow trout
WO2016075277A1 (en) 2014-11-14 2016-05-19 Patogen Analyse As Novel fish virus and method for detection
CR20210528A (es) 2014-12-15 2021-12-06 Univ Columbia VIRUS NUEVO DE TILAPIA Y USOS DEL MISMO(Divisional Exp: 2017-0322)
WO2019110664A1 (en) 2017-12-06 2019-06-13 Intervet International B.V. Use of a non-structural protein from prv to protect against heart and skeletal muscle inflammation
WO2020069658A1 (zh) * 2018-10-05 2020-04-09 福又达生物科技股份有限公司 鱼病原体检测方法
US10688050B1 (en) 2018-12-21 2020-06-23 Synthon B.V. Pharmaceutical composition comprising ibrutinib
NO344967B1 (en) 2019-01-30 2020-08-03 Patogen As Piscine Orthoreovirus Virulence Markers
CN109971890A (zh) * 2019-04-30 2019-07-05 上海海洋大学 Ii型草鱼呼肠孤病毒的微滴式数字pcr检测试剂盒及其专用引物和探针
CN110408637B (zh) * 2019-08-08 2020-12-25 中国水产科学研究院长江水产研究所 一种草鱼出血病酵母口服疫苗及应用
US12502426B2 (en) 2019-12-16 2025-12-23 Intervet Inc. Inactivated piscine orthoreovirus vaccine
NO346211B1 (en) 2020-07-14 2022-04-19 Patogen As Piscine Orthoreovirus Virulence Markers
CN112206317B (zh) * 2020-10-12 2023-09-22 浙江省淡水水产研究所 一种草鱼出血病二价核酸菌蜕疫苗的制备方法
CN112048575A (zh) * 2020-10-26 2020-12-08 深圳市莱孚生物科技有限公司 一种用于鉴定草鱼出血热病毒的引物及探针以及检测方法
CN113527475B (zh) * 2021-06-07 2022-04-29 浙江省农业科学院 一种分泌鸭新型呼肠孤病毒σC蛋白单抗的杂交瘤细胞、单抗及应用
CN114164159B (zh) * 2021-06-21 2023-10-03 湖南师范大学 一种具有防治鱼类杀鲑气和迟缓爱德华氏菌感染的二联疫苗及其制备方法与应用
KR102734012B1 (ko) * 2021-08-19 2024-11-25 성균관대학교산학협력단 바이러스성 출혈성 패혈증 바이러스에 특이적으로 결합하는 항체 또는 이의 항원 결합 단편, 및 이들의 용도
CL2024000227A1 (es) * 2024-01-25 2024-07-12 Univ Santiago Chile Proteína de piscine orthoreovirus; composición de vacuna; y su uso.
CN118853676B (zh) * 2024-09-03 2025-03-07 中国水产科学研究院淡水渔业研究中心 一种草鱼ii型呼肠孤病毒反义rna及其重组载体、试剂盒和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
WO1986006487A1 (en) 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
DK0538496T3 (da) 1991-08-26 2004-02-23 Baxter Healthcare Sa Rekombinant fjerkrækoppevirus med intakt FPV tk-gen
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
CA2327353C (en) 1998-05-08 2010-09-21 Akzo Nobel Nv Structural proteins of fish pancreatic disease virus and uses thereof
US20080256662A1 (en) * 1999-05-10 2008-10-16 Byrum Joseph R Nucleic acid molecules and other molecules associated with plants
WO2001009340A1 (en) 1999-08-03 2001-02-08 Akzo Nobel N.V. Proteins derived from white spot syndrome virus and uses thereof
EP1637614A3 (en) 1999-08-07 2006-11-29 Novartis AG Nucleic acids and antibodies for detection of ISAV (infectious salmon anaemia virus)
DK1094069T4 (da) 1999-10-18 2008-07-21 Intervet Int Bv DNA kodende for strukturelt protein-1 fra infektiös lakseanæmivirus og anvendelser deraf
AU2001240791A1 (en) 2000-03-11 2001-09-24 Novartis Ag Sequence
CA2325088A1 (en) * 2000-12-01 2002-06-01 Fusogenix Inc. Novel membrane fusion proteins derived from poikilothermic reovirus
US6979733B2 (en) * 2001-08-03 2005-12-27 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
US7670604B2 (en) 2002-12-13 2010-03-02 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
WO2004065415A2 (en) * 2003-01-20 2004-08-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. L-amino acid oxidase with cytotoxic activity from aplysia punctata
GB2429711B (en) 2004-06-11 2008-05-21 Pharmaq As Heart and skeletal muscle inflammation (HSMI) virus
US7361468B2 (en) * 2004-07-02 2008-04-22 Affymetrix, Inc. Methods for genotyping polymorphisms in humans
JP4911529B2 (ja) 2005-02-22 2012-04-04 日本碍子株式会社 光変調器
US8088976B2 (en) 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
JPWO2007020983A1 (ja) * 2005-08-18 2009-02-26 独立行政法人科学技術振興機構 オオムギｅｓｔ配列を利用して作製された二倍体コムギ遺伝地図を用いるコムギの育種方法
DK179025B1 (da) * 2005-09-16 2017-08-28 Intervet Int Bv Fiskevaccine
CA2680060A1 (en) * 2007-03-07 2008-09-12 Nventa Biopharmaceuticals Corporation Double-stranded locked nucleic acid compositions
SG191602A1 (en) * 2007-03-12 2013-07-31 Oncolytics Biotech Inc Reoviruses having modified sequences
JPWO2010024284A1 (ja) * 2008-09-01 2012-01-26 国立大学法人北海道大学 魚類抗ウイルスワクチン、魚類免疫賦活剤、および魚類免疫付与方法
WO2011041789A1 (en) 2009-10-02 2011-04-07 The Trustees Of Columbia University In The City Of New York Piscine reovirus immunogenic compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109022617A (zh) * 2014-04-18 2018-12-18 福又达生物科技股份有限公司 鱼呼吸道与肠道病毒、感染性胰脏坏死病毒、鲑鱼甲病毒、感染性鲑鱼贫血病毒检测方法
CN110079507A (zh) * 2019-05-06 2019-08-02 中国海洋大学 抗牙鲆黏膜免疫球蛋白IgT的单克隆抗体及其应用
CN110079507B (zh) * 2019-05-06 2022-05-20 中国海洋大学 抗牙鲆黏膜免疫球蛋白IgT的单克隆抗体及其应用

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CL2013002933A1 (es) 2014-06-27
DK179132B1 (en) 2017-11-27
US20160287694A1 (en) 2016-10-06
CA2776534A1 (en) 2011-04-07
WO2011041789A1 (en) 2011-04-07
CA2776386A1 (en) 2011-04-07
US20130058968A1 (en) 2013-03-07
US20130072542A1 (en) 2013-03-21
US9395356B2 (en) 2016-07-19
EP2482825B1 (en) 2016-11-23
CL2013002907A1 (es) 2014-03-21
CA2776386C (en) 2018-02-27
EP2482824A4 (en) 2013-06-19
US9366667B2 (en) 2016-06-14
EP2482825A4 (en) 2013-06-26
JP2013506672A (ja) 2013-02-28
EP2482825A1 (en) 2012-08-08
EP2482824A1 (en) 2012-08-08
CL2012000822A1 (es) 2012-07-20
DK201170227A (en) 2011-05-11
WO2011041790A1 (en) 2011-04-07
CL2016000240A1 (es) 2016-07-29
CL2012000821A1 (es) 2012-08-03
EP2482824B1 (en) 2016-11-30

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