CL2013002933A1 - Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; polipeptido; uso de la composicion inmunogenica que sirve para tratar afecciones de infeccion por prv en un animal - Google Patents

Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; polipeptido; uso de la composicion inmunogenica que sirve para tratar afecciones de infeccion por prv en un animal

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Publication number
CL2013002933A1
CL2013002933A1 CL2013002933A CL2013002933A CL2013002933A1 CL 2013002933 A1 CL2013002933 A1 CL 2013002933A1 CL 2013002933 A CL2013002933 A CL 2013002933A CL 2013002933 A CL2013002933 A CL 2013002933A CL 2013002933 A1 CL2013002933 A1 CL 2013002933A1
Authority
CL
Chile
Prior art keywords
prv
immunogenic composition
polypeptide
treat
animal
Prior art date
Application number
CL2013002933A
Other languages
English (en)
Inventor
W Ian Lipkin
Ruth Toril Kongtorp
Gustavo Palacios
Edgar Brun
Original Assignee
The Nat Veterinary Institute
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43826692&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013002933(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Nat Veterinary Institute, Univ Columbia filed Critical The Nat Veterinary Institute
Publication of CL2013002933A1 publication Critical patent/CL2013002933A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
    • C12N2720/12222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
    • C12N2720/12234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Immunology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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CL2013002933A 2009-10-02 2013-10-11 Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; polipeptido; uso de la composicion inmunogenica que sirve para tratar afecciones de infeccion por prv en un animal CL2013002933A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24805809P 2009-10-02 2009-10-02
US32504710P 2010-04-16 2010-04-16
US38059410P 2010-09-07 2010-09-07

Publications (1)

Publication Number Publication Date
CL2013002933A1 true CL2013002933A1 (es) 2014-06-27

Family

ID=43826692

Family Applications (5)

Application Number Title Priority Date Filing Date
CL2012000822A CL2012000822A1 (es) 2009-10-02 2012-04-02 Acido nucleico aislado del virus de peces prv; polipeptido aislado; anticuerpo que se une a dicho polipeptido; metodo para determinar la presencia o ausencia de prv en una muestra biologica; arn interferente; metodo para reducir nivel de proteina viral.
CL2012000821A CL2012000821A1 (es) 2009-10-02 2012-04-02 Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; uso de la composicion inmunogenica que sirve para preparar un medicamento util para tratar afecciones de infeccion por prv en un animal.
CL2013002907A CL2013002907A1 (es) 2009-10-02 2013-10-10 Acido nucleico aislado del virus de peces prv; polipeptido aislado; anticuerpo que se une a dicho polipeptido; metodo para determinar la presencia o ausencia de prv en una muestra biologica; arn interferente; y uso para reducir los niveles de proteina viral en una celula de un animal (div.sol.n°822-12).
CL2013002933A CL2013002933A1 (es) 2009-10-02 2013-10-11 Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; polipeptido; uso de la composicion inmunogenica que sirve para tratar afecciones de infeccion por prv en un animal
CL2016000240A CL2016000240A1 (es) 2009-10-02 2016-01-29 Composición inmunogénica de reovirus de peces (prv) que comprende ácido nucleico del prv; polipéptido; virus atenuado o inactivado del prv, uso de la composición inmunogénica que sirve para tratar afecciones de infeción por prv en un animal.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CL2012000822A CL2012000822A1 (es) 2009-10-02 2012-04-02 Acido nucleico aislado del virus de peces prv; polipeptido aislado; anticuerpo que se une a dicho polipeptido; metodo para determinar la presencia o ausencia de prv en una muestra biologica; arn interferente; metodo para reducir nivel de proteina viral.
CL2012000821A CL2012000821A1 (es) 2009-10-02 2012-04-02 Composicion inmunogenica de reovirus de peces (prv) que comprende acido nucleico del prv; uso de la composicion inmunogenica que sirve para preparar un medicamento util para tratar afecciones de infeccion por prv en un animal.
CL2013002907A CL2013002907A1 (es) 2009-10-02 2013-10-10 Acido nucleico aislado del virus de peces prv; polipeptido aislado; anticuerpo que se une a dicho polipeptido; metodo para determinar la presencia o ausencia de prv en una muestra biologica; arn interferente; y uso para reducir los niveles de proteina viral en una celula de un animal (div.sol.n°822-12).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2016000240A CL2016000240A1 (es) 2009-10-02 2016-01-29 Composición inmunogénica de reovirus de peces (prv) que comprende ácido nucleico del prv; polipéptido; virus atenuado o inactivado del prv, uso de la composición inmunogénica que sirve para tratar afecciones de infeción por prv en un animal.

Country Status (8)

Country Link
US (3) US9395356B2 (es)
EP (2) EP2482825B1 (es)
JP (1) JP2013506672A (es)
CN (1) CN102647988A (es)
CA (2) CA2776386C (es)
CL (5) CL2012000822A1 (es)
DK (1) DK179132B1 (es)
WO (2) WO2011041790A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2776386C (en) * 2009-10-02 2018-02-27 The Trustees Of Columbia University In The City Of New York Piscine reovirus immunogenic compositions
WO2015028565A1 (en) * 2013-08-30 2015-03-05 Veterinærinstituttet Method for propagating a virus
IL230970A0 (en) 2014-02-13 2014-09-30 Univ Ramot Tilapia virus vaccines
EP3216875A3 (en) * 2014-04-18 2017-12-13 Schweitzer Biotech Company Ltd. Methods for detecting pathogens piscine reovirus (prv), infectious pancreatic necrosis virus (ipnv), salmonid alphaviurs (sav), and infectious salmon anemia virus (isav) in coldwater fish
NO346439B1 (en) * 2014-06-03 2022-08-15 Veterinærinstituttet New reovirus infecting rainbow trout
WO2016075277A1 (en) 2014-11-14 2016-05-19 Patogen Analyse As Novel fish virus and method for detection
SG10202102695UA (en) 2014-12-15 2021-04-29 Univ Columbia Novel tilapia virus and uses thereof
CA3083873A1 (en) 2017-12-06 2019-06-13 Intervet International B.V. Use of a non-structural protein from prv to protect against heart and skeletal muscle inflammation
WO2020069658A1 (zh) * 2018-10-05 2020-04-09 福又达生物科技股份有限公司 鱼病原体检测方法
US10688050B1 (en) 2018-12-21 2020-06-23 Synthon B.V. Pharmaceutical composition comprising ibrutinib
NO344967B1 (en) 2019-01-30 2020-08-03 Patogen As Piscine Orthoreovirus Virulence Markers
CN109971890A (zh) * 2019-04-30 2019-07-05 上海海洋大学 Ii型草鱼呼肠孤病毒的微滴式数字pcr检测试剂盒及其专用引物和探针
CN110079507B (zh) * 2019-05-06 2022-05-20 中国海洋大学 抗牙鲆黏膜免疫球蛋白IgT的单克隆抗体及其应用
CN110408637B (zh) * 2019-08-08 2020-12-25 中国水产科学研究院长江水产研究所 一种草鱼出血病酵母口服疫苗及应用
US20230105140A1 (en) 2019-12-16 2023-04-06 Intervet Inc. Inactivated piscine orthoreovirus vaccine
NO346211B1 (en) 2020-07-14 2022-04-19 Patogen As Piscine Orthoreovirus Virulence Markers
CN112206317B (zh) * 2020-10-12 2023-09-22 浙江省淡水水产研究所 一种草鱼出血病二价核酸菌蜕疫苗的制备方法
CN112048575A (zh) * 2020-10-26 2020-12-08 深圳市莱孚生物科技有限公司 一种用于鉴定草鱼出血热病毒的引物及探针以及检测方法
CN113527475B (zh) * 2021-06-07 2022-04-29 浙江省农业科学院 一种分泌鸭新型呼肠孤病毒σC蛋白单抗的杂交瘤细胞、单抗及应用
CN114164159B (zh) * 2021-06-21 2023-10-03 湖南师范大学 一种具有防治鱼类杀鲑气和迟缓爱德华氏菌感染的二联疫苗及其制备方法与应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
WO1986006487A1 (en) 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
DK0538496T3 (da) 1991-08-26 2004-02-23 Baxter Healthcare Sa Rekombinant fjerkrækoppevirus med intakt FPV tk-gen
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
DK1075523T3 (da) 1998-05-08 2007-12-27 Intervet Int Bv Strukturelle proteiner hos fiskepankreassygdomsvirus og anvendelser deraf
US20080256662A1 (en) * 1999-05-10 2008-10-16 Byrum Joseph R Nucleic acid molecules and other molecules associated with plants
EP1206550B1 (en) 1999-08-03 2005-11-16 Akzo Nobel N.V. Proteins derived from white spot syndrome virus and uses thereof
ES2267553T3 (es) 1999-08-07 2007-03-16 Novartis Ag Secuencias de acidos nucleicos y de aminoacidos del virus de la anemia infecciosa del salmon y sus usos como vacunas.
DE60017229D1 (de) 1999-10-18 2005-02-10 Akzo Nobel Nv DNA kodierend für das Strukturalprotein-1 vom infektiösen Lachs Anämie Virus und ihre Verwendungen
EP1282710B1 (en) 2000-03-11 2008-03-05 Novartis AG Fish vaccine against piscirickettsia salmonis
CA2325088A1 (en) * 2000-12-01 2002-06-01 Fusogenix Inc. Novel membrane fusion proteins derived from poikilothermic reovirus
CA2456229A1 (en) 2001-08-03 2003-02-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
US7670604B2 (en) * 2002-12-13 2010-03-02 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
EP1585761B1 (en) * 2003-01-20 2013-08-21 Thomas Rudel L-amino acid oxidase with cytotoxic activity from aplysia punctata
GB2429711B (en) * 2004-06-11 2008-05-21 Pharmaq As Heart and skeletal muscle inflammation (HSMI) virus
US7361468B2 (en) * 2004-07-02 2008-04-22 Affymetrix, Inc. Methods for genotyping polymorphisms in humans
EP1868025A4 (en) 2005-02-22 2010-05-12 Ngk Insulators Ltd OPTICAL MODULATOR
US8088976B2 (en) 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
WO2007020983A1 (ja) * 2005-08-18 2007-02-22 Japan Science And Technology Agency オオムギｅｓｔ配列を利用して作製された二倍体コムギ遺伝地図を用いるコムギの育種方法
DK179025B1 (da) * 2005-09-16 2017-08-28 Intervet Int Bv Fiskevaccine
MX2009009530A (es) 2007-03-07 2010-05-19 Nventa Biopharmaceuticals Corp Composiciones de acidos nucleicos cerrados bicatenarios.
CN103710359A (zh) 2007-03-12 2014-04-09 昂科利蒂克斯生物科技公司 具有修饰的序列的呼肠孤病毒
JPWO2010024284A1 (ja) * 2008-09-01 2012-01-26 国立大学法人北海道大学 魚類抗ウイルスワクチン、魚類免疫賦活剤、および魚類免疫付与方法
CA2776386C (en) 2009-10-02 2018-02-27 The Trustees Of Columbia University In The City Of New York Piscine reovirus immunogenic compositions

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