CN102627644B - 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 - Google Patents

一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 Download PDF

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CN102627644B
CN102627644B CN201210103893.3A CN201210103893A CN102627644B CN 102627644 B CN102627644 B CN 102627644B CN 201210103893 A CN201210103893 A CN 201210103893A CN 102627644 B CN102627644 B CN 102627644B
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compound
molar ratio
solvent
ratio
catalyst
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CN102627644A (zh
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洪浩
詹姆斯·盖吉
陈朝勇
卢江平
周炎
刘双勇
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Asymchem Laboratories Fuxin Co Ltd
Asymchem Laboratories Tianjin Co Ltd
Asymchem Laboratories Jilin Co Ltd
Asymchem Life Science Tianjin Co Ltd
Tianjin Asymchem Pharmaceutical Co Ltd
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Asymchem Laboratories Fuxin Co Ltd
Asymchem Laboratories Tianjin Co Ltd
Asymchem Laboratories Jilin Co Ltd
Asymchem Life Science Tianjin Co Ltd
Tianjin Asymchem Pharmaceutical Co Ltd
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Application filed by Asymchem Laboratories Fuxin Co Ltd, Asymchem Laboratories Tianjin Co Ltd, Asymchem Laboratories Jilin Co Ltd, Asymchem Life Science Tianjin Co Ltd, Tianjin Asymchem Pharmaceutical Co Ltd filed Critical Asymchem Laboratories Fuxin Co Ltd
Priority to CN201210103893.3A priority Critical patent/CN102627644B/zh
Publication of CN102627644A publication Critical patent/CN102627644A/zh
Priority to HUE12874350A priority patent/HUE033184T2/en
Priority to PL12874350T priority patent/PL2837630T3/pl
Priority to EP12874350.7A priority patent/EP2837630B1/de
Priority to PCT/CN2012/087737 priority patent/WO2013152609A1/zh
Priority to RS20170076A priority patent/RS55629B1/sr
Priority to US14/391,712 priority patent/US9365573B2/en
Priority to SI201230865A priority patent/SI2837630T1/sl
Priority to DK12874350.7T priority patent/DK2837630T3/en
Priority to PT128743507T priority patent/PT2837630T/pt
Priority to LTEP12874350.7T priority patent/LT2837630T/lt
Priority to ES12874350.7T priority patent/ES2613453T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201210103893.3A 2012-04-10 2012-04-10 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 Active CN102627644B (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201210103893.3A CN102627644B (zh) 2012-04-10 2012-04-10 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
US14/391,712 US9365573B2 (en) 2012-04-10 2012-12-27 Method for synthesizing sapropterin dihydrochloride
DK12874350.7T DK2837630T3 (en) 2012-04-10 2012-12-27 Process for synthesizing sapropterine dihydrochloride
EP12874350.7A EP2837630B1 (de) 2012-04-10 2012-12-27 Verfahren zur synthese von sapropterindihydrochlorid
PCT/CN2012/087737 WO2013152609A1 (zh) 2012-04-10 2012-12-27 一种二盐酸沙丙蝶呤的合成方法
RS20170076A RS55629B1 (sr) 2012-04-10 2012-12-27 Postupak za sintezu sapropterin dihidrohlorida
HUE12874350A HUE033184T2 (en) 2012-04-10 2012-12-27 A method for preparing sapropterin dihydrochloride
SI201230865A SI2837630T1 (sl) 2012-04-10 2012-12-27 Postopek za sintetiziranje sapropterin dihidroklorida
PL12874350T PL2837630T3 (pl) 2012-04-10 2012-12-27 Sposób syntezy dichlorowodorku sapropteryny
PT128743507T PT2837630T (pt) 2012-04-10 2012-12-27 Método para sintetizar dicloridrato de sapropterina
LTEP12874350.7T LT2837630T (lt) 2012-04-10 2012-12-27 Sapropterino dihidrochlorido sintetinimo būdas
ES12874350.7T ES2613453T3 (es) 2012-04-10 2012-12-27 Método para sintetizar diclorhidrato de sapropterina

Applications Claiming Priority (1)

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CN201210103893.3A CN102627644B (zh) 2012-04-10 2012-04-10 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法

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CN102627644A CN102627644A (zh) 2012-08-08
CN102627644B true CN102627644B (zh) 2014-04-16

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Country Link
US (1) US9365573B2 (de)
EP (1) EP2837630B1 (de)
CN (1) CN102627644B (de)
DK (1) DK2837630T3 (de)
ES (1) ES2613453T3 (de)
HU (1) HUE033184T2 (de)
LT (1) LT2837630T (de)
PL (1) PL2837630T3 (de)
PT (1) PT2837630T (de)
RS (1) RS55629B1 (de)
SI (1) SI2837630T1 (de)
WO (1) WO2013152609A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
CN103483170B (zh) * 2013-09-24 2015-02-04 中国科学技术大学 一种拆分手性二酮化合物的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS574990A (en) * 1980-05-09 1982-01-11 Bisukonchiini Matsukusu Polyacylated tetrahydropterin derivative and manufacture
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60204786A (ja) 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
US4713454A (en) * 1985-01-28 1987-12-15 Shiratori Pharmaceutical Co., Ltd. Preparation process of (6R)-tetrahydro-L-biopterin
DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
JP2882116B2 (ja) 1991-09-13 1999-04-12 日本電気株式会社 ヒートシンク付パッケージ
EP1699793A1 (de) 2003-12-30 2006-09-13 Vasopharm Biotech GmbH 4-amino-7,8-dihydropteridine, pharmazeutische zusammensetzungen, die diese enthalten, und deren verwendung bei der behandlung von krankheiten, die durch eine erhöhte stickoxidkonzentration verursacht werden
US7361759B2 (en) * 2004-12-27 2008-04-22 Shiratori Pharmaceutical Co., Ltd Method for producing L-biopterin
MX2010007452A (es) * 2008-01-07 2010-08-18 Biomarin Pharm Inc Metodo para sintetizar tetrahidrobiopterin.
IT1400964B1 (it) * 2010-06-15 2013-07-05 Dipharma Francis Srl Procedimento per la preparazione di derivati pteridinici
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法

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Publication number Publication date
CN102627644A (zh) 2012-08-08
WO2013152609A1 (zh) 2013-10-17
HUE033184T2 (en) 2017-11-28
PL2837630T3 (pl) 2017-06-30
RS55629B1 (sr) 2017-06-30
US20150105555A1 (en) 2015-04-16
EP2837630A4 (de) 2015-12-02
US9365573B2 (en) 2016-06-14
DK2837630T3 (en) 2017-02-27
PT2837630T (pt) 2017-02-24
ES2613453T3 (es) 2017-05-24
EP2837630B1 (de) 2016-11-23
LT2837630T (lt) 2017-02-10
SI2837630T1 (sl) 2017-03-31
EP2837630A1 (de) 2015-02-18

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