PL2837630T3 - Sposób syntezy dichlorowodorku sapropteryny - Google Patents
Sposób syntezy dichlorowodorku sapropterynyInfo
- Publication number
- PL2837630T3 PL2837630T3 PL12874350T PL12874350T PL2837630T3 PL 2837630 T3 PL2837630 T3 PL 2837630T3 PL 12874350 T PL12874350 T PL 12874350T PL 12874350 T PL12874350 T PL 12874350T PL 2837630 T3 PL2837630 T3 PL 2837630T3
- Authority
- PL
- Poland
- Prior art keywords
- sapropterin dihydrochloride
- synthesizing sapropterin
- synthesizing
- dihydrochloride
- sapropterin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210103893.3A CN102627644B (zh) | 2012-04-10 | 2012-04-10 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
| EP12874350.7A EP2837630B1 (en) | 2012-04-10 | 2012-12-27 | Method for synthesizing sapropterin dihydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2837630T3 true PL2837630T3 (pl) | 2017-06-30 |
Family
ID=46586062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12874350T PL2837630T3 (pl) | 2012-04-10 | 2012-12-27 | Sposób syntezy dichlorowodorku sapropteryny |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9365573B2 (pl) |
| EP (1) | EP2837630B1 (pl) |
| CN (1) | CN102627644B (pl) |
| DK (1) | DK2837630T3 (pl) |
| ES (1) | ES2613453T3 (pl) |
| HU (1) | HUE033184T2 (pl) |
| LT (1) | LT2837630T (pl) |
| PL (1) | PL2837630T3 (pl) |
| PT (1) | PT2837630T (pl) |
| RS (1) | RS55629B1 (pl) |
| SI (1) | SI2837630T1 (pl) |
| WO (1) | WO2013152609A1 (pl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102627644B (zh) | 2012-04-10 | 2014-04-16 | 凯莱英医药集团（天津）股份有限公司 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
| CN102633799B (zh) | 2012-04-10 | 2014-06-25 | 凯莱英医药集团（天津）股份有限公司 | 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法 |
| CN103483170B (zh) * | 2013-09-24 | 2015-02-04 | 中国科学技术大学 | 一种拆分手性二酮化合物的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS574990A (en) * | 1980-05-09 | 1982-01-11 | Bisukonchiini Matsukusu | Polyacylated tetrahydropterin derivative and manufacture |
| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法 |
| JPS60204786A (ja) * | 1984-03-29 | 1985-10-16 | Univ Nagoya | （６ｒ）―テトラヒドロビオプテリンの合成法 |
| CA1262347A (en) | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
| EP0318926B1 (en) * | 1987-11-30 | 1995-05-03 | Kabushiki Kaisha Vitamin Kenkyusyo | Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives |
| JP2882116B2 (ja) | 1991-09-13 | 1999-04-12 | 日本電気株式会社 | ヒートシンク付パッケージ |
| EP1699793A1 (en) | 2003-12-30 | 2006-09-13 | Vasopharm Biotech GmbH | 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing them and their use for the treatment of diseases which are caused by an increased nitric oxide level |
| US7361759B2 (en) | 2004-12-27 | 2008-04-22 | Shiratori Pharmaceutical Co., Ltd | Method for producing L-biopterin |
| CN101959891A (zh) | 2008-01-07 | 2011-01-26 | 生物马林药物股份有限公司 | 合成四氢生物蝶呤的方法 |
| IT1400964B1 (it) * | 2010-06-15 | 2013-07-05 | Dipharma Francis Srl | Procedimento per la preparazione di derivati pteridinici |
| CN102627644B (zh) * | 2012-04-10 | 2014-04-16 | 凯莱英医药集团（天津）股份有限公司 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
| CN102633799B (zh) | 2012-04-10 | 2014-06-25 | 凯莱英医药集团（天津）股份有限公司 | 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法 |
-
2012
- 2012-04-10 CN CN201210103893.3A patent/CN102627644B/zh active Active
- 2012-12-27 US US14/391,712 patent/US9365573B2/en not_active Expired - Fee Related
- 2012-12-27 ES ES12874350.7T patent/ES2613453T3/es active Active
- 2012-12-27 HU HUE12874350A patent/HUE033184T2/en unknown
- 2012-12-27 LT LTEP12874350.7T patent/LT2837630T/lt unknown
- 2012-12-27 WO PCT/CN2012/087737 patent/WO2013152609A1/zh active Application Filing
- 2012-12-27 EP EP12874350.7A patent/EP2837630B1/en not_active Not-in-force
- 2012-12-27 DK DK12874350.7T patent/DK2837630T3/en active
- 2012-12-27 PT PT128743507T patent/PT2837630T/pt unknown
- 2012-12-27 SI SI201230865A patent/SI2837630T1/sl unknown
- 2012-12-27 RS RS20170076A patent/RS55629B1/sr unknown
- 2012-12-27 PL PL12874350T patent/PL2837630T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS55629B1 (sr) | 2017-06-30 |
| US9365573B2 (en) | 2016-06-14 |
| SI2837630T1 (sl) | 2017-03-31 |
| EP2837630B1 (en) | 2016-11-23 |
| LT2837630T (lt) | 2017-02-10 |
| WO2013152609A1 (zh) | 2013-10-17 |
| CN102627644A (zh) | 2012-08-08 |
| US20150105555A1 (en) | 2015-04-16 |
| EP2837630A4 (en) | 2015-12-02 |
| EP2837630A1 (en) | 2015-02-18 |
| ES2613453T3 (es) | 2017-05-24 |
| PT2837630T (pt) | 2017-02-24 |
| CN102627644B (zh) | 2014-04-16 |
| HUE033184T2 (en) | 2017-11-28 |
| DK2837630T3 (en) | 2017-02-27 |
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