CN102625809B - 亨廷顿表达的调节 - Google Patents

亨廷顿表达的调节 Download PDF

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Publication number
CN102625809B
CN102625809B CN201080051393.9A CN201080051393A CN102625809B CN 102625809 B CN102625809 B CN 102625809B CN 201080051393 A CN201080051393 A CN 201080051393A CN 102625809 B CN102625809 B CN 102625809B
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China
Prior art keywords
isis
oligonucleotide
certain embodiments
mice
antisense
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CN201080051393.9A
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Chinese (zh)
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CN102625809A (zh
Inventor
G·洪
C·F·贝内特
S·M·弗赖尔
H·柯达赛维茨
L·斯坦尼克
D·W·克利夫兰
L·史哈布丁
S·H·程
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Ionis Pharmaceuticals Inc
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Genzyme Corp
Isis Pharmaceuticals Inc
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Priority to CN202010532625.8A priority Critical patent/CN111705058A/zh
Priority to CN201510262406.1A priority patent/CN104894129B/zh
Publication of CN102625809A publication Critical patent/CN102625809A/zh
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN201080051393.9A 2009-09-11 2010-09-10 亨廷顿表达的调节 Active CN102625809B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202010532625.8A CN111705058A (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节
CN201510262406.1A CN104894129B (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24185309P 2009-09-11 2009-09-11
US61/241,853 2009-09-11
PCT/US2010/048532 WO2011032045A1 (en) 2009-09-11 2010-09-10 Modulation of huntingtin expression

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202010532625.8A Division CN111705058A (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节
CN201510262406.1A Division CN104894129B (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节

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CN102625809A CN102625809A (zh) 2012-08-01
CN102625809B true CN102625809B (zh) 2015-06-24

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CN201080051393.9A Active CN102625809B (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节
CN201510262406.1A Active CN104894129B (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节
CN202010532625.8A Pending CN111705058A (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节

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CN201510262406.1A Active CN104894129B (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节
CN202010532625.8A Pending CN111705058A (zh) 2009-09-11 2010-09-10 亨廷顿表达的调节

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US (8) US8906873B2 (enExample)
EP (3) EP3178933B1 (enExample)
JP (5) JP5809146B2 (enExample)
KR (5) KR101774526B1 (enExample)
CN (3) CN102625809B (enExample)
AU (4) AU2010292003B2 (enExample)
BR (1) BR112012005448B1 (enExample)
CA (2) CA2931725C (enExample)
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IL (4) IL218482A (enExample)
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PT (1) PT2475675T (enExample)
RU (2) RU2562861C2 (enExample)
SI (1) SI2475675T1 (enExample)
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