CN102613396A - Ramie root and leave extract for animal health care and preparation process as well as application thereof - Google Patents
Ramie root and leave extract for animal health care and preparation process as well as application thereof Download PDFInfo
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- CN102613396A CN102613396A CN2012101232670A CN201210123267A CN102613396A CN 102613396 A CN102613396 A CN 102613396A CN 2012101232670 A CN2012101232670 A CN 2012101232670A CN 201210123267 A CN201210123267 A CN 201210123267A CN 102613396 A CN102613396 A CN 102613396A
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- radix boehmeriae
- leaf extract
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Abstract
The invention discloses a ramie root and leaf extract for animal health care and a preparation process as well as application thereof. The ramie root and leaf extract is prepared by adopting the process comprising the steps of: crushing the ramie roots and leaves or adding suitable amount of water, wherein the mass ratio of the ramie roots and leaves to the water is 1: (0-20); crushing until paste is formed; filtering or centrifuging to collect a liquid part; then concentrating to form a concentrated solution with a solid content of 7 wt%-15 wt%; spray-drying at 160-180 DEG C to form the ramie root and leaf extract. The invention further discloses an application of the ramie root and leaf extract in preparation of health-care products for pigs, birds, plant-eating animals and aquatic animals. The ramie root and leaf extract, disclosed by the invention, is extremely easy to dissolve in water, so that the ramie root and leaf extract can be added in fodder and drinking water at the same time and is convenient to operate. The ramie root and leaf extract, disclosed by the invention, not only can improve health condition and production performance of animals, but also functions on supplementing fodder protein.
Description
Technical field
The present invention relates to a kind of radix boehmeriae leaf extract and extraction process and application that is used for animal health.
Background technology
Ramie is a kind of herbaceos perennial, likes warm, moistening growing environment, is distributed widely in China's southern area, mainly concentrates on four provinces such as Hubei, Hunan, Sichuan, Jiangxi, is important water and soil conservation plant.The radix boehmeriae general flavone content is the traditional Chinese medicine material more than 0.35%, has cool blood, hemostasis, the effect of the stasis of blood of loosing; Ramie leaf contains the large number of biological active material, and polyphenol content is more than 0.2%, and chlorogenic acid content is more than 0.35%, and the ramie leaf nutritive value is abundant simultaneously, protein content 20-24%, fatty 5-6%, crude fibre 15-16%.At present, China produces ten thousand tons of ramie 20-30 per year, and the ramie cured leaf is produced ten thousand tons of 40-60 per year, and radix boehmeriae is more than 400,000 tons.But radix boehmeriae has only and is used for traditional Chinese medicine on a small quantity, and major part is abandoned; Ramie leaf also has only the plant-eating animal that is used on a small quantity feed to replenish albumen, seldom is used for pig feed, and the overwhelming majority is abandoned.The seasonality of ramie harvesting is strong, and bright leaf is difficult for preserving, and drying cost is too high, is the main cause that causes ramie leaf to abandon.
At present, generally believe that cultivated animals is difficult, one of the main reasons is exactly that epidemic situation is many and complicated, in case the animal morbidity just is difficult to control; The low inferior situation of breeding animals miscarriage, stillborn foetus, general feelings and breeding animals production capacity happens occasionally, and these all directly influence culture benefit, bring great risk to aquaculture.Present most of producer is still through adopting antibiotic and steroids product to prevent and treating; Yet; Antibiotic is to become increasingly conspicuous as the drawback of feed addictive; Not only result of use is not fully up to expectations, cause in livestock products and the environment toward contact antibiotic residual in a large number, thereby threaten human health and Environmental security.
Therefore, seeking a kind ofly can replace antibiotic, be used for animal health, improve the material of animal health state and production performance, is the task of top priority that develops aquaculture at present.
Summary of the invention
The technical problem that the present invention will solve is; Overcome the above-mentioned defective that prior art exists, provide a kind of and have no drug resistance, drug residue free; Environmentally safe can improve the feed addictive radix boehmeriae leaf extract and the preparation technology thereof of animal health state and breeding performonce fo animals.
The present invention's the radix boehmeriae leaf extract that is used for animal health; Adopt following prepared to form: the radix boehmeriae leaf is pulverized or added an amount of water, and the mass ratio of radix boehmeriae leaf and water is 1: 0-20, pulverizing pulping; Filter or centrifugal back collection liquid part; The concentrate of simmer down to solid content 7wt%-15wt% then, 160-180 ℃ of following spray-drying.
Further, said radix boehmeriae leaf can be dried radix boehmeriae leaf or fresh radix boehmeriae leaf.When used radix boehmeriae leaf was dried radix boehmeriae leaf, the mass ratio of radix boehmeriae leaf and water was 1: 10-20; When used radix boehmeriae leaf was fresh radix boehmeriae leaf, the mass ratio of radix boehmeriae leaf and water was 1: 0-10.
Further, when said radix boehmeriae leaf is selected dried radix boehmeriae leaf for use, behind radix boehmeriae leaf crushing and water-adding, soaked 30 ~ 90 minutes down at 50 ~ 60 ℃, so that process pulpous state.
The present invention's the radix boehmeriae leaf extract that is used for animal health contains protein 30-50wt%, chlorogenic acid 0.1-5wt%, polyphenol 0.2-4wt%, flavones 0.5-4%.
The present invention's the radix boehmeriae leaf extract that is used for animal health can add in animal mixed feed, animal health article or the animal drinking-water according to the mass ratio of 0.01-0.5 wt% (preferred 0.04-0.25 wt%) and use.
The present invention has following good effect: the one; The present invention's radix boehmeriae leaf extract; Animal is had immunological regulation and health-care effect, can be used for improving animal physique, improve animal disease resistant ability and breeding animals production performance; When in feed, adding in the 0.04wt%-0.25wt% ratio, produce sub-survival rate, birth weight, number of weaned, weaning weight and inter oestrual period time all be improved significantly; The 2nd; Given full play to the value of ramie,, not only traditional Chinese medicine material radix boehmeriae has been used through the present invention; Can also fully utilize by the ramie leaf that utilization rate is low; For new approach has been opened up in the application of ramie in animal husbandry, for green health herding production contributes the wasting of resources of having avoided conventional method to cause; The 3rd,, the radix boehmeriae leaf extract derives from nature fully, belongs to pure natural plant extract, does not contain antibiotic, to the environment noresidue, animal is had no side effect, and no withdrawal time has no drug resistance, and noresidue in the animal product can be added for a long time.
Radix boehmeriae leaf extract of the present invention adopts water extraction method to be prepared from, and product is very easily water-soluble, can in feed, drinking-water, add simultaneously, and is easy to operate.
In addition, radix boehmeriae leaf extract of the present invention can not only be used to improve animal health condition and production performance, also has the effect of supplement feed protein.
Description of drawings
Fig. 1 is the influence block diagram of radix boehmeriae leaf extract of the present invention to interleukin-6 content;
Fig. 2 is the influence block diagram of radix boehmeriae leaf extract of the present invention to interleukin-10 content;
Fig. 3 is the influence block diagram of radix boehmeriae leaf extract of the present invention to interleukin-12 content;
Fig. 4 is the influence block diagram of radix boehmeriae leaf extract of the present invention to the macrophage-stimulating colony factor.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
Embodiment 1: the preparation embodiment of radix boehmeriae leaf extract 1.
Take by weighing 10 kilograms on fresh radix boehmeriae, leaf, directly pulverize pulping, filter or centrifugal after, liquid hold-up, with liquid carry out the concentrate of simmer down to solid content 10wt%, after 170 ℃ of following spray-dryings, packing.
Embodiment 2: the preparation embodiment of radix boehmeriae leaf extract 2.
Take by weighing 10 kilograms on fresh radix boehmeriae, leaf, add 10 kilograms of entry, pulverize until pulping, filter or centrifugal after, liquid hold-up carries out the concentrate of simmer down to solid content 9wt% with liquid, after 175 ℃ of following spray-dryings, packs.
Embodiment 3: the preparation embodiment of radix boehmeriae leaf extract 3.
Take by weighing 10 kilograms on dried radix boehmeriae, leaf, fragmentation adds 200 kilograms of entry, soaks 60 minutes down at 55 ℃, pulverizes until pulping, filter or centrifugal after, liquid hold-up is the concentrate of solid content 11wt% with liquid concentration, after 170 ℃ of following spray-dryings, packs.
Embodiment 4: the preparation embodiment of radix boehmeriae leaf extract 4.
Take by weighing 10 kilograms on dried radix boehmeriae, leaf, fragmentation adds the entry double centner,
55 ℃ were soaked 80 minutes down, pulverized until pulping, filter or centrifugal after, liquid hold-up is the concentrate of solid content 8.5wt% with liquid concentration, after 180 ℃ of following spray-dryings, packs.
Embodiment 5: radix boehmeriae leaf extract application implementation example 1.
Take by weighing
Embodiment 11 kilogram of radix boehmeriae leaf extract, get 999 kilograms of corresponding animal mixed feeds, mix.
Embodiment 6: radix boehmeriae leaf extract application implementation example 2.
Take by weighing
Embodiment 2Radix boehmeriae leaf extract 500 gram be dissolved in 1000 kg water, treat all to stir after the dissolving, directly supply animal to drink.
Embodiment 7: the radix boehmeriae leaf extract is to the regulating and controlling effect of inflammatory cell model
Get the radix boehmeriae leaf extract among the embodiment 1, the mouse immunocyte is carried out immunological experiment.
Experimental technique: adopt the mouse immunocyte to make model; Experiment is divided into 6 groups of processing: the blank group; Testing 1,2 group is to stimulate simulation immunocyte inflammatory model with two kinds of lipopolysaccharides respectively; Testing 3,4 groups is that radix boehmeriae leaf extract 40, the 60 μ g/ml that add the preparation of PBS buffer solution after the mouse immunocyte stimulates with lipopolysaccharides more respectively handle, and testing 5 groups of mouse immunocytes does not stimulate with lipopolysaccharides, and directly with 60 μ g/ml radix boehmeriae leaf extracts normal cell is handled.To mouse immunocyte model after the experiment packet transaction, at suspension chip analysis system measurement interleukin-6,10,12 and macrophage colony stimulatory factor content.
Experimental result: with reference to Fig. 1-Fig. 4, can find out from control group, when the mouse immunocyte is in normal condition, interleukin-6,10,12 and macrophage colony stimulatory factor content maintains reduced levels or be zero; Test 1 and 2 group and show, after receiving the lipopolysaccharides stimulation, interleukin-6,10,12 is compared rapid rising with macrophage colony stimulatory factor content with control group; Can know for 3 and 4 groups by test, with the radix boehmeriae leaf extract to after receiving the lipopolysaccharides stimulated cells and handling, interleukin-6,10,12 and macrophage colony stimulatory factor content obviously descend, when addition reached 60 μ g/ml, content was near the control group level; Show that to after the mouse immunocyte is handled under the normal condition, interleukin-6,10,12 does not all have marked change with the corresponding control group of macrophage colony stimulatory factor content with 60 μ g/ml radix boehmeriae leaf extracts and test 5 groups of results.
Conclusion: the present invention's radix boehmeriae leaf extract can make interleukin-6,10,12, macrophage-stimulating colony factor content remain on normal level under animal health condition; Guarantee the normal immunity function of animal; Under the inflammation disease state, can make interleukin-6,10,12, macrophage-stimulating colony factor content return to normal level again; Thereby recovery body normal body temperature, feed intake, minimizing acute phase protein synthesize, and recover the animal normal growth.
Embodiment 8: the radix boehmeriae leaf extract is to the regulating action of breeding animals reproductive performance
Getting the radix boehmeriae leaf extract among the embodiment 1, is subjects to produce the sow and the pig that farrowed, and research radix boehmeriae leaf extract is to the influence of sow reproductive performance.
Test period: 2011.08.12-2011.10.17.
Experimental animal: the 48 first-born product sow and the pigs that farrow.
Test feed: basal diet is with reference to State Standard of the People's Republic of China's 2002 pregnancies, the design of milking sow mixed feed; Control group (antenatal 1 month to end lactation) in basal diet adds antibiotic, (antenatal 1 month to end lactation) interpolation 500 g/t radix boehmeriae leaf extracts in the test group basal diet.
Result of the test: when in feed, adding 500 g/t radix boehmeriae leaf extracts, sow production performance, suckling pig production performance and oestrus of sow at interval be improved significantly, see table 1-3.
Table 1 radix boehmeriae leaf extract is to the influence of sow reproductive performance
| Group | Go out the repiece number | It is young to live | Stillborn foetus | Still birth rate | Healthy and strong young | Healthy and strong young rate | Birth weight |
| Control group | 262 | 242 | 20 | 7.63% | 226 | 93.39% | 1.45kg |
| Test group | 258 | 248 | 10 | 3.88% | 243 | 97.98% | 1.54kg |
Table 2 radix boehmeriae leaf extract is to the influence of suckling pig production performance
| Group | A dead number | A wean number | The wean age in days | The wean counterpoise | Survival rate | The diarrhoea |
| Control group | ||||||
| 20 | 222 | 25 days | 6.35kg | 91.74% | 8.33% | |
| Test group | 11 | 237 | 25 days | 6.99kg | 95.56% | 4.25% |
Table 3 radix boehmeriae leaf extract is to the influence of sow wean inter oestrual period
| Group | Control group | Test group |
| A number of oestrusing in 3 days weans | 3 | 12 |
| A number of oestrusing in 4-5 days weans | 9 | 12 |
| A number of oestrusing in 6-7 days weans | 9 | - |
| The wean rate of oestrusing in 7 | 87.5% | 100% |
[0032]Conclusion: the radix boehmeriae leaf extract can promote foetus health to grow, and improves the newborn piglet vigor, improves the suckling pig growth performance, shortens the inter oestrual period time, has reached the purpose of improving sow reproductive performance.
Claims (4)
1. be used for the radix boehmeriae leaf extract of animal health, it is characterized in that, adopt following prepared to form: the radix boehmeriae leaf is pulverized or added an amount of water; The mass ratio of radix boehmeriae leaf and water is 1: 0-20; Pulverize pulping, filter or centrifugal back collection liquid part, the concentrate of simmer down to solid content 7wt%-15wt% then; 160-180 ℃ of following spray-drying.
2. the preparation technology who is used for the radix boehmeriae leaf extract of animal health according to claim 1; It is characterized in that; Said radix boehmeriae leaf is dried radix boehmeriae leaf or fresh radix boehmeriae leaf, and when used radix boehmeriae leaf was dried radix boehmeriae leaf, the mass ratio of radix boehmeriae leaf and water was 1: 10-20; When used radix boehmeriae leaf was fresh radix boehmeriae leaf, the mass ratio of radix boehmeriae leaf and water was 1: 0-10.
3. the preparation technology who is used for the radix boehmeriae leaf extract of animal health according to claim 2 is characterized in that, when said radix boehmeriae leaf is selected dried radix boehmeriae leaf for use, after the radix boehmeriae leaf pulverized or add water, soaks 30～90 minutes down at 50～60 ℃.
4. the said radix boehmeriae leaf extract that is used for animal health of claim 1 is used at animal mixed feed, animal health article or animal drinking-water.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053837A (en) * | 2012-12-28 | 2013-04-24 | 利川市五洲牧业有限责任公司 | Growth promotion Chinese herbal feed additive for pigs |
| CN103222548A (en) * | 2013-05-22 | 2013-07-31 | 湖南省五季风生物科技有限责任公司 | Composite plant extractive feed additive and application thereof |
| CN103892127A (en) * | 2014-04-11 | 2014-07-02 | 中国农业科学院麻类研究所 | Ramie feed for beef cattle fattening period and processing method thereof |
| CN104171676A (en) * | 2014-08-01 | 2014-12-03 | 福建省农业科学院畜牧兽医研究所 | Feed for improving fertility of goat |
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| CN1060013A (en) * | 1991-10-05 | 1992-04-08 | 刘研成 | Feed addictive and preparation method thereof |
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| CN102273572A (en) * | 2011-09-22 | 2011-12-14 | 湖南农业大学 | Ramie feed for laying hens |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103053837A (en) * | 2012-12-28 | 2013-04-24 | 利川市五洲牧业有限责任公司 | Growth promotion Chinese herbal feed additive for pigs |
| CN103053837B (en) * | 2012-12-28 | 2014-06-11 | 利川市五洲牧业有限责任公司 | Growth promotion Chinese herbal feed additive for pigs |
| CN103222548A (en) * | 2013-05-22 | 2013-07-31 | 湖南省五季风生物科技有限责任公司 | Composite plant extractive feed additive and application thereof |
| CN103222548B (en) * | 2013-05-22 | 2015-04-01 | 湖南省五季风生物科技有限责任公司 | Composite plant extractive feed additive and application thereof |
| CN103892127A (en) * | 2014-04-11 | 2014-07-02 | 中国农业科学院麻类研究所 | Ramie feed for beef cattle fattening period and processing method thereof |
| CN103892127B (en) * | 2014-04-11 | 2015-10-28 | 中国农业科学院麻类研究所 | A kind of beef ox fattening phase ramie feed and processing method thereof |
| CN104171676A (en) * | 2014-08-01 | 2014-12-03 | 福建省农业科学院畜牧兽医研究所 | Feed for improving fertility of goat |
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Application publication date: 20120801 |