CN102600214B - 苦丁茶冬青叶的提取方法、总皂苷及其用途 - Google Patents

苦丁茶冬青叶的提取方法、总皂苷及其用途 Download PDF

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Publication number
CN102600214B
CN102600214B CN201110026026.XA CN201110026026A CN102600214B CN 102600214 B CN102600214 B CN 102600214B CN 201110026026 A CN201110026026 A CN 201110026026A CN 102600214 B CN102600214 B CN 102600214B
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ethanol
kudingcha
aqueous solution
leaf
resin column
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Chinese (zh)
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CN102600214A (zh
Inventor
屠鹏飞
张彤梅
郑娇
马治中
姜勇
高雅
唐丽
车彦云
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Peking University
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Peking University
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Priority to CN201110026026.XA priority Critical patent/CN102600214B/zh
Priority to US13/981,054 priority patent/US9109003B2/en
Priority to EP11856799.9A priority patent/EP2668954B1/en
Priority to PCT/CN2011/084377 priority patent/WO2012100612A1/zh
Priority to JP2013550742A priority patent/JP5955337B2/ja
Publication of CN102600214A publication Critical patent/CN102600214A/zh
Priority to HK13100972.7A priority patent/HK1173952B/xx
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201110026026.XA 2011-01-24 2011-01-24 苦丁茶冬青叶的提取方法、总皂苷及其用途 Active CN102600214B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201110026026.XA CN102600214B (zh) 2011-01-24 2011-01-24 苦丁茶冬青叶的提取方法、总皂苷及其用途
US13/981,054 US9109003B2 (en) 2011-01-24 2011-12-21 Extraction method for Ilex kudingcha C. J. Tseng leaves, total saponins and use thereof
EP11856799.9A EP2668954B1 (en) 2011-01-24 2011-12-21 Extraction method, total saponin and use of ilex kudingcha c.j.tseng leaves
PCT/CN2011/084377 WO2012100612A1 (zh) 2011-01-24 2011-12-21 苦丁茶冬青叶的提取方法、总皂苷及其用途
JP2013550742A JP5955337B2 (ja) 2011-01-24 2011-12-21 苦丁茶冬青の葉の抽出方法、総サポニンおよびその使用
HK13100972.7A HK1173952B (en) 2013-01-22 Extraction method of ilex kudingcha c.j. tseng leaves and the total saponins extracted and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201110026026.XA CN102600214B (zh) 2011-01-24 2011-01-24 苦丁茶冬青叶的提取方法、总皂苷及其用途

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CN102600214A CN102600214A (zh) 2012-07-25
CN102600214B true CN102600214B (zh) 2014-10-08

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US (1) US9109003B2 (enExample)
EP (1) EP2668954B1 (enExample)
JP (1) JP5955337B2 (enExample)
CN (1) CN102600214B (enExample)
WO (1) WO2012100612A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827001B (zh) * 2011-06-16 2016-03-02 东莞市岭奥生物科技有限公司 一种苦丁茶冬青提取物
JP6224894B2 (ja) * 2012-12-20 2017-11-01 花王株式会社 クロロゲン酸類の安定化方法
CN103598367A (zh) * 2013-11-12 2014-02-26 福建省亚热带植物研究所 一种苦丁茶冲剂的制备方法
CN104435025A (zh) * 2014-12-29 2015-03-25 广西梧州制药（集团）股份有限公司 苦丁茶在制备治疗阿尔兹海默病药物方面的新用途
CN106420852B (zh) * 2015-08-04 2020-01-03 上海凯屹医药科技有限公司 一种雾化苦丁茶和用途
JP7134976B2 (ja) * 2017-08-09 2022-09-12 三栄源エフ・エフ・アイ株式会社 苦丁茶加工物
CN111366549A (zh) * 2020-03-24 2020-07-03 广西壮族自治区人民医院 红心猕猴桃总皂苷含量的测定方法
CN115703815B (zh) * 2021-08-04 2024-11-15 上海凯屹医药科技有限公司 苦丁皂苷a化合物的晶型、其药物组合物和用途
CN113801758A (zh) * 2021-09-22 2021-12-17 劲牌有限公司 一种降低保健酒生产过程总皂苷损耗和延缓货架期总皂苷衰减的方法
CN114264763A (zh) * 2021-12-22 2022-04-01 金绿源(中国)生物科技有限公司 一种细梗香草的取样方法
CN115671065B (zh) * 2022-10-27 2023-11-14 重庆市中药研究院 一种保肝养胃的药用片剂及其制作方法
CN120754148A (zh) * 2025-09-09 2025-10-10 天津嘉氏堂科技有限公司 苦丁茶冬青叶提取物在防脱发外用制剂中的应用

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CN1521175A (zh) * 2003-02-14 2004-08-18 浙江养生堂天然药物研究所有限公司 新的苦丁萘提取物及其用途
CN1687008A (zh) * 2005-03-22 2005-10-26 中国药科大学 从忍冬属植物叶中提取酚酸化合物的方法

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JP2001103929A (ja) * 1999-10-05 2001-04-17 Tama Seikagaku Kk 苦丁茶葉由来の抽出物及びその製法
CA2614700C (en) * 2005-07-14 2011-07-19 National Institute Of Pharmaceutical R&D Co., Ltd. Medicinal composition containing ginseng secondary glycosides, its preparation method and application
CN1981803B (zh) * 2005-12-13 2011-10-12 黄伟民 一种防治心血管疾病的中药组合物及其制备方法
JP5093873B2 (ja) * 2006-06-28 2012-12-12 長谷川香料株式会社 精製クロロゲン酸の製造法
CN101361766A (zh) * 2007-08-10 2009-02-11 贺震旦 苦丁茶总苷的应用及其制备方法
CN101284031B (zh) * 2008-06-03 2011-05-04 上海雷允上科技发展有限公司 毛冬青提取物、其制备及应用
CN101775061A (zh) * 2009-09-15 2010-07-14 沈阳药科大学 一组苦丁茶皂苷类化合物
CN101766664B (zh) * 2010-03-04 2012-11-07 广州中医药大学 一种岗梅总皂苷提取物的检测方法

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CN1521175A (zh) * 2003-02-14 2004-08-18 浙江养生堂天然药物研究所有限公司 新的苦丁萘提取物及其用途
CN1687008A (zh) * 2005-03-22 2005-10-26 中国药科大学 从忍冬属植物叶中提取酚酸化合物的方法

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CHE Yan-Yun, et al..Triterpenoid Saponins from the Leaves of Ilex kudingcha.《Chinese Journal of Natural Medicines》.2011,第9卷(第1期),22-25.
Triterpenoid Saponins from the Leaves of Ilex kudingcha;CHE Yan-Yun, et al.;《Chinese Journal of Natural Medicines》;20110120;第9卷(第1期);22-25 *

Also Published As

Publication number Publication date
US20130303469A1 (en) 2013-11-14
JP2014504607A (ja) 2014-02-24
EP2668954A1 (en) 2013-12-04
HK1173952A1 (zh) 2013-05-31
JP5955337B2 (ja) 2016-07-20
EP2668954B1 (en) 2016-03-02
CN102600214A (zh) 2012-07-25
US9109003B2 (en) 2015-08-18
EP2668954A4 (en) 2014-08-06
WO2012100612A1 (zh) 2012-08-02

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