CN102596915B - 2-硫代组氨酸及类似物的合成方法 - Google Patents

2-硫代组氨酸及类似物的合成方法 Download PDF

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Publication number
CN102596915B
CN102596915B CN201080047020.4A CN201080047020A CN102596915B CN 102596915 B CN102596915 B CN 102596915B CN 201080047020 A CN201080047020 A CN 201080047020A CN 102596915 B CN102596915 B CN 102596915B
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China
Prior art keywords
general formula
compound
acid
enantiomers
mixture
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Expired - Fee Related
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CN201080047020.4A
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English (en)
Chinese (zh)
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CN102596915A (zh
Inventor
I·艾德麦尔
S·多奈
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Tetrahedron SAS
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Tetrahedron SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
CN201080047020.4A 2009-10-06 2010-10-06 2-硫代组氨酸及类似物的合成方法 Expired - Fee Related CN102596915B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0956968A FR2950890B1 (fr) 2009-10-06 2009-10-06 Procede de synthese de la 2-thiohistidine et analogues
FR0956968 2009-10-06
PCT/EP2010/064947 WO2011042478A1 (fr) 2009-10-06 2010-10-06 Procede de synthese de la 2-thiohistidine et analogues

Publications (2)

Publication Number Publication Date
CN102596915A CN102596915A (zh) 2012-07-18
CN102596915B true CN102596915B (zh) 2016-04-20

Family

ID=41664356

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080047020.4A Expired - Fee Related CN102596915B (zh) 2009-10-06 2010-10-06 2-硫代组氨酸及类似物的合成方法

Country Status (14)

Country Link
US (1) US8835477B2 (https=)
EP (1) EP2486019B1 (https=)
JP (1) JP5731515B2 (https=)
KR (1) KR101773995B1 (https=)
CN (1) CN102596915B (https=)
AU (1) AU2010305397B2 (https=)
BR (1) BR112012007944A2 (https=)
CA (1) CA2776833C (https=)
ES (1) ES2540279T3 (https=)
FR (1) FR2950890B1 (https=)
HU (1) HUE025487T2 (https=)
IN (1) IN2012DN03819A (https=)
RU (1) RU2548153C2 (https=)
WO (1) WO2011042478A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3021655B1 (fr) 2014-05-30 2016-07-08 Tetrahedron Nouveaux composes de type 5-acylsulfanyl-histidine en tant que precurseurs des 5-sulfanylhistidines correspondantes et de leurs disulfures
JP6864131B1 (ja) * 2020-03-04 2021-04-28 長瀬産業株式会社 Ｌ−エルゴチオネイン含有組成物
US20240199687A1 (en) * 2021-04-22 2024-06-20 University Of Vermont And State Agricultural College Substitution of histidine with 2-thiohistidine in bioactive peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) * 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.
FR2714380B1 (fr) * 1993-12-24 1996-05-24 Bioxytech Utilisation de dérivés 2-mercapto-imidazole substitués en position 4 (ou 5) comme agents antioxydants, leur procédé de préparation et leurs applications en pharmacie, cosmétique ou alimentaire.
ES2194209T3 (es) * 1996-07-22 2003-11-16 Monsanto Co Inhibidores de metaloproteasa de tiol sulfona.
AU2002211666A1 (en) * 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
FR2950889B1 (fr) 2009-10-06 2011-11-18 Tetrahedron Procede de synthese de l'ergothioneine et analogues

Also Published As

Publication number Publication date
CN102596915A (zh) 2012-07-18
JP5731515B2 (ja) 2015-06-10
BR112012007944A2 (pt) 2015-09-22
HUE025487T2 (en) 2016-04-28
EP2486019A1 (fr) 2012-08-15
RU2012117977A (ru) 2013-11-20
FR2950890A1 (fr) 2011-04-08
KR20120100977A (ko) 2012-09-12
WO2011042478A1 (fr) 2011-04-14
CA2776833C (fr) 2019-03-19
JP2013506705A (ja) 2013-02-28
ES2540279T3 (es) 2015-07-09
AU2010305397B2 (en) 2014-07-10
CA2776833A1 (fr) 2011-04-14
KR101773995B1 (ko) 2017-09-01
IN2012DN03819A (https=) 2015-08-28
US8835477B2 (en) 2014-09-16
AU2010305397A1 (en) 2012-05-24
RU2548153C2 (ru) 2015-04-20
EP2486019B1 (fr) 2015-03-25
FR2950890B1 (fr) 2011-12-30
US20120330029A1 (en) 2012-12-27

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