IN2012DN03819A - - Google Patents

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Publication number
IN2012DN03819A
IN2012DN03819A IN3819DEN2012A IN2012DN03819A IN 2012DN03819 A IN2012DN03819 A IN 2012DN03819A IN 3819DEN2012 A IN3819DEN2012 A IN 3819DEN2012A IN 2012DN03819 A IN2012DN03819 A IN 2012DN03819A
Authority
IN
India
Prior art keywords
formula
tautomer
stereoisomer
stereoisomers
proportions
Prior art date
Application number
Inventor
Irene Erdelmeier
Sylvain Daunay
Original Assignee
Tetrahedron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetrahedron filed Critical Tetrahedron
Publication of IN2012DN03819A publication Critical patent/IN2012DN03819A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

The invention relates to a method for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60°C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.
IN3819DEN2012 2009-10-06 2010-10-06 IN2012DN03819A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0956968A FR2950890B1 (en) 2009-10-06 2009-10-06 PROCESS FOR SYNTHESIZING 2-THIOHISTIDINE AND THE LIKE
PCT/EP2010/064947 WO2011042478A1 (en) 2009-10-06 2010-10-06 Method for the synthesis of 2-thiohistidine and the like

Publications (1)

Publication Number Publication Date
IN2012DN03819A true IN2012DN03819A (en) 2015-08-28

Family

ID=41664356

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3819DEN2012 IN2012DN03819A (en) 2009-10-06 2010-10-06

Country Status (14)

Country Link
US (1) US8835477B2 (en)
EP (1) EP2486019B1 (en)
JP (1) JP5731515B2 (en)
KR (1) KR101773995B1 (en)
CN (1) CN102596915B (en)
AU (1) AU2010305397B2 (en)
BR (1) BR112012007944A2 (en)
CA (1) CA2776833C (en)
ES (1) ES2540279T3 (en)
FR (1) FR2950890B1 (en)
HU (1) HUE025487T2 (en)
IN (1) IN2012DN03819A (en)
RU (1) RU2548153C2 (en)
WO (1) WO2011042478A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3021655B1 (en) 2014-05-30 2016-07-08 Tetrahedron NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINS AND THEIR DISULFIDE
JP6864131B1 (en) * 2020-03-04 2021-04-28 長瀬産業株式会社 L-ergothioneine-containing composition
WO2022226360A1 (en) * 2021-04-22 2022-10-27 University Of Vermont And State Agricultural College Substitution of histidine with 2-thiohistidine in bioactive peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (en) 1993-06-28 1995-10-13 Bioxytech New process for the preparation of ergothionein.
FR2714380B1 (en) 1993-12-24 1996-05-24 Bioxytech Use of 2-mercapto-imidazole derivatives substituted in position 4 (or 5) as antioxidants, their preparation process and their applications in pharmacy, cosmetics or food.
ATE233552T1 (en) * 1996-07-22 2003-03-15 Monsanto Co THIOL-SULFONES AS METALLOPROTEINASE INHIBITORS
CA2425674A1 (en) * 2000-10-11 2002-04-18 Jean-Louis H. Dasseux Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
FR2950889B1 (en) 2009-10-06 2011-11-18 Tetrahedron PROCESS FOR SYNTHESIZING ERGOTHIONEIN AND THE LIKE

Also Published As

Publication number Publication date
FR2950890A1 (en) 2011-04-08
CN102596915B (en) 2016-04-20
RU2012117977A (en) 2013-11-20
EP2486019A1 (en) 2012-08-15
RU2548153C2 (en) 2015-04-20
US8835477B2 (en) 2014-09-16
AU2010305397A1 (en) 2012-05-24
KR101773995B1 (en) 2017-09-01
FR2950890B1 (en) 2011-12-30
JP5731515B2 (en) 2015-06-10
HUE025487T2 (en) 2016-04-28
BR112012007944A2 (en) 2015-09-22
AU2010305397B2 (en) 2014-07-10
CN102596915A (en) 2012-07-18
US20120330029A1 (en) 2012-12-27
EP2486019B1 (en) 2015-03-25
KR20120100977A (en) 2012-09-12
CA2776833A1 (en) 2011-04-14
WO2011042478A1 (en) 2011-04-14
JP2013506705A (en) 2013-02-28
CA2776833C (en) 2019-03-19
ES2540279T3 (en) 2015-07-09

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