BR112012007944A2 - processo de síntese da 2-tiohistidina e análogos - Google Patents

processo de síntese da 2-tiohistidina e análogos

Info

Publication number
BR112012007944A2
BR112012007944A2 BR112012007944A BR112012007944A BR112012007944A2 BR 112012007944 A2 BR112012007944 A2 BR 112012007944A2 BR 112012007944 A BR112012007944 A BR 112012007944A BR 112012007944 A BR112012007944 A BR 112012007944A BR 112012007944 A2 BR112012007944 A2 BR 112012007944A2
Authority
BR
Brazil
Prior art keywords
thiohistidine
analogs
synthesis process
synthesis
thiohistidine synthesis
Prior art date
Application number
BR112012007944A
Other languages
English (en)
Inventor
Irene Erdelmeier
Sylvain Daunay
Original Assignee
Tetrahedron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetrahedron filed Critical Tetrahedron
Publication of BR112012007944A2 publication Critical patent/BR112012007944A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
BR112012007944A 2009-10-06 2010-10-06 processo de síntese da 2-tiohistidina e análogos BR112012007944A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0956968A FR2950890B1 (fr) 2009-10-06 2009-10-06 Procede de synthese de la 2-thiohistidine et analogues
PCT/EP2010/064947 WO2011042478A1 (fr) 2009-10-06 2010-10-06 Procede de synthese de la 2-thiohistidine et analogues

Publications (1)

Publication Number Publication Date
BR112012007944A2 true BR112012007944A2 (pt) 2015-09-22

Family

ID=41664356

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012007944A BR112012007944A2 (pt) 2009-10-06 2010-10-06 processo de síntese da 2-tiohistidina e análogos

Country Status (14)

Country Link
US (1) US8835477B2 (pt)
EP (1) EP2486019B1 (pt)
JP (1) JP5731515B2 (pt)
KR (1) KR101773995B1 (pt)
CN (1) CN102596915B (pt)
AU (1) AU2010305397B2 (pt)
BR (1) BR112012007944A2 (pt)
CA (1) CA2776833C (pt)
ES (1) ES2540279T3 (pt)
FR (1) FR2950890B1 (pt)
HU (1) HUE025487T2 (pt)
IN (1) IN2012DN03819A (pt)
RU (1) RU2548153C2 (pt)
WO (1) WO2011042478A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3021655B1 (fr) 2014-05-30 2016-07-08 Tetrahedron Nouveaux composes de type 5-acylsulfanyl-histidine en tant que precurseurs des 5-sulfanylhistidines correspondantes et de leurs disulfures
JP6864131B1 (ja) * 2020-03-04 2021-04-28 長瀬産業株式会社 Ｌ−エルゴチオネイン含有組成物
EP4326302A1 (en) * 2021-04-22 2024-02-28 University of Vermont and State Agricultural College Substitution of histidine with 2-thiohistidine in bioactive peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) * 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.
FR2714380B1 (fr) 1993-12-24 1996-05-24 Bioxytech Utilisation de dérivés 2-mercapto-imidazole substitués en position 4 (ou 5) comme agents antioxydants, leur procédé de préparation et leurs applications en pharmacie, cosmétique ou alimentaire.
WO1998003164A1 (en) * 1996-07-22 1998-01-29 Monsanto Company Thiol sulfone metalloprotease inhibitors
EP1363879A2 (en) * 2000-10-11 2003-11-26 Esperion Therapeutics Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
FR2950889B1 (fr) 2009-10-06 2011-11-18 Tetrahedron Procede de synthese de l'ergothioneine et analogues

Also Published As

Publication number Publication date
IN2012DN03819A (pt) 2015-08-28
WO2011042478A1 (fr) 2011-04-14
FR2950890A1 (fr) 2011-04-08
EP2486019B1 (fr) 2015-03-25
RU2012117977A (ru) 2013-11-20
CN102596915A (zh) 2012-07-18
ES2540279T3 (es) 2015-07-09
JP2013506705A (ja) 2013-02-28
FR2950890B1 (fr) 2011-12-30
AU2010305397B2 (en) 2014-07-10
KR20120100977A (ko) 2012-09-12
RU2548153C2 (ru) 2015-04-20
US20120330029A1 (en) 2012-12-27
CA2776833A1 (fr) 2011-04-14
US8835477B2 (en) 2014-09-16
AU2010305397A1 (en) 2012-05-24
CA2776833C (fr) 2019-03-19
KR101773995B1 (ko) 2017-09-01
EP2486019A1 (fr) 2012-08-15
JP5731515B2 (ja) 2015-06-10
CN102596915B (zh) 2016-04-20
HUE025487T2 (en) 2016-04-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.