CN102575228A - Dna-细胞缀合物 - Google Patents

Dna-细胞缀合物 Download PDF

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Publication number
CN102575228A
CN102575228A CN2010800213506A CN201080021350A CN102575228A CN 102575228 A CN102575228 A CN 102575228A CN 2010800213506 A CN2010800213506 A CN 2010800213506A CN 201080021350 A CN201080021350 A CN 201080021350A CN 102575228 A CN102575228 A CN 102575228A
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China
Prior art keywords
cell
cells
nucleic acid
dna
acid moiety
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Pending
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CN2010800213506A
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English (en)
Chinese (zh)
Inventor
萧世嘉
马修·B·弗朗西斯
卡罗伦·贝尔托齐
理查德·马蒂斯
拉维·钱德拉
埃里克·道格拉斯
艾米·特威特
尼古拉斯·托列洛
尾上弘晃
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University of California San Diego UCSD
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University of California San Diego UCSD
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Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Priority to CN202110460486.7A priority Critical patent/CN113186149A/zh
Priority to CN201710671296.3A priority patent/CN107326002A/zh
Publication of CN102575228A publication Critical patent/CN102575228A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CN2010800213506A 2009-04-08 2010-04-08 Dna-细胞缀合物 Pending CN102575228A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202110460486.7A CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物
CN201710671296.3A CN107326002A (zh) 2009-04-08 2010-04-08 Dna‑细胞缀合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16774809P 2009-04-08 2009-04-08
US61/167,748 2009-04-08
US24312309P 2009-09-16 2009-09-16
US61/243,123 2009-09-16
PCT/US2010/030397 WO2010118235A1 (en) 2009-04-08 2010-04-08 Dna-cell conjugates

Related Child Applications (2)

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CN201710671296.3A Division CN107326002A (zh) 2009-04-08 2010-04-08 Dna‑细胞缀合物
CN202110460486.7A Division CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

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CN102575228A true CN102575228A (zh) 2012-07-11

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CN2010800213506A Pending CN102575228A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物
CN201710671296.3A Pending CN107326002A (zh) 2009-04-08 2010-04-08 Dna‑细胞缀合物
CN202110460486.7A Pending CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

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CN202110460486.7A Pending CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

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US (2) US9327036B2 (enExample)
EP (1) EP2417249B1 (enExample)
JP (2) JP5964746B2 (enExample)
CN (3) CN102575228A (enExample)
CA (1) CA2757884C (enExample)
ES (1) ES2924287T3 (enExample)
WO (1) WO2010118235A1 (enExample)

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CN104212758A (zh) * 2013-05-31 2014-12-17 复旦大学 一种构建遗传性状嵌合多细胞结构方法
CN107037218A (zh) * 2017-05-04 2017-08-11 中南大学 一种膜蛋白检测制剂、非标记肿瘤纳米探针及使用方法
CN107209170A (zh) * 2014-10-28 2017-09-26 多伦多大学管理委员会 电化学代谢活性检测装置
CN112014361A (zh) * 2019-05-30 2020-12-01 华东理工大学 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法
CN112280829A (zh) * 2020-04-07 2021-01-29 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法

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WO2014160363A1 (en) * 2013-03-14 2014-10-02 Baylor Research Institute Surface modification of porcine islets
CN105102627B (zh) * 2013-03-15 2018-10-19 纽约哥伦比亚大学理事会 用于检测样品中多种预定化合物的方法
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WO2015042539A1 (en) * 2013-09-20 2015-03-26 Board Of Regents, The University Of Texas System Fabrication of iridium oxide ph sensors and sensor arrays
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WO2020010366A1 (en) * 2018-07-06 2020-01-09 The Regents Of The University Of California Lipid-modified oligonucleotides and methods of using the same
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BR102019006678A2 (pt) * 2019-04-02 2020-10-06 Universidade Federal de Uberlândia Processo de modificação da superfície de eletrodos para construção de biossensores eletroquímicos
CN110205291A (zh) * 2019-04-28 2019-09-06 蚌埠医学院第一附属医院 一种膜表面工程化nk细胞的制备方法及药物组合物与应用
US12091313B2 (en) 2019-08-26 2024-09-17 The Research Foundation For The State University Of New York Electrodynamically levitated actuator
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CN114630906A (zh) * 2019-11-04 2022-06-14 生物辐射实验室股份有限公司 用于单细胞测序的细胞条码化
US20240125764A1 (en) * 2019-11-08 2024-04-18 The Regents Of The University Of California Compositions and methods for temporal control of cell modulation
CN111534475B (zh) * 2019-11-28 2022-03-15 厦门诺康得生物科技有限公司 一种细胞表面偶联抗体的方法及其应用
US20230294097A1 (en) * 2020-05-04 2023-09-21 The Regents Of The University Of California Electrochemical cellular circuits
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CN114574496B (zh) * 2020-12-01 2024-04-09 上海交通大学医学院附属仁济医院 核苷类衍生物改性的核酸适体sgc8
WO2022190733A1 (ja) * 2021-03-10 2022-09-15 ソニーグループ株式会社 生体粒子分析方法及び生体粒子分析用試薬キット
CN113083383B (zh) * 2021-03-18 2022-10-25 华中农业大学 微流控芯片装置、制备方法及土壤微生物群落培养方法
CN113092425B (zh) * 2021-03-29 2022-09-27 上海交通大学 一种基于pH响应的DNA纳米机器建立可编程细胞间通讯的方法
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104212758A (zh) * 2013-05-31 2014-12-17 复旦大学 一种构建遗传性状嵌合多细胞结构方法
CN107209170A (zh) * 2014-10-28 2017-09-26 多伦多大学管理委员会 电化学代谢活性检测装置
US10449542B2 (en) 2014-10-28 2019-10-22 The Governing Council Of The University Of Toronto Electrochemical metabolic activity detecting device
CN107037218A (zh) * 2017-05-04 2017-08-11 中南大学 一种膜蛋白检测制剂、非标记肿瘤纳米探针及使用方法
CN112014361A (zh) * 2019-05-30 2020-12-01 华东理工大学 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法
CN112014361B (zh) * 2019-05-30 2023-09-15 华东理工大学 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法
CN112280829A (zh) * 2020-04-07 2021-01-29 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法
CN112280829B (zh) * 2020-04-07 2023-12-26 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法

Also Published As

Publication number Publication date
CA2757884C (en) 2019-10-22
CN107326002A (zh) 2017-11-07
CA2757884A1 (en) 2010-10-14
JP2012523569A (ja) 2012-10-04
US20160319238A1 (en) 2016-11-03
ES2924287T3 (es) 2022-10-05
JP2016168062A (ja) 2016-09-23
JP5964746B2 (ja) 2016-08-03
EP2417249A1 (en) 2012-02-15
WO2010118235A1 (en) 2010-10-14
EP2417249B1 (en) 2022-06-08
US20120142088A1 (en) 2012-06-07
US9969970B2 (en) 2018-05-15
EP2417249A4 (en) 2013-06-26
CN113186149A (zh) 2021-07-30
US9327036B2 (en) 2016-05-03

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Application publication date: 20120711