CN102573884B - 从蜘蛛毒液中分离的新型肽及其应用 - Google Patents

从蜘蛛毒液中分离的新型肽及其应用 Download PDF

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Publication number
CN102573884B
CN102573884B CN201080041208.8A CN201080041208A CN102573884B CN 102573884 B CN102573884 B CN 102573884B CN 201080041208 A CN201080041208 A CN 201080041208A CN 102573884 B CN102573884 B CN 102573884B
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China
Prior art keywords
peptide
seq
peptides
venom
pain
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Expired - Fee Related
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CN201080041208.8A
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English (en)
Chinese (zh)
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CN102573884A (zh
Inventor
阿隆·梅厄
罗尼特·西姆哈·切尔基
埃拉·科尔贝
耶尔·兰古特
尼西姆·巴扎约
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Alomone Preclinical Ltd
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Alomone Preclinical Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Insects & Arthropods (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201080041208.8A 2009-09-15 2010-09-13 从蜘蛛毒液中分离的新型肽及其应用 Expired - Fee Related CN102573884B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27233609P 2009-09-15 2009-09-15
US61/272,336 2009-09-15
PCT/IB2010/002275 WO2011033358A2 (en) 2009-09-15 2010-09-13 Novel peptides isolated from spider venom, and uses thereof

Publications (2)

Publication Number Publication Date
CN102573884A CN102573884A (zh) 2012-07-11
CN102573884B true CN102573884B (zh) 2015-01-14

Family

ID=43731158

Family Applications (1)

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CN201080041208.8A Expired - Fee Related CN102573884B (zh) 2009-09-15 2010-09-13 从蜘蛛毒液中分离的新型肽及其应用

Country Status (12)

Country Link
US (1) US8399026B2 (enExample)
EP (1) EP2504023B1 (enExample)
JP (1) JP5555891B2 (enExample)
CN (1) CN102573884B (enExample)
AR (1) AR078374A1 (enExample)
AU (1) AU2010296994B2 (enExample)
BR (1) BR112012005860A2 (enExample)
CA (1) CA2774350A1 (enExample)
IL (1) IL218382A0 (enExample)
MX (1) MX2012003078A (enExample)
SG (1) SG179101A1 (enExample)
WO (1) WO2011033358A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201601789TA (en) 2011-03-16 2016-04-28 Amgen Inc Potent And Selective Inhibitors Of Nav1.3 And Nav1.7
WO2013026105A1 (en) * 2011-08-24 2013-02-28 The University Of Queensland Pest-controlling agents isolated from spider venom and uses thereof
US9102751B2 (en) 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
EP2852397B1 (en) 2012-05-18 2022-02-16 Janssen Biotech, Inc. Huwentoxin-iv variants and methods of use
JP6086378B2 (ja) * 2012-11-30 2017-03-01 国立大学法人お茶の水女子大学 組み換えヒト膵臓リパーゼの調製方法
US9636418B2 (en) 2013-03-12 2017-05-02 Amgen Inc. Potent and selective inhibitors of NAV1.7
TW201446792A (zh) 2013-03-12 2014-12-16 Amgen Inc Nav1．7之強效及選擇性抑制劑
US9624280B2 (en) 2013-10-03 2017-04-18 Janssen Biotech, Inc. Protoxin-II variants and methods of use
GB201410108D0 (en) * 2014-06-06 2014-07-23 Univ Manchester Peptides, and methods and apparatus utilising same
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
ES2888799T3 (es) 2015-04-02 2022-01-07 Janssen Biotech Inc Variantes de Protoxina-II y métodos de uso
CL2016002890A1 (es) * 2016-11-14 2017-06-30 Univ Antofagasta Peptidos con actividad antimicrobiana
CN107141343A (zh) * 2017-06-01 2017-09-08 长沙沁才生物科技有限公司 一种活性多肽spkp‑xi的制备方法
CN107141344A (zh) * 2017-06-01 2017-09-08 长沙沁才生物科技有限公司 一种新型天然活性多肽spkp‑xi
CN107163124A (zh) * 2017-06-22 2017-09-15 长沙沁才生物科技有限公司 SPNP‑IX在制备Nav1.3通道抑制剂中的应用
CN107496904B (zh) * 2017-09-21 2020-03-17 中南大学 多肽Lycosin-Ⅰ在制备抗炎和抗弓形虫药物中的应用
CN108047323B (zh) * 2017-12-20 2022-04-12 深圳羽众医药科技有限公司 一种固相片段法合成GpTx-1及其类似物和合成方法
US20230374084A1 (en) * 2020-09-23 2023-11-23 Aldevron, Llc Potent and selective inhibitors of nav1.7

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877026A (en) * 1996-01-03 1999-03-02 Zeneca Limited Analgesic peptides from venom of Grammostola spatulata and use thereof
CN1307900A (zh) * 2000-04-11 2001-08-15 厦门北大之路生物工程有限公司 虎纹捕鸟蜘蛛毒素提取物在制备镇痛药物中的应用

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Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
WO1985000372A1 (fr) 1983-07-01 1985-01-31 Battelle Memorial Institute Polypeptide biodegradable et son utilisation pour le relargage progressif de medicaments
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
JP2004537253A (ja) * 2000-07-21 2004-12-16 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション ミュー−コノペプチド
US7507717B2 (en) * 2002-12-02 2009-03-24 Xenome Ltd. Type II chi-conotoxin peptides (noradrenaline transporter inhibitors)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877026A (en) * 1996-01-03 1999-03-02 Zeneca Limited Analgesic peptides from venom of Grammostola spatulata and use thereof
CN1307900A (zh) * 2000-04-11 2001-08-15 厦门北大之路生物工程有限公司 虎纹捕鸟蜘蛛毒素提取物在制备镇痛药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes;Frank Bosmans;《MOLECULAR PHARMACOLOGY》;20061231;第69卷(第2期);图1-2以及第427页讨论 *
Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration;Yucheng Xiao;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20081003;第283卷(第40期);第27311页左栏第2段 *

Also Published As

Publication number Publication date
AU2010296994B2 (en) 2013-09-19
US8399026B2 (en) 2013-03-19
JP2013504318A (ja) 2013-02-07
US20110065647A1 (en) 2011-03-17
AR078374A1 (es) 2011-11-02
MX2012003078A (es) 2012-08-03
JP5555891B2 (ja) 2014-07-23
BR112012005860A2 (pt) 2017-01-31
EP2504023A4 (en) 2013-04-10
WO2011033358A3 (en) 2011-07-14
SG179101A1 (en) 2012-05-30
AU2010296994A1 (en) 2012-04-19
WO2011033358A2 (en) 2011-03-24
CN102573884A (zh) 2012-07-11
EP2504023B1 (en) 2015-07-15
CA2774350A1 (en) 2011-03-24
EP2504023A2 (en) 2012-10-03
IL218382A0 (en) 2012-04-30

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Termination date: 20180913