CN102549439B - 用于吸附铁调素的吸附剂 - Google Patents

用于吸附铁调素的吸附剂 Download PDF

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Publication number
CN102549439B
CN102549439B CN201080032425.0A CN201080032425A CN102549439B CN 102549439 B CN102549439 B CN 102549439B CN 201080032425 A CN201080032425 A CN 201080032425A CN 102549439 B CN102549439 B CN 102549439B
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China
Prior art keywords
hepcidin
line set
medical device
patient
blood
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Expired - Fee Related
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CN201080032425.0A
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English (en)
Chinese (zh)
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CN102549439A (zh
Inventor
J.帕斯里克-蒂特詹
W.霍夫曼
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Fresenius Medical Care Deutschland GmbH
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Fresenius Medical Care Deutschland GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN201080032425.0A 2009-07-20 2010-07-15 用于吸附铁调素的吸附剂 Expired - Fee Related CN102549439B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009034150A DE102009034150A1 (de) 2009-07-20 2009-07-20 Adsorbens zur Adsorption von Hepcidin
DE102009034150.1 2009-07-20
PCT/EP2010/004303 WO2011009555A1 (de) 2009-07-20 2010-07-15 Adsorbens zur adsorption von hepcidin

Publications (2)

Publication Number Publication Date
CN102549439A CN102549439A (zh) 2012-07-04
CN102549439B true CN102549439B (zh) 2016-01-20

Family

ID=42797095

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080032425.0A Expired - Fee Related CN102549439B (zh) 2009-07-20 2010-07-15 用于吸附铁调素的吸附剂

Country Status (6)

Country Link
US (1) US8915875B2 (enExample)
EP (1) EP2457097B1 (enExample)
JP (1) JP5898615B2 (enExample)
CN (1) CN102549439B (enExample)
DE (1) DE102009034150A1 (enExample)
WO (1) WO2011009555A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2633053A1 (en) * 2010-10-29 2013-09-04 Noxxon Pharma AG Use of hepcidin binding nucleic acids for depletion of hepcidin from the body
SE1200356A1 (sv) * 2011-10-30 2013-05-01 Kurt Nilsson Polymerbaserad produkt och användning
DE102012025164A1 (de) 2012-12-21 2014-06-26 Fresenius Medical Care Deutschland Gmbh Vorrichtung zur Entfernung proteingebundener Toxine aus Blutplasma
US9585996B2 (en) * 2014-04-02 2017-03-07 Human Biomed, Inc. Blood purifying filter and blood purifying apparatus
US11904082B2 (en) 2016-08-01 2024-02-20 Kaneka Corporation Adsorbent for calciprotein particles, adsorption removal system, and method for utilization thereof
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
US20190247560A1 (en) * 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
EP3946054A4 (en) * 2019-03-26 2022-12-28 Seer, Inc. COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS FROM BIOLIQUIDS AND THEIR USES
KR20220088699A (ko) 2019-09-27 2022-06-28 디스크 메디슨, 인크. 골수섬유증 및 관련 상태의 치료 방법
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476715A (en) * 1989-10-03 1995-12-19 Fresenius Ag Particulate adsorbent for the removal of biomacromolecules such as LDL and endotoxins from whole blood in extracorporeal circuits
CN1346280A (zh) * 1999-03-26 2002-04-24 生化研究股份公司 败血症治疗用免疫吸附剂
CN1408442A (zh) * 2002-09-09 2003-04-09 天津医科大学总医院 全血灌流吸附治疗用吸附剂
CN1572332A (zh) * 2003-05-30 2005-02-02 富瑞森尼尔斯医护德国有限公司 含胆红素液体之体外照射装置及其方法
CN1612746A (zh) * 2001-05-25 2005-05-04 国家健康与医学研究院 Hepcidin作为铁稳态调节剂的用途
WO2006042507A1 (de) * 2004-10-20 2006-04-27 Adexter Technology Limited Immunadsorber für die behandlung von entzündungen
WO2009044284A1 (en) * 2007-10-02 2009-04-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antibodies specific for human hepcidin
WO2009058797A1 (en) * 2007-11-02 2009-05-07 Eli Lilly And Company Anti-hepcidin antibodies and uses thereof

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
JPS56145858A (en) * 1980-04-15 1981-11-12 Unitika Ltd Purifier for body fluid
JPS5897366A (ja) * 1981-12-08 1983-06-09 旭化成株式会社 血液及び体液物質の除去装置
CN1019132B (zh) * 1985-03-29 1992-11-18 格鲁波莱佩蒂特公司 抗尿激酶单克隆抗体，带有它的基质，其试验方法和使用它的生化试验药盒
DE3932971C2 (de) 1989-10-03 2003-03-13 Fresenius Ag Zur Eliminierung von Biomakromolekülen, insbesondere LDL und Endotoxinen, aus Vollblut in extrakorporalem Kreislauf geeignetes Adsorbens
US6416487B1 (en) * 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
CN1116926C (zh) * 2001-09-21 2003-08-06 大连理工大学 用于治疗高胆红素血症的免疫吸附材料
SE0201257D0 (sv) 2002-04-25 2002-04-25 Medical Invest In Sweden Ab Improved Separation
EP1578254B1 (en) * 2002-11-19 2013-03-06 DRG International, Inc. Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor
US8017737B2 (en) * 2002-11-19 2011-09-13 Hasan Kulaksiz Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor
PE20090722A1 (es) * 2007-02-02 2009-07-13 Amgen Inc Hepcidina, antagonistas de la hepcidina y metodos de uso
CN101279242A (zh) 2008-05-20 2008-10-08 大连理工大学 用于抗体清除的血液净化吸附剂

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476715A (en) * 1989-10-03 1995-12-19 Fresenius Ag Particulate adsorbent for the removal of biomacromolecules such as LDL and endotoxins from whole blood in extracorporeal circuits
CN1346280A (zh) * 1999-03-26 2002-04-24 生化研究股份公司 败血症治疗用免疫吸附剂
CN1612746A (zh) * 2001-05-25 2005-05-04 国家健康与医学研究院 Hepcidin作为铁稳态调节剂的用途
CN1408442A (zh) * 2002-09-09 2003-04-09 天津医科大学总医院 全血灌流吸附治疗用吸附剂
CN1572332A (zh) * 2003-05-30 2005-02-02 富瑞森尼尔斯医护德国有限公司 含胆红素液体之体外照射装置及其方法
WO2006042507A1 (de) * 2004-10-20 2006-04-27 Adexter Technology Limited Immunadsorber für die behandlung von entzündungen
WO2009044284A1 (en) * 2007-10-02 2009-04-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antibodies specific for human hepcidin
WO2009058797A1 (en) * 2007-11-02 2009-05-07 Eli Lilly And Company Anti-hepcidin antibodies and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Hepcidin, the hormone of iron metabolism, is bound specifically to α-2-macroglobulin in blood;Gabriela Peslova et al.;《Blood》;20090420;第113卷(第24期);第6225-6236页 *

Also Published As

Publication number Publication date
JP5898615B2 (ja) 2016-04-06
EP2457097B1 (de) 2015-09-09
EP2457097A1 (de) 2012-05-30
US20120063954A1 (en) 2012-03-15
US8915875B2 (en) 2014-12-23
JP2012533582A (ja) 2012-12-27
WO2011009555A1 (de) 2011-01-27
CN102549439A (zh) 2012-07-04
DE102009034150A1 (de) 2011-01-27

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Granted publication date: 20160120

Termination date: 20210715