CN102548582B - 滴眼剂 - Google Patents

滴眼剂 Download PDF

Info

Publication number
CN102548582B
CN102548582B CN201080042270.9A CN201080042270A CN102548582B CN 102548582 B CN102548582 B CN 102548582B CN 201080042270 A CN201080042270 A CN 201080042270A CN 102548582 B CN102548582 B CN 102548582B
Authority
CN
China
Prior art keywords
eye drop
viscosity
monoterpene
eye
carbopol etd2050
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080042270.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN102548582A (zh
Inventor
赤木第子
宫野贵之
井之冈元良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAATSU PHARMECEUTICAL Manufacturing Co Ltd
Original Assignee
SAATSU PHARMECEUTICAL Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SAATSU PHARMECEUTICAL Manufacturing Co Ltd filed Critical SAATSU PHARMECEUTICAL Manufacturing Co Ltd
Publication of CN102548582A publication Critical patent/CN102548582A/zh
Application granted granted Critical
Publication of CN102548582B publication Critical patent/CN102548582B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201080042270.9A 2009-09-30 2010-09-29 滴眼剂 Expired - Fee Related CN102548582B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009-228661 2009-09-30
JP2009228661 2009-09-30
PCT/JP2010/066898 WO2011040433A1 (ja) 2009-09-30 2010-09-29 点眼剤

Publications (2)

Publication Number Publication Date
CN102548582A CN102548582A (zh) 2012-07-04
CN102548582B true CN102548582B (zh) 2015-09-02

Family

ID=43826249

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080042270.9A Expired - Fee Related CN102548582B (zh) 2009-09-30 2010-09-29 滴眼剂

Country Status (6)

Country Link
US (1) US9278062B2 (https=)
EP (1) EP2484384A4 (https=)
JP (3) JP4777477B2 (https=)
CN (1) CN102548582B (https=)
TW (1) TWI498127B (https=)
WO (1) WO2011040433A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2853235A1 (en) * 2011-11-01 2013-05-10 Rohto Pharmaceutical Co., Ltd. Ophthalmological aqueous composition
IN2014CN03951A (https=) * 2011-11-01 2015-09-04 Rohto Pharma
JP6304475B2 (ja) * 2013-01-31 2018-04-04 ロート製薬株式会社 点眼剤
JP6177019B2 (ja) * 2013-01-31 2017-08-09 ロート製薬株式会社 点眼剤
JP6304474B2 (ja) * 2013-01-31 2018-04-04 ロート製薬株式会社 点眼剤
JP6653123B2 (ja) * 2014-03-26 2020-02-26 ロート製薬株式会社 カラーコンタクトレンズ用眼科組成物
US11583496B2 (en) 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof
US11260035B2 (en) 2016-10-12 2022-03-01 Ps Therapies Ltd Topical compositions and methods of use thereof
WO2018071619A1 (en) * 2016-10-12 2018-04-19 Ps Therapies Ltd Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
US20200009044A1 (en) * 2016-10-12 2020-01-09 Ps Therapies Ltd Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
JP7009093B2 (ja) * 2017-06-29 2022-01-25 小林製薬株式会社 油性点眼剤
JP7458159B2 (ja) * 2018-09-28 2024-03-29 ロート製薬株式会社 眼科組成物
US12514749B2 (en) * 2021-07-21 2026-01-06 Meibomian Solutions LLC Eye lubricant

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074224A (zh) * 1991-12-13 1993-07-14 参天制药株式会社 显示牛顿粘性的羧酸乙烯聚合物
WO2009035034A1 (ja) * 2007-09-14 2009-03-19 Rohto Pharmaceutical Co., Ltd. 眼科用組成物
WO2009041549A1 (ja) * 2007-09-28 2009-04-02 Rohto Pharmaceutical Co., Ltd. 眼科用組成物
JP2009132671A (ja) * 2007-11-09 2009-06-18 Rohto Pharmaceut Co Ltd 眼科用組成物

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056684B2 (ja) * 1977-11-07 1985-12-11 東興薬品工業株式会社 点眼剤
JP2707562B2 (ja) 1987-11-17 1998-01-28 富士ゼロックス株式会社 ファクシミリ装置の伝送制御装置
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
US5188826A (en) 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
WO1997028827A1 (fr) 1996-02-07 1997-08-14 Rohto Pharmaceutical Co., Ltd. Composition ophtalmique possedant une viscosite adaptee
DE69736521D1 (de) 1996-09-26 2006-09-28 Rohto Pharma Augentropfen
JP4695315B2 (ja) 1996-09-26 2011-06-08 ロート製薬株式会社 点眼剤
JP3090125B2 (ja) * 1997-08-26 2000-09-18 千寿製薬株式会社 ソフトコンタクトレンズ用の眼科用組成物、ソフトコンタクトレンズの濡れ増強方法およびテルペノイドの吸着抑制方法
JP2002097129A (ja) 2000-07-21 2002-04-02 Rohto Pharmaceut Co Ltd 点眼剤
JP4099624B2 (ja) 2001-04-24 2008-06-11 ライオン株式会社 ソフトコンタクトレンズ用組成物
JP2003055201A (ja) * 2001-08-13 2003-02-26 Lion Corp ビタミンａ類含有可溶化組成物及びビタミンａ類の安定化方法
JP2003183157A (ja) * 2001-12-19 2003-07-03 Lion Corp 眼科用組成物
JP2004123634A (ja) * 2002-10-03 2004-04-22 Lion Corp 眼科用組成物
JP3971329B2 (ja) 2002-10-23 2007-09-05 ロート製薬株式会社 液体用容器のノズル構造
JP4089881B2 (ja) * 2002-10-23 2008-05-28 株式会社青木固研究所 樹脂製の目薬容器
JP2005008596A (ja) 2003-06-20 2005-01-13 Kobayashi Pharmaceut Co Ltd 眼科用組成物
KR101188156B1 (ko) 2003-09-10 2012-10-05 센주 세이야꾸 가부시키가이샤 콘택트렌즈용 안과용 조성물
JP5382973B2 (ja) * 2003-12-26 2014-01-08 ロート製薬株式会社 粘度低下が防止された組成物
US20070197648A1 (en) * 2004-03-30 2007-08-23 Rohto Pharmaceutical Co., Ltd. Pharmaceutical product containing tranilast
JP5649261B2 (ja) * 2004-05-07 2015-01-07 ロート製薬株式会社 高粘度点眼剤
JP5078254B2 (ja) 2004-12-17 2012-11-21 ロート製薬株式会社 眼科用組成物
JP2006219476A (ja) * 2004-12-28 2006-08-24 Rohto Pharmaceut Co Ltd 眼局所適用製剤
JP2006219475A (ja) * 2004-12-28 2006-08-24 Rohto Pharmaceut Co Ltd 眼局所適用製剤
JP5201795B2 (ja) * 2005-01-12 2013-06-05 ロート製薬株式会社 掻痒抑制剤
JP4963359B2 (ja) 2005-01-12 2012-06-27 ロート製薬株式会社 眼局所適用製剤
DE102005035986B4 (de) 2005-07-28 2009-10-15 Bausch & Lomb Incorporated Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat
CN100453086C (zh) 2006-06-22 2009-01-21 武汉远大制药集团有限公司 一种冰珍去翳眼用凝胶制剂及其制备方法
WO2008066644A1 (en) * 2006-11-02 2008-06-05 Riolan Technologies, Inc. Methods of treating epiphora
US9034843B2 (en) 2007-09-14 2015-05-19 Rohto Pharmaceutical Co., Ltd. Ophthalmic composition
US20130244978A1 (en) * 2007-09-14 2013-09-19 Rohto Pharmaceutical Co., Ltd. Ophthalmic composition
JP2009096790A (ja) * 2007-09-28 2009-05-07 Rohto Pharmaceut Co Ltd 疲れ目改善用及び／又はかすみ目改善用コンタクトレンズ装着液
JP2009196903A (ja) * 2008-02-19 2009-09-03 Lion Corp 眼科用組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074224A (zh) * 1991-12-13 1993-07-14 参天制药株式会社 显示牛顿粘性的羧酸乙烯聚合物
WO2009035034A1 (ja) * 2007-09-14 2009-03-19 Rohto Pharmaceutical Co., Ltd. 眼科用組成物
WO2009041549A1 (ja) * 2007-09-28 2009-04-02 Rohto Pharmaceutical Co., Ltd. 眼科用組成物
JP2009132671A (ja) * 2007-11-09 2009-06-18 Rohto Pharmaceut Co Ltd 眼科用組成物

Also Published As

Publication number Publication date
TWI498127B (zh) 2015-09-01
JP2015078248A (ja) 2015-04-23
HK1170685A1 (en) 2013-03-08
TW201119688A (en) 2011-06-16
JP2011093888A (ja) 2011-05-12
WO2011040433A1 (ja) 2011-04-07
JP2011213729A (ja) 2011-10-27
CN102548582A (zh) 2012-07-04
JP4777477B2 (ja) 2011-09-21
EP2484384A1 (en) 2012-08-08
EP2484384A4 (en) 2014-03-05
US20120269760A1 (en) 2012-10-25
US9278062B2 (en) 2016-03-08

Similar Documents

Publication Publication Date Title
CN102548582B (zh) 滴眼剂
JP5659149B2 (ja) ポリマー性人工涙液系
JP7288289B2 (ja) 水性眼科組成物
WO2015029717A1 (ja) 点眼剤
NO316664B1 (no) Sterilt oftalmologisk gelpreparat som kan bli pafort i draper og fremgangsmate for fremstilling av samme
JP2019142979A (ja) 水性液剤
EA030535B1 (ru) Не содержащий консерванта офтальмологический фармацевтический состав
JP2009536940A (ja) 懸濁性ハイドロゲルとその製造方法
JP5736211B2 (ja) 眼科用組成物
CN113577024A (zh) 一种眼用组合物及其制备方法和应用
JP3974431B2 (ja) アルギン酸含有組成物
CN103239390A (zh) 托吡卡胺眼用温度敏感原位凝胶及其制备方法
WO2009099120A1 (ja) 多糖類微粒子状ゲル含有水分散体及びその製造方法
Panchal et al. Development and evaluation ophthalmic in situ gel of betaxolol HCl by temperature dependent method for treatment of glaucoma
CN104288092A (zh) 拉坦前列素滴眼剂
JP2017119693A (ja) 眼科用組成物及びその製造方法
WO2024159979A1 (zh) 一种低浓度的阿托品药物产品及其制造方法
CN105030663B (zh) 一种溶液型醋酸曲安奈德注射液的制备方法
WO2013103830A1 (en) Methods and kits for extending contact lens use
HK1170685B (en) Eye drops
JP7641566B2 (ja) 超微細化水難溶性薬物及び水溶性薬物を含む点眼剤並びにその製造方法及び使用方法
JP2006348055A (ja) アルギン酸含有組成物
JP2010030978A (ja) 多糖類微粒子状ゲル含有水分散体およびその製造方法ならびに多糖類微粒子状ゲル含有保湿剤と多糖類微粒子状ゲル含有眼科用組成物
TW438602B (en) Sterile ophthalmic gel drop preparation and method of its production
HK1167245A (en) Eye drops

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1170685

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1170685

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150902