JP6653123B2 - カラーコンタクトレンズ用眼科組成物 - Google Patents
カラーコンタクトレンズ用眼科組成物 Download PDFInfo
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- JP6653123B2 JP6653123B2 JP2015062634A JP2015062634A JP6653123B2 JP 6653123 B2 JP6653123 B2 JP 6653123B2 JP 2015062634 A JP2015062634 A JP 2015062634A JP 2015062634 A JP2015062634 A JP 2015062634A JP 6653123 B2 JP6653123 B2 JP 6653123B2
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- contact lens
- color contact
- ophthalmic composition
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- 239000000203 mixture Substances 0.000 title claims description 117
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 60
- 150000001875 compounds Chemical class 0.000 claims description 42
- 230000000694 effects Effects 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 36
- 239000005792 Geraniol Substances 0.000 claims description 27
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 27
- 229940113087 geraniol Drugs 0.000 claims description 27
- 229920002554 vinyl polymer Polymers 0.000 claims description 23
- 150000001720 carbohydrates Chemical class 0.000 claims description 22
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 21
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 19
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 19
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 18
- 229920002674 hyaluronan Polymers 0.000 claims description 18
- 229960003160 hyaluronic acid Drugs 0.000 claims description 18
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 18
- 235000010443 alginic acid Nutrition 0.000 claims description 8
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- 150000004781 alginic acids Chemical class 0.000 claims description 8
- 235000000346 sugar Nutrition 0.000 claims description 2
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- -1 polyoxyethylene Polymers 0.000 description 40
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- 150000003505 terpenes Chemical class 0.000 description 19
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 15
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- 239000004094 surface-active agent Substances 0.000 description 9
- 229920002683 Glycosaminoglycan Polymers 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 229940012356 eye drops Drugs 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 238000007654 immersion Methods 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- 239000000341 volatile oil Substances 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
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- 239000008213 purified water Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000723346 Cinnamomum camphora Species 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
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- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 229960001950 benzethonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- 229960000846 camphor Drugs 0.000 description 3
- 229930008380 camphor Natural products 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000007979 citrate buffer Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000007542 hardness measurement Methods 0.000 description 3
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 3
- 229960001983 magnesium aspartate Drugs 0.000 description 3
- 229920001992 poloxamer 407 Polymers 0.000 description 3
- 229920001707 polybutylene terephthalate Polymers 0.000 description 3
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- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229940068988 potassium aspartate Drugs 0.000 description 3
- 210000001747 pupil Anatomy 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 2
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
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- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
- DJDFFEBSKJCGHC-UHFFFAOYSA-N Naphazoline Chemical compound Cl.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 DJDFFEBSKJCGHC-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 125000003282 alkyl amino group Chemical group 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920003174 cellulose-based polymer Polymers 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 229930007050 cineol Natural products 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 229940119743 dextran 70 Drugs 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960001484 edetic acid Drugs 0.000 description 2
- IFQUWYZCAGRUJN-UHFFFAOYSA-N ethylenediaminediacetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
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- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
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- 239000004702 low-density polyethylene Substances 0.000 description 2
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
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- 239000001923 methylcellulose Substances 0.000 description 2
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- 239000000178 monomer Substances 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 229960003330 pentetic acid Drugs 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
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- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
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- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- BJORNXNYWNIWEY-UHFFFAOYSA-N tetrahydrozoline hydrochloride Chemical compound Cl.N1CCN=C1C1C2=CC=CC=C2CCC1 BJORNXNYWNIWEY-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
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- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
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- WYXIGTJNYDDFFH-UHFFFAOYSA-Q triazanium;borate Chemical compound [NH4+].[NH4+].[NH4+].[O-]B([O-])[O-] WYXIGTJNYDDFFH-UHFFFAOYSA-Q 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
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- IYKMDRMCUIFHRA-UHFFFAOYSA-H tripotassium;trisodium;2-hydroxypropane-1,2,3-tricarboxylate;hydrate Chemical compound O.[Na+].[Na+].[Na+].[K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O IYKMDRMCUIFHRA-UHFFFAOYSA-H 0.000 description 1
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Images
Landscapes
- Medicinal Preparation (AREA)
- Eyeglasses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
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Description
[1](A)テルペノイドと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、を含有する、カラーコンタクトレンズ用眼科組成物。
[2](A)成分が、ゲラニオールを含み、(B)成分が、ヒドロキシプロピルメチルセルロース、ヒアルロン酸及びその塩からなる群より選択される少なくとも一種を含む、[1]に記載のカラーコンタクトレンズ用眼科組成物。
[3](B)成分が、ヒドロキシプロピルメチルセルロースを含み、(A)ゲラニオールの含有量1質量部に対して、(B)ヒドロキシプロピルメチルセルロースの含有量が35質量部以下である、[2]に記載のカラーコンタクトレンズ用眼科組成物。
[4](B)成分が、ヒアルロン酸及びその塩からなる群より選択される少なくとも一種を含み、(A)ゲラニオールの含有量1質量部に対して、(B)ヒアルロン酸及びその塩の総含有量が3質量部以下である、[2]に記載のカラーコンタクトレンズ用眼科組成物。
[5](A)テルペノイドと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、をカラーコンタクトレンズ用眼科組成物に含有させることを含む、該カラーコンタクトレンズ用眼科組成物にカラーコンタクトレンズの硬度を低下させる作用を付与する方法。
[6](A)テルペノイドと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、をカラーコンタクトレンズ用眼科組成物に含有させることを含む、該カラーコンタクトレンズ用眼科組成物にカラーコンタクトレンズによる装着感の悪さを低減する作用を付与する方法。
本実施形態に係るカラーコンタクトレンズ用眼科組成物は、(A)テルペノイド(単に「(A)成分」とも表記する。)と、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上(単に「(B)成分」とも表記する。)と、を含有する。
抗アレルギー剤:例えば、クロモグリク酸ナトリウム、トラニラスト、ペミロラストカリウム等。
ステロイド剤:例えば、プロピオン酸フルチカゾン、フランカルボン酸フルチカゾン、フランカルボン酸モメタゾン、プロピオン酸ベクロメタゾン、フルニソリド等。
充血除去剤:塩酸テトラヒドロゾリン、硝酸テトラヒドロゾリン、塩酸ナファゾリン、硝酸ナファゾリン、エピネフリン、塩酸エピネフリン、塩酸エフェドリン、塩酸フェニレフリン、dl−塩酸メチルエフェドリン等。
眼筋調節薬剤:例えば、アセチルコリンと類似した活性中心を有するコリンエステラーゼ阻害剤、具体的にはメチル硫酸ネオスチグミン、トロピカミド、ヘレニエン、硫酸アトロピン等。
殺菌剤:例えば、アクリノール、セチルピリジニウム、塩化ベンザルコニウム、塩化ベンゼトニウム、クロルヘキシジン、ポリヘキサメチレンビグアニド、塩酸アルキルジアミノエチルグリシン等。
ビタミン類:例えば、フラビンアデニンジヌクレオチドナトリウム、シアノコバラミン、塩酸ピリドキシン、パンテノール、パントテン酸カルシウム等。
アミノ酸類:例えば、アスパラギン酸カリウム、アスパラギン酸マグネシウム、アスパラギン酸マグネシウム・カリウム、アミノエチルスルホン酸等。
収斂剤:例えば、亜鉛華、乳酸亜鉛、硫酸亜鉛等。
担体:例えば、水、含水エタノール等の水性担体。
糖アルコール類:例えば、キシリトール、ソルビトール、マンニトール等。これらはD体、L体及びDL体のいずれでもよい。
防腐剤、殺菌剤又は抗菌剤:例えば、塩化亜鉛、塩酸アルキルジアミノエチルグリシン、安息香酸ナトリウム、エタノール、塩化ベンザルコニウム、塩化ベンゼトニウム、グルコン酸クロルヘキシジン、クロロブタノール、ソルビン酸、ソルビン酸カリウム、デヒドロ酢酸ナトリウム、パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル、硫酸オキシキノリン、フェネチルアルコール、ベンジルアルコール、ビグアニド化合物(具体的には、ポリヘキサメチレンビグアニド、塩酸ポリヘキサニド等)、グローキル(ローディア社製 商品名)等。
キレート剤:例えば、エチレンジアミン二酢酸(EDDA)、エチレンジアミン三酢酸、エチレンジアミン四酢酸(エデト酸、EDTA)、N−(2−ヒドロキシエチル)エチレンジアミン三酢酸(HEDTA)、ジエチレントリアミン五酢酸(DTPA)等。
安定化剤:例えば、ジブチルヒドロキシトルエン、トロメタモール、ナトリウムホルムアルデヒドスルホキシレート(ロンガリット)、トコフェロール、ピロ亜硫酸ナトリウム、モノエタノールアミン、モノステアリン酸アルミニウム、モノステアリン酸グリセリン等。
基剤:例えば、オクチルドデカノール、酸化チタン、臭化カリウム、流動パラフィン、プラスチベース、ラノリン、プロピレングリコール等。
その他:リピジュア−PMB(2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体)、リピジュア−HM等。
含水率(%)=(含水した水の重量/含水状態のカラーコンタクトレンズの重量)×100
かかる含水率はISO18369−4:2006の記載に従って、重量測定方法により測定され得る。
本発明に係るカラーコンタクトレンズ用眼科組成物は、カラーコンタクトレンズ特有の硬度を改善する効果を有する。
本発明に係るカラーコンタクトレンズ用眼科組成物は、カラーコンタクトレンズによる装着感の悪さ(装着時の不快感、例えば、ゴロゴロ感)を低減する効果を有する。
表1に示す各種ソフトコンタクトレンズを用いて以下の試験を実施し、ソフトコンタクトレンズの硬度を評価した。なお、本試験に使用したソフトコンタクトレンズは、いずれも市販品である。また、クリアコンタクトレンズは、虹彩又は瞳孔の外観を変えるコンタクトレンズではない一様に透明(有色、無色含む)なコンタクトレンズを指す。
・サイクル試験(サイクル回数1)
・往復幅:2mm
・移動速度:2mm/s
・加速速度:0.1G
・開始位置:126.20mm
ソフトコンタクトレンズ(レンズA、レンズB)をそれぞれ片眼ずつ装着しているモニター3名が、表5に示す0から10の目盛りを付した10cmの直線を用い、VAS法でコンタクトレンズの装着感の悪さ(ゴロゴロ感など)について評価した。具体的には、モニターそれぞれが、コンタクトレンズの装着感の最も悪いと思われる状態を10の目盛り、コンタクトレンズの装着感の悪さを全く感じない状態を0の目盛りとし、各モニターの感じる各レンズの装着感の程度を直線上に記させ、0の目盛りからの長さ(mm)を各モニターの点数とした。3名の装着感評価の平均点を表6に示す。ソフトコンタクトレンズ(レンズC,レンズD)についても同様に試験し、結果を表7に示す。
カラーソフトコンタクトレンズ(レンズA)を両眼に装着しているモニター3名が、表8に示す処方液を1日5回、1回1〜2滴点眼し、以下に示す評価項目に従って、1日装用後のカラーソフトコンタクトレンズの装用感について評価した。結果を表9に示す。レンズCに関しても同様に試験し、結果を表10に示す。
◎:装着感の悪さ(ゴロゴロ感など)を全く感じない
○:装着感の悪さ(ゴロゴロ感など)を殆ど感じない
△:装着感の悪さ(ゴロゴロ感など)を若干感じる
×:装着感の悪さ(ゴロゴロ感など)を明らかに感じる
表11〜13に記載の処方で、カラーコンタクトレンズ用点眼剤、カラーコンタクトレンズ装着液、カラーコンタクトレンズ装着点眼剤、カラーコンタクトレンズ洗浄保存液が調製される。表中の単位は全て(w/v%)である。製剤例1〜19、22〜24、26〜27はポリエチレンテレフタレート製容器に充填され、製剤例20、21はポリプロピレン製容器に充填され、製剤例25はポリエチレン製容器に充填された。
さらに、製剤例1〜12はポリエチレン製ノズルを、製剤例13〜23はポリブチレンテレフタレート製ノズルを容器に装着した。
Claims (6)
- (A)ゲラニオールと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、を含有する、カラーソフトコンタクトレンズ用眼科組成物(但し、アルギン酸又はその塩を含むものを除く。)。
- (A)成分が、ゲラニオールを含み、
(B)成分が、ヒドロキシプロピルメチルセルロース、ヒアルロン酸及びその塩からなる群より選択される少なくとも一種を含む、請求項1に記載のカラーソフトコンタクトレンズ用眼科組成物。 - (B)成分が、ヒドロキシプロピルメチルセルロースを含み、
(A)ゲラニオールの含有量1質量部に対して、(B)ヒドロキシプロピルメチルセルロースの含有量が35質量部以下である、請求項2に記載のカラーソフトコンタクトレンズ用眼科組成物。 - (B)成分が、ヒアルロン酸及びその塩からなる群より選択される少なくとも一種を含み、
(A)ゲラニオールの含有量1質量部に対して、(B)ヒアルロン酸及びその塩の総含有量が3質量部以下である、請求項2に記載のカラーソフトコンタクトレンズ用眼科組成物。 - (A)ゲラニオールと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、をカラーソフトコンタクトレンズ用眼科組成物(但し、アルギン酸又はその塩を含むものを除く。)に含有させることを含む、該カラーソフトコンタクトレンズ用眼科組成物にカラーソフトコンタクトレンズの硬度を低下させる作用を付与する方法。
- (A)ゲラニオールと、(B)ビニル系高分子化合物及び糖類からなる群より選択される1種以上と、をカラーソフトコンタクトレンズ用眼科組成物(但し、アルギン酸又はその塩を含むものを除く。)に含有させることを含む、該カラーソフトコンタクトレンズ用眼科組成物にカラーソフトコンタクトレンズによる装着感の悪さを低減する作用を付与する方法。
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