CN102525603A - 止血植入体 - Google Patents
止血植入体 Download PDFInfo
- Publication number
- CN102525603A CN102525603A CN2011103482290A CN201110348229A CN102525603A CN 102525603 A CN102525603 A CN 102525603A CN 2011103482290 A CN2011103482290 A CN 2011103482290A CN 201110348229 A CN201110348229 A CN 201110348229A CN 102525603 A CN102525603 A CN 102525603A
- Authority
- CN
- China
- Prior art keywords
- porous substrate
- hydrogel precursor
- implant
- substrate
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Polymers & Plastics (AREA)
Abstract
本公开涉及包括多孔基底的含有胶原的植入体，所述多孔基底具有向其应用的第一水凝胶前体和第二水凝胶前体，应用的方式为使得直到所述植入体被置于植入位置并暴露于患者的生理体液时，所述第一水凝胶前体和第二水凝胶前体才彼此反应。
Description
相关申请
本申请为2009年10月5日提交的序列号为12/573,176的共同待决美国专利申请的部分继续申请，第12/573,176号申请要求了2008年10月17日提交的第61/196,534号美国临时申请的权利和优先权。
技术领域
本公开涉及植入体，更具体地讲，涉及包括多孔基底的含有胶原的植入体，所述多孔基底具有向其应用的第一水凝胶前体和第二水凝胶前体。
背景技术
软骨缺陷的原位治疗主要集中在通过在软骨缺陷内将前体溶液转变为固体植入体来产生组织支架或者将预先形成的组织支架机械地固定到软骨缺陷处。已经通过多种方法实现了前体溶液的转变，包括沉淀、聚合、交联和去溶剂化。然而，当使用溶液用于软骨缺陷的原位治疗时存在明显的局限性。在转变和固化发生以前，低粘度的溶液会流走并从应用部位被清除掉。此外，溶液的配方是复杂的，因为前体溶液的制备通常需要前体的重组，或者，当所述溶液是冷冻储藏时，需要融化。三维支架的机械固定通常需要使用伴随进一步组织损伤的缝合线、平头钉或其他机械连接方法来将植入体连接到与软骨缺陷相邻的组织上。
因此，需要提供这样的软骨原位治疗，其包括与通过在含水生理体液存在下而被活化的干燥材料组合的可植入器件。可植入器件与干燥材料的组合保证原位止血治疗在植入的部位发生。
发明内容
本公开提供了植入体和使用该植入体的方法。在实施方式中，本公开提供了一种植入体，其包括：多孔基底，其具有含有胶原的被应用到所述多孔基底的第一水凝胶前体；和膜，其含有被应用到所述多孔基底的第二水凝胶前体。所述多孔基底可为泡沫(foam)、针织物、无纺织物，及其组合等。所述多孔基底可由生物可吸收材料和/或非生物可吸收材料制成。
在其他实施方式中，本公开的植入体可包括：多孔基底，其具有含有胶原的被应用到所述多孔基底的第一部分的第一水凝胶前体；和第二水凝胶前体，其被应用到所述多孔基底的第二部分，其中，所述基底的第一部分与所述多孔基底的第二部分在空间上是分离的。
在实施方式中，本公开的方法包括：识别软骨中的缺陷；定位多孔基底，所述多孔基底具有含有胶原的被应用到所述多孔基底的第一部分的第一水凝胶前体和被应用到所述多孔基底的第二部分的第二水凝胶前体，在所述缺陷内所述第二部分比所述第一部分更接近患者的组织；使定位的植入体与患者的组织接触，其中，生理体液湿润所述第二部分并通过所述多孔基底被芯吸以使所述第一水凝胶前体与所述第二水凝胶前体反应，从而形成水凝胶。
附图说明
并入本说明书并构成本说明书一部分的附图图示了本公开的实施方式，其与上面给出的公开内容概述以及下面给出的实施方式的详细描述一起用于解释本公开的原理。
图1A-D示意性地显示在本公开的至少一个实施方式中描述的第一和第二水凝胶前体在多孔基底上的应用；
图2示意性地显示在图1A-1C中显示的实施方式的变化；
图3示意性地显示在图1A-1C中显示的实施方式的另一变化；
图4A-C示意性地显示在本公开的至少一个实施方式中描述的第一水凝胶前体在多孔基底上的应用；
图5A-C示意性地显示如在本公开的至少一个实施方式中描述的包含第二水凝胶前体的颗粒在多孔基底上的应用，其中，所述多孔基底已具有向其应用的第一水凝胶前体；
图6A-C示意性地显示如在本公开的至少一个实施方式中描述的包含第二水凝胶前体的膜在多孔基底上的应用，其中，所述多孔基底已具有向其应用的第一水凝胶前体；
图7A-B示意性地显示同时形成含有第一水凝胶前体的泡沫和泡沫多孔基底；
图8A-C示意性地显示如在本公开的至少一个实施方式中描述的包含第二水凝胶前体的颗粒在多孔基底上的应用，其中，所述多孔基底已具有向其应用的第一水凝胶前体；
图9A-C示意性地显示如在本公开的至少一个实施方式中描述的包含第二水凝胶前体的膜在多孔基底上的应用，其中，所述多孔基底已具有向其应用的第一水凝胶前体；
图10示意性地显示如在本公开的至少一个实施方式中描述的针织纤维多孔基底和膜，所述针织纤维多孔基底具有包含被应用到该基底第一部分的第一水凝胶前体的颗粒，所述膜包含被应用到所述基底的第二部分的第二水凝胶前体；
图11示意性地显示如在本公开的至少一个实施方式中描述的针织纤维多孔基底和膜，所述针织纤维多孔基底具有包含被应用到该基底第一部分的第一水凝胶前体的涂层，所述膜包含被应用到所述基底的第二部分的第二水凝胶前体；和
图12示意性地显示如在本公开的至少一个实施方式中描述的无纺纤维多孔基底和膜，所述无纺纤维多孔基底具有包含被应用到该基底第一部分的第一水凝胶前体的颗粒，所述膜包含被应用到所述基底第二部分的第二水凝胶前体。
具体实施方式
根据本公开的含有胶原的植入体包括多孔基底，其具有被应用到所述多孔基底的第一部分的第一水凝胶前体和被应用到所述多孔基底的第二部分的第二水凝胶前体。在使用过程中，所述植入体按照向其应用了第一水凝胶前体的部分更接近组织而具有向其应用的第二水凝胶前体的部分更远离组织来定位。在实施方式中，通过加入对比染料、表面纹理、着色剂或其他视觉记号，所述第一和第二部分可彼此区分。一旦与组织(例如，受伤的组织)接触，所述植入体会吸收生理体液并且所述第一水凝胶会被所述体液溶解。当所述体液被芯吸并沿所述植入体移动时，它会携带溶解的第一水凝胶前体穿过所述植入体。最终地，所述体液会充分地穿过植入体并到达向其应用了第二水凝胶前体的所述第二部分，从而溶解第二水凝胶前体。然后所述第一和第二水凝胶前体会反应形成生物相容的交联材料，从而在所述支架降解时协助组织向内生长并重建。在一些实施方式中，通过所述第一和第二水凝胶前体的反应制备的所述生物相容的交联材料还使所述植入体具有防粘连性能。
所述植入体的多孔基底在其表面的至少一部分上具有开口或孔。所述孔可在植入之前或之后在基底内形成。如在下面更详细描述的，用于形成所述多孔基底的合适材料包括，但不限于纤维结构(例如，针织结构、编织结构、无纺结构等)和/或泡沫(例如，开孔或闭孔泡沫)。在一些实施方式中，所述孔的数量和尺寸足以使其在所述多孔基底的整个厚度上互相连接。编织物、针织物和开孔泡沫为其中所述孔的数量和尺寸足以使其在所述多孔基底的整个厚度上互相连接的结构的示例。在另一些实施方式中，所述孔不在所述多孔基底的整个厚度上互相连接。闭孔泡沫或熔合的无纺材料为其中所述孔不在所述多孔基底的整个厚度上互相连接的结构的示例。所述泡沫多孔基底的孔可跨越多孔基底的整个厚度。在其他实施方式中，所述孔不在所述多孔基底的整个厚度上延伸，而是存在于其厚度的一部分上。在一些实施方式中，所述开口或孔位于所述多孔基底的部分表面上，而该多孔基底的其他部分具有无孔结构。在其他实施方式中，所述孔可在原位植入以后形成。所述原位形成孔可使用任何合适的方法来完成。一些非限制性的例子包括使用接触式光蚀刻、活性自由基感光聚合物(LRPP)系统和盐浸法。阅读本公开的本领域的技术人员会预想到用于所述多孔基底的其他的孔分布模式和构造。
当所述多孔基底为纤维时，所述纤维可以为：适合于针织或编织的细丝或线，或者可以为人造短纤维(staple fiber)，例如，那些通常用于制备无纺材料的纤维。所述纤维可由任何生物相容的材料制备。因此，所述纤维可由天然材料或合成材料形成。形成所述纤维的材料可为生物可吸收的或非生物可吸收的。当然应该理解可以使用天然的、合成的、生物可吸收的或非生物可吸收的材料的任意组合来形成所述纤维。可以制备所述纤维的材料的一些非限制性实例包括，但不限于聚(乳酸)、聚(乙醇酸)、聚(丙交酯)、聚(乙交酯)、聚(三亚甲基碳酸酯)、聚(二噁烷酮)、聚(羟基丁酸酯)、聚(膦嗪)、聚酯、聚对苯二甲酸乙二醇酯、超高分子量聚乙烯、聚乙二醇、聚环氧乙烷、聚丙烯酰胺、聚甲基丙烯酸羟乙酯、聚乙烯基吡咯烷酮、聚乙烯醇、聚丙烯酸、聚乙酸酯、聚己酸内酯、聚丙烯、脂族聚酯、甘油、聚(氨基酸)、(醚-酯)共聚物、聚亚烷基草酸酯(polyalkylene oxalate)、多糖、聚酰胺、聚(亚氨基碳酸酯)、聚草酸酯(polyoxaester)、聚原酸酯、聚膦腈、生物聚合物、聚合物药物和共聚物、嵌段聚合物、均聚物，及其混合物和组合。
当所述多孔基底为纤维时，可以使用适于形成纤维结构的任何方法来形成所述多孔基底，所述方法包括但不限于针织、编织、无纺技术、湿纺、电纺、挤出和共挤等。用于制备纤维结构的合适的技术是本领域的技术人员所熟知的。在实施方式中，所述织物具有三维结构，例如，在美国专利7,021,086和6,443,964中所描述的织物，其全部公开内容通过此处的引入并入本申请。在实施方式中，所述多孔基底是由氧化纤维素的纤维制备的。这种材料是已知的并且包括商标名为
的市售氧化纤维素止血材料。制备氧化纤维素止血材料的方法对本领域技术人员是已知的并且已有公开，例如在美国专利3,364,200、4,626,253、5,484,913和6,500,777中。其全部公开内容通过此处的引入并入本申请。
当所述多孔基底为泡沫时，可以使用适于形成泡沫或海绵的任何方法来形成所述多孔基底，所述方法包括但不限于成分的低压冻干法或冷冻干燥。所述泡沫可为交联或非交联的，并且可包括共价键或离子键。用于制备泡沫的合适的技术是本领域技术人员所熟知的。
所述多孔基底可为至少0.1cm厚，在实施方式中为约0.2cm至约1.5cm厚。在所述多孔基底中所述孔的尺寸可为约2μm至约300μm，在实施方式中为约50μm至约150μm。可以预想到所述基底的孔可以在基底内以任何方式布置。例如，所述孔可以以随机的或均匀的方式配置。在一些实施方式中，可以使用藻酸铜来形成孔从而产生蜂窝状的多孔基底。在其他实施方式中，可以配置所述孔以在所述多孔基底中产生倾斜度。所述倾斜度可以进一步提高所述多孔基底吸收生理体液的能力并引导携带第一水凝胶前体的生理体液向第二水凝胶前体的移动。
在实施方式中，所述植入体是由未变性的胶原或者通过加热或任何其他方法至少部分地失去其螺旋结构的胶原制备的，其主要由不水解的α链组成，分子量接近100kDa。术语“未变性的胶原”是指还没有失去其螺旋结构的胶原。用于本公开的植入体的胶原可为天然胶原或去端肽胶原(atelocollagen)，特别是通过胃蛋白酶消化和/或如先前定义的适度加热以后得到的胶原。所述胶原可已先通过氧化、甲基化、乙基化、琥珀酰化或任何其他已知的方法进行了化学修饰。所述胶原还可以用任何合适的交联剂交联，例如，京尼平(genipin)、异氰酸酯和醛。胶原的来源和类型可以与上文指出的用于非植入体的相同。
在其他实施方式中，胶原，包括在此描述的任何胶原，可以用作所述前体中的一种。如在下面更详细的描述，在胶原前体中亲核性的氨基可以是游离的以与第二前体中的亲电基团反应，从而形成本公开的水凝胶。
在实施方式中，所述植入体可以通过在2-50克/升(g/l)的浓度和4-25℃的起始温度下冷冻干燥胶原的水溶性酸溶液来获得。溶液中胶原的浓度可为约1g/l至约30g/l，在实施方式中为约10g/l。将所述溶液中和到pH值为约6-8是有利的。
所述植入体还可以通过冷冻干燥流体泡沫来获得，所述流体泡沫由在各可变数量的空气体积存在下进行乳化(空气∶水的体积比为从约1到约10变化)的胶原或加热胶原的溶液来制备。
所述多孔基底具有向其应用的第一水凝胶前体和向其应用的第二水凝胶前体。术语“第一水凝胶前体”和“第二水凝胶前体”各自表示能够参与反应以形成交联分子网络(例如，水凝胶)的聚合物、官能聚合物、高分子、小分子或者交联剂。
第一和第二水凝胶前体各自是多官能的，即其包含两个以上的亲电或亲核官能团，例如，使得第一水凝胶前体上的亲核官能团可与第二水凝胶前体上的亲电官能团反应以形成共价键。第一或第二水凝胶前体中的至少一种包含多于两个的官能团，这样，作为亲电-亲核反应的结果，所述前体结合形成交联的聚合产物。这种反应被称作“交联反应”。
在实施方式中，只要在交联反应中一起使用亲核和亲电前体，第一和第二水凝胶前体各自仅包含一种官能团，或者仅是亲核官能团或者仅是亲电官能团。因此，例如，如果所述第一水凝胶前体具有亲核官能团例如胺，所述第二水凝胶前体可具有亲电官能团例如N-羟基琥珀酰亚胺。另一方面，如果所述第一水凝胶前体具有亲电官能团例如磺基琥珀酰亚胺，那么所述第二水凝胶前体可具有亲核官能团例如胺或硫醇。因此，可以使用官能聚合物例如蛋白质、聚(烯丙胺)、苯乙烯磺酸或者胺端基的双官能或多官能聚(乙二醇)(“PEG”)。
所述第一和第二水凝胶前体可具有生物学惰性和水溶性的核。当所述核为水溶性的聚合区域时，可以使用的优选聚合物包括：聚醚，例如，如聚乙二醇(“PEG”)、聚环氧乙烷(“PEO”)、聚环氧乙烷-聚环氧丙烷共聚物(“PPO”)、聚环氧乙烷嵌段或无规共聚物和聚乙烯醇(“PVA”)的聚环氧烷；聚(乙烯基吡咯烷酮)(“PVP”)；聚(氨基酸)；多糖，例如，葡聚糖、壳聚糖、藻酸盐、羧甲基纤维素、氧化纤维素、羟乙基纤维素、羟甲基纤维素、透明质酸；以及蛋白质，例如，白蛋白、胶原、酪蛋白和明胶。所述聚醚，更具体地，聚(氧化烯烃)或聚(乙二醇)或聚乙二醇是特别有益的。当所述核本质上是小分子时，可以使用任何种类的亲水官能度来使第一和第二水凝胶前体为水溶性。例如，可以使用如水溶性的羟基、胺、磺酸酯和羧酸酯的官能团来使所述前体为水溶性。此外，辛二酸(subaric acid)的N-羟基琥珀酰亚胺(“NHS”)酯是不溶于水的，但通过将磺酸酯基加入到琥珀酰亚胺环上，可以使得辛二酸的NHS酯是水溶的，不影响其对氨基的反应性。
在实施方式中，所述第一和第二水凝胶前体都可以为能够交联的大分子。例如，在实施方式中，所述前体中的一种可为具有约2,000至约20,000道尔顿的分子量的多官能PEG。这种在实施方式中具有亲电基团的多官能PEG可与具有约100,000道尔顿的分子量的胶原反应。在其他实施方式中，可以使用具有约50,000至约100,000道尔顿的分子量的明胶代替胶原。使用这些大分子前体，得到的水凝胶可被用作适用于包括软骨修复应用的组织支架。
如果希望由所述第一和第二水凝胶前体的反应得到的生物相容的交联聚合物是生物可降解的或可吸收的，所述第一和第二水凝胶前体的一种或多种可具有存在于所述官能团之间的生物可降解的连接。所述生物可降解的连接非必需地还可以用作一种或多种所述前体的水溶性核。任选地，或另外，可选择所述第一和第二水凝胶前体的官能团使得它们之间的反应产物产生生物可降解的连接。对于每种方法，可以选择生物可降解的连接使得产生的生物可降解的、生物相容的交联聚合物在期望的时间段内发生降解、溶解或者被吸收。优选地，选择生物可降解的连接使其在生理条件下降解成无毒的产物。
所述生物可降解的连接可为螯合物、或者为可化学或酶促水解的、或者为可吸收的。示例性的可化学水解的、生物可降解的连接包括乙交酯、dl-丙交酯、l-丙交酯、己内酯、二噁烷酮和三亚甲基碳酸酯的聚合物、共聚物和寡聚物。示例性的可酶促水解的、生物可降解的连接包括可通过金属蛋白酶和胶原酶断裂的肽连接。其他示例性的生物可降解的连接包括多羟基酸、聚(原碳酸酯)、聚(酸酐)、聚(内酯)、聚(氨基酸)、聚(碳酸酯)、多糖和聚(磷酸酯)的聚合物和共聚物。
在实施方式中，所述生物可降解的连接可包含酯连接。一些非限制性的实例包括琥珀酸、戊二酸、丙酸、己二酸或氨基酸的酯，以及羧甲基酯。
在实施方式中，多官能亲电聚合物例如用多个NHS基团官能化的多臂PEG可以用作第一水凝胶前体，而多官能亲核组分例如三赖氨酸可以用作第二水凝胶前体。在其他实施方式中，多官能亲电聚合物例如用多个NHS基团官能化的多臂PEG可以用作第一水凝胶前体，而多官能亲核组分例如胶原和/或胶原衍生物可以用作第二水凝胶前体。所述用多个NHS基团官能化的多臂PEG可具有例如四臂、六臂或八臂并且具有约5,000至约25,000的分子量。合适的第一和第二前体的许多其他的实例记载在美国专利6,152,943、6,165,201、6,179,862、6,514,534、6,566,406、6,605,294、6,673,093、6,703,047、6,818,018、7,009,034和7,347,850中，其全部内容通过此处的引用并入本申请。
所述第一水凝胶前体被应用到所述多孔基底的第一部分且第二水凝胶前体被应用到所述多孔基底的第二部分。例如，所述前体可以以干燥形式(例如，颗粒物质)或者以固体或半固体状态(例如，膜或泡沫)被应用。在实施方式中，所述第一和第二水凝胶前体中的至少一种作为膜被应用到多孔基底上。在实施方式中，具有向其应用第一水凝胶前体的所述基底的第一部分与具有向其应用第二水凝胶前体的所述多孔基底的第二部分在空间上是分离的。使所述第一和第二水凝胶前体在空间上彼此分离以防止它们在所述植入体被放置在植入位置并暴露于患者的生理体液之前彼此反应。
可以使用本领域的技术人员已知的任何合适的方法将所述第一水凝胶前体应用到所述多孔基底上，所述方法包括但不限于喷涂法、刷涂法、浸涂法、倾注法和层压法等。在实施方式中，所述第一水凝胶前体可以作为涂层以能够形成止血植入体的任何浓度、尺寸和构造被应用到所述基底上。在实施方式中，所述第一水凝胶前体的涂层可渗透所述多孔基底的孔。所述涂层可形成无孔的层或有孔的层。在实施方式中，所述第一水凝胶前体作为被层压在所述基底的至少一侧上的膜被应用到所述多孔基底上。
可以使用本领域的技术人员已知的任何合适的方法同样地将所述第二水凝胶前体应用到所述多孔基底上，所述方法包括但不限于喷涂法、刷涂法、浸涂法、倾注法和层压法等。在实施方式中，所述第二水凝胶前体可在形成所述多孔基底之前被引入所述多孔基底。在其他实施方式中，在所述基底形成之后，可以将所述第二水凝胶前体置于所述多孔基底的孔中或置于所述多孔基底的表面上。在其他实施方式中，可以在应用所述第二水凝胶前体之前压延所述多孔基底，从而使第二水凝胶前体渗透进入通过压延方法在所述基底上形成的开口中。在其他实施方式中，所述第二水凝胶前体可以以溶液的形式被应用到所述多孔基底，然后蒸发或低压冻干溶剂。在实施方式中，所述第二水凝胶前体作为在所述基底的至少一侧上的涂层或作为层压在所述基底的至少一侧上的膜被应用到所述多孔基底上。
在第一水凝胶前体或者第二水凝胶前体形成无孔层，即膜的实施方式中，在所述植入体封闭伤口以前，所述膜的厚度可以是足以仅使部分的水凝胶前体与另一水凝胶前体反应。在这种实施方式中，剩余未反应的水凝胶膜可在伤口和周围组织之间起到屏障层的作用来防止粘连的形成。在形成水凝胶植入体时，所述前体还可以向生理体液赋予某些性能，例如抗粘连性能。所述生理体液水凝胶还可以在伤口和周围组织之间起到屏障层的作用来防止粘连的形成。在实施方式中，所述多孔基底可以进一步包含已知的用来减少或防止粘连的非反应性材料，例如透明质酸等。在这种实施方式中，在所述第一和第二水凝胶前体相互作用以后，所述非反应性材料可防止粘连的形成。
在其他实施方式中，本公开的植入体可以被用作三维的生物可降解的支架。在所述支架降解时，所述三维的支架可以促进组织向内生长和重建。在实施方式中，所述支架是自粘性的。因此，在不需要胶合剂、缝合线、吻合钉、平头钉(tack)或其他的第二粘合方法的情况下，所述植入体可以被应用到组织并被固定在合适的位置上。本公开的组织支架可用于修复各种缺陷，包括软骨缺陷；神经修复(脑、脊髓等)；器官缺陷例如心脏(心肌梗塞)、肾和肝；肌肉、脂肪(隆胸、纤体、面部植入体等)、肌腱/韧带修复；骨等。
例如，在实施方式中，可以与在膝部发现的人类软骨大致相同的厚度来构建纤维素支架，即，厚度大约为3mm。所述纤维素可用胶原和碱式盐浸渍。合适的碱式盐包括以下的金属盐：硼酸盐，包括硼酸钠和硼酸钾；碳酸盐，包括碳酸钠和碳酸钾；磷酸盐，包括一代或二代磷酸钠和磷酸钾；碳酸氢盐，包括碳酸氢钠和碳酸氢钾；和上述金属盐的组合等。在实施方式中，可以将所述胶原溶解在碱性缓冲液中，例如，pH值为约8.75的硼酸盐缓冲液。然后可以将所述纤维素浸泡在所述缓冲液中并立即冷冻干燥。然后可以将以上描述的多臂的亲电PEG作为层应用到所述纤维素支架上并干燥以形成本公开的植入体。在其他实施方式中，可以将所述PEG层干涂到所述纤维素的一侧上。
对于在软骨修复中的用途，可以将本公开得到的植入体切割以使其与软骨缺陷相称。使用本领域技术人员所熟知的装置和方法，可以对所述缺陷清创以及可以在缺陷位置进行微骨折术和/或微型打孔操作。可以将本公开的植入体以PEG侧朝下放置在缺陷处。一旦被插入到缺陷处，在缺陷处的血液和体液会湿润PEG、胶原和盐。所述第一水凝胶前体会被所述体液溶解。当所述体液被芯吸并移动通过植入体时，所述体液会携带溶解的第一水凝胶前体通过所述植入体并与所述胶原和盐接触。所述盐会提高pH值，引起亲电PEG和胶原之间的反应，导致纤维素中凝胶的形成以及所述植入体与下面的软骨下骨和相邻软骨的粘合。
除了提供止血和/或用于治疗缺陷(例如，软骨缺陷)，所述植入体可进一步用于生物活性剂的传输。因此，在一些实施方式中，可以将至少一种生物活性剂与第一水凝胶前体或者第二水凝胶前体结合和/或单独地被应用到所述多孔基底上。所述生物活性剂可以游离地与所述前体混合或者可以通过任何种类的化学键连接到所述前体上。在这些实施方式中，本公开的植入体还可以用作传输生物活性剂的载体。在此使用的术语“生物活性剂”，按其最广的含义使用并且包括具有临床用途的任何物质或这些物质的混合物。因此，生物活性剂本身可以具有或不具有药理活性，例如，染料或香料。可选地，生物活性剂可以是具有治疗或预防效果的任何药剂；影响或参与组织生长、细胞生长、细胞分化的化合物；抗粘连化合物；能够引起生物活动(例如，免疫响应)或者在一个或多个生物过程中能够起到任何其他作用的化合物。可以预想到所述生物活性剂可以以任何合适的物质形式，例如，膜、粉末、液体和凝胶等，被应用到本植入体中。
根据本公开可以使用的多种生物活性剂的例子包括：抗粘连剂、抗菌剂、镇痛剂、退热剂、麻醉剂、抗癫痫剂、抗组胺剂、抗炎药、心血管药、诊断剂、拟交感神经药、拟胆碱能药、抗毒蕈碱剂、抗痉挛剂、激素、生长因子、肌肉松弛剂、肾上腺素能神经元阻断剂、抗肿瘤药、免疫原性制剂、免疫抑制剂、肠胃药、利尿剂、类固醇、类脂、脂多糖、多糖、血小板活化药物、凝血因子和酶。也可以使用这些生物活性剂的组合。
抗粘连剂可用于防止在可植入医疗器件与同靶组织相对的周围组织之间形成粘连。此外，抗粘连剂可用于防止在经涂覆的可植入医疗器件与包装材料之间形成粘连。这些制剂的一些例子包括，但不限于，亲水聚合物，例如，聚(乙烯基吡咯烷酮)、羧甲基纤维素、透明质酸、聚环氧乙烷、聚乙烯醇，及其组合。
作为生物活性剂可以被包含在本公开的生物活性涂层中的合适的抗微生物剂包括：三氯生，亦称2，4，4′-三氯-2’-羟基二苯醚；洗必太及其盐，包括醋酸洗必泰、洗必太葡糖酸盐、洗必太盐酸盐和洗必太硫酸盐；银及其盐，包括乙酸银、苯甲酸银、碳酸银、柠檬酸银、碘酸银、碘化银、乳酸银、月桂酸银、硝酸银、氧化银、棕榈酸银、蛋白银和磺胺嘧啶银；多粘菌素；四环素；氨基糖甙类，如妥布霉素和庆大霉素；利福平；杆菌肽；新霉素；氯霉素；霉康唑；喹诺酮类，如噁喹酸、诺氟沙星、萘啶酮酸、培氟沙星、依诺沙星和环丙沙星；青霉素类，如苯唑西林和哌拉西林；壬苯醇醚9；夫西地酸；头孢菌素类及其组合。此外，在本公开的生物活性涂层中可以包含作为生物活性剂的抗菌蛋白质和肽，如牛乳铁传递蛋白和乳铁素B。
在根据本公开应用的涂层组合物中可以作为生物活性剂包含的其他生物活性剂包括：局部麻醉剂；非甾体抗生育剂；拟副交感神经药；精神治疗药物；镇静剂；减充血剂；镇静安眠药；类固醇；磺胺类药；拟交感神经药；疫苗；维他命；抗疟药；抗偏头痛药；抗帕金森药如左旋多巴；抗痉挛剂；抗胆碱能药(例如奥昔布宁)；镇咳药；支气管扩张剂；心血管药，例如冠状血管扩张剂和硝化甘油；生物碱；止痛剂；麻醉剂例如可待因、二氢可待因酮、度冷丁、吗啡等等；非麻醉药，例如水杨酸盐、乙酰水杨酸、对乙酰氨基酚、右旋-丙氧芬等等；阿片样受体拮抗剂，例如纳曲酮和纳洛酮；抗癌药；抗惊厥剂；止吐药；抗细胺剂；抗炎药，例如激素制剂、氢化可的松、氢化泼尼松、强的松、非激素试剂、别嘌呤醇、消炎痛、苯基保泰松等等；前列腺素；细胞毒类药物；化疗药物；雌激素；抗菌剂；抗生素；抗真菌剂；抗病毒剂；抗凝血剂；抗惊厥药；抗抑郁剂；抗组胺剂；和免疫制剂。
可以包含在涂层组合物中的合适的生物活性剂的其他例子包括：病毒和细胞；肽、多肽和蛋白质、其类似物、突变蛋白及其活性片段，例如免疫球蛋白、抗体、细胞因子(例如淋巴因子、单核因子、趋化因子)、凝血因子、造血因子、白介素(IL-2、IL-3、IL-4、IL-6)、干扰素(β-IFN、α-IFN和γ-IFN)、促红细胞生成素、核酸酶、肿瘤坏死因子、集落刺激因子(例如GCSF、GM-CSF、MCSF)、胰岛素、抗肿瘤制剂和肿瘤抑制剂、血液蛋白质、血纤维蛋白、凝血酶、纤维蛋白原、人造的凝血酶、人造的血纤维蛋白、人造的纤维蛋白原、促性腺激素(例如FSH、LH、CG等等)、激素和激素类似物(例如生长激素)、疫苗(例如肿瘤、细菌和病毒抗原)；生长激素释放抑制激素；抗原；凝血因子；生长因子(例如神经生长因子、胰岛素类似生长因子)；成骨蛋白，TGF-B，蛋白质抑制剂，蛋白质拮抗剂和蛋白质激动剂；核酸，例如反义分子、DNA、RNA、RNAi；低聚核苷酸；多核苷酸和核糖酶。
在一些实施方式中，包含生物活性剂(在实施方式中为生长因子)的脂质体可与具有至少一种所述前体的溶液结合，以使其被引入到所述多孔基底中。例如，在某些情况下，具有至少一种生长因子的脂质体可与具有亲核前体(例如，胶原)的缓冲溶液混合，并被应用到所述多孔基底(例如，纤维素)上。在使用时，当通过胶原与亲电PEG反应形成水凝胶时，所述脂质体被释放。在实施方式中，这对软骨修复会是有益的，其中，所述脂质体在缺陷位置释放生长因子来刺激软骨的再生。
现在转到图1A-D，其显示了其中第一水凝胶前体被应用到多孔基底的孔中和第二水凝胶前体被应用到该多孔基底的第二部分的程序。在图1A中，多孔基底20为具有多个限定在其中的孔25的泡沫。包含溶解在溶剂中的第一水凝胶前体的溶液35被储存在容器19中。将多孔基底20浸入并完全淹没在溶液35中。如图1B所示，在被移出后，所述植入体被干燥，除去溶液35的溶剂并将包含第一水凝胶前体的颗粒30沉积在基底20的孔25中。
在图1C中，含有第一水凝胶前体的多孔基底20与第二水凝胶前体的熔体45接触。经冷却，所述第二水凝胶前体的熔体45会固化以形成在基底20的至少一部分上的膜40。在应用第二前体的膜40以后，可以将所述植入体修剪为任何所需的尺寸和形状。图1D显示具有以颗粒30的形式被应用到多孔基底20的第一部分22上的第一水凝胶前体和以膜40的形式被应用到多孔基底20的第二部分24上的第二水凝胶前体的植入体10。
除了多孔基底120为具有以颗粒130的形式向其应用的第一水凝胶前体和以膜140的形式向其应用的第二水凝胶前体的网状材料以外，按照与图1A-D的程序显示的相似的方式制备图2的植入体110。可以预想可以使用无纺材料(未示出)作为所述多孔基底来代替图1A-D所示的泡沫或图2所示的网。
除了多孔基底220为具有以涂层230的形式向其应用的第一水凝胶前体和以膜240的形式向其应用的第二水凝胶前体的网状材料以外，按照与图1A-D的程序显示的相似的方式制备图3的植入体210。第一水凝胶前体的涂层230可通过将多孔基底220浸入到第一水凝胶前体的溶液中或者浸入到第一水凝胶前体的熔体中来形成。任选地，在被应用到所述基底以前，第一水凝胶前体可与成膜聚合物结合来提供涂层230。阅读本公开的本领域的技术人员会想到用于将含有第一水凝胶前体的涂层应用到基底上的其他方法和材料。
现在转到图4A-4C，其显示了其中第一水凝胶前体被应用到多孔基底的第一部分的程序。在图4A中，多孔基底320为具有多个限定在其中的孔325的泡沫材料，所述基底至少包括第一部分322和第二部分324。包含溶解在溶剂中的第一水凝胶前体的溶液335被储存在容器319中。多孔基底320以第一部分322朝向溶液335和第二部分324背向溶液335被置于溶液335之上。
在图4B中，通过向溶液335的方向(图4A的箭头表示的方向)移动多孔基底320将多孔基底320的第一部分322部分地浸入溶液335中。只有多孔基底320的第一部分322与溶液335接触以使足量的溶液335被应用到并填充多孔基底320的第一部分322的孔325。如图4C所示，在被移出后，所述植入体被干燥，除去溶液335的溶剂并将包含第一水凝胶前体的颗粒330沉积在第一部分322上。颗粒330包含干燥形式的第一水凝胶前体并且在空间上被限定在第一部分322。
在图5A-5C中，显示了其中包含溶解在溶剂中的第二水凝胶前体的溶液345被应用到多孔基底320的第二部分324的程序，其中，包含第一水凝胶前体的颗粒330被预先引入到基底320的第一部分322上(参见图4A-4C)。多孔基底320以第二部分324朝向溶液345和第一部分322背向溶液345被置于溶液345之上。
如图5B所示，通过向溶液345的方向(图5A的箭头表示的方向)移动多孔基底320将多孔基底320的第二部分324部分地浸入溶液345中。只有多孔基底320的第二部分324与溶液345接触以使足量的溶液345被应用到第二部分324。在被移出后，所述植入体被干燥以将包含第二水凝胶前体的第二颗粒40沉积在第二部分324内。颗粒340包含干燥形式的第二水凝胶前体并且在空间上被限定在第二部分324。图5C显示具有被应用到所述基底的第一部分上的第一水凝胶前体和被应用到多孔基底的第二部分上的第二水凝胶前体的多孔基底320，其中，所述基底的第一部分与多孔基底的第二部分在空间上是分离的。
在可选的实施方式中，可以以不同的方式将第一和第二水凝胶前体应用到所述植入体。例如，在图6A-6C中，显示了包含含有被应用到第一部分422的第一水凝胶前体的颗粒430的多孔基底，而第二部分424朝向含有已被应用到载体429上的第二水凝胶前体的成膜溶液445。
在图6B中，通过向图6A中的箭头所示的方向移动多孔基底420使多孔基底420的第二部分424与成膜溶液445接触和/或部分地浸入成膜溶液445中。只有多孔基底420的第二部分424与成膜溶液445接触以使足量的材料445被应用到第二部分424。使成膜溶液445固化(使用或不使用热量)以在第二部分424的至少一部分上形成膜。图6C显示具有以颗粒的形式被应用到基底的第一部分上的第一水凝胶前体和以膜的形式被应用到多孔基底的第二部分上的第二水凝胶前体的多孔基底420，其中，该基底的第一部分与该多孔基底的第二部分在空间上是分离的。
现在转到图7A-B，其显示了一起形成的多孔基底和包含第一水凝胶前体的多孔层。在图7A中，容器519包含用来形成多孔基底的第一溶液525和包含第一水凝胶前体的第二溶液535，其中，所述两种溶液实质上保持为独立的层。使用本领域技术人员所熟知的任何方法低压冻干所述两种溶液来形成如图7B所示的多孔基底，其包括由低压冻干的第一溶液525制备的第一多孔基底520，所述第一多孔基底520连接到由低压冻干的第二溶液535制备的第二多孔层530上。第二多孔层530包含第一水凝胶前体并通过第一部分522连接到第一多孔基底520上以形成具有两层多孔材料的植入体。
在图8A-8C中，显示了其中含有第二水凝胶前体的溶液545被应用到多孔基底520的第二部分524上，其中多孔基底520已经具有多孔基底530，多孔基底530包含与在第一部分522的孔结合的第一水凝胶前体。多孔基底520以第二部分524朝向溶液545以及第一部分522和第二多孔层530背向溶液545被置于溶液545之上。
如图8B所示，通过向溶液545的方向(图8A中的箭头表示的方向)移动多孔基底520使多孔基底520的第二部分524部分地浸入具有溶解在溶剂中的第一水凝胶前体的溶液545中。只有多孔基底520的第二部分524与溶液545接触以使足量的溶液545被应用到第二部分524。在被移出后，所述植入体被干燥或使其干燥以除去溶剂并将颗粒540沉积在第二部分524。第二颗粒540包含干燥形式的第二水凝胶前体并在空间上被限定在第二部分524上。图8C显示具有以泡沫的形式被应用到基底的第一部分上的第一水凝胶前体和以颗粒的形式被应用到多孔基底的第二部分上的第二水凝胶前体的多孔基底520，其中，所述基底的第一部分与所述多孔基底的第二部分在空间上是分离的。
在可选的实施方式中，如图7B所示的多孔基底可以与包含第二水凝胶前体的成膜材料结合。如图9A-9C所示，多孔基底620包括第一部分622和第二部分624，其中含有第一水凝胶前体的第二多孔层630与在第一部分622的多孔基底620连接。显示第二部分624朝向被应用在载体629上的成膜溶液645。成膜材料645包含第二水凝胶前体和溶剂。
在图9B中，通过向图9A中的箭头表示的方向移动多孔基底620使多孔基底620的第二部分624与成膜溶液645接触和/或部分地浸入成膜溶液645中。只有多孔基底620的第二部分624与成膜溶液645接触以使足量的材料645被应用到第二部分624。使成膜溶液645在第二部分624的至少一部分上形成膜。图9C显示具有以泡沫的形式被应用到基底的第一部分上的第一水凝胶前体和以膜的形式被应用到多孔基底的第二部分上的第二水凝胶前体的多孔基底620，其中，该基底的第一部分与该多孔基底的第二部分在空间上是分离的。
应该理解除了如图4-9所示的泡沫以外，所述多孔基底可以为纤维结构。因此，在实施方式中，并且如在图10-12中所示意性显示的，所述多孔基底可为纤维结构，即，编织结构或无纺结构。对于泡沫多孔基底20，大体上使用上述相同的方法可以将所述第一和第二水凝胶前体应用到纤维多孔基底上。因此，对于上述的泡沫多孔基底，当所述多孔基底为纤维时，例如，可以将所述第一和/或第二水凝胶前体作为从溶液中沉积的颗粒、通过干燥成膜溶液形成的无孔膜或者作为泡沫被应用到所述纤维多孔基底的至少一部分。如图10所示，例如，植入体710包括含有限定在其中的多个孔725以及具有第一部分722和第二部分724的针织的多孔基底720。对于泡沫多孔基底720，大体上以上述相似的方式，例如，在上述图4A-C中，将以干燥的形式包含第一水凝胶前体的颗粒730应用到第一部分722。对于泡沫多孔基底720，大体上以上述相似的方式，例如，在上述图5A-C中，将包含第二水凝胶前体的膜750应用到第二部分724。在植入时，第二部分750被应用到需要止血的组织。一旦与组织接触，在到达颗粒730之前，生理体液会渗透植入体710并沿箭头A表示的方向移动，从而与液化膜750相互作用。可以预想到当所述体液被朝向基底720的第一部分722芯吸时，膜750的溶液会与也被生理体液溶解在与其混合的颗粒730接触。这种混合会活化第一和第二水凝胶前体并且使它们相互作用并交联以形成协助植入体的止血功能的封闭体。在实施方式中，这种新形成的水凝胶/生理体液植入体还会起到粘连屏障的作用。
可以进一步预想由包含第一和/或第二水凝胶前体的熔体而不是由溶液来应用第一和/或第二水凝胶前体。在图11中，例如，植入体810包括具有第一部分822和第二部分824的针织多孔基底820，其中第二部分824还包括含有第二水凝胶前体的膜850。然而，在这个实施方式中，第一水凝胶前体830作为来自于熔体的涂层而不是作为来自于溶液的颗粒被应用到第一部分822。如图所示，熔体830主要涂敷基底820的第一部分822的纤维的至少一部分而使孔825充分地开放以使体液通过基底820的孔移动。应该理解涂层830可以是不连续的，可以留下基底820的部分832未经涂敷。
如上所述，所述多孔基底可以是无纺纤维多孔基底。在图12中，例如，显示了作为具有第一部分922和第二部分924的无纺多孔基底920的植入体910，其中包含被应用到第一部分922的第一水凝胶前体的颗粒930和包含被应用到第二部分924的第二水凝胶前体的膜940。
提供下列实施例来阐明本公开的实施方式。这些实施例仅用于解释说明，而不是用于限制本公开的范围。同样，除非另有说明，份数和百分数为重量份和重量百分数。如本文所使用的，“室温”指的是从大约20℃到大约25℃的温度。
实施例
实施例1
制备三赖氨酸的饱和硼酸盐缓冲溶液。所述溶液每毫升溶液包含20.6毫克三赖氨酸。溶液的pH值为大约9.2。将氧化纤维素片浸入所述溶液中然后固定到架子上干燥。将所述架子置于真空烘箱中。将烘箱抽真空至约50mTorr并在约25℃下保持约三天以将湿度水平降低至小于2wt％。在约50℃下在热盘上将具有约15,000的分子量的8臂N-羟基琥珀酰亚胺官能化的聚乙二醇熔融。将干燥的含有三赖氨酸的氧化纤维素片与熔融的PEG成分接触。冷却后，PEG成分在植入体的一侧形成膜。
将得到的产品修剪成2英寸×2英寸的正方形，干燥并包装在箔容器中。
使用时，打开箔包装并将植入体以PEG膜一侧对着伤口应用到流血的伤口。在数秒内，发生止血。
实施例2
制备胶原的饱和硼酸盐缓冲溶液。所述溶液每毫升溶液包含10-60毫克胶原。溶液的pH值为大约9.2。将氧化纤维素片浸入所述溶液中然后固定到架子上干燥。将所述架子置于真空烘箱中。将烘箱抽真空至约50mTorr并在约25℃下保持三天以将湿度水平降低至小于2wt％。在约50℃下在热盘上将具有约15,000的分子量的8臂N-羟基琥珀酰亚胺官能化的聚乙二醇熔融。将干燥的含有胶原的氧化纤维素片与熔融的PEG成分接触。冷却后，PEG成分在植入体的一侧形成膜。
将得到的产品修剪成2英寸×2英寸的正方形，干燥并包装在箔容器中。
使用时，打开箔包装并将植入体以PEG面朝下应用到软骨缺陷处。一旦插入缺陷处，在缺陷处的血液和体液湿润PEG、胶原和盐。PEG膜被缺陷处的体液溶解。当所述体液被芯吸并沿植入体移动，所述体液将携带溶解的PEG穿过植入体并与胶原和盐接触。所述盐会提高pH值，引起亲电PEG和胶原之间的反应，并会在纤维素中形成凝胶这样植入体会与下面的软骨下骨以及相邻的软骨粘合。
应该理解，可对此处公开的实施方式进行多种修改。例如，可以将多于两种的前体应用到多孔基底上来形成止血植入体。作为另一个实施例，可以将第一和第二前体各自作为膜应用到多孔基底上。因此，本领域技术人员将能够预想到在权利要求书的范围和实质内的其他修改。
Claims (22)
1.一种植入体，其包括：
多孔基底，其具有包含胶原的被应用到所述多孔基底的第一水凝胶前体；和
膜，其含有被应用到所述多孔基底的第二水凝胶前体。
2.根据权利要求1所述的植入体，其中，所述多孔基底为泡沫。
3.根据权利要求1所述的植入体，其中，所述多孔基底为针织物。
4.根据权利要求1所述的植入体，其中，所述多孔基底为无纺织物。
5.根据权利要求1所述的植入体，其中，所述多孔基底由生物可吸收材料制成。
6.根据权利要求1所述的植入体，其中，所述多孔基底由非生物可吸收材料制成。
7.根据权利要求1所述的植入体，其中，所述多孔基底由氧化纤维素制成。
8.根据权利要求1所述的植入体，其中，所述第一水凝胶前体包含颗粒。
9.根据权利要求1所述的植入体，其中，所述第一水凝胶前体进一步包含至少一种碱式盐，所述碱式盐为硼酸盐、碳酸盐、磷酸盐、碳酸氢盐及其组合。
10.根据权利要求1所述的植入体，其进一步包含生物活性剂。
11.一种植入体，其包括：
多孔基底，其具有含有胶原的被应用到所述多孔基底的第一部分的第一水凝胶前体；和
第二水凝胶前体，其被应用到所述多孔基底的第二部分，
其中，所述基底的第一部分与所述多孔基底的第二部分在空间上是分离的。
12.根据权利要求11所述的植入体，其中，所述多孔基底为泡沫。
13.根据权利要求11所述的植入体，其中，所述多孔基底为针织物。
14.根据权利要求11所述的植入体，其中，所述多孔基底为无纺织物。
15.根据权利要求11所述的植入体，其中，所述多孔基底由生物可吸收材料制成。
16.根据权利要求11所述的植入体，其中，所述多孔基底由非生物可吸收材料制成。
17.根据权利要求11所述的植入体，其中，所述多孔基底由氧化纤维素制成。
18.根据权利要求11所述的植入体，其中，所述第一水凝胶前体包含颗粒。
19.根据权利要求11所述的植入体，其中，所述第二水凝胶前体为泡沫。
20.根据权利要求11所述的植入体，其中，所述第二水凝胶前体为膜。
21.根据权利要求11所述的植入体，其进一步包含生物活性剂。
22.根据权利要求11所述的植入体，其中，所述第一水凝胶前体进一步包含至少一种碱式盐，所述碱式盐为硼酸盐、碳酸盐、磷酸盐、碳酸氢盐及其组合。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/938,491 US9889230B2 (en) | 2008-10-17 | 2010-11-03 | Hemostatic implant |
| US12/938,491 | 2010-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102525603A true CN102525603A (zh) | 2012-07-04 |
Family
ID=45001652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103482290A Pending CN102525603A (zh) | 2010-11-03 | 2011-11-03 | 止血植入体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9889230B2 (zh) |
| EP (1) | EP2457600B1 (zh) |
| JP (1) | JP2012096038A (zh) |
| CN (1) | CN102525603A (zh) |
| AU (1) | AU2011244877B2 (zh) |
| CA (1) | CA2755617C (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496566A (zh) * | 2015-12-14 | 2016-04-20 | 清华大学 | 一种医用多层复合防粘连膜及其制备方法 |
| CN112656498A (zh) * | 2020-05-27 | 2021-04-16 | 北京科仪邦恩医疗器械科技有限公司 | 钉棒系统表面处理方法及钉棒系统 |
| CN116133701A (zh) * | 2020-07-21 | 2023-05-16 | 爱惜康股份有限公司 | 具有可移除中间分隔层的密封剂敷料 |
Families Citing this family (477)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070084897A1 (en) | 2003-05-20 | 2007-04-19 | Shelton Frederick E Iv | Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism |
| US9060770B2 (en) | 2003-05-20 | 2015-06-23 | Ethicon Endo-Surgery, Inc. | Robotically-driven surgical instrument with E-beam driver |
| US8215531B2 (en) | 2004-07-28 | 2012-07-10 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having a medical substance dispenser |
| US11896225B2 (en) | 2004-07-28 | 2024-02-13 | Cilag Gmbh International | Staple cartridge comprising a pan |
| US7669746B2 (en) | 2005-08-31 | 2010-03-02 | Ethicon Endo-Surgery, Inc. | Staple cartridges for forming staples having differing formed staple heights |
| US11246590B2 (en) | 2005-08-31 | 2022-02-15 | Cilag Gmbh International | Staple cartridge including staple drivers having different unfired heights |
| US7934630B2 (en) | 2005-08-31 | 2011-05-03 | Ethicon Endo-Surgery, Inc. | Staple cartridges for forming staples having differing formed staple heights |
| US20070194082A1 (en) | 2005-08-31 | 2007-08-23 | Morgan Jerome R | Surgical stapling device with anvil having staple forming pockets of varying depths |
| US11484312B2 (en) | 2005-08-31 | 2022-11-01 | Cilag Gmbh International | Staple cartridge comprising a staple driver arrangement |
| US10159482B2 (en) | 2005-08-31 | 2018-12-25 | Ethicon Llc | Fastener cartridge assembly comprising a fixed anvil and different staple heights |
| US9237891B2 (en) | 2005-08-31 | 2016-01-19 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical stapling devices that produce formed staples having different lengths |
| US20070106317A1 (en) | 2005-11-09 | 2007-05-10 | Shelton Frederick E Iv | Hydraulically and electrically actuated articulation joints for surgical instruments |
| US20110006101A1 (en) | 2009-02-06 | 2011-01-13 | EthiconEndo-Surgery, Inc. | Motor driven surgical fastener device with cutting member lockout arrangements |
| US20110290856A1 (en) | 2006-01-31 | 2011-12-01 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical instrument with force-feedback capabilities |
| US11224427B2 (en) | 2006-01-31 | 2022-01-18 | Cilag Gmbh International | Surgical stapling system including a console and retraction assembly |
| US7753904B2 (en) | 2006-01-31 | 2010-07-13 | Ethicon Endo-Surgery, Inc. | Endoscopic surgical instrument with a handle that can articulate with respect to the shaft |
| US8708213B2 (en) | 2006-01-31 | 2014-04-29 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a feedback system |
| US7845537B2 (en) | 2006-01-31 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Surgical instrument having recording capabilities |
| US9861359B2 (en) | 2006-01-31 | 2018-01-09 | Ethicon Llc | Powered surgical instruments with firing system lockout arrangements |
| US8820603B2 (en) | 2006-01-31 | 2014-09-02 | Ethicon Endo-Surgery, Inc. | Accessing data stored in a memory of a surgical instrument |
| US11793518B2 (en) | 2006-01-31 | 2023-10-24 | Cilag Gmbh International | Powered surgical instruments with firing system lockout arrangements |
| US20120292367A1 (en) | 2006-01-31 | 2012-11-22 | Ethicon Endo-Surgery, Inc. | Robotically-controlled end effector |
| US20110024477A1 (en) | 2009-02-06 | 2011-02-03 | Hall Steven G | Driven Surgical Stapler Improvements |
| US11278279B2 (en) | 2006-01-31 | 2022-03-22 | Cilag Gmbh International | Surgical instrument assembly |
| US8186555B2 (en) | 2006-01-31 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting and fastening instrument with mechanical closure system |
| US20070225562A1 (en) | 2006-03-23 | 2007-09-27 | Ethicon Endo-Surgery, Inc. | Articulating endoscopic accessory channel |
| US8992422B2 (en) | 2006-03-23 | 2015-03-31 | Ethicon Endo-Surgery, Inc. | Robotically-controlled endoscopic accessory channel |
| US8322455B2 (en) | 2006-06-27 | 2012-12-04 | Ethicon Endo-Surgery, Inc. | Manually driven surgical cutting and fastening instrument |
| US10568652B2 (en) | 2006-09-29 | 2020-02-25 | Ethicon Llc | Surgical staples having attached drivers of different heights and stapling instruments for deploying the same |
| US8720766B2 (en) | 2006-09-29 | 2014-05-13 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments and staples |
| US10130359B2 (en) | 2006-09-29 | 2018-11-20 | Ethicon Llc | Method for forming a staple |
| US11980366B2 (en) | 2006-10-03 | 2024-05-14 | Cilag Gmbh International | Surgical instrument |
| US11291441B2 (en) | 2007-01-10 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with wireless communication between control unit and remote sensor |
| US8684253B2 (en) | 2007-01-10 | 2014-04-01 | Ethicon Endo-Surgery, Inc. | Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor |
| US8652120B2 (en) | 2007-01-10 | 2014-02-18 | Ethicon Endo-Surgery, Inc. | Surgical instrument with wireless communication between control unit and sensor transponders |
| US11039836B2 (en) | 2007-01-11 | 2021-06-22 | Cilag Gmbh International | Staple cartridge for use with a surgical stapling instrument |
| US7434717B2 (en) | 2007-01-11 | 2008-10-14 | Ethicon Endo-Surgery, Inc. | Apparatus for closing a curved anvil of a surgical stapling device |
| US7673782B2 (en) | 2007-03-15 | 2010-03-09 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having a releasable buttress material |
| US8893946B2 (en) | 2007-03-28 | 2014-11-25 | Ethicon Endo-Surgery, Inc. | Laparoscopic tissue thickness and clamp load measuring devices |
| US8931682B2 (en) | 2007-06-04 | 2015-01-13 | Ethicon Endo-Surgery, Inc. | Robotically-controlled shaft based rotary drive systems for surgical instruments |
| US11672531B2 (en) | 2007-06-04 | 2023-06-13 | Cilag Gmbh International | Rotary drive systems for surgical instruments |
| US8308040B2 (en) | 2007-06-22 | 2012-11-13 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with an articulatable end effector |
| US7753245B2 (en) | 2007-06-22 | 2010-07-13 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments |
| US11849941B2 (en) | 2007-06-29 | 2023-12-26 | Cilag Gmbh International | Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis |
| US7905381B2 (en) | 2008-09-19 | 2011-03-15 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument with cutting member arrangement |
| US8561870B2 (en) | 2008-02-13 | 2013-10-22 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument |
| US8758391B2 (en) | 2008-02-14 | 2014-06-24 | Ethicon Endo-Surgery, Inc. | Interchangeable tools for surgical instruments |
| US8573465B2 (en) | 2008-02-14 | 2013-11-05 | Ethicon Endo-Surgery, Inc. | Robotically-controlled surgical end effector system with rotary actuated closure systems |
| US11986183B2 (en) | 2008-02-14 | 2024-05-21 | Cilag Gmbh International | Surgical cutting and fastening instrument comprising a plurality of sensors to measure an electrical parameter |
| US7819298B2 (en) | 2008-02-14 | 2010-10-26 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with control features operable with one hand |
| US7866527B2 (en) | 2008-02-14 | 2011-01-11 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with interlockable firing system |
| US8636736B2 (en) | 2008-02-14 | 2014-01-28 | Ethicon Endo-Surgery, Inc. | Motorized surgical cutting and fastening instrument |
| JP5410110B2 (ja) | 2008-02-14 | 2014-02-05 | エシコン・エンド−サージェリィ・インコーポレイテッド | Ｒｆ電極を有する外科用切断・固定器具 |
| US9179912B2 (en) | 2008-02-14 | 2015-11-10 | Ethicon Endo-Surgery, Inc. | Robotically-controlled motorized surgical cutting and fastening instrument |
| US8657174B2 (en) | 2008-02-14 | 2014-02-25 | Ethicon Endo-Surgery, Inc. | Motorized surgical cutting and fastening instrument having handle based power source |
| US11272927B2 (en) | 2008-02-15 | 2022-03-15 | Cilag Gmbh International | Layer arrangements for surgical staple cartridges |
| US9770245B2 (en) | 2008-02-15 | 2017-09-26 | Ethicon Llc | Layer arrangements for surgical staple cartridges |
| PL3476312T3 (pl) | 2008-09-19 | 2024-03-11 | Ethicon Llc | Stapler chirurgiczny z urządzeniem do dopasowania wysokości zszywek |
| US9386983B2 (en) | 2008-09-23 | 2016-07-12 | Ethicon Endo-Surgery, Llc | Robotically-controlled motorized surgical instrument |
| US9005230B2 (en) | 2008-09-23 | 2015-04-14 | Ethicon Endo-Surgery, Inc. | Motorized surgical instrument |
| US11648005B2 (en) | 2008-09-23 | 2023-05-16 | Cilag Gmbh International | Robotically-controlled motorized surgical instrument with an end effector |
| US8210411B2 (en) | 2008-09-23 | 2012-07-03 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting instrument |
| US8608045B2 (en) | 2008-10-10 | 2013-12-17 | Ethicon Endo-Sugery, Inc. | Powered surgical cutting and stapling apparatus with manually retractable firing system |
| US8517239B2 (en) | 2009-02-05 | 2013-08-27 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument comprising a magnetic element driver |
| RU2525225C2 (ru) | 2009-02-06 | 2014-08-10 | Этикон Эндо-Серджери, Инк. | Усовершенствование приводного хирургического сшивающего инструмента |
| US8444036B2 (en) | 2009-02-06 | 2013-05-21 | Ethicon Endo-Surgery, Inc. | Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector |
| US8851354B2 (en) | 2009-12-24 | 2014-10-07 | Ethicon Endo-Surgery, Inc. | Surgical cutting instrument that analyzes tissue thickness |
| US8220688B2 (en) | 2009-12-24 | 2012-07-17 | Ethicon Endo-Surgery, Inc. | Motor-driven surgical cutting instrument with electric actuator directional control assembly |
| US8783543B2 (en) | 2010-07-30 | 2014-07-22 | Ethicon Endo-Surgery, Inc. | Tissue acquisition arrangements and methods for surgical stapling devices |
| US8893949B2 (en) | 2010-09-30 | 2014-11-25 | Ethicon Endo-Surgery, Inc. | Surgical stapler with floating anvil |
| US8978954B2 (en) | 2010-09-30 | 2015-03-17 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising an adjustable distal portion |
| US10405854B2 (en) | 2010-09-30 | 2019-09-10 | Ethicon Llc | Surgical stapling cartridge with layer retention features |
| US9232941B2 (en) | 2010-09-30 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator comprising a reservoir |
| US9314246B2 (en) | 2010-09-30 | 2016-04-19 | Ethicon Endo-Surgery, Llc | Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent |
| CA2812553C (en) | 2010-09-30 | 2019-02-12 | Ethicon Endo-Surgery, Inc. | Fastener system comprising a retention matrix and an alignment matrix |
| US9839420B2 (en) | 2010-09-30 | 2017-12-12 | Ethicon Llc | Tissue thickness compensator comprising at least one medicament |
| US9220501B2 (en) | 2010-09-30 | 2015-12-29 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensators |
| US11298125B2 (en) | 2010-09-30 | 2022-04-12 | Cilag Gmbh International | Tissue stapler having a thickness compensator |
| US9301752B2 (en) | 2010-09-30 | 2016-04-05 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator comprising a plurality of capsules |
| US9364233B2 (en) | 2010-09-30 | 2016-06-14 | Ethicon Endo-Surgery, Llc | Tissue thickness compensators for circular surgical staplers |
| US9629814B2 (en) | 2010-09-30 | 2017-04-25 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator configured to redistribute compressive forces |
| US9332974B2 (en) | 2010-09-30 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Layered tissue thickness compensator |
| US9307989B2 (en) | 2012-03-28 | 2016-04-12 | Ethicon Endo-Surgery, Llc | Tissue stapler having a thickness compensator incorportating a hydrophobic agent |
| US9386988B2 (en) | 2010-09-30 | 2016-07-12 | Ethicon End-Surgery, LLC | Retainer assembly including a tissue thickness compensator |
| US10945731B2 (en) | 2010-09-30 | 2021-03-16 | Ethicon Llc | Tissue thickness compensator comprising controlled release and expansion |
| US11812965B2 (en) | 2010-09-30 | 2023-11-14 | Cilag Gmbh International | Layer of material for a surgical end effector |
| US10123798B2 (en) | 2010-09-30 | 2018-11-13 | Ethicon Llc | Tissue thickness compensator comprising controlled release and expansion |
| US11849952B2 (en) | 2010-09-30 | 2023-12-26 | Cilag Gmbh International | Staple cartridge comprising staples positioned within a compressible portion thereof |
| US9216019B2 (en) | 2011-09-23 | 2015-12-22 | Ethicon Endo-Surgery, Inc. | Surgical stapler with stationary staple drivers |
| US9301753B2 (en) | 2010-09-30 | 2016-04-05 | Ethicon Endo-Surgery, Llc | Expandable tissue thickness compensator |
| US8695866B2 (en) | 2010-10-01 | 2014-04-15 | Ethicon Endo-Surgery, Inc. | Surgical instrument having a power control circuit |
| RU2606493C2 (ru) | 2011-04-29 | 2017-01-10 | Этикон Эндо-Серджери, Инк. | Кассета со скобками, содержащая скобки, расположенные внутри ее сжимаемой части |
| US9072535B2 (en) | 2011-05-27 | 2015-07-07 | Ethicon Endo-Surgery, Inc. | Surgical stapling instruments with rotatable staple deployment arrangements |
| US11207064B2 (en) | 2011-05-27 | 2021-12-28 | Cilag Gmbh International | Automated end effector component reloading system for use with a robotic system |
| TW201311303A (zh) * | 2011-06-21 | 2013-03-16 | Bvw Holding Ag | 植入定位裝置 |
| US9149511B2 (en) | 2011-06-30 | 2015-10-06 | Ethicon, Inc. | Procoagulant peptides and their derivatives and uses therefor |
| US9050084B2 (en) | 2011-09-23 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Staple cartridge including collapsible deck arrangement |
| US20150328062A9 (en) | 2011-11-10 | 2015-11-19 | Covidien Lp | Hydrophilic medical devices |
| US20130123816A1 (en) | 2011-11-10 | 2013-05-16 | Gerald Hodgkinson | Hydrophilic medical devices |
| WO2013074099A1 (en) * | 2011-11-16 | 2013-05-23 | Empire Technology Development Llc | Three-dimensional porous biodegradable cell scaffold |
| US9044230B2 (en) | 2012-02-13 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status |
| JP6224070B2 (ja) | 2012-03-28 | 2017-11-01 | エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ． | 組織厚さコンペンセータを含む保持具アセンブリ |
| CN104321021B (zh) * | 2012-03-28 | 2019-03-22 | 伊西康内外科公司 | 可扩展的组织厚度补偿件 |
| US9198662B2 (en) | 2012-03-28 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator having improved visibility |
| MX358135B (es) | 2012-03-28 | 2018-08-06 | Ethicon Endo Surgery Inc | Compensador de grosor de tejido que comprende una pluralidad de capas. |
| BR112014024098B1 (pt) | 2012-03-28 | 2021-05-25 | Ethicon Endo-Surgery, Inc. | cartucho de grampos |
| US9101358B2 (en) | 2012-06-15 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Articulatable surgical instrument comprising a firing drive |
| US20140001234A1 (en) | 2012-06-28 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Coupling arrangements for attaching surgical end effectors to drive systems therefor |
| US20140005718A1 (en) | 2012-06-28 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Multi-functional powered surgical device with external dissection features |
| US9072536B2 (en) | 2012-06-28 | 2015-07-07 | Ethicon Endo-Surgery, Inc. | Differential locking arrangements for rotary powered surgical instruments |
| US9028494B2 (en) | 2012-06-28 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Interchangeable end effector coupling arrangement |
| BR112014032776B1 (pt) | 2012-06-28 | 2021-09-08 | Ethicon Endo-Surgery, Inc | Sistema de instrumento cirúrgico e kit cirúrgico para uso com um sistema de instrumento cirúrgico |
| US9125662B2 (en) | 2012-06-28 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Multi-axis articulating and rotating surgical tools |
| US9289256B2 (en) | 2012-06-28 | 2016-03-22 | Ethicon Endo-Surgery, Llc | Surgical end effectors having angled tissue-contacting surfaces |
| US20140001231A1 (en) | 2012-06-28 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Firing system lockout arrangements for surgical instruments |
| US9561038B2 (en) | 2012-06-28 | 2017-02-07 | Ethicon Endo-Surgery, Llc | Interchangeable clip applier |
| US9101385B2 (en) | 2012-06-28 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Electrode connections for rotary driven surgical tools |
| CN104487005B (zh) | 2012-06-28 | 2017-09-08 | 伊西康内外科公司 | 空夹仓闭锁件 |
| US9119657B2 (en) | 2012-06-28 | 2015-09-01 | Ethicon Endo-Surgery, Inc. | Rotary actuatable closure arrangement for surgical end effector |
| US9649111B2 (en) | 2012-06-28 | 2017-05-16 | Ethicon Endo-Surgery, Llc | Replaceable clip cartridge for a clip applier |
| US11202631B2 (en) | 2012-06-28 | 2021-12-21 | Cilag Gmbh International | Stapling assembly comprising a firing lockout |
| US9700310B2 (en) | 2013-08-23 | 2017-07-11 | Ethicon Llc | Firing member retraction devices for powered surgical instruments |
| US9386984B2 (en) | 2013-02-08 | 2016-07-12 | Ethicon Endo-Surgery, Llc | Staple cartridge comprising a releasable cover |
| US9468438B2 (en) | 2013-03-01 | 2016-10-18 | Eticon Endo-Surgery, LLC | Sensor straightened end effector during removal through trocar |
| BR112015021082B1 (pt) | 2013-03-01 | 2022-05-10 | Ethicon Endo-Surgery, Inc | Instrumento cirúrgico |
| MX368026B (es) | 2013-03-01 | 2019-09-12 | Ethicon Endo Surgery Inc | Instrumento quirúrgico articulable con vías conductoras para la comunicación de la señal. |
| US9345481B2 (en) | 2013-03-13 | 2016-05-24 | Ethicon Endo-Surgery, Llc | Staple cartridge tissue thickness sensor system |
| US9629629B2 (en) | 2013-03-14 | 2017-04-25 | Ethicon Endo-Surgey, LLC | Control systems for surgical instruments |
| US9351726B2 (en) | 2013-03-14 | 2016-05-31 | Ethicon Endo-Surgery, Llc | Articulation control system for articulatable surgical instruments |
| US9572577B2 (en) | 2013-03-27 | 2017-02-21 | Ethicon Endo-Surgery, Llc | Fastener cartridge comprising a tissue thickness compensator including openings therein |
| US9795384B2 (en) | 2013-03-27 | 2017-10-24 | Ethicon Llc | Fastener cartridge comprising a tissue thickness compensator and a gap setting element |
| US9332984B2 (en) | 2013-03-27 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Fastener cartridge assemblies |
| US9801626B2 (en) | 2013-04-16 | 2017-10-31 | Ethicon Llc | Modular motor driven surgical instruments with alignment features for aligning rotary drive shafts with surgical end effector shafts |
| BR112015026109B1 (pt) | 2013-04-16 | 2022-02-22 | Ethicon Endo-Surgery, Inc | Instrumento cirúrgico |
| US9574644B2 (en) | 2013-05-30 | 2017-02-21 | Ethicon Endo-Surgery, Llc | Power module for use with a surgical instrument |
| JP6416260B2 (ja) | 2013-08-23 | 2018-10-31 | エシコン エルエルシー | 動力付き外科用器具のための発射部材後退装置 |
| US9724092B2 (en) | 2013-12-23 | 2017-08-08 | Ethicon Llc | Modular surgical instruments |
| US9839428B2 (en) | 2013-12-23 | 2017-12-12 | Ethicon Llc | Surgical cutting and stapling instruments with independent jaw control features |
| US20150173756A1 (en) | 2013-12-23 | 2015-06-25 | Ethicon Endo-Surgery, Inc. | Surgical cutting and stapling methods |
| US20150173749A1 (en) | 2013-12-23 | 2015-06-25 | Ethicon Endo-Surgery, Inc. | Surgical staples and staple cartridges |
| US9962161B2 (en) | 2014-02-12 | 2018-05-08 | Ethicon Llc | Deliverable surgical instrument |
| JP6462004B2 (ja) | 2014-02-24 | 2019-01-30 | エシコン エルエルシー | 発射部材ロックアウトを備える締結システム |
| US20140166725A1 (en) | 2014-02-24 | 2014-06-19 | Ethicon Endo-Surgery, Inc. | Staple cartridge including a barbed staple. |
| US9690362B2 (en) | 2014-03-26 | 2017-06-27 | Ethicon Llc | Surgical instrument control circuit having a safety processor |
| BR112016021943B1 (pt) | 2014-03-26 | 2022-06-14 | Ethicon Endo-Surgery, Llc | Instrumento cirúrgico para uso por um operador em um procedimento cirúrgico |
| US10004497B2 (en) | 2014-03-26 | 2018-06-26 | Ethicon Llc | Interface systems for use with surgical instruments |
| US9913642B2 (en) | 2014-03-26 | 2018-03-13 | Ethicon Llc | Surgical instrument comprising a sensor system |
| US10028761B2 (en) | 2014-03-26 | 2018-07-24 | Ethicon Llc | Feedback algorithms for manual bailout systems for surgical instruments |
| BR112016023807B1 (pt) | 2014-04-16 | 2022-07-12 | Ethicon Endo-Surgery, Llc | Conjunto de cartucho de prendedores para uso com um instrumento cirúrgico |
| CN106456176B (zh) | 2014-04-16 | 2019-06-28 | 伊西康内外科有限责任公司 | 包括具有不同构型的延伸部的紧固件仓 |
| US9844369B2 (en) | 2014-04-16 | 2017-12-19 | Ethicon Llc | Surgical end effectors with firing element monitoring arrangements |
| CN106456158B (zh) | 2014-04-16 | 2019-02-05 | 伊西康内外科有限责任公司 | 包括非一致紧固件的紧固件仓 |
| US10426476B2 (en) | 2014-09-26 | 2019-10-01 | Ethicon Llc | Circular fastener cartridges for applying radially expandable fastener lines |
| US20150297222A1 (en) | 2014-04-16 | 2015-10-22 | Ethicon Endo-Surgery, Inc. | Fastener cartridges including extensions having different configurations |
| US10045781B2 (en) | 2014-06-13 | 2018-08-14 | Ethicon Llc | Closure lockout systems for surgical instruments |
| BR112017004361B1 (pt) | 2014-09-05 | 2023-04-11 | Ethicon Llc | Sistema eletrônico para um instrumento cirúrgico |
| US11311294B2 (en) | 2014-09-05 | 2022-04-26 | Cilag Gmbh International | Powered medical device including measurement of closure state of jaws |
| US20160066913A1 (en) | 2014-09-05 | 2016-03-10 | Ethicon Endo-Surgery, Inc. | Local display of tissue parameter stabilization |
| US10105142B2 (en) | 2014-09-18 | 2018-10-23 | Ethicon Llc | Surgical stapler with plurality of cutting elements |
| US11523821B2 (en) | 2014-09-26 | 2022-12-13 | Cilag Gmbh International | Method for creating a flexible staple line |
| MX2017003960A (es) | 2014-09-26 | 2017-12-04 | Ethicon Llc | Refuerzos de grapas quirúrgicas y materiales auxiliares. |
| US10076325B2 (en) | 2014-10-13 | 2018-09-18 | Ethicon Llc | Surgical stapling apparatus comprising a tissue stop |
| US9924944B2 (en) | 2014-10-16 | 2018-03-27 | Ethicon Llc | Staple cartridge comprising an adjunct material |
| US11141153B2 (en) | 2014-10-29 | 2021-10-12 | Cilag Gmbh International | Staple cartridges comprising driver arrangements |
| US10517594B2 (en) | 2014-10-29 | 2019-12-31 | Ethicon Llc | Cartridge assemblies for surgical staplers |
| US9844376B2 (en) | 2014-11-06 | 2017-12-19 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
| US10736636B2 (en) | 2014-12-10 | 2020-08-11 | Ethicon Llc | Articulatable surgical instrument system |
| US10004501B2 (en) | 2014-12-18 | 2018-06-26 | Ethicon Llc | Surgical instruments with improved closure arrangements |
| US9987000B2 (en) | 2014-12-18 | 2018-06-05 | Ethicon Llc | Surgical instrument assembly comprising a flexible articulation system |
| US10188385B2 (en) | 2014-12-18 | 2019-01-29 | Ethicon Llc | Surgical instrument system comprising lockable systems |
| US9844374B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member |
| RU2703684C2 (ru) | 2014-12-18 | 2019-10-21 | ЭТИКОН ЭНДО-СЕРДЖЕРИ, ЭлЭлСи | Хирургический инструмент с упором, который выполнен с возможностью избирательного перемещения относительно кассеты со скобами вокруг дискретной неподвижной оси |
| US10085748B2 (en) | 2014-12-18 | 2018-10-02 | Ethicon Llc | Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors |
| US10117649B2 (en) | 2014-12-18 | 2018-11-06 | Ethicon Llc | Surgical instrument assembly comprising a lockable articulation system |
| US9844375B2 (en) | 2014-12-18 | 2017-12-19 | Ethicon Llc | Drive arrangements for articulatable surgical instruments |
| US11154301B2 (en) | 2015-02-27 | 2021-10-26 | Cilag Gmbh International | Modular stapling assembly |
| US10180463B2 (en) | 2015-02-27 | 2019-01-15 | Ethicon Llc | Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band |
| US10226250B2 (en) | 2015-02-27 | 2019-03-12 | Ethicon Llc | Modular stapling assembly |
| US10182816B2 (en) | 2015-02-27 | 2019-01-22 | Ethicon Llc | Charging system that enables emergency resolutions for charging a battery |
| US10045776B2 (en) | 2015-03-06 | 2018-08-14 | Ethicon Llc | Control techniques and sub-processor contained within modular shaft with select control processing from handle |
| US9895148B2 (en) | 2015-03-06 | 2018-02-20 | Ethicon Endo-Surgery, Llc | Monitoring speed control and precision incrementing of motor for powered surgical instruments |
| US10617412B2 (en) | 2015-03-06 | 2020-04-14 | Ethicon Llc | System for detecting the mis-insertion of a staple cartridge into a surgical stapler |
| US9924961B2 (en) | 2015-03-06 | 2018-03-27 | Ethicon Endo-Surgery, Llc | Interactive feedback system for powered surgical instruments |
| US10245033B2 (en) | 2015-03-06 | 2019-04-02 | Ethicon Llc | Surgical instrument comprising a lockable battery housing |
| US9808246B2 (en) | 2015-03-06 | 2017-11-07 | Ethicon Endo-Surgery, Llc | Method of operating a powered surgical instrument |
| US10687806B2 (en) | 2015-03-06 | 2020-06-23 | Ethicon Llc | Adaptive tissue compression techniques to adjust closure rates for multiple tissue types |
| US10052044B2 (en) | 2015-03-06 | 2018-08-21 | Ethicon Llc | Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures |
| US10441279B2 (en) | 2015-03-06 | 2019-10-15 | Ethicon Llc | Multiple level thresholds to modify operation of powered surgical instruments |
| US9901342B2 (en) | 2015-03-06 | 2018-02-27 | Ethicon Endo-Surgery, Llc | Signal and power communication system positioned on a rotatable shaft |
| JP2020121162A (ja) | 2015-03-06 | 2020-08-13 | エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ | 測定の安定性要素、クリープ要素、及び粘弾性要素を決定するためのセンサデータの時間依存性評価 |
| US9993248B2 (en) | 2015-03-06 | 2018-06-12 | Ethicon Endo-Surgery, Llc | Smart sensors with local signal processing |
| US10550225B2 (en) | 2015-03-10 | 2020-02-04 | The University Of Tokyo | Process for producing low-concentration gel using gel-precursor clusters, and gel obtained by said production process |
| US10390825B2 (en) | 2015-03-31 | 2019-08-27 | Ethicon Llc | Surgical instrument with progressive rotary drive systems |
| US10154841B2 (en) | 2015-06-18 | 2018-12-18 | Ethicon Llc | Surgical stapling instruments with lockout arrangements for preventing firing system actuation when a cartridge is spent or missing |
| US10835249B2 (en) | 2015-08-17 | 2020-11-17 | Ethicon Llc | Implantable layers for a surgical instrument |
| US10390829B2 (en) | 2015-08-26 | 2019-08-27 | Ethicon Llc | Staples comprising a cover |
| MX2022009705A (es) | 2015-08-26 | 2022-11-07 | Ethicon Llc | Metodo para formar una grapa contra un yunque de un instrumento de engrapado quirurgico. |
| BR112018003693B1 (pt) | 2015-08-26 | 2022-11-22 | Ethicon Llc | Cartucho de grampos cirúrgicos para uso com um instrumento de grampeamento cirúrgico |
| MX2022006189A (es) | 2015-09-02 | 2022-06-16 | Ethicon Llc | Configuraciones de grapas quirurgicas con superficies de leva situadas entre porciones que soportan grapas quirurgicas. |
| US10357252B2 (en) | 2015-09-02 | 2019-07-23 | Ethicon Llc | Surgical staple configurations with camming surfaces located between portions supporting surgical staples |
| US10327769B2 (en) | 2015-09-23 | 2019-06-25 | Ethicon Llc | Surgical stapler having motor control based on a drive system component |
| US10105139B2 (en) | 2015-09-23 | 2018-10-23 | Ethicon Llc | Surgical stapler having downstream current-based motor control |
| US10076326B2 (en) | 2015-09-23 | 2018-09-18 | Ethicon Llc | Surgical stapler having current mirror-based motor control |
| US10363036B2 (en) | 2015-09-23 | 2019-07-30 | Ethicon Llc | Surgical stapler having force-based motor control |
| US10085751B2 (en) | 2015-09-23 | 2018-10-02 | Ethicon Llc | Surgical stapler having temperature-based motor control |
| US10238386B2 (en) | 2015-09-23 | 2019-03-26 | Ethicon Llc | Surgical stapler having motor control based on an electrical parameter related to a motor current |
| US10299878B2 (en) | 2015-09-25 | 2019-05-28 | Ethicon Llc | Implantable adjunct systems for determining adjunct skew |
| US10980539B2 (en) | 2015-09-30 | 2021-04-20 | Ethicon Llc | Implantable adjunct comprising bonded layers |
| US10285699B2 (en) | 2015-09-30 | 2019-05-14 | Ethicon Llc | Compressible adjunct |
| US10561420B2 (en) | 2015-09-30 | 2020-02-18 | Ethicon Llc | Tubular absorbable constructs |
| US11890015B2 (en) | 2015-09-30 | 2024-02-06 | Cilag Gmbh International | Compressible adjunct with crossing spacer fibers |
| US10265068B2 (en) | 2015-12-30 | 2019-04-23 | Ethicon Llc | Surgical instruments with separable motors and motor control circuits |
| US10368865B2 (en) | 2015-12-30 | 2019-08-06 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
| US10292704B2 (en) | 2015-12-30 | 2019-05-21 | Ethicon Llc | Mechanisms for compensating for battery pack failure in powered surgical instruments |
| BR112018016098B1 (pt) | 2016-02-09 | 2023-02-23 | Ethicon Llc | Instrumento cirúrgico |
| US10245030B2 (en) | 2016-02-09 | 2019-04-02 | Ethicon Llc | Surgical instruments with tensioning arrangements for cable driven articulation systems |
| US11213293B2 (en) | 2016-02-09 | 2022-01-04 | Cilag Gmbh International | Articulatable surgical instruments with single articulation link arrangements |
| US10448948B2 (en) | 2016-02-12 | 2019-10-22 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
| US11224426B2 (en) | 2016-02-12 | 2022-01-18 | Cilag Gmbh International | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
| US10258331B2 (en) | 2016-02-12 | 2019-04-16 | Ethicon Llc | Mechanisms for compensating for drivetrain failure in powered surgical instruments |
| US10617413B2 (en) | 2016-04-01 | 2020-04-14 | Ethicon Llc | Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts |
| US10485542B2 (en) | 2016-04-01 | 2019-11-26 | Ethicon Llc | Surgical stapling instrument comprising multiple lockouts |
| US10405859B2 (en) | 2016-04-15 | 2019-09-10 | Ethicon Llc | Surgical instrument with adjustable stop/start control during a firing motion |
| US10335145B2 (en) | 2016-04-15 | 2019-07-02 | Ethicon Llc | Modular surgical instrument with configurable operating mode |
| US11179150B2 (en) | 2016-04-15 | 2021-11-23 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
| US10456137B2 (en) | 2016-04-15 | 2019-10-29 | Ethicon Llc | Staple formation detection mechanisms |
| US10357247B2 (en) | 2016-04-15 | 2019-07-23 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
| US10492783B2 (en) | 2016-04-15 | 2019-12-03 | Ethicon, Llc | Surgical instrument with improved stop/start control during a firing motion |
| US10828028B2 (en) | 2016-04-15 | 2020-11-10 | Ethicon Llc | Surgical instrument with multiple program responses during a firing motion |
| US10426467B2 (en) | 2016-04-15 | 2019-10-01 | Ethicon Llc | Surgical instrument with detection sensors |
| US11607239B2 (en) | 2016-04-15 | 2023-03-21 | Cilag Gmbh International | Systems and methods for controlling a surgical stapling and cutting instrument |
| US20170296173A1 (en) | 2016-04-18 | 2017-10-19 | Ethicon Endo-Surgery, Llc | Method for operating a surgical instrument |
| US11317917B2 (en) | 2016-04-18 | 2022-05-03 | Cilag Gmbh International | Surgical stapling system comprising a lockable firing assembly |
| US10426469B2 (en) | 2016-04-18 | 2019-10-01 | Ethicon Llc | Surgical instrument comprising a primary firing lockout and a secondary firing lockout |
| US10702270B2 (en) | 2016-06-24 | 2020-07-07 | Ethicon Llc | Stapling system for use with wire staples and stamped staples |
| JP6957532B2 (ja) | 2016-06-24 | 2021-11-02 | エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ | ワイヤステープル及び打ち抜き加工ステープルを含むステープルカートリッジ |
| USD826405S1 (en) | 2016-06-24 | 2018-08-21 | Ethicon Llc | Surgical fastener |
| USD847989S1 (en) | 2016-06-24 | 2019-05-07 | Ethicon Llc | Surgical fastener cartridge |
| USD850617S1 (en) | 2016-06-24 | 2019-06-04 | Ethicon Llc | Surgical fastener cartridge |
| JP6774495B2 (ja) * | 2016-09-30 | 2020-10-21 | 株式会社ジーシー | 生体吸収性膜の製造方法 |
| JP7010956B2 (ja) | 2016-12-21 | 2022-01-26 | エシコン エルエルシー | 組織をステープル留めする方法 |
| US10426471B2 (en) | 2016-12-21 | 2019-10-01 | Ethicon Llc | Surgical instrument with multiple failure response modes |
| US20180168575A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical stapling systems |
| US10945727B2 (en) | 2016-12-21 | 2021-03-16 | Ethicon Llc | Staple cartridge with deformable driver retention features |
| US20180168608A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical instrument system comprising an end effector lockout and a firing assembly lockout |
| US10973516B2 (en) | 2016-12-21 | 2021-04-13 | Ethicon Llc | Surgical end effectors and adaptable firing members therefor |
| US10675025B2 (en) | 2016-12-21 | 2020-06-09 | Ethicon Llc | Shaft assembly comprising separately actuatable and retractable systems |
| US10588631B2 (en) | 2016-12-21 | 2020-03-17 | Ethicon Llc | Surgical instruments with positive jaw opening features |
| US10537324B2 (en) | 2016-12-21 | 2020-01-21 | Ethicon Llc | Stepped staple cartridge with asymmetrical staples |
| US20180168633A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments and staple-forming anvils |
| JP6983893B2 (ja) | 2016-12-21 | 2021-12-17 | エシコン エルエルシーEthicon LLC | 外科用エンドエフェクタ及び交換式ツールアセンブリのためのロックアウト構成 |
| US10687810B2 (en) | 2016-12-21 | 2020-06-23 | Ethicon Llc | Stepped staple cartridge with tissue retention and gap setting features |
| US11684367B2 (en) | 2016-12-21 | 2023-06-27 | Cilag Gmbh International | Stepped assembly having and end-of-life indicator |
| US20180168615A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument |
| US10980536B2 (en) | 2016-12-21 | 2021-04-20 | Ethicon Llc | No-cartridge and spent cartridge lockout arrangements for surgical staplers |
| US11419606B2 (en) | 2016-12-21 | 2022-08-23 | Cilag Gmbh International | Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems |
| CN110087565A (zh) | 2016-12-21 | 2019-08-02 | 爱惜康有限责任公司 | 外科缝合系统 |
| US10888322B2 (en) | 2016-12-21 | 2021-01-12 | Ethicon Llc | Surgical instrument comprising a cutting member |
| US20180168625A1 (en) | 2016-12-21 | 2018-06-21 | Ethicon Endo-Surgery, Llc | Surgical stapling instruments with smart staple cartridges |
| US10537325B2 (en) | 2016-12-21 | 2020-01-21 | Ethicon Llc | Staple forming pocket arrangement to accommodate different types of staples |
| US11134942B2 (en) | 2016-12-21 | 2021-10-05 | Cilag Gmbh International | Surgical stapling instruments and staple-forming anvils |
| US10682138B2 (en) | 2016-12-21 | 2020-06-16 | Ethicon Llc | Bilaterally asymmetric staple forming pocket pairs |
| US10779823B2 (en) | 2016-12-21 | 2020-09-22 | Ethicon Llc | Firing member pin angle |
| US10993715B2 (en) | 2016-12-21 | 2021-05-04 | Ethicon Llc | Staple cartridge comprising staples with different clamping breadths |
| US10327767B2 (en) | 2017-06-20 | 2019-06-25 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
| US10307170B2 (en) | 2017-06-20 | 2019-06-04 | Ethicon Llc | Method for closed loop control of motor velocity of a surgical stapling and cutting instrument |
| US11071554B2 (en) | 2017-06-20 | 2021-07-27 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements |
| US11653914B2 (en) | 2017-06-20 | 2023-05-23 | Cilag Gmbh International | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector |
| US11090046B2 (en) | 2017-06-20 | 2021-08-17 | Cilag Gmbh International | Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument |
| US10368864B2 (en) | 2017-06-20 | 2019-08-06 | Ethicon Llc | Systems and methods for controlling displaying motor velocity for a surgical instrument |
| US10624633B2 (en) | 2017-06-20 | 2020-04-21 | Ethicon Llc | Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument |
| US10813639B2 (en) | 2017-06-20 | 2020-10-27 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions |
| US10646220B2 (en) | 2017-06-20 | 2020-05-12 | Ethicon Llc | Systems and methods for controlling displacement member velocity for a surgical instrument |
| US11382638B2 (en) | 2017-06-20 | 2022-07-12 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance |
| US10881396B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Surgical instrument with variable duration trigger arrangement |
| US10888321B2 (en) | 2017-06-20 | 2021-01-12 | Ethicon Llc | Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument |
| US10779820B2 (en) | 2017-06-20 | 2020-09-22 | Ethicon Llc | Systems and methods for controlling motor speed according to user input for a surgical instrument |
| US10881399B2 (en) | 2017-06-20 | 2021-01-05 | Ethicon Llc | Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument |
| USD879809S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with changeable graphical user interface |
| US11517325B2 (en) | 2017-06-20 | 2022-12-06 | Cilag Gmbh International | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval |
| US10390841B2 (en) | 2017-06-20 | 2019-08-27 | Ethicon Llc | Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation |
| USD879808S1 (en) | 2017-06-20 | 2020-03-31 | Ethicon Llc | Display panel with graphical user interface |
| US10980537B2 (en) | 2017-06-20 | 2021-04-20 | Ethicon Llc | Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations |
| USD890784S1 (en) | 2017-06-20 | 2020-07-21 | Ethicon Llc | Display panel with changeable graphical user interface |
| US11266405B2 (en) | 2017-06-27 | 2022-03-08 | Cilag Gmbh International | Surgical anvil manufacturing methods |
| US11090049B2 (en) | 2017-06-27 | 2021-08-17 | Cilag Gmbh International | Staple forming pocket arrangements |
| US10993716B2 (en) | 2017-06-27 | 2021-05-04 | Ethicon Llc | Surgical anvil arrangements |
| US10856869B2 (en) | 2017-06-27 | 2020-12-08 | Ethicon Llc | Surgical anvil arrangements |
| US10772629B2 (en) | 2017-06-27 | 2020-09-15 | Ethicon Llc | Surgical anvil arrangements |
| US11324503B2 (en) | 2017-06-27 | 2022-05-10 | Cilag Gmbh International | Surgical firing member arrangements |
| US11259805B2 (en) | 2017-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical instrument comprising firing member supports |
| US11246592B2 (en) | 2017-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical instrument comprising an articulation system lockable to a frame |
| US11484310B2 (en) | 2017-06-28 | 2022-11-01 | Cilag Gmbh International | Surgical instrument comprising a shaft including a closure tube profile |
| USD854151S1 (en) | 2017-06-28 | 2019-07-16 | Ethicon Llc | Surgical instrument shaft |
| USD851762S1 (en) | 2017-06-28 | 2019-06-18 | Ethicon Llc | Anvil |
| US11564686B2 (en) | 2017-06-28 | 2023-01-31 | Cilag Gmbh International | Surgical shaft assemblies with flexible interfaces |
| US10211586B2 (en) | 2017-06-28 | 2019-02-19 | Ethicon Llc | Surgical shaft assemblies with watertight housings |
| US10716614B2 (en) | 2017-06-28 | 2020-07-21 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies with increased contact pressure |
| US10588633B2 (en) | 2017-06-28 | 2020-03-17 | Ethicon Llc | Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing |
| US10903685B2 (en) | 2017-06-28 | 2021-01-26 | Ethicon Llc | Surgical shaft assemblies with slip ring assemblies forming capacitive channels |
| USD906355S1 (en) | 2017-06-28 | 2020-12-29 | Ethicon Llc | Display screen or portion thereof with a graphical user interface for a surgical instrument |
| EP4070740A1 (en) | 2017-06-28 | 2022-10-12 | Cilag GmbH International | Surgical instrument comprising selectively actuatable rotatable couplers |
| USD869655S1 (en) | 2017-06-28 | 2019-12-10 | Ethicon Llc | Surgical fastener cartridge |
| US10765427B2 (en) | 2017-06-28 | 2020-09-08 | Ethicon Llc | Method for articulating a surgical instrument |
| US10932772B2 (en) | 2017-06-29 | 2021-03-02 | Ethicon Llc | Methods for closed loop velocity control for robotic surgical instrument |
| US10898183B2 (en) | 2017-06-29 | 2021-01-26 | Ethicon Llc | Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing |
| US11007022B2 (en) | 2017-06-29 | 2021-05-18 | Ethicon Llc | Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument |
| US10398434B2 (en) | 2017-06-29 | 2019-09-03 | Ethicon Llc | Closed loop velocity control of closure member for robotic surgical instrument |
| US10258418B2 (en) | 2017-06-29 | 2019-04-16 | Ethicon Llc | System for controlling articulation forces |
| US11974742B2 (en) | 2017-08-03 | 2024-05-07 | Cilag Gmbh International | Surgical system comprising an articulation bailout |
| US11471155B2 (en) | 2017-08-03 | 2022-10-18 | Cilag Gmbh International | Surgical system bailout |
| US11304695B2 (en) | 2017-08-03 | 2022-04-19 | Cilag Gmbh International | Surgical system shaft interconnection |
| US11944300B2 (en) | 2017-08-03 | 2024-04-02 | Cilag Gmbh International | Method for operating a surgical system bailout |
| USD907647S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
| US10796471B2 (en) | 2017-09-29 | 2020-10-06 | Ethicon Llc | Systems and methods of displaying a knife position for a surgical instrument |
| USD917500S1 (en) | 2017-09-29 | 2021-04-27 | Ethicon Llc | Display screen or portion thereof with graphical user interface |
| US10743872B2 (en) | 2017-09-29 | 2020-08-18 | Ethicon Llc | System and methods for controlling a display of a surgical instrument |
| USD907648S1 (en) | 2017-09-29 | 2021-01-12 | Ethicon Llc | Display screen or portion thereof with animated graphical user interface |
| US10765429B2 (en) | 2017-09-29 | 2020-09-08 | Ethicon Llc | Systems and methods for providing alerts according to the operational state of a surgical instrument |
| US10729501B2 (en) | 2017-09-29 | 2020-08-04 | Ethicon Llc | Systems and methods for language selection of a surgical instrument |
| US11399829B2 (en) | 2017-09-29 | 2022-08-02 | Cilag Gmbh International | Systems and methods of initiating a power shutdown mode for a surgical instrument |
| US11134944B2 (en) | 2017-10-30 | 2021-10-05 | Cilag Gmbh International | Surgical stapler knife motion controls |
| US11090075B2 (en) | 2017-10-30 | 2021-08-17 | Cilag Gmbh International | Articulation features for surgical end effector |
| US10842490B2 (en) | 2017-10-31 | 2020-11-24 | Ethicon Llc | Cartridge body design with force reduction based on firing completion |
| US10779903B2 (en) | 2017-10-31 | 2020-09-22 | Ethicon Llc | Positive shaft rotation lock activated by jaw closure |
| US10779826B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Methods of operating surgical end effectors |
| US11071543B2 (en) | 2017-12-15 | 2021-07-27 | Cilag Gmbh International | Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges |
| US10743875B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member |
| US10779825B2 (en) | 2017-12-15 | 2020-09-22 | Ethicon Llc | Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments |
| US10687813B2 (en) | 2017-12-15 | 2020-06-23 | Ethicon Llc | Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments |
| US10869666B2 (en) | 2017-12-15 | 2020-12-22 | Ethicon Llc | Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument |
| US10743874B2 (en) | 2017-12-15 | 2020-08-18 | Ethicon Llc | Sealed adapters for use with electromechanical surgical instruments |
| US11006955B2 (en) | 2017-12-15 | 2021-05-18 | Ethicon Llc | End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments |
| US11197670B2 (en) | 2017-12-15 | 2021-12-14 | Cilag Gmbh International | Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed |
| US10966718B2 (en) | 2017-12-15 | 2021-04-06 | Ethicon Llc | Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments |
| US11033267B2 (en) | 2017-12-15 | 2021-06-15 | Ethicon Llc | Systems and methods of controlling a clamping member firing rate of a surgical instrument |
| US10828033B2 (en) | 2017-12-15 | 2020-11-10 | Ethicon Llc | Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto |
| US11020112B2 (en) | 2017-12-19 | 2021-06-01 | Ethicon Llc | Surgical tools configured for interchangeable use with different controller interfaces |
| US10729509B2 (en) | 2017-12-19 | 2020-08-04 | Ethicon Llc | Surgical instrument comprising closure and firing locking mechanism |
| US10835330B2 (en) | 2017-12-19 | 2020-11-17 | Ethicon Llc | Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly |
| US10716565B2 (en) | 2017-12-19 | 2020-07-21 | Ethicon Llc | Surgical instruments with dual articulation drivers |
| USD910847S1 (en) | 2017-12-19 | 2021-02-16 | Ethicon Llc | Surgical instrument assembly |
| US11045270B2 (en) | 2017-12-19 | 2021-06-29 | Cilag Gmbh International | Robotic attachment comprising exterior drive actuator |
| US11129680B2 (en) | 2017-12-21 | 2021-09-28 | Cilag Gmbh International | Surgical instrument comprising a projector |
| US11311290B2 (en) | 2017-12-21 | 2022-04-26 | Cilag Gmbh International | Surgical instrument comprising an end effector dampener |
| US20190192151A1 (en) | 2017-12-21 | 2019-06-27 | Ethicon Llc | Surgical instrument having a display comprising image layers |
| US11076853B2 (en) | 2017-12-21 | 2021-08-03 | Cilag Gmbh International | Systems and methods of displaying a knife position during transection for a surgical instrument |
| US11045192B2 (en) | 2018-08-20 | 2021-06-29 | Cilag Gmbh International | Fabricating techniques for surgical stapler anvils |
| USD914878S1 (en) | 2018-08-20 | 2021-03-30 | Ethicon Llc | Surgical instrument anvil |
| US11324501B2 (en) | 2018-08-20 | 2022-05-10 | Cilag Gmbh International | Surgical stapling devices with improved closure members |
| US10779821B2 (en) | 2018-08-20 | 2020-09-22 | Ethicon Llc | Surgical stapler anvils with tissue stop features configured to avoid tissue pinch |
| US11083458B2 (en) | 2018-08-20 | 2021-08-10 | Cilag Gmbh International | Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions |
| US11291440B2 (en) | 2018-08-20 | 2022-04-05 | Cilag Gmbh International | Method for operating a powered articulatable surgical instrument |
| US11253256B2 (en) | 2018-08-20 | 2022-02-22 | Cilag Gmbh International | Articulatable motor powered surgical instruments with dedicated articulation motor arrangements |
| US10912559B2 (en) | 2018-08-20 | 2021-02-09 | Ethicon Llc | Reinforced deformable anvil tip for surgical stapler anvil |
| US10856870B2 (en) | 2018-08-20 | 2020-12-08 | Ethicon Llc | Switching arrangements for motor powered articulatable surgical instruments |
| US11207065B2 (en) | 2018-08-20 | 2021-12-28 | Cilag Gmbh International | Method for fabricating surgical stapler anvils |
| US11039834B2 (en) | 2018-08-20 | 2021-06-22 | Cilag Gmbh International | Surgical stapler anvils with staple directing protrusions and tissue stability features |
| US10842492B2 (en) | 2018-08-20 | 2020-11-24 | Ethicon Llc | Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system |
| US11147551B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
| US11696761B2 (en) | 2019-03-25 | 2023-07-11 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
| US11147553B2 (en) | 2019-03-25 | 2021-10-19 | Cilag Gmbh International | Firing drive arrangements for surgical systems |
| US11172929B2 (en) | 2019-03-25 | 2021-11-16 | Cilag Gmbh International | Articulation drive arrangements for surgical systems |
| US11253254B2 (en) | 2019-04-30 | 2022-02-22 | Cilag Gmbh International | Shaft rotation actuator on a surgical instrument |
| US11426251B2 (en) | 2019-04-30 | 2022-08-30 | Cilag Gmbh International | Articulation directional lights on a surgical instrument |
| US11432816B2 (en) | 2019-04-30 | 2022-09-06 | Cilag Gmbh International | Articulation pin for a surgical instrument |
| US11903581B2 (en) | 2019-04-30 | 2024-02-20 | Cilag Gmbh International | Methods for stapling tissue using a surgical instrument |
| US11471157B2 (en) | 2019-04-30 | 2022-10-18 | Cilag Gmbh International | Articulation control mapping for a surgical instrument |
| US11452528B2 (en) | 2019-04-30 | 2022-09-27 | Cilag Gmbh International | Articulation actuators for a surgical instrument |
| US11648009B2 (en) | 2019-04-30 | 2023-05-16 | Cilag Gmbh International | Rotatable jaw tip for a surgical instrument |
| US11350938B2 (en) | 2019-06-28 | 2022-06-07 | Cilag Gmbh International | Surgical instrument comprising an aligned rfid sensor |
| US11291451B2 (en) | 2019-06-28 | 2022-04-05 | Cilag Gmbh International | Surgical instrument with battery compatibility verification functionality |
| US11684434B2 (en) | 2019-06-28 | 2023-06-27 | Cilag Gmbh International | Surgical RFID assemblies for instrument operational setting control |
| US11246678B2 (en) | 2019-06-28 | 2022-02-15 | Cilag Gmbh International | Surgical stapling system having a frangible RFID tag |
| US11638587B2 (en) | 2019-06-28 | 2023-05-02 | Cilag Gmbh International | RFID identification systems for surgical instruments |
| US11464601B2 (en) | 2019-06-28 | 2022-10-11 | Cilag Gmbh International | Surgical instrument comprising an RFID system for tracking a movable component |
| US11051807B2 (en) | 2019-06-28 | 2021-07-06 | Cilag Gmbh International | Packaging assembly including a particulate trap |
| US11478241B2 (en) | 2019-06-28 | 2022-10-25 | Cilag Gmbh International | Staple cartridge including projections |
| US11771419B2 (en) | 2019-06-28 | 2023-10-03 | Cilag Gmbh International | Packaging for a replaceable component of a surgical stapling system |
| US11399837B2 (en) | 2019-06-28 | 2022-08-02 | Cilag Gmbh International | Mechanisms for motor control adjustments of a motorized surgical instrument |
| US11553971B2 (en) | 2019-06-28 | 2023-01-17 | Cilag Gmbh International | Surgical RFID assemblies for display and communication |
| US11298132B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Inlernational | Staple cartridge including a honeycomb extension |
| US11627959B2 (en) | 2019-06-28 | 2023-04-18 | Cilag Gmbh International | Surgical instruments including manual and powered system lockouts |
| US11219455B2 (en) | 2019-06-28 | 2022-01-11 | Cilag Gmbh International | Surgical instrument including a lockout key |
| US11497492B2 (en) | 2019-06-28 | 2022-11-15 | Cilag Gmbh International | Surgical instrument including an articulation lock |
| US11376098B2 (en) | 2019-06-28 | 2022-07-05 | Cilag Gmbh International | Surgical instrument system comprising an RFID system |
| US11224497B2 (en) | 2019-06-28 | 2022-01-18 | Cilag Gmbh International | Surgical systems with multiple RFID tags |
| US11660163B2 (en) | 2019-06-28 | 2023-05-30 | Cilag Gmbh International | Surgical system with RFID tags for updating motor assembly parameters |
| US11426167B2 (en) | 2019-06-28 | 2022-08-30 | Cilag Gmbh International | Mechanisms for proper anvil attachment surgical stapling head assembly |
| US11259803B2 (en) | 2019-06-28 | 2022-03-01 | Cilag Gmbh International | Surgical stapling system having an information encryption protocol |
| US11523822B2 (en) | 2019-06-28 | 2022-12-13 | Cilag Gmbh International | Battery pack including a circuit interrupter |
| US11298127B2 (en) | 2019-06-28 | 2022-04-12 | Cilag GmbH Interational | Surgical stapling system having a lockout mechanism for an incompatible cartridge |
| US11576672B2 (en) | 2019-12-19 | 2023-02-14 | Cilag Gmbh International | Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw |
| US11529137B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
| US11911032B2 (en) | 2019-12-19 | 2024-02-27 | Cilag Gmbh International | Staple cartridge comprising a seating cam |
| US11607219B2 (en) | 2019-12-19 | 2023-03-21 | Cilag Gmbh International | Staple cartridge comprising a detachable tissue cutting knife |
| US11701111B2 (en) | 2019-12-19 | 2023-07-18 | Cilag Gmbh International | Method for operating a surgical stapling instrument |
| US11234698B2 (en) | 2019-12-19 | 2022-02-01 | Cilag Gmbh International | Stapling system comprising a clamp lockout and a firing lockout |
| US11529139B2 (en) | 2019-12-19 | 2022-12-20 | Cilag Gmbh International | Motor driven surgical instrument |
| US11844520B2 (en) | 2019-12-19 | 2023-12-19 | Cilag Gmbh International | Staple cartridge comprising driver retention members |
| US11504122B2 (en) | 2019-12-19 | 2022-11-22 | Cilag Gmbh International | Surgical instrument comprising a nested firing member |
| US11446029B2 (en) | 2019-12-19 | 2022-09-20 | Cilag Gmbh International | Staple cartridge comprising projections extending from a curved deck surface |
| US11464512B2 (en) | 2019-12-19 | 2022-10-11 | Cilag Gmbh International | Staple cartridge comprising a curved deck surface |
| US11304696B2 (en) | 2019-12-19 | 2022-04-19 | Cilag Gmbh International | Surgical instrument comprising a powered articulation system |
| US11559304B2 (en) | 2019-12-19 | 2023-01-24 | Cilag Gmbh International | Surgical instrument comprising a rapid closure mechanism |
| US11291447B2 (en) | 2019-12-19 | 2022-04-05 | Cilag Gmbh International | Stapling instrument comprising independent jaw closing and staple firing systems |
| US11931033B2 (en) | 2019-12-19 | 2024-03-19 | Cilag Gmbh International | Staple cartridge comprising a latch lockout |
| US20210213157A1 (en) | 2020-01-09 | 2021-07-15 | Ethicon, Inc. | Flexible Gelatin Sealant Dressing with Reactive Components |
| US20210252185A1 (en) | 2020-02-18 | 2021-08-19 | Ethicon, Inc. | Melt Blown Dressing with Gradient Density |
| USD974560S1 (en) | 2020-06-02 | 2023-01-03 | Cilag Gmbh International | Staple cartridge |
| USD966512S1 (en) | 2020-06-02 | 2022-10-11 | Cilag Gmbh International | Staple cartridge |
| USD967421S1 (en) | 2020-06-02 | 2022-10-18 | Cilag Gmbh International | Staple cartridge |
| USD976401S1 (en) | 2020-06-02 | 2023-01-24 | Cilag Gmbh International | Staple cartridge |
| USD975850S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
| USD975278S1 (en) | 2020-06-02 | 2023-01-10 | Cilag Gmbh International | Staple cartridge |
| USD975851S1 (en) | 2020-06-02 | 2023-01-17 | Cilag Gmbh International | Staple cartridge |
| US20210379237A1 (en) | 2020-06-08 | 2021-12-09 | Ethicon, Inc. | Napped Coated Wound Dressing |
| US20220031346A1 (en) | 2020-07-28 | 2022-02-03 | Cilag Gmbh International | Articulatable surgical instruments with articulation joints comprising flexible exoskeleton arrangements |
| WO2022046801A1 (en) * | 2020-08-25 | 2022-03-03 | Canary Medical Switzerland Ag | Occlusion device with sensing functionality |
| US20220062492A1 (en) * | 2020-08-31 | 2022-03-03 | Ethicon, Inc. | Sealant Dressing with Protected Reactive Components |
| US11779330B2 (en) | 2020-10-29 | 2023-10-10 | Cilag Gmbh International | Surgical instrument comprising a jaw alignment system |
| US11534259B2 (en) | 2020-10-29 | 2022-12-27 | Cilag Gmbh International | Surgical instrument comprising an articulation indicator |
| USD980425S1 (en) | 2020-10-29 | 2023-03-07 | Cilag Gmbh International | Surgical instrument assembly |
| USD1013170S1 (en) | 2020-10-29 | 2024-01-30 | Cilag Gmbh International | Surgical instrument assembly |
| US11452526B2 (en) | 2020-10-29 | 2022-09-27 | Cilag Gmbh International | Surgical instrument comprising a staged voltage regulation start-up system |
| US11844518B2 (en) | 2020-10-29 | 2023-12-19 | Cilag Gmbh International | Method for operating a surgical instrument |
| US11717289B2 (en) | 2020-10-29 | 2023-08-08 | Cilag Gmbh International | Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable |
| US11517390B2 (en) | 2020-10-29 | 2022-12-06 | Cilag Gmbh International | Surgical instrument comprising a limited travel switch |
| US11931025B2 (en) | 2020-10-29 | 2024-03-19 | Cilag Gmbh International | Surgical instrument comprising a releasable closure drive lock |
| US11617577B2 (en) | 2020-10-29 | 2023-04-04 | Cilag Gmbh International | Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable |
| US11896217B2 (en) | 2020-10-29 | 2024-02-13 | Cilag Gmbh International | Surgical instrument comprising an articulation lock |
| US11737751B2 (en) | 2020-12-02 | 2023-08-29 | Cilag Gmbh International | Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings |
| US11627960B2 (en) | 2020-12-02 | 2023-04-18 | Cilag Gmbh International | Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections |
| US11944296B2 (en) | 2020-12-02 | 2024-04-02 | Cilag Gmbh International | Powered surgical instruments with external connectors |
| US11744581B2 (en) | 2020-12-02 | 2023-09-05 | Cilag Gmbh International | Powered surgical instruments with multi-phase tissue treatment |
| US11653920B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Powered surgical instruments with communication interfaces through sterile barrier |
| US11890010B2 (en) | 2020-12-02 | 2024-02-06 | Cllag GmbH International | Dual-sided reinforced reload for surgical instruments |
| US11678882B2 (en) | 2020-12-02 | 2023-06-20 | Cilag Gmbh International | Surgical instruments with interactive features to remedy incidental sled movements |
| US11849943B2 (en) | 2020-12-02 | 2023-12-26 | Cilag Gmbh International | Surgical instrument with cartridge release mechanisms |
| US11653915B2 (en) | 2020-12-02 | 2023-05-23 | Cilag Gmbh International | Surgical instruments with sled location detection and adjustment features |
| US11749877B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Stapling instrument comprising a signal antenna |
| US11701113B2 (en) | 2021-02-26 | 2023-07-18 | Cilag Gmbh International | Stapling instrument comprising a separate power antenna and a data transfer antenna |
| US11793514B2 (en) | 2021-02-26 | 2023-10-24 | Cilag Gmbh International | Staple cartridge comprising sensor array which may be embedded in cartridge body |
| US11925349B2 (en) | 2021-02-26 | 2024-03-12 | Cilag Gmbh International | Adjustment to transfer parameters to improve available power |
| US11812964B2 (en) | 2021-02-26 | 2023-11-14 | Cilag Gmbh International | Staple cartridge comprising a power management circuit |
| US11744583B2 (en) | 2021-02-26 | 2023-09-05 | Cilag Gmbh International | Distal communication array to tune frequency of RF systems |
| US11751869B2 (en) | 2021-02-26 | 2023-09-12 | Cilag Gmbh International | Monitoring of multiple sensors over time to detect moving characteristics of tissue |
| US11950777B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Staple cartridge comprising an information access control system |
| US11696757B2 (en) | 2021-02-26 | 2023-07-11 | Cilag Gmbh International | Monitoring of internal systems to detect and track cartridge motion status |
| US11730473B2 (en) | 2021-02-26 | 2023-08-22 | Cilag Gmbh International | Monitoring of manufacturing life-cycle |
| US11723657B2 (en) | 2021-02-26 | 2023-08-15 | Cilag Gmbh International | Adjustable communication based on available bandwidth and power capacity |
| US11950779B2 (en) | 2021-02-26 | 2024-04-09 | Cilag Gmbh International | Method of powering and communicating with a staple cartridge |
| US11980362B2 (en) | 2021-02-26 | 2024-05-14 | Cilag Gmbh International | Surgical instrument system comprising a power transfer coil |
| US11826042B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Surgical instrument comprising a firing drive including a selectable leverage mechanism |
| US11717291B2 (en) | 2021-03-22 | 2023-08-08 | Cilag Gmbh International | Staple cartridge comprising staples configured to apply different tissue compression |
| US11759202B2 (en) | 2021-03-22 | 2023-09-19 | Cilag Gmbh International | Staple cartridge comprising an implantable layer |
| US11723658B2 (en) | 2021-03-22 | 2023-08-15 | Cilag Gmbh International | Staple cartridge comprising a firing lockout |
| US11737749B2 (en) | 2021-03-22 | 2023-08-29 | Cilag Gmbh International | Surgical stapling instrument comprising a retraction system |
| US11806011B2 (en) | 2021-03-22 | 2023-11-07 | Cilag Gmbh International | Stapling instrument comprising tissue compression systems |
| US11826012B2 (en) | 2021-03-22 | 2023-11-28 | Cilag Gmbh International | Stapling instrument comprising a pulsed motor-driven firing rack |
| US11903582B2 (en) | 2021-03-24 | 2024-02-20 | Cilag Gmbh International | Leveraging surfaces for cartridge installation |
| US11896218B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Method of using a powered stapling device |
| US11744603B2 (en) | 2021-03-24 | 2023-09-05 | Cilag Gmbh International | Multi-axis pivot joints for surgical instruments and methods for manufacturing same |
| US11793516B2 (en) | 2021-03-24 | 2023-10-24 | Cilag Gmbh International | Surgical staple cartridge comprising longitudinal support beam |
| US11849945B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Rotary-driven surgical stapling assembly comprising eccentrically driven firing member |
| US11786243B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Firing members having flexible portions for adapting to a load during a surgical firing stroke |
| US11857183B2 (en) | 2021-03-24 | 2024-01-02 | Cilag Gmbh International | Stapling assembly components having metal substrates and plastic bodies |
| US11786239B2 (en) | 2021-03-24 | 2023-10-17 | Cilag Gmbh International | Surgical instrument articulation joint arrangements comprising multiple moving linkage features |
| US11849944B2 (en) | 2021-03-24 | 2023-12-26 | Cilag Gmbh International | Drivers for fastener cartridge assemblies having rotary drive screws |
| US11896219B2 (en) | 2021-03-24 | 2024-02-13 | Cilag Gmbh International | Mating features between drivers and underside of a cartridge deck |
| US11832816B2 (en) | 2021-03-24 | 2023-12-05 | Cilag Gmbh International | Surgical stapling assembly comprising nonplanar staples and planar staples |
| US11944336B2 (en) | 2021-03-24 | 2024-04-02 | Cilag Gmbh International | Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments |
| US11918217B2 (en) | 2021-05-28 | 2024-03-05 | Cilag Gmbh International | Stapling instrument comprising a staple cartridge insertion stop |
| US11957337B2 (en) | 2021-10-18 | 2024-04-16 | Cilag Gmbh International | Surgical stapling assembly with offset ramped drive surfaces |
| US11877745B2 (en) | 2021-10-18 | 2024-01-23 | Cilag Gmbh International | Surgical stapling assembly having longitudinally-repeating staple leg clusters |
| US11980363B2 (en) | 2021-10-18 | 2024-05-14 | Cilag Gmbh International | Row-to-row staple array variations |
| US11937816B2 (en) | 2021-10-28 | 2024-03-26 | Cilag Gmbh International | Electrical lead arrangements for surgical instruments |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020116063A1 (en) * | 1999-08-02 | 2002-08-22 | Bruno Giannetti | Kit for chondrocyte cell transplantation |
| CN1377257A (zh) * | 1999-10-05 | 2002-10-30 | 核转移治疗公司 | 杂合基质和杂合基质混合物 |
| US20030077260A1 (en) * | 1995-10-25 | 2003-04-24 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
| CN101721233A (zh) * | 2008-10-17 | 2010-06-09 | 综合性外科公司 | 止血植入体 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3364200A (en) * | 1960-03-28 | 1968-01-16 | Johnson & Johnson | Oxidized cellulose product and method for preparing the same |
| US3666750A (en) * | 1969-12-15 | 1972-05-30 | Johnson & Johnson | Hemostatic material |
| US3937223A (en) * | 1974-04-19 | 1976-02-10 | American Cyanamid Company | Compacted surgical hemostatic felt |
| US4663163A (en) * | 1983-02-14 | 1987-05-05 | Hou Kenneth C | Modified polysaccharide supports |
| US4511478A (en) * | 1983-11-10 | 1985-04-16 | Genetic Systems Corporation | Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides |
| US4626253A (en) * | 1984-10-05 | 1986-12-02 | Johnson & Johnson Products, Inc. | Surgical hemostat comprising oxidized cellulose |
| US5160745A (en) * | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| IL82834A (en) * | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
| US5201745A (en) | 1988-03-15 | 1993-04-13 | Imedex | Visceral surgery patch |
| US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| IL90193A (en) * | 1989-05-04 | 1993-02-21 | Biomedical Polymers Int | Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5626863A (en) * | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| BR9306038A (pt) | 1992-02-28 | 1998-01-13 | Univ Texas | Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada |
| US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| CA2175203A1 (en) * | 1993-11-03 | 1995-05-11 | Thaddeus P. Pruss | Hemostatic patch |
| CZ288792B6 (cs) * | 1993-12-23 | 2001-09-12 | Johnson & Johnson Medical, Inc. | Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby |
| US5505952A (en) * | 1994-04-19 | 1996-04-09 | United States Surgical Corporation | Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom |
| US5580923A (en) * | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
| US5527864A (en) * | 1995-08-08 | 1996-06-18 | Suggs; Laura J. | Poly(propylene fumarate-co-ethylene oxide) |
| DK2111876T3 (da) * | 1995-12-18 | 2011-12-12 | Angiodevice Internat Gmbh | Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf |
| US6833408B2 (en) * | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
| US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| US6500777B1 (en) * | 1996-06-28 | 2002-12-31 | Ethicon, Inc. | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| US20090324721A1 (en) | 1996-09-23 | 2009-12-31 | Jack Kennedy | Hydrogels Suitable For Use In Polyp Removal |
| US6566406B1 (en) * | 1998-12-04 | 2003-05-20 | Incept, Llc | Biocompatible crosslinked polymers |
| US7009034B2 (en) * | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
| EP1009291B8 (en) * | 1997-03-20 | 2006-01-11 | Genzyme Corporation | Biodegradable tissue retractor |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| FR2766698B1 (fr) | 1997-08-01 | 1999-11-05 | Cogent Sarl | Tissu prothetique tridimensionnel ajoure |
| ZA987019B (en) * | 1997-08-06 | 1999-06-04 | Focal Inc | Hemostatic tissue sealants |
| US6410044B1 (en) | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
| US7335220B2 (en) * | 2004-11-05 | 2008-02-26 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
| US7347850B2 (en) * | 1998-08-14 | 2008-03-25 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
| US6152943A (en) * | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| US6179862B1 (en) * | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| WO2000009199A1 (en) * | 1998-08-14 | 2000-02-24 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| US6514534B1 (en) * | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6703047B2 (en) * | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| US6605294B2 (en) * | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| US20080114092A1 (en) * | 1998-12-04 | 2008-05-15 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
| US6376742B1 (en) * | 1999-02-17 | 2002-04-23 | Richard J. Zdrahala | In vivo tissue engineering with biodegradable polymers |
| US20030035786A1 (en) * | 1999-11-04 | 2003-02-20 | Medtronic, Inc. | Biological tissue adhesives, articles, and methods |
| US7052713B2 (en) * | 2001-02-13 | 2006-05-30 | Nycomed Pharma As | Carrier with solid fibrinogen and solid thrombin |
| WO2003020191A1 (en) * | 2001-09-04 | 2003-03-13 | University Of Iowa Research Foundation | Cellulose membranes for biodegradable scaffolds |
| FR2830434B1 (fr) | 2001-10-05 | 2004-01-02 | Sofradim Production | Renfort de paroi en tricot tridimensionnel et ajoure |
| US20040106344A1 (en) | 2002-06-28 | 2004-06-03 | Looney Dwayne Lee | Hemostatic wound dressings containing proteinaceous polymers |
| US20040101546A1 (en) * | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
| US7252837B2 (en) * | 2002-06-28 | 2007-08-07 | Ethicon, Inc. | Hemostatic wound dressing and method of making same |
| US20040265371A1 (en) * | 2003-06-25 | 2004-12-30 | Looney Dwayne Lee | Hemostatic devices and methods of making same |
| US20050208095A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
| US7157428B2 (en) | 2003-11-26 | 2007-01-02 | Histogenics, Corp. | Method for treatment and repair of meniscal injuries |
| JP4840136B2 (ja) * | 2004-03-31 | 2011-12-21 | ニプロ株式会社 | 癒着防止用キット、癒着防止用キットの製造方法および癒着防止方法 |
| AU2005258231A1 (en) * | 2004-06-23 | 2006-01-05 | Angiotech Pharmaceuticals (Us), Inc. | Methods and crosslinked polymer compositions for cartilage repair |
| FR2873700B1 (fr) * | 2004-07-29 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Procede d'oxydation controlee de polysaccharides |
| US20070014862A1 (en) * | 2004-10-12 | 2007-01-18 | Cornelis Pameijer | Device for treating wound gaps |
| WO2007095005A1 (en) * | 2006-02-10 | 2007-08-23 | Z-Medica Corporation | Agents and devices for providing blood clotting functions to wounds |
| US7968114B2 (en) * | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
| US20080027365A1 (en) * | 2006-06-01 | 2008-01-31 | Huey Raymond J | Hemostatic device with oxidized cellulose pad |
| US7935363B2 (en) * | 2006-12-12 | 2011-05-03 | Synthasome, Inc. | Composite material for tissue repair |
| US9289196B2 (en) * | 2006-12-12 | 2016-03-22 | Cook Medical Technologies Llc | Hemostatic substance with a coating |
| US20090227689A1 (en) | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| US20090227981A1 (en) | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| US20090054984A1 (en) * | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| US8207264B2 (en) | 2008-07-11 | 2012-06-26 | Tyco Healthcare Group Lp | Functionalized inclusion complexes as crosslinkers |
| WO2010043980A2 (en) | 2008-10-17 | 2010-04-22 | Sofradim Production | Surgical patch |
| US8349354B2 (en) * | 2009-09-22 | 2013-01-08 | Ethicon, Inc. | Composite layered hemostasis device |
| US8470355B2 (en) * | 2009-10-01 | 2013-06-25 | Covidien Lp | Mesh implant |
-
2010
- 2010-11-03 US US12/938,491 patent/US9889230B2/en active Active
-
2011
- 2011-10-20 CA CA2755617A patent/CA2755617C/en active Active
- 2011-10-28 AU AU2011244877A patent/AU2011244877B2/en active Active
- 2011-11-02 JP JP2011241476A patent/JP2012096038A/ja active Pending
- 2011-11-02 EP EP11187581.1A patent/EP2457600B1/en active Active
- 2011-11-03 CN CN2011103482290A patent/CN102525603A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030077260A1 (en) * | 1995-10-25 | 2003-04-24 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
| US20020116063A1 (en) * | 1999-08-02 | 2002-08-22 | Bruno Giannetti | Kit for chondrocyte cell transplantation |
| CN1377257A (zh) * | 1999-10-05 | 2002-10-30 | 核转移治疗公司 | 杂合基质和杂合基质混合物 |
| CN101721233A (zh) * | 2008-10-17 | 2010-06-09 | 综合性外科公司 | 止血植入体 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496566A (zh) * | 2015-12-14 | 2016-04-20 | 清华大学 | 一种医用多层复合防粘连膜及其制备方法 |
| CN105496566B (zh) * | 2015-12-14 | 2018-07-13 | 清华大学 | 一种医用多层复合防粘连膜及其制备方法 |
| CN112656498A (zh) * | 2020-05-27 | 2021-04-16 | 北京科仪邦恩医疗器械科技有限公司 | 钉棒系统表面处理方法及钉棒系统 |
| CN116133701A (zh) * | 2020-07-21 | 2023-05-16 | 爱惜康股份有限公司 | 具有可移除中间分隔层的密封剂敷料 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2457600B1 (en) | 2018-06-06 |
| AU2011244877A1 (en) | 2012-05-17 |
| CA2755617C (en) | 2019-10-01 |
| US20110045047A1 (en) | 2011-02-24 |
| US9889230B2 (en) | 2018-02-13 |
| EP2457600A2 (en) | 2012-05-30 |
| JP2012096038A (ja) | 2012-05-24 |
| EP2457600A3 (en) | 2014-09-03 |
| CA2755617A1 (en) | 2012-05-03 |
| AU2011244877B2 (en) | 2014-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102525603A (zh) | 止血植入体 | |
| CN101721233B (zh) | 止血植入体 | |
| US8470355B2 (en) | Mesh implant | |
| US8617206B2 (en) | Wound closure device | |
| AU2009305115B2 (en) | Auto-sealant matrix for tissue repair | |
| JP2011110424A (ja) | 創傷プラグ | |
| US9833225B2 (en) | Wound closure device | |
| US20110087273A1 (en) | Wound Closure Device | |
| US20110087274A1 (en) | Wound Closure Device | |
| CN116133701A (zh) | 具有可移除中间分隔层的密封剂敷料 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: CONFLUENT SUGICAL INC. Effective date: 20120621 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20120621 Address after: American Connecticut Applicant after: TYCO Healthcare Address before: American Connecticut Applicant before: TYCO Healthcare Co-applicant before: Confluent Surgical Inc. |
|
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: American Connecticut Applicant after: Covidien LP Address before: American Connecticut Applicant before: TYCO Healthcare |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: TYCO HEALTHCARE TO: COVIDIEN LP COMPANY |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120704 |