CN102512446A - Sodium sulphate compound composition spray and preparation method for same - Google Patents
Sodium sulphate compound composition spray and preparation method for same Download PDFInfo
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- CN102512446A CN102512446A CN2011104224614A CN201110422461A CN102512446A CN 102512446 A CN102512446 A CN 102512446A CN 2011104224614 A CN2011104224614 A CN 2011104224614A CN 201110422461 A CN201110422461 A CN 201110422461A CN 102512446 A CN102512446 A CN 102512446A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
A sodium sulphate compound composition spray and a preparation method for the same are disclosed, which relate to the field of animal medicine. The preparation method disclosed by the invention comprises the following steps of: (1) weighing 10-25 parts by weight of anhydrous sodium sulphate, 3-7 parts by weight of anhydrous cupric sulphate, 3-7 parts by weight of anhydrous zinc sulphate, 2-5 parts by weight of dimethyl sulfoxide and 60-90 parts by weight of distilled water; (2) orderly adding the anhydrous sodium sulphate, the anhydrous cupric sulphate and the anhydrous zinc sulphate in 50-70 parts by weight of the distilled water, and stirring for 5-10 minutes to uniformly dissolve; (3) taking 2-5 parts by weight of dimethyl sulfoxide, adding the dimethyl sulfoxide in 10 parts by weight of the distilled water, and stirring to uniformly dissolve; and (4) combining the solution prepared in the step (2) and the solution prepared in the step (3), uniformly stirring, adding the remainder distilled water, continuing to stir for 10-15 minutes, and filtering after the medicine solution is clear. The sodium sulphate compound composition spray and the preparation method for the same disclosed by the invention are reasonable in prescription, simple in process, convenient in use, stable in quality, and remarkable in curative effect on the foot-and-mouth disease, infectious vesicular disease, mammitis and the like of livestock.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of sodium sulfate compound spray and preparation method thereof.
Background technology
Garget was a female animal before just before giving birth or pregnancy duration, a kind of common multiple disease that mainly caused by infection such as antibacterial such as escherichia coli, streptococcus, staphylococcus aureuses, can cause the swollen hard or atrophy of breast, the matter of suckling decline, milk yield reduction etc.Livestock foot-and-mouth disease is to infect the artiodactylous a kind of deadly infectious disease that causes by foot and mouth disease virus, suffers from positions such as poultry mouth, hoof and blister and ulcer occur, and ill piglet can excite diseases such as myocarditis, and mortality rate is up to 50%-60%.Domestic animal infectiousness blister disease is a kind of acute, hot, the contagious disease that is caused by Vesiculovirus, is characteristic with hoof skin generation blister and speck.They are to cause one of the most serious disease of domestic animal economic loss.
Garget, foot and mouth disease and infectiousness blister disease have spread all over world major country at present.In decades; Comprise all over the world China successively medicines such as PCs, chloromycetin, aminoglycosides, quinolones list in the treatment this sick choice drug in; Because a kind of (class) antibiotic of prolonged and repeated use or antimicrobial drug cause this pathogenic microorganism that medicine has been produced drug resistance, have reduced curative effect; Drug residue is strengthened, and it is healthy to influence people.
Present medicine effect is outstanding inadequately, can produce drug resistance again with the existing drug residue of western medicine, and environment and human health are constituted a serious threat.Present application method is also mostly to be injection; To domestic animal stress be very big, therefore research and develop and a kind ofly treat that the sick specially good effect of livestock foot-and-mouth disease, mastitis and infectiousness blister and convenient is used, the less medicine of irritability is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, outstanding effect sodium sulfate compound spray and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of sodium sulfate compound spray, process than uniform mixing by following components in weight portion number: 60～90 parts of 10～25 parts of anhydrous sodium sulfates, 3～7 parts of anhydrous cupric sulfates, 3～7 parts of anhydro-zinc sulfates, dimethyl sulfoxide 2-5 part, distilled water.
On the basis of such scheme, said various component optimum ratio amounts are: 15 parts of anhydrous sodium sulfates, 5 parts of anhydrous cupric sulfates, 5 parts of anhydro-zinc sulfates, 3 parts of dimethyl sulfoxide, 80 parts of distilled water.
A kind of method for preparing of sodium sulfate compound spray, carry out as follows:
(1) takes by weighing 60～90 parts of 10～25 parts of anhydrous sodium sulfates, 3～7 parts of anhydrous cupric sulfates, 3～7 parts of anhydro-zinc sulfates, dimethyl sulfoxide 2-5 part, distilled water by weight;
(2) said anhydrous sodium sulfate, anhydrous cupric sulfate, anhydro-zinc sulfate are added in 50～70 parts the distilled water successively, stir 5～10 minutes to dissolving evenly;
(3) get dimethyl sulfoxide 2-5 part, add in 10 parts of distilled water, stirring and dissolving is even;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, add the residue distilled water, continue to stir 10～15 minutes, treat the clear and bright after-filtration of medicinal liquid.
The medicinal property of each component is following:
Anhydrous sodium sulfate: be prism-shaped rectangle or irregular crystallization, bitter in the mouth is salty and refrigerant sense is arranged, and is soluble in water, and the effect of clearing heat for detumescence is arranged, and can treat cards such as the skin skin ulcer is swollen, skin infection, acute mastitis, carbuncle.
Anhydrous cupric sulfate: very stable under the normal temperature and pressure, very easily water-soluble, putrefaction removing is arranged, the antidotal effect can be treated diseases such as toxic swelling, carbuncle sore, has very strong antibacterial to press down toxic action.
Anhydro-zinc sulfate: colourless or white crystals, granule or powder, soluble in water, there is very strong antibacterial to press down toxic action, but the healing of acceleration of wound, burn, ulcer etc. etc.
Dimethyl sulfoxide: be transdermal enhancer, the effect that has good promotion drug transdermal to absorb.
Anhydrous sodium sulfate, anhydrous cupric sulfate and anhydro-zinc sulfate all have antibacterial to press down the effect of poison, and have other effects concurrently; Dimethyl sulfoxide is a transdermal enhancer, can promote drug transdermal to absorb, and performance is effect better.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, the curative effect highly significant.The present invention is the employing compound preparation, and makes them form compound preparation according to best proportioning, and clinical practice proves that treatment livestock foot-and-mouth disease, mastitis and infectiousness blister disease etc. are had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of sodium sulfate compound spray and preparation method thereof carries out: (every part by 10g) as follows
(1) takes by weighing 100 parts of anhydrous sodium sulfates, 30 parts of anhydrous cupric sulfates, 30 parts of anhydro-zinc sulfates, 20 parts of dimethyl sulfoxide, 900 parts of distilled water by weight;
(2) said anhydrous sodium sulfate, anhydrous cupric sulfate, anhydro-zinc sulfate are added in 500 parts the distilled water successively, stir 5～10 minutes to dissolving evenly;
(3) get 20 parts of dimethyl sulfoxide, add in 100 parts of distilled water, stirring and dissolving is even;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, add the residue distilled water, continue to stir 10～15 minutes, treat the clear and bright after-filtration of medicinal liquid.
Embodiment 2
A kind of sodium sulfate compound spray and preparation method thereof carries out: (every part by 10g) as follows
(1) takes by weighing 150 parts of anhydrous sodium sulfates, 50 parts of anhydrous cupric sulfates, 50 parts of anhydro-zinc sulfates, 30 parts of dimethyl sulfoxide, 750 parts of distilled water by weight;
(2) said anhydrous sodium sulfate, anhydrous cupric sulfate, anhydro-zinc sulfate are added in 600 parts the distilled water successively, stir 5～10 minutes to dissolving evenly;
(3) get 30 parts of dimethyl sulfoxide, add in 100 parts of distilled water, stirring and dissolving is even;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, add the residue distilled water, continue to stir 10～15 minutes, treat the clear and bright after-filtration of medicinal liquid.
Embodiment 3
A kind of sodium sulfate compound spray and preparation method thereof carries out: (every part by 10g) as follows
(1) takes by weighing 250 parts of anhydrous sodium sulfates, 70 parts of anhydrous cupric sulfates, 70 parts of anhydro-zinc sulfates, 50 parts of dimethyl sulfoxide, 600 parts of distilled water by weight;
(2) said anhydrous sodium sulfate, anhydrous cupric sulfate, anhydro-zinc sulfate are added in 700 parts the distilled water successively, stir 5～10 minutes to dissolving evenly;
(3) get 50 parts of dimethyl sulfoxide, add in 100 parts of distilled water, stirring and dissolving is even;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, add the residue distilled water, continue to stir 10～15 minutes, treat the clear and bright after-filtration of medicinal liquid.
Clinical trial:
Product of the present invention is sprayed directly on to surface, trouble poultry position, 2～3 times/inferior, 2-3 time on the one, logotype 3～5 days.
The field applicable cases contrast of table the present invention and other medicines treatment Schweineseuche:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| Ⅰ | The blank group | 5.3 | - | 20.2 |
| Ⅱ | Enrofloxacin spray group | 3.1 | 84.0 | 12.9 |
| Ⅲ | Present composition group | 1.0 | 92.3 | 6.7 |
This result of the test is through statistical analysis, and the present invention treats the sodium sulfate compound spray treatment group of livestock foot-and-mouth disease and compares difference extremely significantly (P＜0.01) with enrofloxacin spray treatment group.
Above-mentioned detailed description of sodium sulfate compound spray of this treatment livestock foot-and-mouth disease and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. sodium sulfate compound spray is characterized in that being processed than uniform mixing by following components in weight portion number: 60～90 parts of 10～25 parts of anhydrous sodium sulfates, 3～7 parts of anhydrous cupric sulfates, 3～7 parts of anhydro-zinc sulfates, dimethyl sulfoxide 2-5 part, distilled water.
2. a kind of sodium sulfate compound spray according to claim 1 is characterized in that being processed than uniform mixing by following components in weight portion number: 15 parts of anhydrous sodium sulfates, 5 parts of anhydrous cupric sulfates, 5 parts of anhydro-zinc sulfates, 3 parts of dimethyl sulfoxide, 80 parts of distilled water.
3. the method for preparing of a sodium sulfate compound spray according to claim 1 and 2 is characterized in that carrying out as follows:
(1) takes by weighing 60～90 parts of 10～25 parts of anhydrous sodium sulfates, 3～7 parts of anhydrous cupric sulfates, 3～7 parts of anhydro-zinc sulfates, dimethyl sulfoxide 2-5 part, distilled water by weight;
(2) said anhydrous sodium sulfate, anhydrous cupric sulfate, anhydro-zinc sulfate are added in 50～70 parts the distilled water successively, stir 5～10 minutes to dissolving evenly;
(3) get dimethyl sulfoxide 2-5 part, add in 10 parts of distilled water, stirring and dissolving is even;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, add the residue distilled water, continue to stir 10～15 minutes, treat the clear and bright after-filtration of medicinal liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104224614A CN102512446A (en) | 2011-12-16 | 2011-12-16 | Sodium sulphate compound composition spray and preparation method for same |
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| CN2011104224614A CN102512446A (en) | 2011-12-16 | 2011-12-16 | Sodium sulphate compound composition spray and preparation method for same |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009055799A2 (en) * | 2007-10-25 | 2009-04-30 | Kenneke Eli L | Compositions and methods for treatment of diseases of the foot of an animal |
| CN101683074A (en) * | 2008-09-25 | 2010-03-31 | 天津生机集团股份有限公司 | Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof |
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- 2011-12-16 CN CN2011104224614A patent/CN102512446A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009055799A2 (en) * | 2007-10-25 | 2009-04-30 | Kenneke Eli L | Compositions and methods for treatment of diseases of the foot of an animal |
| CN101683074A (en) * | 2008-09-25 | 2010-03-31 | 天津生机集团股份有限公司 | Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 宋亚攀等: "奶牛腐蹄病喷雾治疗研究", 《中国奶牛》, no. 4, 31 December 2010 (2010-12-31), pages 36 - 38 * |
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Application publication date: 20120627 |