CN101683074A - Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof - Google Patents
Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof Download PDFInfo
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- CN101683074A CN101683074A CN200810151742A CN200810151742A CN101683074A CN 101683074 A CN101683074 A CN 101683074A CN 200810151742 A CN200810151742 A CN 200810151742A CN 200810151742 A CN200810151742 A CN 200810151742A CN 101683074 A CN101683074 A CN 101683074A
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Abstract
The invention relates to a pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and a preparation method thereof, belonging to the field of raising environment improvement in raising industry, in particular to a medicament for disinfecting raising environments and a preparation method thereof. The pharmaceutical composition comprises the followingmaterials in parts by weight: 1-18 parts of trichloroiminocyanuric acid, 5-20 parts of copper sulfate, 1-20 parts of sodium sulfate, 2-86 parts of milk sugar, 5-20 parts of aqueous PVP solution withthe concentration of 1%, 1-10 parts of citric acid and 1-10 parts of adipic acid. The preparation method comprises the following steps: respectively weighing the trichloroiminocyanuric acid, the copper sulfate, the sodium sulfate, the milk sugar and the citric acid in the parts by weight; sieving and uniformly mixing; then adding the aqueous PVP solution for mixing, and then preparing wet granules; drying to obtain dry granules; and finally adding lubricating agent adipic acid for tabletting so as to prepare a finished product. The invention effectively overcomes the defects of poor stabilityand easy volatilization of the traditional trichloroiminocyanuric acid powder, has the advantages of wide sterilizing range, quick effect, good disintegrating property and high stability by compounding the trichloroiminocyanuric acid and overcomes the potential safety hazards of production and storage links of a veterinary drug chlorine preparation.
Description
Technical field
The present invention relates in the aquaculture to the improvement field of breeding environment particularly a kind of medicine and manufacture method thereof that breeding environment is carried out disinfection
Background technology
At present, the aquaculture of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, breeding environment is abominable, lack relevant feeding and management and disease prevention and cure knowledge, cause the incidence of disease and the recurrence rate of some diseases to significantly improve, and the quality of production of preventing and treating various livestock and poultry vaccines also height is different, these all impelled some diseases by typicalness to atypical development.In these diseases of treatment, good breeding environment is to reduce an importance of disease incident to aquaculture, often uses chlorinated product that livestock and poultry cultivation environment and aquatic water bodies are carried out disinfection to these people.But the potential safety hazard that the excitant of the chlorinated product that uses in the background technology is strong, poor stability, characteristics such as inflammable, volatile make it to become veterinary drug manufacturing enterprise particularly very easily causes the generation of security incidents such as fire, blast in summer.Therefore a kind of preservation convenience, sterile products safe, that stability is high is significant for veterinary drug manufacturing enterprise.
Summary of the invention
The objective of the invention is to by a kind of pharmaceutical composition that is used for the sterilization of livestock and poultry environment and aquatic water bodies and preparation method thereof is provided, and then solved the problem that exists in the above-mentioned background technology.
For achieving the above object, the present invention adopts following technical scheme:
Contain in the prescription of per 100 parts of parts by weight pharmaceutical compositions: 1～18 part of TCCA (Trichloroisocyanuric acid), 5～20 parts in copper sulphate, sodium sulphate 1-20 part, lactose 2-86 part, concentration are PVP aqueous solution 5-20 part, citric acid 1-10 part, adipic acid 1-10 part of 1%.
During above-mentioned umber was formed, best umber composition can be 1% 5 parts of 12 parts of the PVP aqueous solution, citric acids, 3 parts of adipic acids for 12 parts of TCCA (Trichloroisocyanuric acid), 8 parts in copper sulphate, 8 parts in sodium sulphate, 52 parts of lactose, concentration.
Described TCCA (Trichloroisocyanuric acid), sodium sulphate, copper sulphate, citric acid, PVP(polyvinyl pyrrolidone) (PVP), adipic acid are commercially available product, and should meet the relevant regulations of " Chinese veterinary drug allusion quotation ".
TCCA (Trichloroisocyanuric acid) sodium is a kind of disinfection preservative in the said composition, almost effectively to various bacteriums, fungi and virus, hydrolyzable is a hypochlorous acid in water, has strong oxidizing property, can be at normal temperatures multiple pathogenic microorganisms such as kill virus, bacterium, protozoon, mould, worm's ovum, bacillus rapidly, can be used for the water body disinfection of livestock and fowl drinking water, environment and fish, shrimp bacterial disease and fish, shrimp.Sodium sulphate, copper sulphate also have the effect of desinsection and sterilization except that the trophism of itself, cooperate with TCCA (Trichloroisocyanuric acid) sodium to strengthen its sterilization antisepsis.Citric acid, adipic acid in the composition play function of stabilizer, and lactose is a filler, and the PVP aqueous solution is meant the PVP(polyvinyl pyrrolidone) aqueous solution, for a kind of disintegrant commonly used, can promote the disintegration of medicine.
Described lactose uses as filler, and in fact described filler also can be the sucrose of equivalent or the mixture of lactose and sucrose, and wherein lactose, sucrose are commercially available product, and should meet the relevant regulations of " Chinese veterinary drug allusion quotation ".
Preparation of drug combination method of the present invention is: take by weighing 1～18 part of TCCA (Trichloroisocyanuric acid), 5～20 parts in copper sulphate, sodium sulphate 1-20 part, lactose 86-2 part, citric acid 1-10 part by weight respectively; Sieve and mix; Be added to concentration and be PVP aqueous solution 5-20 part of 1% and mix, make mixture be loose shape; Above-mentioned mixture is added to the wet grain of the mechanism of granulation; Sieve and dryly must do particle; Add adipic acid 1-10 part compression molding at last.
Above-mentioned preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 40-100 mesh sieve also mixes, and makes component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made makes the wet grain of particle diameter 0.2～1cm with the granulator of routine;
(4). the wet grain that make (3) is crossed 10～60 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 0.5～2cm.
The using method of pharmaceutical composition of the present invention is: when being used for the livestock and poultry environment disinfected, after can every separating so that 3-5kg is water-soluble, carry out spraying disinfection; When the livestock and poultry drinking water is carried out disinfection, can every drink to livestock and poultry with water 20-30kg dissolving back; When aquatic products and breeding water body thereof were carried out disinfection, according to breed pond consumption a slice of 1 meter of every mu of depth of water, every with water 1000～1500kg dissolving back full pool spilling head, every day 1 time, logotype 1～2 time.
Clinical testing shows that pharmaceutical composition of the present invention all greater than 99.4%, is 95.3% to the bacillus killing rate to Escherichia coli, staphylococcus aureus killing rate, is 99.8% to the killing effect of Avian pneumo-encephalitis virus.
The preparation method of pharmaceutical composition of the present invention, effectively solved poor, the volatile shortcoming of traditional TCCA (Trichloroisocyanuric acid) powder preparation stability, by carrying out compound to TCCA (Trichloroisocyanuric acid), fully keep wide, the rapid-action advantage of its bactericidal range, has the advantage that disintegrating property is good, stability is high, thereby better bring into play the effect of drug purification breeding environment, overcome the potential safety hazard of production of background technology herbal medicine chlorinated product and storage link simultaneously.
The clinical testing example:
1. summary has carried out disinfection effect test according to Ministry of Agriculture's calendar year 2001 " veterinary drug experimental technique standard " to pharmaceutical composition of the present invention.The result shows, pharmaceutical composition of the present invention to Escherichia coli, staphylococcus aureus killing rate all greater than 99.4%; To bacillus killing rate 95.3%; Killing effect 99.8% to Avian pneumo-encephalitis virus.
2. test report pharmaceutical composition of the present invention all has more significant killing effect to various bacteriums, is to have the effect of significantly killing the virus at 1: 1500 in concentration
3. test objective is along with the development of aquaculture, the quality of breeding environment directly affects the income of aquaculture, therefore can in time kill the pathogenic microorganism in the environment, still not improve key link of culture benefit, but also be important measures of producing pollution-free food.Therefore, various pathogenic microorganisms had very heavy that the pharmaceutical composition of the present invention of fine killing action shows, and this pharmaceutical composition has had the advantage of iodine disinfectant and quaternary ammonium salt disinfectant concurrently, can be at normal temperatures multiple pathogenic microorganisms such as kill virus, bacterium, protozoon, mould, worm's ovum, bacillus rapidly.The purpose of this experiment is exactly by the killing action to Escherichia coli, staphylococcus aureus, Avian pneumo-encephalitis virus, further verifies the Disinfection Effect of pharmaceutical composition of the present invention, for clinical practice provides foundation.
4. experiment content
4.1 experimental bacteria seed culture of viruses and standard medium bacterial classification are Escherichia coli O
1Strain C83845, staphylococcus aureus ATCC6538, medium are broth medium.Seed culture of viruses is the chicken embryo of newcastle disease virus inoculation hatching 9-11 age in days, collects the chicken blastochyle, and it is 10 that every 0.1mL contains virus
8.5EID
50
4.2 the preparation of test organisms seed culture of viruses and numeration
4.2.1 Escherichia coli are got in preparation of Escherichia coli liquid and staphylococcus aureus and numeration and the staphylococcus aureus freeze-drying lactobacillus is cultivated after the separation and purification of Mai Kangkai medium with the breeding of Martin's soup, get colony inoculation then in the 10mL broth medium, put in 37 ℃ of isothermal vibration incubators and cultivated 5 hours, the bacterium liquid of results is that 0.5 Maxwell is than turbid standard (bacteria containing amount about 10 with the sterile saline corrected concentrations
8CFU/mL), (bacteria containing amount is about 10 to do 1: 10 with sterile saline again
7CFU/mL).
4.2.2 the preparation of Avian pneumo-encephalitis virus is done 100 times of dilutions with Avian pneumo-encephalitis virus, is inoculated in 9-11 age in days susceptible chicken embryo, every embryo allantoic inoculation 0.1ml, putting 37 ℃ cultivated 24-72 hour, collect dead embryo liquid, put-20 ℃ standby, measure chicken embryo median infective dose (EID before the test
50), the test poison
5EID
50Answer＞10
8/ ml, blood clotting valency＞1: 80.
4.3 the removal of residual disinfectancy agent and the selection of neutralizer
4.3.1 the removal method of residual disinfectancy agent adopts neutralisation to remove the residual disinfectancy agent
4.3.2 the selection test organisms of neutralizer is Escherichia coli.Test is divided into 6 groups (1) group and is pharmaceutical composition of the present invention+bacterium liquid group; (2) group is pharmaceutical composition of the present invention+bacterium liquid)+neutralizer; (3) group is neutralizer+bacterium liquid; (4) group is (pharmaceutical composition+neutralizer of the present invention)+bacterium liquid; (5) group is normal bacterium control group; (6) group is not for inoculating the medium controls of bacterium.Result of the test judges that if the 6th group long bacterium, the bacterium number differs and is no more than 10%, the 2 group leader bacterium and bacterium number 〉=100CFU/mL between the 3rd, 4,5 group of group, does not grow bacterium or bacterium number for the 1st group and obviously is less than the 2nd group, then can be judged to selected neutralizer and concentration thereof and suit.In the experiment, act on the thimerosal that contains disinfectant as neutralizer, meet the neutralization requirement, see Table 1 with the solution that contains 0.5% Tween-80 and 0.1% sodium thiosulfate:
Table 1 neutralization test result
| Group | Average bacterium number/(CFUM1 -1) |
| (1) pharmaceutical composition solution of the present invention+bacterium liquid | ??0 |
| (2) (pharmaceutical composition solution of the present invention+bacterium liquid)+neutralizer | ??345 |
| (3) neutralizer+bacterium liquid | ??3.08×10 66 |
| (4) (pharmaceutical composition solution+neutralizer of the present invention)+bacterium liquid | ??3.12×10 6 |
| (5) normal bacterium contrast | ??3.34×10 6 |
| Nonvaccinated medium contrast | ??0 |
4.4 authentication method
Place 20 ℃ of water-bath preheatings respectively 4.4.1. quantitatively kill the test tube that coli test will fill the different dilution factors of 4.5ml pharmaceutical composition solution of the present invention (contrast is phosphate buffer), the Escherichia coli bacteria liquid 0.5ml that gets preparation under the 1.4.2.1 item adds in the thimerosal mixing.Continue to put in 20 ℃ of water-baths and act on 5min, get 0.5ml bacterium medicine mixed liquor and add mixing is housed in the test tube of 4.5ml neutralizer.Neutralization 10min makes count plate, calculates killing rate.It the results are shown in Table 2:
Table 2 pharmaceutical composition solution of the present invention is to colibacillary killing effect
| Pharmaceutical composition solution dilution multiple of the present invention | Killing rate/% of effect 5min |
| ??1∶1500 | ??100.0 |
| ??1∶2000 | ??99.97 |
| ??1∶3000 | ??99.94 |
4.4.2 the new freshly-slaughtered poultry blastochyle 2.5ml for preparing newcastle disease virus (NDV) by the 1.4.2.2 item is down got in the qualitative test of killing the virus, add in the pharmaceutical composition solution of the present invention of 2.5ml variable concentrations preheating, mixing continues to put and acts on 10 and 30min in 20 ℃ of water-baths respectively.Get the above-mentioned mixed liquor of 0.5ml respectively and be added in the 4.5ml neutralizer, mixing, effect 10min.Get above-mentioned solution, injection chicken embryo, every embryo 0.2ml observes the growing state of respectively organizing virus in the chicken embryo.The results are shown in Table 3:
Table 3 composition solution is to the killing effect of Avian pneumo-encephalitis virus
| Pharmaceutical composition solution dilution multiple of the present invention | The situation of killing of effect 10min |
| ??1∶600 | ??5/5 * |
| ??1∶800 | ??5/5 |
| ??1∶1000 | ??5/5 |
Annotate: the positive embryo number of */test embryo number, test temperature is 20 ℃, control group is all survived.
5. brief summary pharmaceutical composition solution of the present invention all has more significant killing effect to bacterium, can reach 100% to colibacillary killing rate when extension rate is 1500 times.Killing effect to Avian pneumo-encephalitis virus when extension rate is 1000 times is very good.
Embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1:
Described pharmaceutical composition is that 1% PVP aqueous solution 18g, citric acid 3g, adipic acid 5g form by TCCA (Trichloroisocyanuric acid) 10g, copper sulphate 12g, sodium sulphate 12g, lactose 40g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 40 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.6cm;
(4). the wet grain that make (3) is crossed 20 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 2cm.
Embodiment 2:
Described pharmaceutical composition is that 1% PVP aqueous solution 10g, citric acid 2g, adipic acid 2g form by TCCA (Trichloroisocyanuric acid) 5g, copper sulphate 8g, sodium sulphate 5g, sucrose 68g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 80 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.5cm;
(4). the wet grain that make (3) is crossed 60 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 0.8cm.
Embodiment 3:
Described pharmaceutical composition is that 1% PVP aqueous solution 12g, citric acid 5g, adipic acid 5g form by TCCA (Trichloroisocyanuric acid) 8g, copper sulphate 10g, sodium sulphate 15g, lactose 20g, sucrose 25g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 60 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.2cm;
(4). the wet grain that make (3) is crossed 50 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 0.5cm.
Embodiment 4:
Described pharmaceutical composition is that 1% PVP aqueous solution 15g, citric acid 3g, adipic acid 4g form by TCCA (Trichloroisocyanuric acid) 16g, copper sulphate 15g, sodium sulphate 15g, lactose 32g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 100 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 1cm;
(4). the wet grain that make (3) is crossed 40 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 1.5cm.
Embodiment 5:
Described pharmaceutical composition is that 1% PVP aqueous solution 20g, citric acid 10g, adipic acid 10g form by TCCA (Trichloroisocyanuric acid) 18g, copper sulphate 20g, sodium sulphate 20g, lactose 2g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 50 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.2cm;
(4). the wet grain that make (3) is crossed 10 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 1.5cm.
Embodiment 6:
Described pharmaceutical composition is that 1% PVP aqueous solution 5g, citric acid 1g, adipic acid 1g form by TCCA (Trichloroisocyanuric acid) 1g, copper sulphate 5g, sodium sulphate 1g, lactose 86g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 70 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.6cm;
(4). the wet grain that make (3) is crossed 20 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 2cm.
Embodiment 7:
Described pharmaceutical composition is that 1% PVP aqueous solution 15g, citric acid 5g, adipic acid 7g form by TCCA (Trichloroisocyanuric acid) 12g, copper sulphate 12g, sodium sulphate 12g, lactose 37g, concentration.
Described preparation method carries out according to following steps successively:
(1). take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 50 mesh sieves also mix, and make component mixture A;
(2). compound concentration is 1% the PVP aqueous solution, and the component mixture A that by weight (1) is made is added in the PVP aqueous solution of parts by weight, stirs, and makes loose shape component mixture B;
(3). the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.4cm;
(4). the wet grain that make (3) is crossed 50 mesh sieves with the vibratory sieve of routine, carry out 45 ℃ of conventional dryings, get moisture and be not higher than 8% dried particle;
(5). in the dried particle that make (4), add quantitative adipic acid and mix, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 0.8cm.
Claims (5)
1. the pharmaceutical composition that is used for the sterilization of livestock and poultry environment and aquatic water bodies is characterized in that containing in the prescription of per 100 parts of parts by weight 1～18 part of commercially available TCCA (Trichloroisocyanuric acid), 5～20 parts in copper sulphate, sodium sulphate 1-20 part, lactose 2-86 part, concentration and is PVP aqueous solution 5-20 part, citric acid 1-10 part, adipic acid 1-10 part of 1%; Above-mentioned each composition should meet the relevant regulations of " Chinese veterinary drug allusion quotation "
2. the pharmaceutical composition that is used for livestock and poultry environment and aquatic water bodies sterilization according to claim 1, it is characterized in that in the prescription of per 100 parts of parts by weight that it is 1% 5 parts of 12 parts of the PVP aqueous solution, citric acids, 3 parts of adipic acids that best umber consists of 12 parts of TCCA (Trichloroisocyanuric acid), 8 parts in copper sulphate, 8 parts in sodium sulphate, 52 parts of lactose, concentration.
3. according to claim 1 or the 2 described pharmaceutical compositions that are used for livestock and poultry environment and aquatic water bodies sterilization, it is characterized in that in described prescription, can also using the sucrose of equivalent or the mixture of lactose and sucrose to replace lactose to use.
4. be used to make the preparation of drug combination method of livestock and poultry environment and aquatic water bodies sterilization, it is characterized in that in the prescription of per 100 parts of parts by weight, take by weighing 1～18 part of TCCA (Trichloroisocyanuric acid), 5～20 parts in copper sulphate, sodium sulphate 1-20 part, lactose 2-86 part, citric acid 1-10 part respectively; Sieve and mix; Be added to concentration and be PVP aqueous solution 5-20 part of 1% and mix, make mixture be loose shape; With mixture with the wet grain of the mechanism of granulating; Sieve and dryly must do particle; Add adipic acid 1-10 part at last and mix also compression molding.
5. the preparation of drug combination method that is used for livestock and poultry environment and aquatic water bodies sterilization according to claim 4 is characterized in that described method is:
(1) take by weighing TCCA (Trichloroisocyanuric acid), copper sulphate, sodium sulphate, lactose, citric acid by weight respectively, mistake 40-100 mesh sieve also mixes, and makes component mixture A;
(2) compound concentration is 1% the PVP aqueous solution, adds the PVP aqueous solution by weight and stir in the component mixture A that make (1), makes loose shape component mixture B;
(3) the component mixture B that (2) are made is added in the conventional granulator, makes the wet grain of particle diameter 0.2～1cm with conventional method;
(4) the wet grain of (3) being made is crossed 10～60 mesh sieves with the vibratory sieve of routine, carries out 45 ℃ of conventional dryings, gets moisture and is not higher than 8% dried particle;
(5) in the dried particle that make (4), add quantitative adipic acid and mixing, with the tablet press machine compressing tablet of routine, diameter be the flake drug composition finished product of 0.5～2cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151742A CN101683074A (en) | 2008-09-25 | 2008-09-25 | Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810151742A CN101683074A (en) | 2008-09-25 | 2008-09-25 | Pharmaceutical composition for disinfecting livestock and poultry environments and aquatic water bodies and preparation method thereof |
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|---|---|
| CN101683074A true CN101683074A (en) | 2010-03-31 |
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ID=42046645
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|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512446A (en) * | 2011-12-16 | 2012-06-27 | 青岛绿曼生物工程有限公司 | Sodium sulphate compound composition spray and preparation method for same |
| CN106342819A (en) * | 2016-08-30 | 2017-01-25 | 濮阳可利威化工有限公司 | Fishery water quality stabilizer |
| CN112956595A (en) * | 2021-04-01 | 2021-06-15 | 南通大学 | Livestock and poultry breeding sterilization nutrition tablet and preparation method thereof |
| CN114698570A (en) * | 2021-12-23 | 2022-07-05 | 江苏沿海地区农业科学研究所 | Waterline purification conditioning method for repairing intestinal villi of laying hens |
-
2008
- 2008-09-25 CN CN200810151742A patent/CN101683074A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512446A (en) * | 2011-12-16 | 2012-06-27 | 青岛绿曼生物工程有限公司 | Sodium sulphate compound composition spray and preparation method for same |
| CN106342819A (en) * | 2016-08-30 | 2017-01-25 | 濮阳可利威化工有限公司 | Fishery water quality stabilizer |
| CN112956595A (en) * | 2021-04-01 | 2021-06-15 | 南通大学 | Livestock and poultry breeding sterilization nutrition tablet and preparation method thereof |
| CN114698570A (en) * | 2021-12-23 | 2022-07-05 | 江苏沿海地区农业科学研究所 | Waterline purification conditioning method for repairing intestinal villi of laying hens |
| CN114698570B (en) * | 2021-12-23 | 2024-04-30 | 江苏沿海地区农业科学研究所 | Waterline purifying and conditioning method for repairing intestinal villi of laying hens |
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Open date: 20100331 |