CN103858934B - A kind of fumigation pharmaceutical composition for animals and its preparation method and application - Google Patents
A kind of fumigation pharmaceutical composition for animals and its preparation method and application Download PDFInfo
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- CN103858934B CN103858934B CN201410099477.XA CN201410099477A CN103858934B CN 103858934 B CN103858934 B CN 103858934B CN 201410099477 A CN201410099477 A CN 201410099477A CN 103858934 B CN103858934 B CN 103858934B
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Abstract
The invention discloses a kind of fumigation pharmaceutical composition for animals, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9-9.5 weight portion, potassium permanganate 0.25-0.45 weight portion, hexa 0.05-0.75 weight portion.Beneficial effect of the present invention is: one provided by the invention fumigation pharmaceutical composition for animals, be mainly used in the conventional fumigation sterilization of livestock and poultry colony house, solve the following shortcoming of prior art: 1, overcome formaldehyde gas and the pollution of reaction residue to environment, animal product and the harmful effect to producers that similar traditional sootiness disinfectant preparation produces; 2, be only made up of three kinds of raw materials, main ingredient can Homogeneous phase mixing, without the need to bag distribution packaging, has good stability; 3, compared with existing similar fumigating disinfectant, light during use without naked light, only with a small amount of more than 80 DEG C hot water, " product mist " reaction can occur, it is safer, convenient to store, transport and use.
Description
Technical field
The present invention relates to disinfecting drug field, be specifically related to a kind of fumigation pharmaceutical composition for animals and its preparation method and application.
Background technology
At present, in the nearly all plant of China and countries in the world, Ge great customs, import-export ports, the field such as the large storage of goods and transport, customs quarantine control, bio-pharmaceuticals, health care and food storage, fumigation is widely used as a kind of quick, thorough, effective sterilization method.Excellent fumigant, have that penetration is strong, toxicity is low, not burn into nondiscolouring, the feature such as electrical insulation capability is good, serviceability temperature is wide, consumption is little, adsorbing capacity is few and desorb is fast.Fumigation, can to agricultural byproducts sterilizations such as colony house, fodder store, hair, cotton, chemical fibre fabric, timber, grain, leather, tobacco, bamboo woodenware and handicrafts by selecting suitable fumigant.On the other hand, current used various fumigation medicaments are all harmful to people and animals, if use or process control improper, all may jeopardize person poultry safety, cause contingency, cause larger pollution.Therefore, in order to give full play to the advantage of fumigation, farthest reduce its drawback and unfavorable factor, better protection of the environment and food security, development of new is efficient, safety, low toxicity, economic fumigant be very necessary.
In large-scale health culture industry, livestock and poultry circle, give up after rinsing well, fumigation must be carried out with fumigant, the new animal introduced could be allowed to enter colony house and normally raise.So-called fumigation or sootiness sterilization utilize fumigating disinfectant (formalin and potassium permanganate generation chemical reaction) to discharge formaldehyde gas rapidly, kill pathogenic microorganism through certain hour, it is that livestock and poultry colony house is commonly used and effective a kind of traditional disinfection methods.Fumigating disinfectant studies have reported that at home very early, and once carries out a large amount of laboratory and on-the-spot disinfection research.More successful fumigating disinfectant is still the sour chlorine fumigating disinfectant of sterilization component with chlorine-containing disinfectant, a lot of similar gas and sootiness disinfectant preparation has also been there is successively in research report thereafter, but all fumigating disinfectants all do not solve major ingredient and the mixed stability problem of auxiliary material, due to main ingredient bag distribution packaging, could mix during application, cause such preparation to be difficult to form formal product.Such as sodium dichloro cyanurate mixes the fumigating disinfectant (sootiness king) that forms with polyformaldehyde and sym-closene powder mixes the fumigating disinfectant (sootiness is aerosol bomb again only) formed with polyformaldehyde, because mixing rear stability is poor, slow hypergolic reaction can be there is, in a packaging, main materials and auxiliary materials must separately be packed.Similar utility model patent " fumigation smoke grenade " (application number is CN201120210181.2), still the mixed stability problem of main ingredient is not solved, therefore unitary packaging cannot be formed, the host of fumigating disinfectant is equipped with in one of them bag of chamber, and the assistant agent of fumigating disinfectant is equipped with in another bag of chamber.Patent of invention " a kind of Youlvjing disinfecting agent (also known as the distant board Youlvjing disinfecting agent of Ji) and application thereof " (application number is CN200810071823.8), formed by sodium dichloro cyanurate, adipic acid, potassium permanganate, rosin, precipitated calcium carbonate, sodium acetate and auxiliary material seven kinds of composition mixed preparing, be respectively Babysafe, adipic acid, potassium permanganate, rosin, precipitated calcium carbonate, sodium acetate and auxiliary material (as plant amylum) etc.The disinfectant that this invention relates to, because auxiliary material composition is too much, auxiliary material proportion is large, and the content of sterilization main component reduces, and its process is complicated, and Disinfection Effect is also had a greatly reduced quality.In sum, up at present, still formed without satisfied formal sootiness sterile products, " People's Republic of China's veterinary drug allusion quotation " does not record any fumigation preparation yet.In addition, traditional fumigation method of its feeding place application is divided into two kinds, and a kind of is the sterilization method of formaldehyde and potassium permanganate generation oxidation reaction; Another kind is that polyformaldehyde adds water to be placed in container and directly puts fire upper heating volatilization sterilization.Not only containing chlorine in the smog that above fumigation is produced; also containing a large amount of formaldehyde; remain contaminated environment, animal products and threaten the latency of worker safety's health, but also there is serious potential safety hazard, be unfavorable for the formal sterile products forming large-scale production.2004 formalin (formaldehyde) be decided to be carcinogen by the World Health Organization, easily cause respiratory disease, a lot of breeding enterprise seldom uses.Potassium permanganate, because rise in price cost was higher in recent years, adds that low-quality goods (containing quantity not sufficient) also seldom uses.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, and provide a kind of composition simple, processing is convenient, and main ingredient mixing rear stability is good, and to environment and the free of contamination fumigation pharmaceutical composition for animals of product.
To achieve these goals, technical scheme provided by the invention is:
A kind of fumigation pharmaceutical composition for animals, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9-9.5 weight portion, potassium permanganate 0.25-0.45 weight portion, hexa, 0.05-0.75 weight portion.
Further, above-mentioned one fumigation pharmaceutical composition for animals, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9.3 weight portion, potassium permanganate 0.3 weight portion, hexa 0.4 weight portion.
Second object of the present invention, there is provided a kind of preparation method of fumigation pharmaceutical composition for animals, is take each component according to above-mentioned weight proportion, after mixing, with the packing of laminated aluminum film bag.
3rd object of the present invention, there is provided the application of above-mentioned a kind of fumigation pharmaceutical composition for animals in poultry house sterilization.
Further, above-mentioned application, that described fumigation pharmaceutical composition for animals is placed in container, evenly divide and be put in each position in poultry house, effective sterilization dose in every cubic metre of space is 6 grams, and add 10 milliliters of hot water in every 100 grams of fumigation pharmaceutical compositions for animals, hot water temperature is 80 DEG C, airtight poultry house more than 24 hours after speeding away, ventilation.
Beneficial effect of the present invention is: one provided by the invention fumigation pharmaceutical composition for animals, is mainly used in the conventional fumigation sterilization of livestock and poultry colony house, solves the following shortcoming of prior art:
1, fumigation pharmaceutical composition for animals provided by the present invention overcomes the formaldehyde gas and the pollution of reaction residue to environment, animal product and the harmful effect to producers that similar traditional sootiness disinfectant preparation produces, environmental protection more compared with existing product;
2, fumigation pharmaceutical composition for animals provided by the present invention is only made up of three kinds of raw materials, main ingredient can Homogeneous phase mixing, without the need to bag distribution packaging, have good stability, solve existing similar sootiness disinfectant preparation auxiliary material major ingredient and the immiscible drawback of auxiliary material too much and in production and processing, transportation;
3, fumigation pharmaceutical composition for animals provided by the present invention is compared with existing similar fumigating disinfectant, lights during use without naked light, only with a small amount of more than 80 DEG C hot water, " product mist " reaction can occur, and it is safer, convenient to store, transport and use.
In order to confirm fumigation pharmaceutical composition fumigation effect for animals provided by the present invention, successively carrying out hen house, having planted the fumigation of egg and feed etc.Air sterilization effect calculates by relevant air sterillization sterilizing rate (PT) computing formula of Ministry of Agriculture's " disinfectant for animals measurement specification " (before the rear viable count sterilization of the front viable count-sterilization of sterilizing rate (%)=sterilization viable count × 100%).
1. hen house on-site disinfection test:the vacant house of brooding of not sterilized in volume 350 cubic metres (average every between 70 cubic metres) more than 30 skies is amounted to, as testing ground between test selection 5.Be divided into high, medium and low 3 groups according to drug concentration, and establish formaldehyde control group, blank group simultaneously.Fumigating method: hen house rinses one time with clear water in first 1 hour in stifling, keep temperature 20 ~ 23 DEG C, relative moisture 70 ~ 80%, then respectively fumigation is carried out to house of wherein brooding between 3 with the present invention's fumigation pharmaceutical composition for animals with 12.0 grams every cubic metre, 6.0 grams, 3.0 grams, be put in three different positions, treat that namely dense smoke people of emerging leaves, close door and window.Formaldehyde control group, put three pottery pots at interior three diverse locations of house, first pour formalin into, then add potassium permanganate, namely people leaves, and closes door and window.
1.1, chicken coop air sterilization:adopt plate sedimentation.Sterilize first 1 hour, sterilize latter 24 hours, often organizing the substantially identical position of hen house, placing three agar plate, simultaneously open dish lid, exposing 10 minutes in atmosphere, build immediately.Then put in 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.
Chicken coop air Disinfection Effect: the present invention's fumigation for animals pharmaceutical composition is tested with 12.0 grams every cubic metre, 6.0 grams, 3.0 grams high, normal, basic three kinds of concentration.As a result, the present invention's fumigation pharmaceutical composition for animals of high, medium and low dosage is fumigated, and is respectively 94.60%, 94.81% and 94.15% to air sterillization sterilizing rate, and each group difference is not significantly (P >=0.05); The disinfection rate of formaldehyde control group to air be 94.27% and the present invention's fumigation pharmaceutical composition for animals Disinfection Effect difference not significantly (P >=0.05).
1.2, hen house wall sterilization:the position of two piece of 5 cm x 5 centimetres is marked respectively, as sterilization front l hour and latter 24 hours wall bacterial sampling of sterilizing in the position that hen house wall is identical.After being infiltrated with 0.9% physiological saline by aseptic cotton swab during sampling, draw position respectively firmly wiping 10 times anyhow in every block institute, and continuous conversion swab wiping surface, clip swab is cotton to be held, and puts into sample solution, jolting 100 times of exerting oneself, eluting bacterial.With physiological saline, washing lotion is done 5 times, 50 times dilutions, be inoculated in respectively on 10% serum Martin agar medium, put in 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.Result is 93.88%, 92.20% and 90.00% to wall surface disinfection rate respectively, and difference is not remarkable; The disinfection rate of formaldehyde control group to wall surface is 92.31%, with the present invention's fumigation pharmaceutical composition for animals Disinfection Effect difference remarkable (P >=0.05).
2. feed disinfection:by feed sample, brooding, same position in house is paved into 20 cm x 20 cm x, 5 centimetres of sizes, starts fumigation, and fumigation method is with 1, and humidity keeps material storehouse previous status.Adopt 1.0 grams of samples respectively before sterilization with after sterilization, make the dilution of 5 times, 50 times, 500 times, 5000 times of physiological saline after, be seeded on plain agar medium, put 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.Because formaldehyde has larger toxicity and penetrating odor, therefore do not do feed disinfection check experiment.It is respectively 85.36%, 84.57% and 83.03% to feed disinfection sterilizing rate, and each group difference is not remarkable.
3. kind of egg sterilization:due to kind of an egg embryo's particularity, experimental group selects 3.0 grams of/cubic metre of the present invention's fumigation pharmaceutical compositions for animals; Maintenance temperature 16 ~ 18 DEG C, relative moisture are 70 ~ 80%.Control group every cubic metre uses formalin 25 milliliters, potassium permanganate 12.5 grams of fumigations.In sterilization before and sterilization after within 1 hour, 12 hours, 24 hours, take 5 pieces, kind of egg respectively, do surface bacteria cultivation and colony counting.Random selecting 60 pieces of qualified kind of eggs, are divided into experimental group, formaldehyde control group, often organize 30 pieces.Plant egg sterilization to carry out in kind of egg case, method is with 1.After fumigation 1 hour, the sterilizing rate of planting egg surface was respectively 97.2%, 95.6%; Sterilize latter 12 hours, the sterilizing rate of planting egg surface is respectively 99.9% and 100%; Sterilize latter 24 hours, the sterilizing rate of planting egg surface all reaches 100%.
4. stability study:the present invention's fumigation pharmaceutical composition for animals stability observing comprises mensuration self-ignition point, heat endurance and bin stability.
After measured, the present invention's fumigation pharmaceutical composition for animals self-ignition point is 95 DEG C.Illustrate that this formula at room temperature not easily spontaneous combustion occurs.Then in oil bath, sample temperature is maintained 45 ~ 51 DEG C (oil bath temperature is 48 ± 3 DEG C), go through 2 hours and do not play any reaction.Compared with unheated control sample, the effect killing wax-like bacillus brood cell does not reduce.Formula briquetting packaging, after storage in 18 months, profile does not see change, and the effect killing wax-like bacillus brood cell does not also decline.
5. toxicity research:rat oral LD
50: 420mg/kg, rabbit is through skin LD
50: 3160mg/kg, Eye irritation is tested: 100mg/24h, and reaction is slight, belongs to low toxicity disinfectant.
conclusion:
China in poultry house, feed, incubator and the fumigation of kind egg, still adopts traditional formalin, potassium permanganate fumigation at present mostly, has certain harmfulness to environment, kind egg embryo, practitioner.Result of the test shows, the present invention's fumigation pharmaceutical composition sterilization for animals and formalin, potassium permanganate fumigation effect quite, and also have many advantages, and its development prospect is very wide, can be applicable in actual production.
From medicinal property and sterilization method analysis, the advantages such as the present invention's fumigation for animals pharmaceutical composition has transportation safety, the flames of anger, sufficient reacting compared with methanal plus potassium permanganate fumigating, smog is dense, diffusion is good, little to toxicity to man and livestock, medicament residue is low.
From the present invention's fumigation pharmaceutical composition for animals to the Analysis of Disinfection Effect of feed, after sootiness, feed bacteria containing amount obviously reduces, and this has very important significance to cut-out poultry diease route of transmission tool.For the poultry house crossed with scour without sediment motion after sky house, the conventional sterilization consumption of the present invention's fumigation for animals pharmaceutical composition is 3.0 ~ 6.0 grams of/cubic metre of spaces, airtight door window 24 hours; Plant egg sterilization to be advisable 3.0 grams of/cubic metre stifling half an hour.
Embodiment
embodiment 1:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: sodium dichloro cyanurate 9kg, potassium permanganate 0.25kg, hexa 0.75kg, takes each component respectively by formula dosage, after mixing, for subsequent use with the packing of laminated aluminum film bag.
Function and usage is: chlorine has high affinity to somatic cells magma, easy infiltration cell, make the amino chlorination of magma albumen, destroy thalline or change membrane passage, or the powerful killing action suppressing various sulfydryl enzyme and present bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, particularly also has extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks to reproduction type bacterium and brood cell, virus, fungal spore.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: on average every cubic metre of space this product 6.0 grams, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 80 DEG C of hot water 10 milliliters, evenly speed away behind instillation disinfectant surface, airtight more than 24 hours, ventilation again, can introduce its feeding without the need to again rinsing.
embodiment 2:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: sodium dichloro cyanurate 9.5g, potassium permanganate 0.45g, hexa 0.05g, takes each component respectively by formula dosage, after mixing, for subsequent use with the packing of laminated aluminum film bag.
Function and usage is: chlorine has high affinity to somatic cells magma, easy infiltration cell, make the amino chlorination of magma albumen, destroy thalline or change membrane passage, or the powerful killing action suppressing various sulfydryl enzyme and present bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, particularly also has extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks to reproduction type bacterium and brood cell, virus, fungal spore.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: on average every cubic metre of space this product 6.0 grams, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 80 DEG C of hot water 10 milliliters, evenly speed away behind instillation disinfectant surface, airtight more than 24 hours, ventilation again, can introduce its feeding without the need to again rinsing.
embodiment 3:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: sodium dichloro cyanurate 9.3 tons, 0.3 ton, potassium permanganate, hexa 0.4 ton, takes each component respectively by formula dosage, after mixing, for subsequent use with the packing of laminated aluminum film bag.
Function and usage is: chlorine has high affinity to somatic cells magma, easy infiltration cell, make the amino chlorination of magma albumen, destroy thalline or change membrane passage, or the powerful killing action suppressing various sulfydryl enzyme and present bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, particularly also has extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks to reproduction type bacterium and brood cell, virus, fungal spore.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: on average every cubic metre of space this product 6.0 grams, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 80 DEG C of hot water 10 milliliters, evenly speed away behind instillation disinfectant surface, airtight more than 24 hours, ventilation again, can introduce its feeding without the need to again rinsing.
Basic ideas of the present invention:
Along with the continuous expansion of intensive culture scale, people are also more and more strict to the selection of disinfectant.Environmental protection, safety, convenience, economy, imitate good become people select target.Fumigation pharmaceutical composition for animals is a kind of novel organochlorine fumigant, and its main component is sodium dichloro cyanurate, and sodium dichloro cyanurate is crystallization pulvis, containing available chlorine 60%.Research confirms, and its fungicidal spectrum is wide, all has comparatively pretend use to bacterium, virus, fungi and bacterial spore.When the available chlorine of 3ppm, act on and can kill Escherichia coli more than 99.9% in 30 minutes, within 5 ~ 30 minutes, can all kill bacterial spore effect.This product feature is that pH is lower, acts on stronger.Therefore, sodium dichloro cyanurate is as disinfection of drinking water, environment disinfected, wastewater disinfection and the extensive use already of tableware disinfection product, and its disinfective action has lot of documents and records.Fumigation pharmaceutical composition for animals involved in the present invention, be intended to solve similar conventional smoke fumigant defect and make up its producing, transport and the deficiency in using.
Sodium dichloro cyanurate of the present invention is conventional disinfectant or sterilization bulk drug, for a long time, in livestock breeding industry production practices, after by a certain percentage sodium dichloro cyanurate is water-soluble, for the spraying disinfection of livestock and poultry colony house or " spilling " sterilization of environment.Sodium dichloro cyanurate and solid formaldehyde mix latter made smog disinfectant preparation, owing to producing a large amount of formaldehyde gas in using, and not only direct contaminated environment and animal products, and also have potential threat to human health.Not containing formaldehyde in the present invention's formula, and light without naked light, only it can be made to react generation chlorine with 80 DEG C of warm water, thus play disinfective action.Said preparation after completion of the reaction simultaneously, is condensed into white cellular block, can not pollutes environment.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. a fumigation pharmaceutical composition for animals, is characterized in that, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9.3 weight portion, potassium permanganate 0.3 weight portion, hexa 0.4 weight portion.
2. a preparation method for fumigation pharmaceutical composition for animals, is characterized in that, is to take each component according to weight proportion according to claim 1, after mixing, with the packing of laminated aluminum film bag.
3. the application of a kind of fumigation pharmaceutical composition for animals according to claim 1 in poultry house sterilization.
4. application according to claim 3, it is characterized in that, that described fumigation pharmaceutical composition for animals is placed in container, evenly divide and be put in each position in poultry house, effective sterilization dose in every cubic metre of space is 6 grams, and add 10 milliliters of hot water in every 100 grams of fumigation pharmaceutical compositions for animals, hot water temperature is 80 DEG C, airtight poultry house more than 24 hours after speeding away, ventilation.
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| CN107232131A (en) * | 2017-06-14 | 2017-10-10 | 太仓市金诸农业发展有限公司 | A kind of method for culturing pigs of energy-conserving and environment-protective |
| JP2019156785A (en) * | 2018-03-15 | 2019-09-19 | 学校法人 京都産業大学 | Antiseptic to influenza virus and its production method, and, deactivation method of influenza virus |
| CN111345265B (en) * | 2020-02-24 | 2022-01-04 | 北京德青源农业科技股份有限公司 | Method for improving hatching rate and chick viability of Tibetan chickens in high altitude areas |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260117A (en) * | 1999-09-15 | 2000-07-19 | 山东农业大学动物保健品厂 | Smoke and water dual-purpose disinfectant |
| CN101273734A (en) * | 2008-02-01 | 2008-10-01 | 康可新 | Smokes applied in producing edible or medicinal fungi for sterilization |
| CN101411336A (en) * | 2008-11-27 | 2009-04-22 | 河北科技大学 | Aerosol disinfectant for edible fungus and preparation method thereof |
| CN101584319A (en) * | 2009-06-11 | 2009-11-25 | 汪文华 | Smoke disinfectant for hygiene sterilization and preparation method thereof |
-
2014
- 2014-03-18 CN CN201410099477.XA patent/CN103858934B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1260117A (en) * | 1999-09-15 | 2000-07-19 | 山东农业大学动物保健品厂 | Smoke and water dual-purpose disinfectant |
| CN101273734A (en) * | 2008-02-01 | 2008-10-01 | 康可新 | Smokes applied in producing edible or medicinal fungi for sterilization |
| CN101411336A (en) * | 2008-11-27 | 2009-04-22 | 河北科技大学 | Aerosol disinfectant for edible fungus and preparation method thereof |
| CN101584319A (en) * | 2009-06-11 | 2009-11-25 | 汪文华 | Smoke disinfectant for hygiene sterilization and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 乌洛托品用于空气消毒实验;贺俊生 等;《华西药学杂志》;19931231;第8卷(第2期);117-118 * |
| 二氯烟剂配方中供热剂的选用;袁永昌 等;《食用菌》;20091231(第4期);63 * |
| 兽用消毒药在畜禽养殖中的合理使用及注意事项;李文平 等;《中国兽药杂志》;20100831;第44卷(第8期);57-60 * |
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