CN103858934A - Veterinary suffumigation medicine composition and preparation method and application thereof - Google Patents
Veterinary suffumigation medicine composition and preparation method and application thereof Download PDFInfo
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- CN103858934A CN103858934A CN201410099477.XA CN201410099477A CN103858934A CN 103858934 A CN103858934 A CN 103858934A CN 201410099477 A CN201410099477 A CN 201410099477A CN 103858934 A CN103858934 A CN 103858934A
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- 239000000203 mixture Substances 0.000 title abstract description 11
- 239000003814 drug Substances 0.000 title abstract description 8
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- 239000012286 potassium permanganate Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000003958 fumigation Methods 0.000 claims description 67
- 238000004659 sterilization and disinfection Methods 0.000 claims description 48
- 239000008194 pharmaceutical composition Substances 0.000 claims description 44
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a veterinary suffumigation medicine composition which comprises the following three components in parts by weight: 9-9.5 parts of sodium dichloroisocyanurate, 0.25-0.45 part of potassium permanganate and 0.05-0.75 part of hexamethylenetetramine. The veterinary suffumigation medicine composition is mainly used for conventional suffumigation of a livestock housing and has the advantages that the pollution of a formaldehyde gas and a reaction residue to the environment and the animal byproducts and the harmful effect to a producer caused by the similar conventional suffumigation preparations in the prior art is overcome; 2, only three raw materials are used, main and auxiliary materials can be uniformly mixed, and the stability is good without being packaged by bags; 3, the open fire ignition is not required during use, mist producing reaction can be generated by only consuming a small amount of hot water with the temperature of above 80 DEG C, and the storing, the transporting and the use are safer and more convenient compared with existing similar suffumigation disinfectants.
Description
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Technical field
The present invention relates to disinfecting drug field, be specifically related to a kind of fumigation pharmaceutical composition for animals and its preparation method and application.
Background technology
At present, in fields such as nearly all plant, Ge great customs, import-export ports, the large storage of goods and transport, customs quarantine control, bio-pharmaceuticals, health care and the grain storages of China and countries in the world, fumigation is widely used as a kind of quick, thorough, effective sterilization method.Good fumigant, has that penetration is strong, toxicity is low, a not burn into nondiscolouring, the feature such as electrical insulation capability is good, serviceability temperature is wide, consumption is little, adsorbing capacity is few and desorb is fast.Fumigation, can be to agricultural byproducts sterilizations such as colony house, fodder store, hair, cotton, chemical fibre fabric, timber, grain, leather, tobacco, bamboo woodenware and handicrafts by selecting suitable fumigant.On the other hand, current used various fumigation medicaments, are all harmful to people and animals, if use or process control are improper, all may jeopardize person poultry safety, cause contingency, cause larger pollution.Therefore, in order to give full play to the advantage of fumigation, farthest reduce its drawback and unfavorable factor, better protection of the environment and food security, development of new is efficient, safety, low toxicity, economic fumigant are very necessary.
In large-scale health culture industry, livestock and poultry circle, house, after rinsing well, must carry out fumigation with fumigant, could allow the new animal of introducing to enter colony house and normally raise.So-called fumigation or sootiness sterilization are to utilize fumigating disinfectant (formalin and potassium permanganate generation chemical reaction) to discharge rapidly formaldehyde gas, through certain hour killing microorganism, it is that livestock and poultry colony house is commonly used and the traditional sterilization method of effective one.Fumigating disinfectant studies have reported that very early at home, and once carried out a large amount of laboratories and on-the-spot sterilization research.More successful fumigating disinfectant or the sour chlorine fumigating disinfectant taking chlorine-containing disinfectant as sterilization component, in research report thereafter, a lot of similar gas and sootiness disinfectant preparation are also there is successively, but all fumigating disinfectants all do not solve the mixed stability problem of major ingredient and auxiliary material, due to main ingredient bag distribution packaging, when application, could mix, cause such preparation to be difficult to form formal product.For example sodium dichloro cyanurate mixes composition fumigating disinfectant (sootiness king) and sym-closene powder with polyformaldehyde mix the fumigating disinfectant (aerosol bomb is again in sootiness only) forming with polyformaldehyde, owing to mixing, rear stability is poor, can there is slow hypergolic reaction, in a packaging, main materials and auxiliary materials must separately be packed.Similar utility model patent " fumigation smoke grenade " (application number is CN201120210181.2), still do not solve the mixed stability problem of main ingredient, therefore cannot form monobasic packaging, the host of fumigating disinfectant is equipped with in one of them bag of chamber, and the assistant agent of fumigating disinfectant is equipped with in another bag of chamber.Patent of invention " a kind of Youlvjing disinfecting agent (also claiming lucky distant board Youlvjing disinfecting agent) and application thereof " (application number is CN200810071823.8), formed by sodium dichloro cyanurate, adipic acid, potassium permanganate, rosin, precipitated calcium carbonate, sodium acetate and seven kinds of composition mixed preparing of auxiliary material, be respectively Babysafe, adipic acid, potassium permanganate, rosin, precipitated calcium carbonate, sodium acetate and auxiliary material (as plant amylum) etc.The disinfectant that this invention relates to, because auxiliary material composition is too much, auxiliary material ratio is large, and the content of sterilization main component reduces, its process complexity, Disinfection Effect is also had a greatly reduced quality.In sum, up at present, still form without satisfied formal sootiness sterile products, " People's Republic of China's veterinary drug allusion quotation " do not record any fumigation preparation yet.In addition, the applied traditional fumigation method in its feeding field is divided into two kinds, and a kind of is the sterilization method of formaldehyde and potassium permanganate generation oxidation reaction; Another kind is that polyformaldehyde adds water to be placed on and in container, directly puts the upper heating volatilization of fire sterilization.In the smog that above fumigation is produced, not only contain chlorine; also contain a large amount of formaldehyde; the latency that remains contaminated environment, animal products and threaten staff's safety and Health, but also there is serious potential safety hazard, be unfavorable for forming the formal sterile products of large-scale production.2004 formalin (formaldehyde) be decided to be carcinogen by the World Health Organization, easily cause respiratory disease, a lot of breeding enterprises seldom use.Potassium permanganate, because rise in price cost was higher in recent years, adds that low-quality goods (containing quantity not sufficient) also seldom uses.
Summary of the invention
Object of the present invention is exactly for above-mentioned defect of the prior art, provides a kind of composition simple, and processing is convenient, and main ingredient mixing rear stability is good, and to environment and the free of contamination fumigation pharmaceutical composition for animals of product.
To achieve these goals, technical scheme provided by the invention is:
A kind of fumigation pharmaceutical composition for animals, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9-9.5 weight portion, potassium permanganate 0.25-0.45 weight portion, hexa, 0.05-0.75 weight portion.
Further, above-mentioned one fumigation pharmaceutical composition for animals, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9.3 weight portions, potassium permanganate 0.3 weight portion, hexa 0.4 weight portion.
Second object of the present invention, has been to provide a kind of preparation method of fumigation pharmaceutical composition for animals, is to take each component according to above-mentioned weight proportion, after mixing, with aluminum plastic film packaging bag packing.
The 3rd object of the present invention, has been to provide the application of above-mentioned a kind of fumigation pharmaceutical composition for animals in poultry house sterilization.
Further, above-mentioned application, that described fumigation pharmaceutical composition for animals is placed in to container, evenly divide and be put in each position in poultry house, effective sterilization dose in every cubic metre of space is 6 grams, in every 100 grams of fumigation pharmaceutical compositions for animals, adds 10 milliliters of hot water, and hot water temperature is 80 DEG C, after speeding away, airtight poultry house is more than 24 hours, ventilation.
Beneficial effect of the present invention is: one provided by the invention fumigation pharmaceutical composition for animals, be mainly used in the conventional fumigation of livestock and poultry colony house, and solve the following shortcoming of prior art:
1, fumigation pharmaceutical composition for animals provided by the present invention has overcome formaldehyde gas and the pollution of reaction residue to environment, animal product and the harmful effect to producers that similar traditional sootiness disinfectant preparation produces, environmental protection more compared with existing product;
2, fumigation pharmaceutical composition for animals provided by the present invention is only made up of three kinds of raw materials, main ingredient can evenly mix, without bag distribution packaging, have good stability, solved existing similar sootiness disinfectant preparation auxiliary material too much and major ingredient and the immiscible drawback of auxiliary material in production and processing, transportation;
3, fumigation pharmaceutical composition for animals provided by the present invention is compared with existing similar fumigating disinfectant, when use, lights without naked light, only with a small amount of more than 80 DEG C hot water, " product mist " reaction can occur, and stores, transports and use safer, convenience.
In order to confirm fumigation pharmaceutical composition fumigation effect for animals provided by the present invention, successively carry out the fumigation of hen house, kind egg and feed etc.Air sterilization effect calculates by relevant air sterillization sterilizing rate (PT) computing formula of Ministry of Agriculture's " disinfectant for animals measurement specification " (viable count × 100% before the rear viable count sterilization of the front viable count-sterilization of sterilizing rate (%)=sterilization).
1. hen house on-site disinfection test:test selects 5 to amount to the vacant house of brooding that 350 cubic metres of volumes (average 70 cubic metres every) had not been sterilized for more than 30 days, as testing ground.Be divided into high, medium and low 3 groups according to drug concentration, and establish formaldehyde control group, blank group simultaneously.Fumigating method: hen house rinsed one time with clear water in stifling first 1 hour, keep 20～23 DEG C of temperature, relative moisture 70～80%, then respectively 3 houses of brooding are wherein carried out to fumigation with the present invention's fumigation pharmaceutical composition for animals with 12.0 grams every cubic metre, 6.0 grams, 3.0 grams, be put in three different positions, treat that the dense smoke people of emerging leaves, sealing door and window.Formaldehyde control group, puts three pottery pots at interior three diverse locations of house, first pours formalin into, then adds potassium permanganate, and people leaves, sealing door and window.
1.1, chicken coop air sterilization:adopt plate sedimentation.Sterilize first 1 hour, sterilize latter 24 hours, every group of essentially identical position of hen house, place three agar culture dish, simultaneously open dish lid exposes 10 minutes in air, builds immediately.Then put in 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.
Chicken coop air Disinfection Effect: the present invention's fumigation pharmaceutical composition for animals is tested with 12.0 grams every cubic metre, 6.0 grams, 3.0 grams high, normal, basic three kinds of concentration.As a result, the present invention of high, medium and low dosage fumigation pharmaceutical composition for animals is stifling, and air sterillization sterilizing rate is respectively to 94.60%, 94.81% and 94.15%, and each group difference is remarkable (P >=0.05) not; Formaldehyde control group to the disinfection rate of air be 94.27%, with not significantly (P >=0.05) of the present invention's fumigation pharmaceutical composition for animals Disinfection Effect difference.
1.2, hen house wall sterilization:mark respectively the position of 5 centimetres of two 5 cm x in the identical position of hen house wall, as sterilization front l hour and latter 24 hours wall bacterial sampling of sterilization.After aseptic cotton swab being infiltrated with 0.9% physiological saline when sampling, the respectively firmly wiping 10 times anyhow the every institute position of drawing, and constantly change swab wiping surface, clip swab is cotton to be held, and puts into sample solution, the jolting 100 times of exerting oneself, wash-out bacterium.Washing lotion is done to 5 times, 50 times dilutions with physiological saline, be inoculated in respectively on 10% serum Martin agar medium, put in 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.Result is respectively 93.88%, 92.20% and 90.00% to wall surface disinfection rate, and difference is not remarkable; Formaldehyde control group is 92.31% to the disinfection rate of wall surface, with not remarkable (P >=0.05) of the present invention's fumigation pharmaceutical composition for animals Disinfection Effect difference.
2. feed disinfection:by feed sample, be paved into 5 centimetres of sizes of 20 cm x 20 cm x in the same position in house of brooding, start fumigation, fumigation method is with 1, and humidity keeps material storehouse previous status.Before sterilization with after sterilization, adopt respectively 1.0 grams of samples, make of physiological saline after the dilution of 5 times, 50 times, 500 times, 5000 times, be seeded on plain agar medium, put 37 DEG C of insulating boxs and cultivate 24 hours, do count of bacteria.Because formaldehyde has larger toxicity and penetrating odor, therefore do not do feed disinfection check experiment.It is respectively 85.36%, 84.57% and 83.03% to feed disinfection sterilizing rate, and each group difference is not remarkable.
3. kind of egg sterilization:due to kind of egg embryo's a particularity, experimental group is selected 3.0 grams of/cubic metre of the present invention's fumigation pharmaceutical compositions for animals; Keeping 16～18 DEG C of temperature, relative moisture is 70～80%.Every cubic metre of 25 milliliters of formalin of use of control group, 12.5 grams of fumigations of potassium permanganate.Before sterilization and after sterilization, within 1 hour, 12 hours, 24 hours, take respectively 5 pieces, kind of egg, do surface bacteria cultivation and colony counting.Choose at random 60 pieces of qualified kind of eggs, be divided into experimental group, formaldehyde control group, 30 pieces every group.Plant egg sterilization and carry out in kind of egg case, method is with 1.After fumigation 1 hour, the sterilizing rate of planting egg surface was respectively 97.2%, 95.6%; Sterilize latter 12 hours, the sterilizing rate of planting egg surface is respectively 99.9% and 100%; Sterilize latter 24 hours, the sterilizing rate of planting egg surface all reaches 100%.
4. stability study:the present invention's fumigation pharmaceutical composition for animals stability observing comprises measures self-ignition point, heat endurance and bin stability.
After measured, the present invention's fumigation pharmaceutical composition for animals self-ignition point is 95 DEG C.Illustrate that this formula is at room temperature difficult for occurring spontaneous combustion.Then sample temperature is maintained to 45～51 DEG C (oil bath temperature is 48 ± 3 DEG C) in oil bath, go through 2 hours and do not play any reaction.Compared with unheated control sample, the effect of killing wax-like bacillus brood cell does not reduce.Formula briquetting packaging, after storage in 18 months, profile is not seen variation, the effect of killing wax-like bacillus brood cell does not also decline.
5. toxicity research:rat oral LD
50: 420 mg/kg, rabbit is through skin LD
50: 3160 mg/kg, eye stimulation test: 100 mg/24h, reaction is slight, belongs to low toxicity disinfectant.
conclusion:
China in poultry house, feed, incubator and the fumigation of kind egg, still adopts traditional formalin, potassium permanganate fumigation at present mostly, and environment, kind egg embryo, practitioner are had to certain harmfulness.Result of the test shows, the present invention's fumigation pharmaceutical composition for animals sterilization and formalin, potassium permanganate fumigation effect are suitable, and also have many advantages, and its development prospect is very wide, can in actual production, be applicable.
From medicinal property and sterilization method analysis, the advantage such as the present invention's fumigation pharmaceutical composition for animals has transportation safety, the flames of anger, sufficient reacting compared with methanal plus potassium permanganate fumigating, smog is dense, diffusion is good, little to toxicity to man and livestock, medicament residue is low.
Analysis of Disinfection Effect from the present invention's fumigation pharmaceutical composition for animals to feed, after sootiness, feed bacteria containing amount obviously reduces, and this has very important significance to cutting off poultry diease route of transmission tool.For the poultry house of crossing with scour without sediment motion after sky house, the conventional sterilization consumption of the present invention's fumigation pharmaceutical composition for animals is 3.0～6.0 grams of/cubic metre of spaces, airtight door window 24 hours; Planting egg sterilizes to be advisable 3.0 grams of/cubic metre stifling half an hour.
Embodiment
embodiment 1:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: sodium dichloro cyanurate 9kg, potassium permanganate 0.25kg, hexa 0.75kg, take respectively each component by formula dosage, and after mixing, for subsequent use with aluminum plastic film packaging bag packing.
Function and usage is: chlorine has high affinity to somatic cells magma, easily infiltrate cell, make the amino chlorination of magma albumen, destroy the permeability of thalline or change cell membrane, or suppress various sulfydryl enzymes and present the powerful killing action to bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, and reproduction type bacterium and brood cell, virus, fungal spore are particularly also had to extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: average 6.0 grams of this product for every cubic metre of space, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 10 milliliters of 80 DEG C of hot water, speed away after evenly splashing into disinfectant surface, airtight more than 24 hours, ventilation again, without again rinsing and can introduce its feeding.
embodiment 2:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: sodium dichloro cyanurate 9.5g, potassium permanganate 0.45g, hexa 0.05g, take respectively each component by formula dosage, and after mixing, for subsequent use with aluminum plastic film packaging bag packing.
Function and usage is: chlorine has high affinity to somatic cells magma, easily infiltrate cell, make the amino chlorination of magma albumen, destroy the permeability of thalline or change cell membrane, or suppress various sulfydryl enzymes and present the powerful killing action to bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, and reproduction type bacterium and brood cell, virus, fungal spore are particularly also had to extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: average 6.0 grams of this product for every cubic metre of space, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 10 milliliters of 80 DEG C of hot water, speed away after evenly splashing into disinfectant surface, airtight more than 24 hours, ventilation again, without again rinsing and can introduce its feeding.
embodiment 3:
A kind of fumigation pharmaceutical composition for animals, its formula consists of sodium dichloro cyanurate, potassium permanganate, hexa.
Preparation method is: 9.3 tons of sodium dichloro cyanurates, 0.3 ton, potassium permanganate, 0.4 ton of hexa, take respectively each component by formula dosage, and after mixing, for subsequent use with aluminum plastic film packaging bag packing.
Function and usage is: chlorine has high affinity to somatic cells magma, easily infiltrate cell, make the amino chlorination of magma albumen, destroy the permeability of thalline or change cell membrane, or suppress various sulfydryl enzymes and present the powerful killing action to bacterium, virus, fungi, mould, parasitic ovum, be the conventional disinfectant of animal feeding field fumigation.This product fungicidal spectrum is wide, and reproduction type bacterium and brood cell, virus, fungal spore are particularly also had to extremely strong killing action to various pathogene such as newcastle disease, bird flu, the bursa of farbricius, biography larynx, horse Garricks.Be mainly used in the fumigation of animal chicken, pigsty house, material storehouse, egg storehouse and incubator,
Usage and dosage is: average 6.0 grams of this product for every cubic metre of space, be contained in Disposable paper cup or other container, evenly divide and be put in different parts in poultry house, every 100 grams of fumigation pharmaceutical compositions for animals, add 10 milliliters of 80 DEG C of hot water, speed away after evenly splashing into disinfectant surface, airtight more than 24 hours, ventilation again, without again rinsing and can introduce its feeding.
Basic ideas of the present invention:
Along with the continuous expansion of intensive culture scale, people are also more and more strict to the selection of disinfectant.Environmental protection, safety, convenience, economy, imitate good become people select target.Fumigation pharmaceutical composition for animals is a kind of novel organochlorine fumigant, and its main component is sodium dichloro cyanurate, and sodium dichloro cyanurate is crystallization pulvis, containing available chlorine 60%.Study and confirm, its fungicidal spectrum is wide, and bacterium, virus, fungi and bacterial spore are all had and pretend use.In the time of the available chlorine of 3ppm, act on and within 30 minutes, can kill Escherichia coli more than 99.9%, within 5～30 minutes, can all kill bacterial spore effect.This product feature is that pH is lower, acts on stronger.Therefore, sodium dichloro cyanurate is as disinfection of drinking water, environment disinfected, wastewater disinfection and the extensive use already of tableware disinfection product, and the existing lot of documents of its disinfective action is recorded.Fumigation pharmaceutical composition for animals involved in the present invention, is intended to solve the defect of similar conventional smoke fumigant and makes up its deficiency in producing, transport and using.
Sodium dichloro cyanurate of the present invention is conventional disinfectant or sterilization bulk drug, for a long time, in livestock breeding industry production practices, by a certain percentage sodium dichloro cyanurate is water-soluble after, for the spraying disinfection of livestock and poultry colony house or environment " spilling " sterilization.Sodium dichloro cyanurate and solid formaldehyde mix latter made smog disinfectant preparation, in use owing to producing a large amount of formaldehyde gases, not only directly contaminated environment and animal products, and human health is also had to potential threat.In the present invention's formula, do not contain formaldehyde, and light without naked light, only can make its reaction produce chlorine with 80 DEG C of warm water, thereby play disinfective action.Said preparation, after reaction completes, is condensed into white cellular block simultaneously, can not pollute environment.
Finally it should be noted that: the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. a fumigation pharmaceutical composition for animals, it is characterized in that, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9-9.5 weight portion, potassium permanganate 0.25-0.45 weight portion, hexa 0.05-0.75 weight portion.
2. one according to claim 1 fumigation pharmaceutical composition for animals, it is characterized in that, described pharmaceutical composition is made up of following three kinds of components by weight: sodium dichloro cyanurate 9.3 weight portions, potassium permanganate 0.3 weight portion, hexa 0.4 weight portion.
3. a preparation method for fumigation pharmaceutical composition for animals, is characterized in that, is to take each component according to the weight proportion described in claim 1 or 2, after mixing, with aluminum plastic film packaging bag packing.
4. the application of a kind of fumigation pharmaceutical composition for animals according to claim 1 and 2 in poultry house sterilization.
5. application according to claim 4, it is characterized in that, that described fumigation pharmaceutical composition for animals is placed in to container, evenly divide and be put in each position in poultry house, effective sterilization dose in every cubic metre of space is 6 grams, in every 100 grams of fumigation pharmaceutical compositions for animals, adds 10 milliliters of hot water, and hot water temperature is 80 DEG C, after speeding away, airtight poultry house is more than 24 hours, ventilation.
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| CN107232131A (en) * | 2017-06-14 | 2017-10-10 | 太仓市金诸农业发展有限公司 | A kind of method for culturing pigs of energy-conserving and environment-protective |
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| CN111345265A (en) * | 2020-02-24 | 2020-06-30 | 北京德青源农业科技股份有限公司 | Method for improving hatching rate and chick viability of Tibetan chickens in high altitude areas |
| CN114848877A (en) * | 2022-05-06 | 2022-08-05 | 顺丰航空有限公司 | Automatic bulk cargo killing channel |
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