CN102482214B - 制备4-(乙酰基氨基)-3-[(4-氯-苯基)硫基]-2-甲基-1h-吲哚-1-乙酸的中间体和方法 - Google Patents
制备4-(乙酰基氨基)-3-[(4-氯-苯基)硫基]-2-甲基-1h-吲哚-1-乙酸的中间体和方法 Download PDFInfo
- Publication number
- CN102482214B CN102482214B CN201080039492.5A CN201080039492A CN102482214B CN 102482214 B CN102482214 B CN 102482214B CN 201080039492 A CN201080039492 A CN 201080039492A CN 102482214 B CN102482214 B CN 102482214B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- formula
- salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*(*)(C(C)=O)c1cccc2c1C(Nc(cc1)ccc1N)=C(C)*2CC(OC)=O Chemical compound C*(*)(C(C)=O)c1cccc2c1C(Nc(cc1)ccc1N)=C(C)*2CC(OC)=O 0.000 description 5
- UEEZJXIMEVAFPP-UHFFFAOYSA-N CC1N(CC(O)=O)c2cccc(NC(C)=O)c2C1(C)Sc(cc1)ccc1Cl Chemical compound CC1N(CC(O)=O)c2cccc(NC(C)=O)c2C1(C)Sc(cc1)ccc1Cl UEEZJXIMEVAFPP-UHFFFAOYSA-N 0.000 description 1
- UPXZLQCKZWLZRO-FMIVXFBMSA-N Cc1cc(/C(/CCC2)=N/O)c2[n]1CC(O)=O Chemical compound Cc1cc(/C(/CCC2)=N/O)c2[n]1CC(O)=O UPXZLQCKZWLZRO-FMIVXFBMSA-N 0.000 description 1
- CVPYWZLGRGEGHN-UHFFFAOYSA-N Cc1cc(C(CCC2)=O)c2[n]1CC(O)=O Chemical compound Cc1cc(C(CCC2)=O)c2[n]1CC(O)=O CVPYWZLGRGEGHN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22316309P | 2009-07-06 | 2009-07-06 | |
| US61/223,163 | 2009-07-06 | ||
| PCT/GB2010/051100 WO2011004182A1 (en) | 2009-07-06 | 2010-07-05 | Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1h-indole-1-acetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102482214A CN102482214A (zh) | 2012-05-30 |
| CN102482214B true CN102482214B (zh) | 2014-08-27 |
Family
ID=42780497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080039492.5A Expired - Fee Related CN102482214B (zh) | 2009-07-06 | 2010-07-05 | 制备4-(乙酰基氨基)-3-[(4-氯-苯基)硫基]-2-甲基-1h-吲哚-1-乙酸的中间体和方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8227622B2 (enExample) |
| EP (1) | EP2451780B1 (enExample) |
| JP (1) | JP5675800B2 (enExample) |
| KR (1) | KR101752932B1 (enExample) |
| CN (1) | CN102482214B (enExample) |
| AR (1) | AR077457A1 (enExample) |
| AU (1) | AU2010270050B9 (enExample) |
| BR (1) | BR112012000353B1 (enExample) |
| CA (1) | CA2767132C (enExample) |
| ES (1) | ES2426679T3 (enExample) |
| IL (1) | IL217088A0 (enExample) |
| MX (1) | MX2012000229A (enExample) |
| RU (1) | RU2551852C2 (enExample) |
| SG (1) | SG177286A1 (enExample) |
| TW (1) | TW201118067A (enExample) |
| WO (1) | WO2011004182A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104817544B (zh) * | 2015-03-23 | 2017-05-10 | 三峡大学 | 一种四氢吲哚‑4‑酮肟类药物，制备方法及其应用 |
| JP6472419B2 (ja) * | 2015-09-30 | 2019-02-20 | 富士フイルム株式会社 | 芳香族化合物の製造方法 |
| JP6452584B2 (ja) * | 2015-09-30 | 2019-01-16 | 富士フイルム株式会社 | 芳香族化合物の製造方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1795174A (zh) * | 2003-05-27 | 2006-06-28 | 阿斯利康(瑞典)有限公司 | 新型取代的3－硫吲哚 |
| CN101102999A (zh) * | 2005-01-13 | 2008-01-09 | 阿斯利康(瑞典)有限公司 | 制备取代的吲哚的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| WO2001032621A1 (en) | 1999-10-29 | 2001-05-10 | Wakunaga Pharmaceutical Co., Ltd. | Novel indole derivatives and drugs containing the same as the active ingredient |
| TWI317634B (en) | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| GB0428100D0 (en) | 2004-12-23 | 2005-01-26 | Astrazeneca Ab | Chemical processes & intermediates |
| GB0500643D0 (en) | 2005-01-13 | 2005-02-23 | Renovo Ltd | Medicaments |
| GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| JP2009538289A (ja) | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | ビアリールまたはヘテロアリール置換インドール |
| CA2654026A1 (en) | 2006-06-08 | 2007-12-13 | Neurokey A/S | Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia |
| CA2656150A1 (en) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | New cxcr2 inhibitors |
-
2010
- 2010-07-05 BR BR112012000353-4A patent/BR112012000353B1/pt not_active IP Right Cessation
- 2010-07-05 SG SG2011094166A patent/SG177286A1/en unknown
- 2010-07-05 CA CA2767132A patent/CA2767132C/en not_active Expired - Fee Related
- 2010-07-05 EP EP10752114.8A patent/EP2451780B1/en not_active Not-in-force
- 2010-07-05 MX MX2012000229A patent/MX2012000229A/es active IP Right Grant
- 2010-07-05 CN CN201080039492.5A patent/CN102482214B/zh not_active Expired - Fee Related
- 2010-07-05 KR KR1020127000311A patent/KR101752932B1/ko not_active Expired - Fee Related
- 2010-07-05 WO PCT/GB2010/051100 patent/WO2011004182A1/en not_active Ceased
- 2010-07-05 TW TW099122052A patent/TW201118067A/zh unknown
- 2010-07-05 ES ES10752114T patent/ES2426679T3/es active Active
- 2010-07-05 AU AU2010270050A patent/AU2010270050B9/en not_active Ceased
- 2010-07-05 RU RU2012103466/04A patent/RU2551852C2/ru active
- 2010-07-05 JP JP2012519061A patent/JP5675800B2/ja not_active Expired - Fee Related
- 2010-07-06 AR ARP100102423A patent/AR077457A1/es unknown
- 2010-07-06 US US12/830,577 patent/US8227622B2/en not_active Expired - Fee Related
-
2011
- 2011-12-19 IL IL217088A patent/IL217088A0/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1795174A (zh) * | 2003-05-27 | 2006-06-28 | 阿斯利康(瑞典)有限公司 | 新型取代的3－硫吲哚 |
| CN101102999A (zh) * | 2005-01-13 | 2008-01-09 | 阿斯利康(瑞典)有限公司 | 制备取代的吲哚的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201118067A (en) | 2011-06-01 |
| JP2012532186A (ja) | 2012-12-13 |
| BR112012000353A2 (pt) | 2017-06-13 |
| JP5675800B2 (ja) | 2015-02-25 |
| IL217088A0 (en) | 2012-02-29 |
| US8227622B2 (en) | 2012-07-24 |
| WO2011004182A1 (en) | 2011-01-13 |
| AU2010270050A1 (en) | 2012-02-02 |
| CA2767132C (en) | 2017-06-20 |
| SG177286A1 (en) | 2012-02-28 |
| AU2010270050B9 (en) | 2013-06-27 |
| US20110046394A1 (en) | 2011-02-24 |
| AU2010270050B2 (en) | 2013-06-06 |
| CN102482214A (zh) | 2012-05-30 |
| ES2426679T3 (es) | 2013-10-24 |
| RU2012103466A (ru) | 2013-08-20 |
| EP2451780B1 (en) | 2013-06-19 |
| KR101752932B1 (ko) | 2017-07-03 |
| RU2551852C2 (ru) | 2015-05-27 |
| EP2451780A1 (en) | 2012-05-16 |
| AR077457A1 (es) | 2011-08-31 |
| MX2012000229A (es) | 2012-01-25 |
| HK1169404A1 (en) | 2013-01-25 |
| CA2767132A1 (en) | 2011-01-13 |
| BR112012000353B1 (pt) | 2020-06-02 |
| KR20120030525A (ko) | 2012-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140827 Termination date: 20210705 |
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| CF01 | Termination of patent right due to non-payment of annual fee |