KR101752932B1 - 4-(아세틸아미노))-3-［(4-클로로-페닐)티오］-2-메틸-1ｈ-인돌-1-아세트산의 중간체 및 그의 제조 방법 - Google Patents

4-(아세틸아미노))-3-［(4-클로로-페닐)티오］-2-메틸-1ｈ-인돌-1-아세트산의 중간체 및 그의 제조 방법 Download PDF

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Publication number
KR101752932B1
KR101752932B1 KR1020127000311A KR20127000311A KR101752932B1 KR 101752932 B1 KR101752932 B1 KR 101752932B1 KR 1020127000311 A KR1020127000311 A KR 1020127000311A KR 20127000311 A KR20127000311 A KR 20127000311A KR 101752932 B1 KR101752932 B1 KR 101752932B1
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South Korea
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alkyl
formula
compound
hydrogen
methyl
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Korean (ko)
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KR20120030525A (ko
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데브라 에인지
마이클 부터스
에릭 메리필드
라비 라마크리쉬난
라비 나이두 라야파티
파할라드 레이 샤르마
콜린 톰슨
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아스트라제네카 아베
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020127000311A 2009-07-06 2010-07-05 4-(아세틸아미노))-3-［(4-클로로-페닐)티오］-2-메틸-1ｈ-인돌-1-아세트산의 중간체 및 그의 제조 방법 Expired - Fee Related KR101752932B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22316309P 2009-07-06 2009-07-06
US61/223,163 2009-07-06
PCT/GB2010/051100 WO2011004182A1 (en) 2009-07-06 2010-07-05 Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1h-indole-1-acetic acid

Publications (2)

Publication Number Publication Date
KR20120030525A KR20120030525A (ko) 2012-03-28
KR101752932B1 true KR101752932B1 (ko) 2017-07-03

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KR1020127000311A Expired - Fee Related KR101752932B1 (ko) 2009-07-06 2010-07-05 4-(아세틸아미노))-3-［(4-클로로-페닐)티오］-2-메틸-1ｈ-인돌-1-아세트산의 중간체 및 그의 제조 방법

Country Status (16)

Country Link
US (1) US8227622B2 (enExample)
EP (1) EP2451780B1 (enExample)
JP (1) JP5675800B2 (enExample)
KR (1) KR101752932B1 (enExample)
CN (1) CN102482214B (enExample)
AR (1) AR077457A1 (enExample)
AU (1) AU2010270050B9 (enExample)
BR (1) BR112012000353B1 (enExample)
CA (1) CA2767132C (enExample)
ES (1) ES2426679T3 (enExample)
IL (1) IL217088A0 (enExample)
MX (1) MX2012000229A (enExample)
RU (1) RU2551852C2 (enExample)
SG (1) SG177286A1 (enExample)
TW (1) TW201118067A (enExample)
WO (1) WO2011004182A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104817544B (zh) * 2015-03-23 2017-05-10 三峡大学 一种四氢吲哚‑4‑酮肟类药物，制备方法及其应用
JP6472419B2 (ja) * 2015-09-30 2019-02-20 富士フイルム株式会社 芳香族化合物の製造方法
JP6452584B2 (ja) * 2015-09-30 2019-01-16 富士フイルム株式会社 芳香族化合物の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005537265A (ja) 2002-07-17 2005-12-08 アストラゼネカ・アクチエボラーグ インドール−３−硫黄誘導体
JP2007501269A (ja) 2003-05-27 2007-01-25 アストラゼネカ・アクチエボラーグ 新規３位硫黄置換インドール

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
WO2001032621A1 (en) 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Novel indole derivatives and drugs containing the same as the active ingredient
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
GB0428100D0 (en) 2004-12-23 2005-01-26 Astrazeneca Ab Chemical processes & intermediates
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB0500643D0 (en) 2005-01-13 2005-02-23 Renovo Ltd Medicaments
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
JP2009538289A (ja) 2006-05-26 2009-11-05 アストラゼネカ・アクチエボラーグ ビアリールまたはヘテロアリール置換インドール
CA2654026A1 (en) 2006-06-08 2007-12-13 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
CA2656150A1 (en) 2006-06-28 2008-01-03 Sanofi-Aventis New cxcr2 inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005537265A (ja) 2002-07-17 2005-12-08 アストラゼネカ・アクチエボラーグ インドール−３−硫黄誘導体
JP2007501269A (ja) 2003-05-27 2007-01-25 アストラゼネカ・アクチエボラーグ 新規３位硫黄置換インドール

Also Published As

Publication number Publication date
TW201118067A (en) 2011-06-01
JP2012532186A (ja) 2012-12-13
BR112012000353A2 (pt) 2017-06-13
JP5675800B2 (ja) 2015-02-25
IL217088A0 (en) 2012-02-29
US8227622B2 (en) 2012-07-24
WO2011004182A1 (en) 2011-01-13
AU2010270050A1 (en) 2012-02-02
CA2767132C (en) 2017-06-20
SG177286A1 (en) 2012-02-28
AU2010270050B9 (en) 2013-06-27
US20110046394A1 (en) 2011-02-24
CN102482214B (zh) 2014-08-27
AU2010270050B2 (en) 2013-06-06
CN102482214A (zh) 2012-05-30
ES2426679T3 (es) 2013-10-24
RU2012103466A (ru) 2013-08-20
EP2451780B1 (en) 2013-06-19
RU2551852C2 (ru) 2015-05-27
EP2451780A1 (en) 2012-05-16
AR077457A1 (es) 2011-08-31
MX2012000229A (es) 2012-01-25
HK1169404A1 (en) 2013-01-25
CA2767132A1 (en) 2011-01-13
BR112012000353B1 (pt) 2020-06-02
KR20120030525A (ko) 2012-03-28

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