CN102470135A - 抑制jak途径的组合物和方法 - Google Patents

抑制jak途径的组合物和方法 Download PDF

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Publication number
CN102470135A
CN102470135A CN2010800344786A CN201080034478A CN102470135A CN 102470135 A CN102470135 A CN 102470135A CN 2010800344786 A CN2010800344786 A CN 2010800344786A CN 201080034478 A CN201080034478 A CN 201080034478A CN 102470135 A CN102470135 A CN 102470135A
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CN
China
Prior art keywords
compound
eye
compounds
disease
acid
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CN2010800344786A
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English (en)
Chinese (zh)
Inventor
V·泰勒
李慧
R·辛格
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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Priority to CN201610848344.7A priority Critical patent/CN106420756A/zh
Publication of CN102470135A publication Critical patent/CN102470135A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN2010800344786A 2009-07-28 2010-07-28 抑制jak途径的组合物和方法 Pending CN102470135A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610848344.7A CN106420756A (zh) 2009-07-28 2010-07-28 抑制jak途径的组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22919109P 2009-07-28 2009-07-28
US61/229,191 2009-07-28
PCT/US2010/043592 WO2011017178A1 (en) 2009-07-28 2010-07-28 Compositions and methods for inhibition of the jak pathway

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610848344.7A Division CN106420756A (zh) 2009-07-28 2010-07-28 抑制jak途径的组合物和方法

Publications (1)

Publication Number Publication Date
CN102470135A true CN102470135A (zh) 2012-05-23

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010800344786A Pending CN102470135A (zh) 2009-07-28 2010-07-28 抑制jak途径的组合物和方法
CN201610848344.7A Pending CN106420756A (zh) 2009-07-28 2010-07-28 抑制jak途径的组合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610848344.7A Pending CN106420756A (zh) 2009-07-28 2010-07-28 抑制jak途径的组合物和方法

Country Status (11)

Country Link
US (1) US20110028503A1 (enExample)
EP (1) EP2459195A1 (enExample)
JP (1) JP5738292B2 (enExample)
KR (1) KR101740076B1 (enExample)
CN (2) CN102470135A (enExample)
AU (3) AU2010281404A1 (enExample)
BR (1) BR112012002001A2 (enExample)
CA (1) CA2768543C (enExample)
MX (1) MX337849B (enExample)
RU (1) RU2557982C2 (enExample)
WO (1) WO2011017178A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105636590A (zh) * 2013-10-21 2016-06-01 日本烟草产业株式会社 眼病的治疗剂或预防剂
CN110573157A (zh) * 2017-05-01 2019-12-13 施万生物制药研发Ip有限责任公司 使用jak抑制剂化合物的治疗方法

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US9040061B2 (en) * 2011-12-08 2015-05-26 Rigel Pharmaceuticals, Inc. Topical formulation for administering a compound
US20140370060A1 (en) * 2012-02-02 2014-12-18 The University Of Sydney Tear Film Stability
CA2884710A1 (en) 2012-09-12 2014-03-20 Rigel Pharmaceuticals, Inc. Treatment for vitiligo
US20140206708A1 (en) * 2013-01-24 2014-07-24 Rigel Pharmaceuticals, Inc. Composition for ophthalmic administration
US20160022648A1 (en) 2013-03-13 2016-01-28 Santen Pharmaceutical Co., Ltd. Therapeutic agent for meibomian gland dysfunction
US9556148B2 (en) 2013-08-07 2017-01-31 Cadila Healthcare Limited N-cyanomethylamides as inhibitors of janus kinase
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
CN107805212B (zh) * 2017-11-03 2021-08-20 宿迁德威化工股份有限公司 一种2-甲基-5-氨基苯磺酰胺的制备方法
BR112022001418A2 (pt) 2019-08-08 2022-06-07 Rigel Pharmaceuticals Inc Compostos e método para tratar a síndrome de liberação de citocinas
CN111973599A (zh) * 2020-08-07 2020-11-24 杭州邦顺制药有限公司 用于眼部疾病治疗的化合物
TW202317550A (zh) 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN105636590A (zh) * 2013-10-21 2016-06-01 日本烟草产业株式会社 眼病的治疗剂或预防剂
CN105636590B (zh) * 2013-10-21 2019-01-01 日本烟草产业株式会社 眼病的治疗剂或预防剂
CN110573157A (zh) * 2017-05-01 2019-12-13 施万生物制药研发Ip有限责任公司 使用jak抑制剂化合物的治疗方法
CN110573157B (zh) * 2017-05-01 2023-04-04 施万生物制药研发Ip有限责任公司 使用jak抑制剂化合物的治疗方法

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KR20120089449A (ko) 2012-08-10
BR112012002001A2 (pt) 2016-05-10
MX337849B (es) 2016-03-09
AU2010281404A1 (en) 2012-02-09
AU2018217196A1 (en) 2018-08-30
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JP5738292B2 (ja) 2015-06-24
WO2011017178A1 (en) 2011-02-10

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