CN102458462B - 一种温度敏感的猪肺炎支原体疫苗株及其应用 - Google Patents

一种温度敏感的猪肺炎支原体疫苗株及其应用 Download PDF

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CN102458462B
CN102458462B CN201080031403.2A CN201080031403A CN102458462B CN 102458462 B CN102458462 B CN 102458462B CN 201080031403 A CN201080031403 A CN 201080031403A CN 102458462 B CN102458462 B CN 102458462B
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vaccine
putative
mycoplasma hyopneumoniae
strain
protein
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CN102458462A (zh
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R·尤伟尔
Y·艾博斯艾尔奥斯塔
G·布朗宁
P·马克姆
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University of Melbourne
Bioproperties Pty Ltd
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Bioproperties Pty Ltd
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CN201080031403.2A 2009-05-19 2010-05-19 一种温度敏感的猪肺炎支原体疫苗株及其应用 Active CN102458462B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009902255 2009-05-19
AU2009902255A AU2009902255A0 (en) 2009-05-19 Bacterial strain, vaccine and uses thereof
PCT/AU2010/000590 WO2010132932A1 (en) 2009-05-19 2010-05-19 A temperature sensitive vaccine strain of mycoplasma hyopneumoniae and uses thereof

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CN102458462A CN102458462A (zh) 2012-05-16
CN102458462B true CN102458462B (zh) 2014-03-19

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US (1) US8524252B2 (enExample)
EP (1) EP2453913B1 (enExample)
JP (1) JP5744852B2 (enExample)
KR (1) KR101734590B1 (enExample)
CN (1) CN102458462B (enExample)
AU (1) AU2010251761B2 (enExample)
BR (1) BRPI1010679B1 (enExample)
CA (1) CA2762587C (enExample)
CL (1) CL2011002923A1 (enExample)
DK (1) DK2453913T3 (enExample)
EA (1) EA021102B1 (enExample)
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PE (1) PE20120909A1 (enExample)
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Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
EA201291175A1 (ru) 2010-05-19 2013-06-28 Байопропертис Пти Лтд. Способы, относящиеся к аттенуированной микоплазме
EP2684959A1 (en) * 2012-07-10 2014-01-15 Laboratorios Hipra, S.A. Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
CN104685057B (zh) * 2012-07-10 2019-04-16 海博莱科学有限公司 用于转化猪肺炎支原体的载体，转化的猪肺炎支原体菌株及其用途
UA121193C2 (uk) 2012-12-28 2020-04-27 Бьорінгер Інгельхайм Ветмедіка Гмбх Спосіб одержання імуногенної композиції проти мікоплазми
JP6195630B2 (ja) 2012-12-28 2017-09-13 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ マイコプラズマ抗原を含む免疫原性組成物
EP2913947B1 (en) * 2014-02-27 2019-11-27 ADVA Optical Networking SE Passive optical network and optical line terminal
KR20160099223A (ko) * 2015-02-12 2016-08-22 강원대학교산학협력단 마이코플라스마 하이오뉴모니애 박테린 백신 및 이의 제조방법
US10071149B2 (en) 2016-05-03 2018-09-11 Brigham Young University Temperature sensitive multivalent Bordetella avium vaccines
CN113278575B (zh) * 2021-07-13 2021-12-31 南华大学 一种肺炎支原体减毒突变株及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1461338A (zh) * 2000-07-27 2003-12-10 明尼苏达大学评议会 猪肺炎支原体温度敏感型活疫苗
CN1489472A (zh) * 2000-12-19 2004-04-14 改良型猪肺炎支原体菌苗疫苗
CN1612749A (zh) * 2001-07-02 2005-05-04 辉瑞产品公司 用于减弱牲畜体内牛支原体肺炎的猪肺炎支原体疫苗和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN178995A0 (en) * 1995-03-16 1995-04-13 University Of Melbourne, The Antigen composition
CN1100871C (zh) * 1999-06-25 2003-02-05 江苏省农业科学院畜牧兽医研究所 猪肺炎支原体克隆致弱株
US6673567B2 (en) * 2000-03-23 2004-01-06 E. I. Du Pont De Nemours And Company Method of determination of gene function
US7691368B2 (en) * 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
CA2644195A1 (en) * 2006-03-03 2007-09-13 Merial Limited Mycoplasma hyopneumoniae vaccine
ME01000B (me) * 2007-11-06 2012-10-20 Zoetis Services Llc Živa vakcina avirulentne mycoplasma hyopneumoniae sa adjuvansom
PT2475384T (pt) * 2009-09-10 2016-11-17 Merial Inc Novas formulações de vacina que compreendem ajuvantes contendo saponina
US9324223B2 (en) 2012-06-08 2016-04-26 3M Innovative Properties Company Electronic monitoring home unit and installation methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1461338A (zh) * 2000-07-27 2003-12-10 明尼苏达大学评议会 猪肺炎支原体温度敏感型活疫苗
CN1489472A (zh) * 2000-12-19 2004-04-14 改良型猪肺炎支原体菌苗疫苗
CN1612749A (zh) * 2001-07-02 2005-05-04 辉瑞产品公司 用于减弱牲畜体内牛支原体肺炎的猪肺炎支原体疫苗和方法

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AU2010251761B2 (en) 2014-10-09
BRPI1010679A2 (pt) 2017-07-18
AU2010251761A1 (en) 2011-12-22
PE20120909A1 (es) 2012-08-19
JP5744852B2 (ja) 2015-07-08
CL2011002923A1 (es) 2012-08-31
EA021102B1 (ru) 2015-04-30
KR101734590B1 (ko) 2017-05-11
US8524252B2 (en) 2013-09-03
EP2453913B1 (en) 2016-06-22
EA201190311A1 (ru) 2012-06-29
MX2011012362A (es) 2012-04-19
ZA201109185B (en) 2012-09-26
CA2762587C (en) 2017-11-28
KR20120016282A (ko) 2012-02-23
CA2762587A1 (en) 2010-11-25
BRPI1010679B1 (pt) 2020-09-24
JP2012527218A (ja) 2012-11-08
CN102458462A (zh) 2012-05-16
WO2010132932A1 (en) 2010-11-25
NZ596722A (en) 2013-08-30
DK2453913T3 (en) 2016-07-25
ES2579935T3 (es) 2016-08-17
US20120135040A1 (en) 2012-05-31
EP2453913A1 (en) 2012-05-23
EP2453913A4 (en) 2013-10-30

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