CN102448476A - 器官和组织的脱细胞化和再细胞化 - Google Patents

器官和组织的脱细胞化和再细胞化 Download PDF

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CN102448476A
CN102448476A CN2010800248990A CN201080024899A CN102448476A CN 102448476 A CN102448476 A CN 102448476A CN 2010800248990 A CN2010800248990 A CN 2010800248990A CN 201080024899 A CN201080024899 A CN 201080024899A CN 102448476 A CN102448476 A CN 102448476A
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decellularized
cells
organ
liver
heart
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D·泰勒
H·奥特
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University of Minnesota System
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University of Minnesota System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone

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  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
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CN2010800248990A 2009-03-31 2010-03-31 器官和组织的脱细胞化和再细胞化 Pending CN102448476A (zh)

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US21161309P 2009-03-31 2009-03-31
US61/211,613 2009-03-31
PCT/US2010/029463 WO2010120539A2 (en) 2009-03-31 2010-03-31 Decellularization and recellularization of organs and tissues

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EP (1) EP2413946A2 (enExample)
JP (7) JP2012522511A (enExample)
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CN (1) CN102448476A (enExample)
AU (1) AU2010236855C1 (enExample)
CA (1) CA2757457C (enExample)
IL (1) IL215463A0 (enExample)
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CN103751843A (zh) * 2013-12-05 2014-04-30 南方医科大学珠江医院 制备全肝脏生物支架的试剂盒及全肝脏生物支架制备方法
CN103966092A (zh) * 2014-04-10 2014-08-06 欧东波 器官脱细胞循环灌流再生培养瓶
CN106148270A (zh) * 2015-04-13 2016-11-23 中国科学院大连化学物理研究所 一种用于生物人工肝支持系统的三维微肝组织单元的构建方法
CN106267345A (zh) * 2016-08-04 2017-01-04 中国人民解放军第三军医大学第附属医院 一种具有生物活性的再生期器官去细胞生物支架的制备方法及其产品和应用
CN106693055A (zh) * 2015-07-26 2017-05-24 复旦大学附属华山医院 一种小脑脱细胞再生生物支架及其制备方法和用途
CN107096070A (zh) * 2017-03-09 2017-08-29 中国医学科学院阜外医院 一种脱细胞肺支架及其制备方法
CN107412865A (zh) * 2016-10-27 2017-12-01 浙江保尔曼生物科技有限公司 高强度的具有抗凝血功能的去细胞化肾脏生物支架及制备方法
CN108465126A (zh) * 2018-05-25 2018-08-31 中国人民解放军总医院 模拟生理过程的膀胱脱细胞基质的制备装置
CN114949357A (zh) * 2022-05-20 2022-08-30 上海市第十人民医院 一种阴茎脱细胞支架及其制备方法和应用
CN117100912A (zh) * 2023-06-08 2023-11-24 北京科昕恒业生物科技有限公司 一种肺脏脱细胞基质及其制备方法

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US20120064537A1 (en) * 2010-06-30 2012-03-15 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
EP2611472B1 (en) 2010-09-01 2016-02-10 Regents of the University of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
JP6158175B2 (ja) * 2011-05-27 2017-07-05 デピュイ・シンセス・プロダクツ・インコーポレイテッド バイオ人工近位尿細管システム及びその使用方法
CN103173920B (zh) * 2011-12-26 2014-08-27 广野精机有限公司 纬纱输送控线装置
EP2809152B1 (en) 2012-02-01 2019-11-20 Nayacure Therapeutics Ltd Method for inducing immune tolerance to organ transplants
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US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
US10111740B2 (en) 2012-08-21 2018-10-30 Regents Of The University Of Minnesota Decellularized biologically-engineered tubular grafts
US11284987B2 (en) 2013-01-09 2022-03-29 Biostage, Inc. Synthetic scaffolds
KR20230061578A (ko) * 2013-03-15 2023-05-08 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
US9888680B2 (en) 2013-04-04 2018-02-13 The Trustees Of Columbia University In The City Of New York Functional recovery of human lungs for transplantation
RU2539918C1 (ru) * 2013-11-29 2015-01-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ получения тканеспецифического матрикса для тканевой инженерии паренхиматозного органа
KR101637548B1 (ko) 2013-12-24 2016-07-20 연세대학교 산학협력단 세포 배양 및 세포 분화를 위한 탈세포화 기관 매트릭스 동결건조 분쇄물 및 이의 제조 방법
CN117694335A (zh) 2014-03-14 2024-03-15 通用医疗公司 肺生物反应器
WO2015181245A1 (en) * 2014-05-27 2015-12-03 Novahep Ab Bioengineered allogeneic valve
CA3217634A1 (en) 2014-09-02 2016-03-10 United Therapeutics Corporation Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system
US20170240854A1 (en) * 2014-09-23 2017-08-24 Nanyang Technological University A bioreactor module, a bioreactor system and methods for thick tissue seeding and cultivation in an hirearchical organization and physiological mimiking conditions
JP2016185115A (ja) * 2015-03-27 2016-10-27 シスメックス株式会社 臓器灌流方法および臓器灌流装置
CN104771788B (zh) * 2015-05-05 2017-08-25 北京帝康医药投资管理有限公司 一种基于大网膜脱细胞基质的组织工程皮肤及其构建方法
CN108699513B (zh) 2015-09-11 2022-03-18 通用医疗公司 功能性肺血管床的再生
WO2017136786A1 (en) * 2016-02-05 2017-08-10 The Trustees Of Columbia University In The City Of New York Rigionally specific tissua-derived extracellular metrix
KR20180133253A (ko) 2016-04-05 2018-12-13 리젠츠 오브 더 유니버시티 오브 미네소타 조직에 매립되어 있는 구조적 구성요소를 갖는 공학처리된 조직, 및 제조 및 사용하는 방법
ITUA20164238A1 (it) * 2016-06-09 2017-12-09 G F S P A Metodo e apparato per la decellularizzazione di organi
CN107621462B (zh) * 2016-07-13 2020-03-31 王志伟 一种组织透明化液sut及其制备和应用
WO2018048899A1 (en) * 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering
US12227727B2 (en) * 2018-02-28 2025-02-18 Pop Test Oncology Llc Medical devices and uses thereof
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
WO2020158794A1 (ja) * 2019-01-30 2020-08-06 国立大学法人 長崎大学 疾患モデル
AU2020241583A1 (en) * 2019-03-21 2021-10-14 Miromatrix Medical Inc. Improved decellularization of isolated organs
WO2020243298A1 (en) 2019-05-28 2020-12-03 Regents Of The University Of Minnesota An engineered valve and method of making
WO2021034911A1 (en) * 2019-08-19 2021-02-25 Miromatrix Medical Inc. Sealing of decellularized and recellularized engineered organ grafts
CA3191775A1 (en) * 2020-09-04 2022-03-10 Narendra R. Vyavahare Systems and methods for processing tissue
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
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WO2007025233A1 (en) * 2005-08-26 2007-03-01 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues

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