CN102428185B - 破囊壶菌、脂肪酸组合物和其制备方法及用途 - Google Patents
破囊壶菌、脂肪酸组合物和其制备方法及用途 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
- C12N1/125—Unicellular algae isolates
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C12P7/6432—Eicosapentaenoic acids [EPA]
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
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Abstract
Description
破囊壶菌 | 相同性% |
科格仑斯奥兰壶菌(Aplanochytrium kerguelense) | 100 |
斯托凯奥兰壶菌(Aplanochytrium stocchinoi) | 100 |
麦尼日本壶菌 | 100 |
拉普利壶菌(Labyrinthula)N8 | 100 |
破囊壶菌RT49 | 100 |
黃金石斛破囊壶菌 | 100 |
破囊壶菌HU1 | 100 |
奥雷姆破囊壶菌 | 100 |
凯尼破囊壶菌(Thraustochytrium kinnei) | 100 |
破囊壶菌#32 | 100 |
破囊壶菌PW19 | 100 |
黃金石斛裂殖壶菌 | 100 |
裂殖壶菌ATCC 20888 | 100 |
生物质 | 粗制油 | 甾醇酯 | TAG | FFA | DAG | |
脂肪酸 | %FAME | %FAME | %FAME | %FAME | %FAME | %FAME |
C12:0<sup>*</sup> | 0.1 | 0.0 | 0.4 | 0.3 | 0.3 | 0.0 |
C14:0<sup>*</sup> | 1.4 | 1.5 | 2.9 | 2.1 | 2.1 | 2.2 |
C14:1<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C15:0 | 0.3 | 0.4 | 0.7 | 0.3 | 0.3 | 0.3 |
C16:0<sup>*</sup> | 25.8 | 25.6 | 51.0 | 28.6 | 29.6 | 28.6 |
C16:1<sup>*</sup> | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 |
C18:0<sup>*</sup> | 1.6 | 1.8 | 9.9 | 1.8 | 1.6 | 1.8 |
C18:1 N9<sup>*</sup> | 0.0 | 0.4 | 0.4 | 0.3 | 0.2 | 0.4 |
C18:1 N7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C18:2 N6<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:0<sup>*</sup> | 0.4 | 0.6 | 3.0 | 0.5 | 0.3 | 0.4 |
C18:3 N3<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C18:4 N3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 |
C20:2 N6<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:3 N6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:0<sup>*</sup> | 0.0 | 0.1 | 1.7 | 0.1 | 0.0 | 0.1 |
C20:4 N7 | 0.0 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 |
C20:3 N3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N6<sup>*</sup> | 0.3 | 0.4 | 0.0 | 0.3 | 0.3 | 0.2 |
C22:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N3 | 0.4 | 0.4 | 0.4 | 0.4 | 0.3 | 0.3 |
C20:5 N3<sup>*</sup> | 4.5 | 4.2 | 0.8 | 4.0 | 4.9 | 5.4 |
C24:0<sup>*</sup> | 0.0 | 0.0 | 1.4 | 0.0 | 0.0 | 0.0 |
C22:4 N9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C24:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:5 N6<sup>*</sup> | 2.9 | 3.2 | 2.1 | 2.8 | 2.4 | 2.4 |
C22:5 N3<sup>*</sup> | 0.3 | 0.5 | 0.2 | 0.4 | 0.5 | 0.3 |
C22:6 N3<sup>*</sup> | 62.0 | 61.0 | 24.6 | 58.1 | 56.9 | 57.4 |
FAME%的总和 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
生物质 | 粗制油 | 甾醇酯 | TAG | FFA | DAG | |
脂肪酸 | %FAME | %FAME | %FAME | %FAME | %FAME | %FAME |
C12:0<sup>*</sup> | 0.1 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 |
C14:0<sup>*</sup> | 1.4 | 1.4 | 2.4 | 1.5 | 1.3 | 0.8 |
C14:1<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C15:0 | 0.3 | 0.4 | 0.8 | 0.4 | 0.3 | 0.3 |
C16:0<sup>*</sup> | 25.8 | 25.2 | 50.7 | 25.9 | 21.9 | 20.4 |
C16:1<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 |
C18:0<sup>*</sup> | 1.6 | 1.8 | 6.5 | 1.8 | 1.5 | 0.8 |
C18:1 N9<sup>*</sup> | 0.0 | 0.8 | 1.4 | 0.5 | 0.3 | 0.4 |
C18:1 N7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C18:2 N6<sup>*</sup> | 0.0 | 0.2 | 0.2 | 0.2 | 0.1 | 0.8 |
C20:0<sup>*</sup> | 0.4 | 0.6 | 3.3 | 0.6 | 0.4 | 0.2 |
C18:3 N3<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C18:4 N3 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 |
C20:2 N6<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:3 N6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:0<sup>*</sup> | 0.0 | 0.1 | 1.7 | 0.1 | 0.1 | 0.0 |
C20:4 N7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:3 N3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N6<sup>*</sup> | 0.3 | 0.3 | 0.0 | 0.3 | 0.3 | 0.2 |
C22:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N3 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.2 |
C20:5 N3<sup>*</sup> | 4.5 | 4.2 | 0.7 | 4.1 | 5.4 | 6.8 |
C24:0<sup>*</sup> | 0.0 | 0.0 | 1.3 | 0.1 | 0.0 | 0.0 |
C22:4 N9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C24:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:5 N6<sup>*</sup> | 2.9 | 3.0 | 2.4 | 3.1 | 2.5 | 2.2 |
C22:5 N3<sup>*</sup> | 0.3 | 0.4 | 0.0 | 0.4 | 0.3 | 0.3 |
C22:6 N3<sup>*</sup> | 62.0 | 61.2 | 28.2 | 60.4 | 65.1 | 66.5 |
FAME%的总和 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
最终油 | 甾醇酯 | TAG | FFA | 甾醇 | DAG | |
脂肪酸 | %FAME | %FAME | %FAME | %FAME | %FAME | %FAME |
C12:0<sup>*</sup> | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | 0.1 |
C14:0<sup>*</sup> | 1.2 | 0.9 | 1.2 | 0.9 | 1.2 | 0.8 |
C14:1<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C15:0 | 0.2 | 0.0 | 0.2 | 0.2 | 0.2 | 0.3 |
C16:0<sup>*</sup> | 19.6 | 14.0 | 18.7 | 14.5 | 18.7 | 17.9 |
C16:1<sup>*</sup> | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.1 |
C18:0<sup>*</sup> | 2.1 | 3.1 | 2.0 | 1.1 | 2.0 | 0.9 |
C18:1 N9<sup>*</sup> | 26.0 | 42.4 | 25.8 | 9.1 | 23.9 | 11.4 |
C18:1 N7 | 0.2 | 0.3 | 0.2 | 0.1 | 0.2 | 0.1 |
C18:2 N6<sup>*</sup> | 1.5 | 1.0 | 1.4 | 0.9 | 1.8 | 1.2 |
C20:0<sup>*</sup> | 0.5 | 1.1 | 0.5 | 0.2 | 0.5 | 0.2 |
C18:3 N3<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 |
C18:4 N3 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.1 |
C20:2 N6<sup>*</sup> | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 |
C20:3 N6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:0<sup>*</sup> | 0.4 | 10.7 | 0.3 | 0.2 | 0.4 | 0.2 |
C20:4 N7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:3 N3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N6<sup>*</sup> | 0.2 | 0.0 | 0.2 | 0.2 | 0.2 | 0.2 |
C22:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C20:4 N3 | 0.3 | 0.8 | 0.3 | 0.3 | 0.3 | 0.2 |
C20:5 N3<sup>*</sup> | 3.0 | 0.5 | 2.9 | 5.6 | 3.2 | 5.9 |
C24:0<sup>*</sup> | 0.2 | 11.2 | 0.1 | 0.0 | 0.2 | 0.1 |
C22:4 N9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C24:1 N9<sup>*</sup> | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
C22:5 N6<sup>*</sup> | 2.1 | 1.3 | 2.2 | 1.5 | 2.2 | 1.9 |
C22:5 N3<sup>*</sup> | 0.3 | 0.0 | 0.3 | 0.5 | 0.4 | 0.4 |
C22:6 N3<sup>*</sup> | 43.6 | 12.7 | 43.1 | 64.5 | 44.0 | 58.1 |
FAME%的总和 | 100 | 100 | 100 | 100 | 100 | 100 |
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