EA201190218A1 - Траустохитридиевые композиции жирных кислот и способы их получения и применения - Google Patents

Траустохитридиевые композиции жирных кислот и способы их получения и применения

Info

Publication number
EA201190218A1
EA201190218A1 EA201190218A EA201190218A EA201190218A1 EA 201190218 A1 EA201190218 A1 EA 201190218A1 EA 201190218 A EA201190218 A EA 201190218A EA 201190218 A EA201190218 A EA 201190218A EA 201190218 A1 EA201190218 A1 EA 201190218A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compositions
trausothitrid
receiving
application
Prior art date
Application number
EA201190218A
Other languages
English (en)
Other versions
EA030161B1 (ru
Inventor
Кирк Е. Эпт
Джозеф В. Пфайфер III
Джон Милтон Хансен
Пол Уоррен Беренс
Росс Зиркл
Трейси Линн Шталь
Original Assignee
Мартек Байосайенсиз Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42739887&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201190218(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мартек Байосайенсиз Корпорейшн filed Critical Мартек Байосайенсиз Корпорейшн
Publication of EA201190218A1 publication Critical patent/EA201190218A1/ru
Publication of EA030161B1 publication Critical patent/EA030161B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Abstract

Изобретение относится к выделенным траустохитридиевым микроорганизмам, а также к их штаммам и мутантам. Настоящее изобретение также относится к биомассе, жирам микробного происхождения, композициям, культурам, способам получения микробных жиров и способам применения выделенных траустохитрид, биомасс и жиров микробного происхождения.
EA201190218A 2009-03-19 2009-03-19 Траустохитридиевые, композиции жирных кислот и способы их получения и применения EA030161B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/001720 WO2010107415A1 (en) 2009-03-19 2009-03-19 Thraustochytrids, fatty acid compositions, and methods of making and uses thereof

Publications (2)

Publication Number Publication Date
EA201190218A1 true EA201190218A1 (ru) 2012-07-30
EA030161B1 EA030161B1 (ru) 2018-06-29

Family

ID=42739887

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190218A EA030161B1 (ru) 2009-03-19 2009-03-19 Траустохитридиевые, композиции жирных кислот и способы их получения и применения

Country Status (17)

Country Link
EP (6) EP2408922B1 (ru)
JP (1) JP5762393B2 (ru)
KR (1) KR101861375B1 (ru)
CN (2) CN109609562A (ru)
AU (2) AU2009342676B2 (ru)
BR (1) BRPI0923968B1 (ru)
CA (1) CA2754952C (ru)
DK (3) DK3530740T3 (ru)
EA (1) EA030161B1 (ru)
ES (3) ES2895261T3 (ru)
IL (1) IL215141A0 (ru)
MX (2) MX2011009750A (ru)
NZ (3) NZ703725A (ru)
PL (1) PL2408922T3 (ru)
SG (1) SG174383A1 (ru)
WO (1) WO2010107415A1 (ru)
ZA (1) ZA201107517B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2895261T3 (es) 2009-03-19 2022-02-18 Dsm Ip Assets Bv Composiciones de ácidos grasos de traustoquítridos y métodos de fabricación y usos de las mismas
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
KR20150013667A (ko) 2010-01-19 2015-02-05 디에스엠 아이피 어셋츠 비.브이. 에이코사펜타엔산 생산 미생물, 지방산 조성물 및 이의 제조방법 및 용도
EP2576801B1 (en) 2010-06-01 2019-10-02 DSM IP Assets B.V. Extraction of lipid from cells and products therefrom
KR102149068B1 (ko) 2011-07-21 2020-08-31 디에스엠 아이피 어셋츠 비.브이. 지방산 조성물
SG10201605966TA (en) * 2011-07-21 2016-09-29 Dsm Ip Assets Bv Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
AU2014369040B2 (en) 2013-12-20 2019-12-05 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
SG11201605033UA (en) 2013-12-20 2016-07-28 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
TWI698520B (zh) 2013-12-20 2020-07-11 荷蘭商Ｄｓｍ智慧財產有限公司 用於從微生物細胞獲得微生物油之方法（三）
KR102426987B1 (ko) 2013-12-20 2022-07-28 디에스엠 아이피 어셋츠 비.브이. 미생물 세포로부터의 미생물 오일의 수득 방법
CN103725617A (zh) * 2014-01-01 2014-04-16 北京大学深圳研究生院 一株富含甘油酯型DHA的破囊壶菌Aurantiochytrium sp.及其应用
CN113278529B (zh) * 2014-05-22 2023-10-10 合成基因组股份有限公司 用于生产二十二碳六烯酸的网粘菌纲菌株
CN104206864A (zh) * 2014-08-28 2014-12-17 青岛海智源生命科技有限公司 一种富含二十二碳六烯酸的饲料
CN106998742A (zh) * 2014-12-12 2017-08-01 帝斯曼知识产权资产管理有限公司 用于水产养殖饲料中的饲料补充物质
FR3038913B1 (fr) * 2015-07-17 2020-05-01 Fermentalg Biomasse de thraustochytrides, procede de culture et utilisations
FR3038914B1 (fr) * 2015-07-17 2020-03-13 Fermentalg Biomasse de thraustochytrides, procede de culture et utilisations
WO2017131188A1 (ja) * 2016-01-28 2017-08-03 日本水産株式会社 高度不飽和脂肪酸を含む油脂の製造方法
US11419350B2 (en) 2016-07-01 2022-08-23 Corbion Biotech, Inc. Feed ingredients comprising lysed microbial cells
GB201718423D0 (en) * 2017-11-07 2017-12-20 Polglase Jane Lesley Microorganism
FR3085825B1 (fr) 2018-09-14 2021-07-16 Fermentalg Huile de microorganismes riche en acide docosahexaenoique
FR3085962B1 (fr) 2018-09-14 2021-06-18 Fermentalg Procede d'extracton d'une huile riche en pufa
MX2021008018A (es) 2019-01-03 2021-12-10 Corbion Biotech Inc Procedimiento para la fabricacion de suspension de celulas lisadas.
FR3111912A1 (fr) 2020-06-24 2021-12-31 Fermentalg Procédé de culture de microorganismes pour l’accumulation de lipides
SE2151489A1 (en) * 2021-12-07 2023-06-08 Mycorena Ab A food product or food ingredient comprising fungi biomass with an increased intracellular fat content

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451567B1 (en) * 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5407957A (en) 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
ATE264099T1 (de) 1993-06-09 2004-04-15 Martek Biosciences Corp Für die behandlung neurologischer erkrankungen nützliche methoden und pharmazeutische zusammensetzungen
US20050027004A1 (en) 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
US6582941B1 (en) 1995-04-17 2003-06-24 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
AU6252196A (en) * 1995-06-07 1996-12-30 Martek Biosciences Corporation Methods for controlling highly unsaturated fatty acid content in various tissues
CN1217029A (zh) 1996-03-28 1999-05-19 吉斯特-布罗卡迪斯股份有限公司 从用巴氏法灭菌的生物量中制备含有微生物多不饱和脂肪酸的油的方法
WO1998003671A1 (en) * 1996-07-23 1998-01-29 Nagase Biochemicals, Ltd. Process for preparing docosahexaenoic acid and docosapentaenoic acid
ATE305048T1 (de) 1997-08-01 2005-10-15 Martek Biosciences Corp Dha-enthaltende naehrzusammensetzungen und verfahren zu deren herstellung
JP4283351B2 (ja) 1998-08-27 2009-06-24 サントリー酒類株式会社 新規な油脂組成物の製造方法および用途
AU3001400A (en) 1999-02-26 2000-09-14 Monsanto Company Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides
CN100460513C (zh) 2000-01-19 2009-02-11 马泰克生物科学公司 无溶剂的提取方法
DE10151155A1 (de) 2001-10-19 2003-05-08 Nutrinova Gmbh Native PUFA-Triglyceridmischungen mit einem hohen Gehalt an mehrfach ungesättigten Fettsäuren sowie Verfahren zu deren Herstellung und deren Verwendung
BR0314799A (pt) * 2002-09-27 2005-07-26 Market Biosciences Corp Controle glicêmico aperfeiçoado para pré-diabetes e/ou diabetes do tipo ii usando ácido docosahexaenóico
JP4280158B2 (ja) 2002-12-27 2009-06-17 富士フイルム株式会社 ドコサヘキサエン酸生産能を有する微生物及びその利用
EP1605930B1 (en) * 2003-03-27 2020-06-03 Suntory Holdings Limited Use of arachidonic acid for normalization of infradian rhythm
CN1264967C (zh) * 2004-12-08 2006-07-19 中国海洋大学 海洋真菌裂殖壶菌ouc88的工业应用
DE102005003625A1 (de) 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Herstellung einer DHA-haltigen Fettsäure-Zusammensetzung
EP2630869B1 (en) 2005-07-01 2016-12-14 DSM IP Assets B.V. Polyunsaturated fatty acid-containing oil product and uses and production thereof
US9145534B2 (en) * 2006-07-28 2015-09-29 Bioriginal Food & Science Corporation Fat containing composition
JP5531324B2 (ja) 2006-08-01 2014-06-25 ディーエスエム ニュートリショナル プロダクツ アーゲー 油生産微生物およびその改変方法
US20100086979A1 (en) * 2006-10-27 2010-04-08 Thomas Kiy Production of omega-3 fatty acids in microflora of thraustochytriales using modified media
CL2008002020A1 (es) 2007-07-12 2008-11-14 Ocean Nutrition Canada Ltd Metodo de modificacion de un aceite, que comprende hidrolizar gliceridos con una solucion de lipasa thermomyces lanuginosus, separar la fraccion de acido graso saturado de la fraccion de glicerido hidrolizado y esterificar los gliceridos hidrolizados en la presencia de candida antarctica lipasa b; y composicion de aceite.
TWI337229B (en) 2007-08-27 2011-02-11 Htc Corp Portable electronic apparatus with dual hinges
ES2895261T3 (es) 2009-03-19 2022-02-18 Dsm Ip Assets Bv Composiciones de ácidos grasos de traustoquítridos y métodos de fabricación y usos de las mismas

Also Published As

Publication number Publication date
EP4353826A2 (en) 2024-04-17
EP2408922B1 (en) 2016-08-10
DK3530740T3 (da) 2021-10-18
NZ613586A (en) 2015-06-26
AU2016203427A1 (en) 2016-06-16
EP3926050A1 (en) 2021-12-22
MX356532B (es) 2018-06-01
DK3196309T3 (da) 2019-11-25
EP2408922A4 (en) 2013-06-05
AU2009342676B2 (en) 2016-02-25
EP3530740A1 (en) 2019-08-28
EP3530740B1 (en) 2021-07-28
NZ595599A (en) 2013-12-20
NZ703725A (en) 2017-06-30
AU2009342676A1 (en) 2011-11-03
ES2757878T3 (es) 2020-04-30
WO2010107415A1 (en) 2010-09-23
CN109609562A (zh) 2019-04-12
SG174383A1 (en) 2011-11-28
BRPI0923968A2 (pt) 2015-07-21
KR20110128944A (ko) 2011-11-30
CN102428185B (zh) 2020-07-10
CN102428185A (zh) 2012-04-25
EP3196309B1 (en) 2019-09-04
JP5762393B2 (ja) 2015-08-12
CA2754952A1 (en) 2010-09-23
PL2408922T3 (pl) 2017-02-28
EA030161B1 (ru) 2018-06-29
ES2602121T3 (es) 2017-02-17
JP2012520673A (ja) 2012-09-10
EP3196309A3 (en) 2017-09-06
KR101861375B1 (ko) 2018-05-25
EP4183883A1 (en) 2023-05-24
ES2895261T3 (es) 2022-02-18
BRPI0923968B1 (pt) 2020-04-28
AU2016203427B2 (en) 2018-03-22
IL215141A0 (en) 2011-12-29
MX2011009750A (es) 2011-09-29
ZA201107517B (en) 2012-06-27
CA2754952C (en) 2018-11-06
EP3196309A2 (en) 2017-07-26
DK2408922T3 (en) 2016-12-05
EP2408922A1 (en) 2012-01-25
BRPI0923968A8 (pt) 2018-11-06

Similar Documents

Publication Publication Date Title
EA201190218A1 (ru) Траустохитридиевые композиции жирных кислот и способы их получения и применения
EA201290656A1 (ru) Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот и способы их получения и применения
EA201400151A1 (ru) Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот, способы их получения и применения
EA201201278A1 (ru) Штаммы дрожжей и их использование при производстве липидов
WO2011127409A3 (en) Methods and compositions related to fatty alcohol biosynthetic enzymes
EA201200091A1 (ru) Штаммы talaromyces и ферментные композиции
CO6351813A2 (es) "metodos y composiciones para mejorar la produccion de productos en microorganismos"
TR201903336T4 (tr) Fermantasyonda gelişmiş karbon yakalama.
EA201101626A1 (ru) Бактерии с высокоэффективным метаболизмом
MY158663A (en) Fermentation broth formulations
MX2014003212A (es) Microorganismos y metodos para producir alquenos.
EA201270151A1 (ru) Способы и композиции для рекомбинантного биосинтеза h-алканов
EA201070605A1 (ru) Применение бактерий для производства биоэнергии
BR112013028621A2 (pt) "microalgas oleaginosas recombinantes, método para produzir biomassa de microalga ou um produto produzido da biomassa, e método para produzir uma composição lipídica de microalga".
MX2011004049A (es) Produccion de etanol en microorganismos.
EA201291487A1 (ru) Переработка биомассы
EA201101213A1 (ru) Композиции и способы деградации лигноцеллюлозной биомассы
BRPI0914440A8 (pt) Método para produção biogênica de etanol e cianobactéria geneticamente modificada
MX2015007361A (es) Produccion mediada por la proteina portadora de acilo de los derivados de acidos grasos.
MX336787B (es) Microorganismos deseñados geneticamente que comprenden 4-hidroxibenzoil-coa tioesterasas y metodos de uso de los mismos para producir acidos grasos libes y derivados de acidos grasos.
MX2017012554A (es) Microalgas adaptadas para condiciones de cultivo heterotrofo.
TN2012000275A1 (en) Process for the production of bio-oil from phototrophic and heterotrophic algae
MY152262A (en) Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
MX2019007315A (es) Metodos para producir biomasa rica en dha, acido palmitico y proteinas con un microorganismo eucariota.
MY174023A (en) Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM