CN102414207B - 氟化氨基三唑衍生物 - Google Patents

氟化氨基三唑衍生物 Download PDF

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Publication number
CN102414207B
CN102414207B CN201080018293.6A CN201080018293A CN102414207B CN 102414207 B CN102414207 B CN 102414207B CN 201080018293 A CN201080018293 A CN 201080018293A CN 102414207 B CN102414207 B CN 102414207B
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methyl
ethyl
oxazole
difluoro
carboxylic acid
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Expired - Fee Related
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CN102414207A (zh
Inventor
丹尼尔·布尔
奥利维尔·考米波夫
塞尔文·库恩
科琳娜·格里索斯托米
泽维尔·莱罗尔
西尔维娅·里卡德-比尔德斯滕
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Aidu West Pharmaceutical Co Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
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  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
CN201080018293.6A 2009-06-09 2010-06-07 氟化氨基三唑衍生物 Expired - Fee Related CN102414207B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009052445 2009-06-09
IBPCT/IB2009/052445 2009-06-09
PCT/IB2010/052509 WO2010143116A1 (en) 2009-06-09 2010-06-07 Fluorinated aminotriazole derivatives

Publications (2)

Publication Number Publication Date
CN102414207A CN102414207A (zh) 2012-04-11
CN102414207B true CN102414207B (zh) 2015-09-30

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CN201080018293.6A Expired - Fee Related CN102414207B (zh) 2009-06-09 2010-06-07 氟化氨基三唑衍生物

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US (1) US8580831B2 (OSRAM)
EP (1) EP2440555B1 (OSRAM)
JP (2) JP5095035B2 (OSRAM)
KR (1) KR101444559B1 (OSRAM)
CN (1) CN102414207B (OSRAM)
AR (1) AR077032A1 (OSRAM)
AU (1) AU2010258334B2 (OSRAM)
BR (1) BRPI1010738A8 (OSRAM)
CA (1) CA2760588C (OSRAM)
CL (1) CL2011003097A1 (OSRAM)
ES (1) ES2587139T3 (OSRAM)
IL (1) IL216792A (OSRAM)
MA (1) MA33420B1 (OSRAM)
MX (1) MX342440B (OSRAM)
MY (1) MY161243A (OSRAM)
NZ (1) NZ597453A (OSRAM)
PL (1) PL2440555T3 (OSRAM)
RU (1) RU2544862C2 (OSRAM)
SG (1) SG175363A1 (OSRAM)
TW (1) TWI404717B (OSRAM)
WO (1) WO2010143116A1 (OSRAM)
ZA (1) ZA201200127B (OSRAM)

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MX2010006241A (es) 2007-12-18 2010-06-30 Actelion Pharmaceuticals Ltd Derivados de aminotriazol como agonistas de alx.
DK2432760T3 (da) 2009-05-18 2013-09-08 Actelion Pharmaceuticals Ltd Brokoblede spiro [2.4]-heptanderivater som alx-receptor og/eller fprl2-agonister
EP2440536B1 (en) 2009-06-12 2013-11-06 Actelion Pharmaceuticals Ltd. Oxazole and thiazole derivatives as ALX receptor agonists
CA2814826C (en) 2010-11-17 2019-02-12 Actelion Pharmaceuticals Ltd Bridged spiro[2.4]heptane ester derivatives
KR101864463B1 (ko) * 2010-12-07 2018-06-04 이도르시아 파마슈티컬스 리미티드 Alx 수용체 작용제로서의 옥사졸릴-메틸에테르 유도체
AU2011340103A1 (en) * 2010-12-07 2013-07-25 Actelion Pharmaceuticals Ltd. Hydroxylated aminotriazole derivatives as ALX receptor agonists
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
TW201348219A (zh) 2012-05-16 2013-12-01 Actelion Pharmaceuticals Ltd 作爲ａｌｘ受體激動劑之經１－（對－甲苯基）環丙基取代橋聯螺［２．４］庚烷衍生物
MY169986A (en) 2012-06-04 2019-06-19 Idorsia Pharmaceuticals Ltd Benzimidazole-proline derivatives
AR092955A1 (es) 2012-10-10 2015-05-06 Actelion Pharmaceuticals Ltd Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)-pirrolidin-1-il]-metanona
WO2014141065A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
WO2014174704A1 (ja) * 2013-04-22 2014-10-30 国立大学法人東京大学 炎症性疾患の予防又は治療剤
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
RU2016105310A (ru) 2013-07-18 2017-08-23 Актелион Фармасьютиклз Лтд Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
JP6421185B2 (ja) 2013-12-04 2018-11-07 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ベンゾイミダゾール−プロリン誘導体の使用
KR20220162640A (ko) 2021-06-01 2022-12-08 주식회사 에즈큐리스 신규 옥사졸 유도체 및 이를 포함하는 알러지성 질환의 예방 또는 치료용 약학적 조성물

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