CL2011003097A1 - Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras. - Google Patents
Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras.Info
- Publication number
- CL2011003097A1 CL2011003097A1 CL2011003097A CL2011003097A CL2011003097A1 CL 2011003097 A1 CL2011003097 A1 CL 2011003097A1 CL 2011003097 A CL2011003097 A CL 2011003097A CL 2011003097 A CL2011003097 A CL 2011003097A CL 2011003097 A1 CL2011003097 A1 CL 2011003097A1
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- Prior art keywords
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- pharmaceutical composition
- diseases
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2009052445 | 2009-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011003097A1 true CL2011003097A1 (es) | 2012-07-06 |
Family
ID=42371383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011003097A CL2011003097A1 (es) | 2009-06-09 | 2011-12-07 | Compuestos derivados fluorados de amino-triazol, agonistas del receptor alx; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para el tratamiento de enfermedades inflamatorias, enfermedades obstructivas de las vias respiratorias, trastornos cardiovasculares y otras. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8580831B2 (OSRAM) |
| EP (1) | EP2440555B1 (OSRAM) |
| JP (2) | JP5095035B2 (OSRAM) |
| KR (1) | KR101444559B1 (OSRAM) |
| CN (1) | CN102414207B (OSRAM) |
| AR (1) | AR077032A1 (OSRAM) |
| AU (1) | AU2010258334B2 (OSRAM) |
| BR (1) | BRPI1010738A8 (OSRAM) |
| CA (1) | CA2760588C (OSRAM) |
| CL (1) | CL2011003097A1 (OSRAM) |
| ES (1) | ES2587139T3 (OSRAM) |
| IL (1) | IL216792A (OSRAM) |
| MA (1) | MA33420B1 (OSRAM) |
| MX (1) | MX342440B (OSRAM) |
| MY (1) | MY161243A (OSRAM) |
| NZ (1) | NZ597453A (OSRAM) |
| PL (1) | PL2440555T3 (OSRAM) |
| RU (1) | RU2544862C2 (OSRAM) |
| SG (1) | SG175363A1 (OSRAM) |
| TW (1) | TWI404717B (OSRAM) |
| WO (1) | WO2010143116A1 (OSRAM) |
| ZA (1) | ZA201200127B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| SI2225231T1 (sl) | 2007-12-18 | 2011-12-30 | Actelion Pharmaceuticals Ltd | Derivati aminotriazola kot alx agonisti |
| TWI490190B (zh) | 2009-05-18 | 2015-07-01 | Actelion Pharmaceuticals Ltd | 橋聯螺〔２．４〕庚烷衍生物 |
| ES2440790T3 (es) * | 2009-06-12 | 2014-01-30 | Actelion Pharmaceuticals Ltd. | Derivados de oxazol y tiazol como agonistas del receptor del ALX |
| JP5917541B2 (ja) | 2010-11-17 | 2016-05-18 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 架橋スピロ［２．４］ヘプタンエステル誘導体 |
| KR101847672B1 (ko) * | 2010-12-07 | 2018-04-10 | 이도르시아 파마슈티컬스 리미티드 | Alx 수용체 작용제로서의 히드록실화 아미노트리아졸 유도체 |
| ES2526132T3 (es) | 2010-12-07 | 2015-01-07 | Actelion Pharmaceuticals Ltd. | Derivados de oxazolil-metiléter como agonistas del receptor de ALX |
| JP6101788B2 (ja) | 2012-05-16 | 2017-03-22 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ＡＬＸ受容体アゴニストとしての１−（ｐ−トリル）シクロプロピル置換架橋スピロ［２．４］ヘプタン誘導体 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| HRP20170351T1 (hr) | 2012-06-04 | 2017-04-21 | Actelion Pharmaceuticals Ltd. | Derivati benzimidazol-prolina |
| EP2906553B1 (en) | 2012-10-10 | 2019-06-26 | Idorsia Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero)aryl)-pyrrolidin-1-yl]-methanone derivatives |
| WO2014141065A1 (en) | 2013-03-12 | 2014-09-18 | Actelion Pharmaceuticals Ltd | Azetidine amide derivatives as orexin receptor antagonists |
| EP3560960A1 (en) | 2013-04-22 | 2019-10-30 | The University of Tokyo | Preventive or therapeutic agent for inflammatory disease |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| WO2015007830A1 (en) | 2013-07-18 | 2015-01-22 | Actelion Pharmaceuticals Ltd | Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| HRP20181710T1 (hr) | 2013-12-04 | 2018-12-28 | Idorsia Pharmaceuticals Ltd | Uporaba derivata benzimidazol-prolina |
| KR20220162640A (ko) | 2021-06-01 | 2022-12-08 | 주식회사 에즈큐리스 | 신규 옥사졸 유도체 및 이를 포함하는 알러지성 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| FR2763337B1 (fr) * | 1997-05-13 | 1999-08-20 | Sanofi Sa | Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant |
| KR20030030029A (ko) | 2000-09-22 | 2003-04-16 | 니혼노야쿠가부시키가이샤 | Ｎ-(4-피라졸릴)아미드 유도체 및 농원예용 약제 그리고그 사용방법 |
| JP2005536187A (ja) | 2002-04-03 | 2005-12-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | Ｎ−ホルミルペプチド受容体様１（ｆｐｒｌ１）に関連する疾患の診断および治療 |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| WO2005047899A2 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| US7323480B2 (en) * | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| ATE493401T1 (de) * | 2004-09-17 | 2011-01-15 | Vertex Pharma | Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen |
| US20060293288A1 (en) | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| JP2009514858A (ja) | 2005-11-03 | 2009-04-09 | メルク エンド カムパニー インコーポレーテッド | アリール−ピラゾリルモチーフを有するヒストンデアセチラーゼ阻害剤 |
| WO2009025793A2 (en) | 2007-08-21 | 2009-02-26 | Senomyx, Inc. | Human t2r bitterness receptors and uses thereof |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| SI2225231T1 (sl) * | 2007-12-18 | 2011-12-30 | Actelion Pharmaceuticals Ltd | Derivati aminotriazola kot alx agonisti |
| TWI490190B (zh) | 2009-05-18 | 2015-07-01 | Actelion Pharmaceuticals Ltd | 橋聯螺〔２．４〕庚烷衍生物 |
| ES2440790T3 (es) | 2009-06-12 | 2014-01-30 | Actelion Pharmaceuticals Ltd. | Derivados de oxazol y tiazol como agonistas del receptor del ALX |
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2010
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- 2010-06-07 MY MYPI2011005927A patent/MY161243A/en unknown
- 2010-06-07 US US13/376,966 patent/US8580831B2/en not_active Expired - Fee Related
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- 2010-06-07 SG SG2011078706A patent/SG175363A1/en unknown
- 2010-06-07 AU AU2010258334A patent/AU2010258334B2/en not_active Ceased
- 2010-06-07 MA MA34521A patent/MA33420B1/fr unknown
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- 2010-06-07 EP EP10725500.2A patent/EP2440555B1/en not_active Not-in-force
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- 2010-06-07 KR KR1020127000486A patent/KR101444559B1/ko not_active Expired - Fee Related
- 2010-06-08 TW TW099118594A patent/TWI404717B/zh not_active IP Right Cessation
- 2010-06-09 AR ARP100102022A patent/AR077032A1/es unknown
-
2011
- 2011-12-06 IL IL216792A patent/IL216792A/en not_active IP Right Cessation
- 2011-12-07 CL CL2011003097A patent/CL2011003097A1/es unknown
-
2012
- 2012-01-06 ZA ZA2012/00127A patent/ZA201200127B/en unknown
- 2012-08-01 JP JP2012171081A patent/JP5775496B2/ja not_active Expired - Fee Related
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