KR101444559B1 - 불화 아미노트리아졸 유도체 - Google Patents

불화 아미노트리아졸 유도체 Download PDF

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Publication number
KR101444559B1
KR101444559B1 KR1020127000486A KR20127000486A KR101444559B1 KR 101444559 B1 KR101444559 B1 KR 101444559B1 KR 1020127000486 A KR1020127000486 A KR 1020127000486A KR 20127000486 A KR20127000486 A KR 20127000486A KR 101444559 B1 KR101444559 B1 KR 101444559B1
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South Korea
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methyl
ethyl
oxazole
amide
triazol
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Expired - Fee Related
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KR1020127000486A
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KR20120089380A (ko
Inventor
다니엘 부르
올리비에 꼬르망뵈프
실뱅 크렌
코리나 그리조스토미
자비에 르루아
실비아 리샤르-빌드스텡
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액테리온 파마슈티칼 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
KR1020127000486A 2009-06-09 2010-06-07 불화 아미노트리아졸 유도체 Expired - Fee Related KR101444559B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009052445 2009-06-09
WOPCT/IB2009/052445 2009-06-09
PCT/IB2010/052509 WO2010143116A1 (en) 2009-06-09 2010-06-07 Fluorinated aminotriazole derivatives

Publications (2)

Publication Number Publication Date
KR20120089380A KR20120089380A (ko) 2012-08-09
KR101444559B1 true KR101444559B1 (ko) 2014-09-26

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US (1) US8580831B2 (OSRAM)
EP (1) EP2440555B1 (OSRAM)
JP (2) JP5095035B2 (OSRAM)
KR (1) KR101444559B1 (OSRAM)
CN (1) CN102414207B (OSRAM)
AR (1) AR077032A1 (OSRAM)
AU (1) AU2010258334B2 (OSRAM)
BR (1) BRPI1010738A8 (OSRAM)
CA (1) CA2760588C (OSRAM)
CL (1) CL2011003097A1 (OSRAM)
ES (1) ES2587139T3 (OSRAM)
IL (1) IL216792A (OSRAM)
MA (1) MA33420B1 (OSRAM)
MX (1) MX342440B (OSRAM)
MY (1) MY161243A (OSRAM)
NZ (1) NZ597453A (OSRAM)
PL (1) PL2440555T3 (OSRAM)
RU (1) RU2544862C2 (OSRAM)
SG (1) SG175363A1 (OSRAM)
TW (1) TWI404717B (OSRAM)
WO (1) WO2010143116A1 (OSRAM)
ZA (1) ZA201200127B (OSRAM)

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AR069650A1 (es) 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
BRPI0821115A8 (pt) 2007-12-18 2017-12-26 Actelion Pharmaceuticals Ltd Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
HRP20130972T1 (hr) 2009-05-18 2013-11-22 Actelion Pharmaceuticals Ltd. Premošteni derivati spiro [2,4] heptana kao alx-receptori i/ili fprl2-agonisti
CA2760887A1 (en) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Oxazole and thiazole derivatives as alx receptor agonists
CA2814826C (en) 2010-11-17 2019-02-12 Actelion Pharmaceuticals Ltd Bridged spiro[2.4]heptane ester derivatives
BR112013014035A2 (pt) * 2010-12-07 2016-09-13 Actelion Pharmaceuticals Ltd derivados de aminotriazol hidroxilado como agonistas dos receptores de alx
TWI523853B (zh) * 2010-12-07 2016-03-01 艾克泰聯製藥有限公司 作為ａｌｘ受體促效劑之唑基－甲醚衍生物
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
US9284288B2 (en) 2012-05-16 2016-03-15 Actelion Pharmaceuticals Ltd. 1-(p-tolyl) cyclopropyl substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists
KR101995683B1 (ko) 2012-06-04 2019-07-02 이도르시아 파마슈티컬스 리미티드 벤즈이미다졸-프롤린 유도체
CA2885180C (en) 2012-10-10 2021-03-02 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
EP3560960A1 (en) * 2013-04-22 2019-10-30 The University of Tokyo Preventive or therapeutic agent for inflammatory disease
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
WO2015007830A1 (en) 2013-07-18 2015-01-22 Actelion Pharmaceuticals Ltd Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
UA116053C2 (uk) 2013-12-04 2018-01-25 Ідорсія Фармасьютікалз Лтд Застосування похідних бензоімідазолу-проліну
CN117396465A (zh) 2021-06-01 2024-01-12 阿斯克里斯有限公司 用于预防或治疗变应性疾病的新的噁唑衍生物和含有所述衍生物的药物组合物

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BRPI0821115A8 (pt) 2007-12-18 2017-12-26 Actelion Pharmaceuticals Ltd Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
HRP20130972T1 (hr) 2009-05-18 2013-11-22 Actelion Pharmaceuticals Ltd. Premošteni derivati spiro [2,4] heptana kao alx-receptori i/ili fprl2-agonisti
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WO2005047899A2 (en) 2003-11-07 2005-05-26 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
US20060293288A1 (en) 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases

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EP2440555B1 (en) 2016-05-18
CN102414207A (zh) 2012-04-11
JP2012255002A (ja) 2012-12-27
JP2012529491A (ja) 2012-11-22
ZA201200127B (en) 2014-06-25
MX2011012739A (es) 2011-12-16
SG175363A1 (en) 2011-12-29
PL2440555T3 (pl) 2016-11-30
TW201102383A (en) 2011-01-16
IL216792A0 (en) 2012-02-29
CN102414207B (zh) 2015-09-30
AU2010258334B2 (en) 2015-02-26
AR077032A1 (es) 2011-07-27
RU2544862C2 (ru) 2015-03-20
ES2587139T3 (es) 2016-10-20
MA33420B1 (fr) 2012-07-03
WO2010143116A1 (en) 2010-12-16
US20120101138A1 (en) 2012-04-26
NZ597453A (en) 2013-03-28
EP2440555A1 (en) 2012-04-18
IL216792A (en) 2014-05-28
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US8580831B2 (en) 2013-11-12
TWI404717B (zh) 2013-08-11
BRPI1010738A8 (pt) 2017-12-26
CL2011003097A1 (es) 2012-07-06
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